Hélène Lemieux

Professor, Campus Saint-Jean - Soutien Académique

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Contact

Professor, Campus Saint-Jean - Soutien Académique

Email: hlne@ualberta.ca
Phone: (780) 465-8738
Address: 3-61C CSJ Pavillon McMahon
8406 Marie-Anne-Gaboury St (91 St)

Edmonton AB

T6C 4G9

Overview

Area of Study / Keywords

CSJ Researchers - Health Sciences

About

Hélène Lemieux is currently appointed as Associate Adjunct Professor in the Department of Medicine in the Faculty of Medicine & Dentistry.

Featured Publications

Fatty acid oxidation: A neglected factor in understanding the adjustment of mitochondrial function to cold temperatures

Mast H, Holody CD, Lemieux H

J. Exp. Biol.. 2022 October; Accepted

Eccentric Exercise Causes Specific Adjustment in Pyruvate Oxidation by Mitochondria

Hody S, Warren BE, Votion D-M, Rogister B, Lemieux H

Med. Sci. Sports Exerc.. 2022 August; 54 (8):1300-1308

Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways

Lemieux H, Blier PU

Metabolites. 2022 April; 12 (4):1-20

In Vitro Assays for the Assessment of Impaired Mitochondrial Bioenergetics in Equine Atypical Myopathy

Kruse C-J, Stern D, Mouithys-Mickalad A, Niesten A, Art T, Lemieux H, Votion D-M

Life (Basel). 2021 July; 11 (7)

Divergences in the Control of Mitochondrial Respiration Are Associated With Life-Span Variation in Marine Bivalves

Rodriguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU

J. Gerontol. A. Biol. Sci. Med. Sci.. 2021 April; 75 (5):796-804

Nanoparticle-encapsulated antioxidant improves placental mitochondrial function in a sexually dimorphic manner in a rat model of prenatal hypoxia

Ganguly E, Kirschenman R, Spaans F, Holody CD, Phillips TEJ, Case CP, Cooke C-LM, Murphy MP, Lemieux H, Davidge ST

FASEB J.. 2021 February; 35 (2)

Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction

Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H

Mitochondrion. 2021 January; 56

The FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial-to-mesenchymal transition and lipid-derived energy production in prostate cancer cells

Liu R-Z, Choi W-S, Jain S, Dinakaran D, Xu X, Han WH, Yang X-H, Glubrecht DD, Moore RB, Lemieux H, Godbout R

Mol. Oncol.. 2020 December; 14 (12):3100-3120

Altered mitochondrial metabolism in the insulin-resistant heart

Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux H, Dambrova M, Tepp K, Puurand M, Kaambre T, Han WH, de Goede P, O'Brien K, Turan B, Tuncay E, Olgar Y, Rolo AP, Palmeira CM, Boardman NT, Wust RCI, Larsen TS

Acta Physiol. (Oxf). 2020 March; 228 (3)

Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat

Schneider J, Han WH, Matthew R, Sauvé Y, Lemieux H

Plos One. 2020 February; 15 (2)

BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis

Mann J, Yang N, Montpetit R, Kirschenman R, Lemieux H, Goping IS

Sci. Rep.. 2020 January; 10 (1)

Disruption of Beta-Cell Mitochondrial Networks by the Orphan Nuclear Receptor Nor1/Nr4a3

Close A-F, Dadheech N, Lemieux H, Wang Q, Buteau J

Cells. 2020 January; 9 (1)

Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress

Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL

Cardiovasc. Res.. 2020 January; 116 (1):183-192

Adjustments in the control of mitochondrial respiratory capacity to tolerate temperature fluctuations

Scott KY, Matthew R, Woolcock J, Silva M, Lemieux H

J. Exp. Biol.. 2019 September; 222

The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics

Scavuzzo CJ, LeBlancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT

J. Neurophysiol.. 2019 September; 122 (3):1123-1135

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism

Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS

Oncogene. 2019 May; 38 (18):3325-3339

Cardiovascular sexual dimorphism in a diet-induced type 2 diabetes rodent model, the Nile rat (Arvicanthis niloticus)

Schneider J, Kuny S, Beker D, Sauvé Y, Lemieux H

Plos One. 2018 December; 13 (12)

Altered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy

Tosi I, Art T, Cassart D, Farnir F, Ceusters J, Serteyn D, Lemieux H, Votion D-M

J. Bioenerg. Biomembr.. 2018 October; 50 (5)

Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver

Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL

FASEB J.. 2018 June; 32 (6)

Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3)

Dejos C, Kuny S, Han WH, Capel H, Lemieux H, Sauvé Y

Sci. Rep.. 2018 April; 8 (1)

Temperature-related differences in mitochondrial function among clones of the cladoceran Daphnia pulex

Kake-Guena SA, Touisse K, Warren BE, Scott KY, Dufresne F, Blier PU, Lemieux H

J. Therm. Biol.. 2017 October; 69

Alterations in fatty acid metabolism and sirtuin signaling characterize early type‐2 diabetic hearts of fructose‐fed rats

Lou P-H, Lucchinetti E, Scott KY, Huang Y, Gandhi M, Hersberger M, Clanachan AS, Lemieux H, Zaugg M

Physiol. Rep.. 2017 August; 5 (16)

