Ted Tredget
Contact
Professor, Faculty of Medicine & Dentistry - Surgery Dept
- etredget@ualberta.ca
- Phone
- (780) 407-6979
- Address
-
2D2 WMC Mackenzie Health Science Centre
8440 - 112 StEdmonton ABT6G 2B7
Overview
Area of Study / Keywords
incisional wound creation tolerability assessment pharmacokineti profile gene expression histological assessment
About
Summary of Activity: Dr. Edward (Ted) Tredget received his medical degree with distinction from the University of Alberta, Canada and completed his internship, general surgery and plastic surgery training from the University of Alberta. He undertook a Post Doctoral Fellowship at the Massachusetts Institute of Technology, Massachusetts General Hospital and Harvard Medical School where he received his Masters of Science degree. Currently, Dr. Tredget is the Director of the Firefighters' Burn Treatment Unit at the University of Alberta Hospital and the Burn Wound Healing Research Laboratory of the University of Alberta. The focus of their research is basic science research is wound healing, hypertrophic scarring and tissue engineering after burn injury. Their work has explored the cellular, proteomic and immunologic features of hypertrophic scarring using biobanked tissues, large and small animal models, and in vivoclinical trials in human volunteers and burn patients. They have developed novel models of scarring in animals and standardized scar models in humans with the goal to reduce scarring and regenerate healing wounds. Dr. Tredget is a Professor in the Department of Surgery, Divisions of Plastic & Reconstructive Surgery and Critical Care Medicine at the University of Alberta. Dr. Tredget is the Past President (2015-16) of the American Burn Association and the Canadian Society of Plastic Surgeons (2014-15).
Research
GRANTS / FUNDING (2014-19 RELEVANT TO SUBJECT)
ScarX Technologies Inc. (2016-18)
A Double Blind, Placebo Controlled, Randomized, Dose Ranging Study to Evaluate the Safety and Tolerability of SCX-001 Cream in Healthy Volunteers with Induced Dermal Incisions.
E.E. Tredget (PI) Total amount $461,216
Exciton Technologies (2013-14)
A randomized, Site-Matched Controlled Trial of exSalt PTF wound dressing compared to Xeroform Petrolatum Dressing for the Management of Partial Thickness Donor Site
E.E. Tredget (PI) Total amount $19,054
United States Department of Defense Research Grants
1. The Role of Nefopam in Hypertrophic Scarring following Burn Injury.
TE Tredget, PI, David Greenhalgh, MD (site PI),
Dates: October 2019 – Dec 2023
Budget: $3,458,000 US over 4 years
2. Acute Burn ResUscitation Prospective Multicenter Trial (ABRUPT)
David Greenhalgh, MD (PI), Robert Cartotto (CoI) TE Tredget, Site PI
Dates: October 2016 – September 2020
3. Transfusion requirements in burn care evaluation (TRIBE): A multicenter randomized prospective trial of blood transfusion in major burn injury. (completed)
Tina Palmieri (PI) TE Tredget (Site PI)
4. Glutamine supplementation in burn patients (completed Phase I, Phase II on going)
Darren Hyland(PI) TE Tredget (site PI)
OPERATING GRANTS
1. Edmonton Civic Employees (2015-16)
Therapeutic Potential of Phase-Dependent Macrophage Depletion for Dermal Fibroproliferative Disorders
E.E. Tredget (PI) Total amount $10,000
2. Klox Technologies Inc. (2014-17)
Development and Characterization of Dermal Fibrosis Following Burn Injury
E.E. Tredget (PI) Total amount $92,000
3. Edmonton Civic Employees (2014-15)
Development of a Mouse Model to Study New Therapeutic Approaches for Heterotopic Ossification in Burn Patient
