Andy Mason

Area of Study / Keywords

digital droplet PCR Linker mediated PCR Retroviral Integrations Viral ELISA T lymphocyte assays Primary biliary cholangitis Anti-retroviral therapy Human betaretrovirus Virus discovery Metagenomics

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About

Dr. Mason is a Professor of Medicine and an Alberta Heritage Foundation for Medical Research Senior Scholar. He trained at the Liver Unit, Kings College Hospital, in London, England and then moved to Washington University, St. Louis as a Gastroenterology Fellow to train in molecular virology. At Ochsner Clinic Foundation, New Orleans he became the Medical Director of Liver Transplantation and an Assistant Professor in the Department of Medicine, Tulane University Medical Center. He relocated to the University of Alberta in 2002; he is currently the Director Research for the Division of Gastroenterology and Director of The Applied Genomics Centre. In the laboratory, he has identified a human betaretrovirus in patients with the autoimmune liver disease, Primary Biliary Cirrhosis (PBC). His laboratory studies are now focused on investigating the prevalence of the human betaretrovirus in patients with PBC. A causal association of virus and disease is being investigated using an in vitro model of PBC and a mouse model of disease, which is also being used to find novel combination antiviral therapies for patients with PBC. Dr. Mason is also principal investigator for an international, multi-center, double blind, randomized controlled trial using highly active anti-retroviral therapy to treat patients with PBC. Other viral cloning studies are underway with identification of a novel retrovirus associated with Primary Sclerosing Cholangitis. Dr. Mason also co-directs a viral discovery program in collaboration with Dr. Gane KS Wong, University of Alberta using a metagenomic, deep sequencing approach. The targeted diseases include autoimmune and chronic inflammatory disorders, such as inflammatory bowel disease, SLE, sarcoidosis, multiple sclerosis as well as neoplastic disorders, such as breast cancer, lymphoma and colon cancer.

Additional positions that I hold:
�Adjunct Professor in the Department of Medical Microbiology and Immunology
�Director of Research for Division of Gastroenterology and Hepatology
�Director of The Applied Genomics Core (TAGC)
�Co-Director, Centre of Excellent for GastroIntestinal Inflammation and Immunity Research (CEGIIR)
�Hepatologist, Alberta Health Services

Clinical Interests

Management of autoimmune liver diseases pre and post liver transplantation. 

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Research

Anti-retroviral therapies for the treatment of primary biliary cholangitis. Pilot study of Tenofovir Alafenamide, Emtricitabine and Raltegravir therapy for patients with primary biliary cholangitis CIHR (PS156013)

Viral discovery in samples from transplant recipients with recurrent liver disease and other idiopathic disorders. Actively chracterizing viruses in patients with primary sclerosing cholangitis, ulcerative colitis and Crohn disease

Betaretroviral induction of autoimmune biliary disease in a mouse model of primary biliary cholangitis

Studying the role to betaretrovirus infection in patients with primary biliary cholangitis, breast cancer, Parkinson's disease, type 1 diabetes and other autoimmune disorders.  Diagnostic assay development to detect immune responses to human betaretrovirus with an ELISA assay and an interferon gamma release assay.

Umeshappa C.S., Solé P., Yamanouchi J., Mohapatra S., Surewaard B.G.J., Garnica J., Singha S., Mondal D., Cortés-Vicente E., D’Mello C., Mason A., Kubes P., Serra P., Yang Y., Santamaria P.

Nature Communications. 2022 December; 13 (1) 10.1038/s41467-022-30759-w

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Christoph Schramm, Heiner Wedemeyer, Andrew Mason, Gideon M. Hirschfield, Cynthia Levy, Kris V. Kowdley, Piotr Milkiewicz, Ewa Janczewska, Elena Sergeevna Malova, Johanne Sanni, Phillip Koo, Jin Chen, Subhajit Choudhury, Lloyd B. Klickstein, Michael K. Badman, David Jones

Journal of Hepatology Reports . 2022 July; 10.1016/j.jhepr.2022.100544

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Goubran M., Wang W., Indik S., Faschinger A., Wasilenko S.T., Bintner J., Carpenter E.J., Zhang G., Nuin P., Macintyre G., Wong G.K.S., Mason A.L.

Viruses. 2022 May; 14 (5) 10.3390/v14050886

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Turvey S.L., Saxinger L., Mason A.L.