Modifications in retinal mitochondrial respiration precede type 2 diabetes and protracted microvascular retinopathy

Han WH, Gotzmann J, Kuny S, Huang H, Chan CB, Lemieux H, Sauvé Y

Invest. Ophthalmol. Vis Sci.. 2017 August; 58 (10):3826-3839

Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers

Lemieux H, Blier PU, Gnaiger E

Sci. Rep.. 2017 June; 7 (2840):DOI:10.1038/s41598-017-02789-8

Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis

Yang N, Weinfeld M, Lemieux H, Montpetit B, Goping IS

Cell Death Dis.. 2017 February; 8 (2):e2587

Mitochondrial function is altered in horse atypical myopathy

Lemieux H, Boemer F, van Galen G, Serteyn D, Amory H, Baise E, Cassart D, van Loon G, Marcillaud-Pitel C, Votion DM

Mitochondrion. 2016 September; 30 (Sep 30):35-41

Assessment of mitochondrial functions in Daphnia pulex clones using high-resolution respirometry.

Kake-Guena SA, Touisse K, Vergilino R, Dufresne F, Blier PU, Lemieux H.

Journal of Experimental Zoology Part A: Ecological Genetics and Physiology. 2015 June; 323 (5):277-342

Loss of Intralipid®- but not sevoflurane-mediated cardioprotection in early type-2 diabetic hearts of fructose-fed rats: importance of ROS signaling

Lou P-H, Lucchinetti E, Zhang L, Affolter A, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M

Plos One. 2014 August; 9 (8)

Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat

Warren BE, Lou P-H, Lucchinetti E, Zhang L, Clanachan AS, Affolter A, Hersberger M, Zaugg M, Lemieux H

Am. J. Physiol. Endocrinol. Metab.. 2014 March; 306 (6)

The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases

Lou P-H, Lucchinetti E, Zhang L, Affolter A, Schaub MC, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M

Plos One. 2014 January; 9 (1)

An animal model to study human muscular diseases involving mitochondrial oxidative phosphorylation

Lemieux H, Warren BE

J. Bioenerg. Biomembr.. 2012 August; 44 (4)

Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle

Votion D-M, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D

Plos One. 2012 April; 7 (4)

Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing

Lucchinetti E, Awad AE, Rahman M, Feng J, Lou P-H, Zhang L, Ionescu L, Lemieux H, Thébaud B, Zaugg M

Anesthesiology. 2012 April; 116 (4)

Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart

Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E

Int. J. Biochem. Cell Biol.. 2011 December; 43 (12)

Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism

Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, Anderson VE, Fujioka H, Stavnezer E

J. Biol. Chem.. 2011 November; 286 (46)

Dietary fatty acids and oxidative stress in the heart mitochondria

Lemieux H, Bulteau AL, Friguet B, Tardif J-C, Blier PU

Mitochondrion. 2011 January; 11 (1)

Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype

Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL

J. Gerontol. A. Biol. Sci. Med. Sci.. 2010 November; 65 (11)

Thermal sensitivity of oxidative phosphorylation in rat heart mitochondria: Does pyruvate dehydrogenase dictate the response to temperature?

Lemieux H, Tardif J-C, Blier PU

J. Therm. Biol.. 2010 February; 35 (2)

Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?

Rosca MG, Lemieux H, Hoppel CL

Adv. Drug Deliv. Rev.. 2009 November; 61 (14)

Mitochondria in the human heart

Lemieux H, Hoppel CL

J. Bioenerg. Biomembr.. 2009 April; 41 (2)

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Julián Aragonés 1, Martin Schneider, Katie Van Geyte, Peter Fraisl, Tom Dresselaers, Massimiliano Mazzone, Ruud Dirkx, Serena Zacchigna, Hélène Lemieux, Nam Ho Jeoung, Diether Lambrechts, Tammie Bishop, Peggy Lafuste, Antonio Diez-Juan, Sarah K Harten, Pieter Van Noten, Katrien De Bock, Carsten Willam, Marc Tjwa, Alexandra Grosfeld, Rachel Navet, Lieve Moons, Thierry Vandendriessche, Christophe Deroose, Bhathiya Wijeyekoon, Johan Nuyts, Benedicte Jordan, Robert Silasi-Mansat, Florea Lupu, Mieke Dewerchin, Chris Pugh, Phil Salmon, Luc Mortelmans, Bernard Gallez, Frans Gorus, Johan Buyse, Francis Sluse, Robert A Harris, Erich Gnaiger, Peter Hespel, Paul Van Hecke, Frans Schuit, Paul Van Veldhoven, Peter Ratcliffe, Myriam Baes, Patrick Maxwell, Peter Carmeliet

Nat. Genet.. 2008 February; 40 (2)

The early ontogeny of digestive and metabolic enzyme activities in two commercial strains of arctic charr (Salvelinus alpinus L.)

Lemieux H, Le François NR, Blier PU

J. Exp. Zool. A. Comp. Exp. Biol.. 2003 October; 299 (2)

The impact of the thermal sensitivity of cytochrome c oxidase on the respiration rate of Arctic charr red muscle mitochondria

Blier PU, Lemieux H

J. Comp. Physiol. B.. 2001 April; 171 (3)