Adetola Adesida

Area of Study / Keywords

Joint Repair Meniscus Tissue Engineering Prevention of Post-traumatic Osteoarthritis Stem Cells Scaffolds Bioreactors Tissue Engineering human meniscus cells

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About

Dr. Adetola B. Adesida is a Professor (full) in the Department of Surgery at the University of Alberta. In 1999, Dr. Adesida received his PhD in Pharmacy from the Victoria University of Manchester, studying drug delivery systems. During his postdoc at the Wellcome Trust Centre for Cell-Matrix Research at the Victoria University of Manchester, he moved into musculoskeletal tissue engineering with a focus on meniscal fibrocartilage of the knee joint. In 2006, he was awarded a dual fellowship from Harvard University and Massachusetts General Hospital to study the role of insulin-like growth factor binding proteins (IGFBPs) in the pathogenesis of osteoarthritis. In 2007, Dr. Adesida received a European Commission Marie-Curie transfer of knowledge fellowship to work on CelluCart - an industry-academia partnership project for a novel treatment of knee injuries. The project was a collaboration between CellCoTec, a development-stage orthopaedic company in the Netherlands and Tissue Engineering Group in the Department of Surgery at University Hospital Basel in Switzerland. In 2009, Dr. Adesida was appointed as an Assistant Professor in Department of Surgery at the University of Alberta. In 2013, Dr. Adesida received a CIHR award to study tissue engineering of knee meniscus using mesenchymal stem cells. In 2015, he was granted tenure at the University of Alberta. His research interests lie generally in stem cell biology, tissue engineering and regenerative medicine (TERM) strategies of the meniscus and articular cartilage.

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Research

Adetola Adesida- Laboratory of Orthopaedic Tissue Engineering
The ultimate goal of the research group is to develop autologous cell-based tissue engineering strategies to repair cartilage and meniscus defects. Adult-derived mesenchymal stem cells (MSCs) have the capacity to form a variety of mesenchymal tissues including bone, adipose and cartilage. In addition, MSCs secrete a myriad of bioactive molecules (i.e. trophic factors) that have the potency to promote cell proliferation and enhance the differentiated status of mature cells. The laboratory’s current focus is to investigate the interplay between MSCs from bone marrow (BMSCs) or adipose (ADSCs) sources, and mature cartilage cells (chondrocytes) and meniscus cells for cartilage and meniscus tissue formation. The scientific questions addressed are related to (i) optimal stem cell source of factors promoting cell proliferation and differentiation, (ii) differentiation and anatomical privilege, (iii) identification of potent bioactive molecules for chondrogenic and fibrochondrogenic differentiation, (iv) effect of oxygen tension on profiles of bioactive agents in (iii) and (v) fabrication of bioactive molecules in (iii) into clinically applicable matrices for cartilage and meniscus formation. These projects are at the interface of basic and applied research fostering the expertise and collaborative efforts of chemists, biologist, clinicians, bio-engineers and material scientists. 

37th Annual Meeting of the Canadian Biomaterials Society, Banff, Canada. 2022 May;

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International Cartilage Regeneration & Joint Preservation Society (ICRS) World Congress 2022 Berlin, Germany. 2022 April;

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International Cartilage Regeneration & Joint Preservation Society (ICRS) World Congress 2022 Berlin, Germany. 2022 April;

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Lan X., Liang Y., Vyhlidal M., Erkut E.J.N., Kunze M., Mulet-Sierra A., Osswald M., Ansari K., Seikaly H., Boluk Y., Adesida A.B.

Journal of Tissue Engineering. 2022 March; 13 10.1177/20417314221086368

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Ma Z., Li D.X., Kunze M., Mulet-Sierra A., Westover L., Adesida A.B.

Frontiers in Bioengineering and Biotechnology. 2022 February; 10 10.3389/fbioe.2022.823679

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Vyhlidal M.J., Adesida A.B.

JOURNAL OF CELLULAR PHYSIOLOGY. 2022 February; 237 (2):1171-1181 10.1002/jcp.30616

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Lan X., Ma Z., Szojka A.R.A., Kunze M., Mulet-Sierra A., Vyhlidal M.J., Boluk Y., Adesida A.B.

Frontiers in Bioengineering and Biotechnology. 2021 November; 9 10.3389/fbioe.2021.766399

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Szojka A.R.A., Li D.X., Sopcak M.E.J., Ma Z., Kunze M., Mulet-Sierra A., Adeeb S.M., Westover L., Jomha N.M., Adesida A.B.

Frontiers in Bioengineering and Biotechnology. 2021 September; 9 10.3389/fbioe.2021.739438

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Rahman S., Szojka A.R.A., Liang Y., Kunze M., Goncalves V., Mulet-Sierra A., Jomha N.M., Adesida A.B.

Frontiers in Cell and Developmental Biology. 2021 July; 9 10.3389/fcell.2021.703038

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Elkhenany H.A., Szojka A.R.A., Mulet-Sierra A., Liang Y., Kunze M., Lan X., Sommerfeldt M., Jomha N.M., Adesida A.B.

Tissue Engineering Part A. 2021 July; 27 (13-14):914-928 10.1089/ten.tea.2020.0183

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Rahman S., Szojka A.R.A., Liang Y., Kunze M., Goncalves V., Mulet-Sierra A., Jomha N.M., Adesida A.B.

Frontiers in Cell and Developmental Biology. 2021 July; 9 10.3389/fcell.2021.703038

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Baddam P., Young D., Dunsmore G., Nie C., Eaton F., Elahi S., Jovel J., Adesida A.B., Dufour A., Graf D.

Frontiers in Cell and Developmental Biology. 2021 June; 9 10.3389/fcell.2021.696545

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Canadian Lunar Workshop. Canadian Space Agency (virtual), . 2021 June;

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CSA-IRAP Colloquium "Healthcare without Boundaries" Canadian Space Agency (virtual). 2021 June;

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Lan X., Liang Y., Erkut E.J.N., Kunze M., Mulet-Sierra A., Gong T., Osswald M., Ansari K., Seikaly H., Boluk Y., Adesida A.B.

FASEB JOURNAL. 2021 March; 35 (3) 10.1096/fj.202002081R

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Szojka A.R.A., Moore C.N., Liang Y., Andrews S.H.J., Kunze M., Mulet-Sierra A., Jomha N.M., Adesida A.B.

PLoS One. 2021 March; 16 (3 March) 10.1371/journal.pone.0249513

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Baddam P., Kung T., Adesida A.B., Graf D.

Journal of Anatomy. 2021 March; 238 (3):751-764 10.1111/joa.13332