Viruses. 2022 March; 14 (3) 10.3390/v14030516

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Bui D.T., Jung J., Kitova E.N., Li Z., Willows S.D., Boddington M.E., Kitov P.I., Mason A.L., Capicciotti C.J., Mahal L.K., Macauley M.S., Klassen J.S.

Analytical Chemistry. 2022 March; 94 (12):4997-5005 10.1021/acs.analchem.1c04779

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Roberts S.B., Hirschfield G.M., Worobetz L.J., Vincent C., Flemming J.A., Cheung A., Qumosani K., Swain M., Grbic D., Ko H.H., Peltekian K., Selzner N., Abrahamyan L., Aziz B., Lytvyak E., Tirona K., Gulamhusein A.F., Janssen H.L.A., Montano-Loza A.J., Mason A.L., Hansen B.E.

Hepatology. 2022 February; 76 (2):303-316 10.1002/hep.32426

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Jovel J., Nimaga A., Jordan T., O’Keefe S., Patterson J., Thiesen A., Hotte N., Bording-Jorgensen M., Subedi S., Hamilton J., Carpenter E.J., Lauga B., Elahi S., Madsen K.L., Wong G.K.S., Mason A.L.

Frontiers in Microbiology. 2022 February; 13 10.3389/fmicb.2022.829378

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Montano-Loza A.J., Ronca V., Ebadi M., Hansen B.E., Hirschfield G., Elwir S., Alsaed M., Milkiewicz P., Janik M.K., Marschall H.U., Burza M.A., Efe C., Caliskan A.R., Harputluoglu M., Kabaçam G., Terrabuio D., de Quadros Onofrio F., Selzner N., Bonder A., Parés A., Llovet L., Akyildiz M., Arikan C., Manns M.P., Taubert R., Weber A.L., Schiano T.D., Haydel B., Czubkowski P., Socha P., Oldak N., Akamatsu N., Tanaka A., Levy C., Martin E.F., Goel A., Sedki M., Jankowska I., Ikegami T., Rodriguez M., Sterneck M., Weiler-Normann C., Schramm C., Donato M.F., Lohse A., Andrade R.J., Patwardhan V.R., van Hoek B., Biewenga M., Kremer A.E., Ueda Y., Deneau M., Pedersen M., Mayo M.J., Floreani A., Burra P., Secchi M.F., Beretta-Piccoli B.T., Sciveres M., Maggiore G., Jafri S.M., Debray D., Girard M., Lacaille F., Lytvyak E., Mason A.L., Heneghan M., Oo Y.H.

JOURNAL OF HEPATOLOGY. 2022 February; 77 (1):84-97 10.1016/j.jhep.2022.01.022

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Ebadi M., Ip S., Lytvyak E., Asghari S., Rider E., Mason A., Montano-Loza A.J.

Nutrients. 2022 January; 14 (4) 10.3390/nu14040878

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Nguyen L., McCord K.A., Bui D.T., Bouwman K.M., Kitova E.N., Elaish M., Kumawat D., Daskhan G.C., Tomris I., Han L., Chopra P., Yang T.J., Willows S.D., Mason A.L., Mahal L.K., Lowary T.L., West L.J., Hsu S.T.D., Hobman T., Tompkins S.M., Boons G.J., de Vries R.P., Macauley M.S., Klassen J.S.

Nature Chemical Biology. 2021 November; 18 (1):81-90 10.1038/s41589-021-00924-1

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HEPATOLOGY. 2021 November;

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Lytvyak E., Niazi M., Pai R., He D., Zhang G., Hübscher S.G., Mason A.L.

LIVER INTERNATIONAL. 2021 August; 41 (8):1879-1883 10.1111/liv.14964

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EASL International Liver Congress. Journal of Hepatology. 2021 July;

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EASL International Liver Congress. Journal of Hepatology. 2021 July;

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EASL International Liver Congress. Journal of Hepatology . 2021 July;

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EASL International Liver Congress. Journal of Hepatology . 2021 July;

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EASL International Liver Congress. Journal of Hepatology . 2021 July;