E.E. Tredget (PI) Total amount $10,000
4. CIHR, Network Catalyst Grant (2014-17)
Creation of an Advancement in Burn Care in Canada Network, Multi Centre Study
E.E. Tredget (Member) Total amount $600,000
5.Canadian Institute for Health Research (2005-2008)
Fibroproliferative Disorders of the Skin: The Role of Bone Marrow Derived Stem Cells and TH1/TH2/TH3 cytokines
EE Tredget (PI), A Ghahary, PG Scott Total amount $382,881
6. Canadian Institutes of Health Research (2004-2007)
Identification and Role of Keratinocyte Derived Anti-Fibrogenic Factors in Wound Healing
A Ghahary(PI), EE Tredget$122,127 / year for 3 years Total amount $366,381
7. Alberta Heritage Foundation for Medical Research, Technology Commercialization Program (2004-2005) Methods for Prevention and Treatment of Fibroproliferative Disorders
A Ghahary(PI), EE Tredget Total amount$98,363
8. Canadian Institute for Health Research (2003-2005)
Discovery of a Novel Collagenase Stimulating Factor in Human Serum
A Ghahary(PI), EE Tredget, W Maksymowych Total amount $120,000
9. Canadian Institute for Health Research (2002-2003)
Development and Application of Non-Rejectable Skin Substitute in Wound Healing
A Ghahary(PI), EE Tredget Total amount $146,000
10. Canadian Institute for Health Research (2000-2005)
Fibroproliferative Disorders of the Skin: The role of TGF-beta and TH1/TH2 Lymphokines
EE Tredget (PI), A Ghahary, PG Scott Total amount $502,730
11. Medical Research Council of Canada (2000-2005)
Purification and Characterization of KDAF and its Functional Role in Wound Healing
A Ghahary(PI), EE Tredget Total amount $162,123
12. Medical Research Council of Canada (1999-2001)
Topical Transforming Growth Factor-beta Gene Therapy in Wound Healing
A Ghahary(PI), EE Tredget, PG Scott Total amount $186,567
Featured Publications
Eremenko E., Ding J., Kwan P., Tredget E.E.
Advances in Wound Care. 2022 May; 11 (5):234-254 10.1089/wound.2020.1257
Budden C., Donaldson E.K., Tredget E., Tsui B.C.H.
Plastic Surgery. 2022 February; 30 (1):16-19 10.1177/2292550320925911
Schaffrick L., Ding J., Kwan P., Tredget E.E.
Advances in Wound Care. 2021 December; 11 (4):163-178 10.1089/wound.2021.0060
Agrawal A., Ding J., Agrawal B., Kwan P.O., Tredget E.E.
Wound Repair and Regeneration. 2021 September; 29 (5):810-819 10.1111/wrr.12940
David G Greenhalgh, Robert Cartotto, Sandra L Taylor, Jeffrey R Fine, Giavonni M. Lewis, David J Smith, Michael A Marano, Angela Gibson, Lucy A Wibbenmeyer, James H Holmes, Julie A Rizzo, Kevin N Foster, Anjay Khandelwal, Sarah Fischer, Mark Hemmila, David Hill, Aballay Ariel, Edward Tredget, Jeremy Goverman, Herbert Phelan, Carlos J Jimenez, Anthony Baldea, Rajiv Sood
Annals of Surgery. 2021 August; 10.1097/SLA.0000000000005166
Wang J., Wang X., Xie J., Yao B., Mo M., Ma D., Huang C., Xu R., Fu X., Tredget E.E., Wu Y.
Biomedicines. 2021 April; 9 (4) 10.3390/biomedicines9040400
Vrouwe S.Q., Zuo K.J., Grotski C.H., Tredget E.E., Chew H.F., Cartotto R.
Journal of burn care & research : official publication of the American Burn Association. 2021 March; 42 (2):193-199 10.1093/jbcr/iraa126
Ding J., Mellergaard M., Zhu Z., Kwan P., Edge D., Ma Z., Hebert L., Alrobaiea S., Iwasaki T., Nielsen M.C.E., Tredget E.E.
Open Medicine (Poland). 2021 January; 16 (1):1240-1255 10.1515/med-2021-0329
Reduced Intraoperative Blood Loss and Hypothermia in Burn Surgery using Cardiopulmonary Bypass Pumps
Persad A., Mowbrey K., Tredget E.
Plastic Surgery. 2021 January; 10.1177/22925503211024744