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Cordell H.J., Fryett J.J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S.S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B.D., Atkinson E.J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M.A.R., Sun D., Jones D.E., Flack S., Spicer A., Mulcahy V., Byan J., Han Y., Sandford R.N., Lazaridis K.N., Amos C.I., Hirschfield G.M., Seldin M.F., Invernizzi P., Siminovitch K.A., Ma X., Nakamura M., Mells G., Mason A., , Affronti A., Almasio P.L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P.M., Benedetti A., Bragazzi M.C., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Crocè L.S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G.A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L.A., Overton J.D., Reid J.G., Shuldiner A., Beechert C., Forsythe C., Fuller E.D., Gu Z., Lattari M., Lopez A., Schleicher T.D., Padilla M.S., Toledo K., Widom L., Wolf S.E., Pradhan M., Manoochehri K., Ulloa R.H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E.K., Salerno W., Staples J.C., Jones M.B., Mitnaul L.J., Sturgess R., Healey C., Yeoman A., Gunasekera A.V., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J.A., Gorard D.A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M.R., Collins C.E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M.J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I.R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H.M., Ridpath J., Ngatchu T., Bob Grover V.P., Shidrawi R.G., Abouda G., Corless L., Narain M., Rees I., Brown A., et al.

Journal of Hepatology. 2021 June; 75 (3):572-581 10.1016/j.jhep.2021.04.055

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Asselta R., Paraboschi E.M., Gerussi A., on behalf of PBC Consortia; Canadian PBC Consortium; Chinese PBC Consortium; Italian PBC Study Group; Japan-PBC-GWAS Consortium; US PBC Consortium; UK-PBC Consortium

GASTROENTEROLOGY. 2021 June; 160 (7):2483-2495.e26 10.1053/j.gastro.2021.02.061

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Cordell H.J., Fryett J.J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S.S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B.D., Atkinson E.J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M.A.R., Sun D., Jones D.E., Flack S., Spicer A., Mulcahy V., Byan J., Han Y., Sandford R.N., Lazaridis K.N., Amos C.I., Hirschfield G.M., Seldin M.F., Invernizzi P., Siminovitch K.A., Ma X., Nakamura M., Mells G., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P.L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P.M., Benedetti A., Bragazzi M.C., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Crocè L.S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G.A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L.A., Overton J.D., Reid J.G., Shuldiner A., Beechert C., Forsythe C., Fuller E.D., Gu Z., Lattari M., Lopez A., Schleicher T.D., Padilla M.S., Toledo K., Widom L., Wolf S.E., Pradhan M., Manoochehri K., Ulloa R.H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E.K., Salerno W., Staples J.C., Jones M.B., Mitnaul L.J., Sturgess R., Healey C., Yeoman A., Gunasekera A.V., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J.A., Gorard D.A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M.R., Collins C.E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M.J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I.R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H.M., Ridpath J., Ngatchu T., Bob Grover V.P., Shidrawi R.G., Abouda G., Corless L., Nar.

JOURNAL OF HEPATOLOGY. 2021 May; 75 (3):572-581 10.1016/j.jhep.2021.04.055

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Zhang G., Bashiri K., Kneteman M., Cave K., Hong Y., Mackey J.R., Alter H.J., Mason A.L.

Journal of Oncology. 2020 December; 2020 10.1155/2020/7406146

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Murillo Perez CF, Gulamhusein A, Carbone M, Trivedi PJ, van der Meer AJ, Corpechot C, Battezzati PM, Lammers WJ, Cazzagon N, Floreani A, Parés A, Nevens F, Lleo A, Mayo MJ, Kowdley KV, Ponsioen CY, Dalekos GN, Gatselis NK, Thorburn D, Mason AL, Janssen H, Verhelst X, Bruns T, Lindor KD, Chazouillères O, Invernizzi P, Hansen BE, Hirschfield GM; GLOBAL PBC Study Group.

European Journal of Gastroenterology and Hepatology. 2020 December; 10.1097/MEG.0000000000002029

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Goubran M., Aderibigbe A., Jacquemin E., Guettier C., Girgis S., Bain V., Mason A.L.

BMC Med Genetics. 2020 November; 21 (1) 10.1186/s12881-020-01173-0

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American Association for the Study of Liver Disease Annual Meeting Hepatology. 2020 November;

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American Association for the Study of Liver Disease Annual Meeting Hepatology. 2020 November;

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American Association for the Study of Liver Disease Annual Meeting Hepatology. 2020 November;

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American Association for the Study of Liver Disease Annual Meeting Hepatology. 2020 November;

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American Association for the Study of Liver Disease Annual Meeting Hepatology. 2020 November;

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American Association for the Study of Liver Disease Annual Meeting Hepatology. 2020 November;

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American Association for the Study of Liver Disease Annual Meeting Hepatology . 2020 November;