Andrew Pepper

Assistant Professor, Faculty of Medicine & Dentistry - Surgery Dept

Contact

Assistant Professor, Faculty of Medicine & Dentistry - Surgery Dept
Email
apepper@ualberta.ca
Address
6-002D Li Ka Shing Centre For Research
8602 112 St NW
Edmonton AB
T6G 2E1

Overview

Area of Study / Keywords

Type 1 Diabetes Beta Cell Transplantation Islet Biology Stem Cells Biomaterials Immunosuppression


About

Dr. Pepper is an Assistant Professor in the Department of Surgery at the University of Alberta. In 2012, Dr. Pepper received his PhD in Pathology from the University of Western Ontario under the mentorship of transplant pioneer Dr. David White, studying methods to predict islet transplant function based on mitochondrial respiration. In parallel, Dr. Pepper worked for the Clinical Islet Transplantation Program (LHSC), building skills in human organ procurement and islet isolation. He further gained translational industry experience as a Scientist where he spearheaded projects with pig islet transplant models using medical devices. In 2012, Dr. Pepper join the world-renowned lab of Dr. James Shapiro (developer of the ´┐ŻEdmonton Protocol’), in the Alberta Diabetes Institute as postdoctoral fellow. In 2018, Dr. Pepper was appointed as an Assistant Professor at the University of Alberta.

Selected Awards and Fellowships:

2020 - JDRF (International) - Career Development Award

2017 - Med Star Postdoctoral Fellows Award

2017 - International Pancreas and Islet Transplantation Association - Scientific Award

2016 - Alberta Innovates Health Solutions Postgraduate Fellowship

2016 - Canadian Society of Transplantation - Basic Science Award

2015 - Transplantation Society (TTS-IPITA) - Young Investigator Scientific Award

2015 - JDRF-Canadian Clinical Trial Network/ Eli Lilly Canada Post-Doctoral Fellowship




Clinical Interests

Clinical Islet and stem cell transplantation

Research

Currently, Dr. Pepper's laboratory seeks to better understand how pancreatic islet cells survive and function post-transplant, to better treat type 1 diabetes (T1D). His group develops original cell-based therapies for T1D by bridging basic science (stem cell/islet biology) and clinical science (transplantation). His studies range from in vitro models to clinical transplants, including:

1) Developing cell transplant technologies without immunosuppression.
2) Improving function of pancreatic ´┐Ż cell grafts.
3) Translating alternative beta cell sources into an unlimited supply of insulin-producing cells.

Featured Publications

Pre-transplant exercise may improve glycemic outcomes after marginal islet mass transplant in type 1 diabetes

Diabetes Canada Professional Conference . 2023 November;


Blood glucose levels following repetitive aerobic exercise in fasted rats with type 1 diabetes

Diabetes Canada Professional Conference. 2023 November;


Aggarwal S., Pepper A.R., Korbutt G.S.

Current Opinion in Endocrine and Metabolic Research. 2022 June; 24 10.1016/j.coemr.2022.100354


Saloni Aggarwal, Andrew R.Pepper, Najwa Al Jahdhami

Journal of Immunology and Regenerative Medicine. 2022 May; 16 https://doi.org/10.1016/j.regen.2021.100058


Evaluation of assembly and disassembly behaviour of drug loaded ELP nanoparticles

Canadian Biomaterials Society. 2022 May;


Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiaoqing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia P Roma, Emmanuel Ampofo, Wen-hong Li, Patrick E MacDonald

BioRxiv. 2022 April; 10.1101/2022.04.05.487203


Kuppan P., Kelly S., Seeberger K., Castro C., Rosko M., Pepper A.R., Korbutt G.S.

Polymers. 2022 March; 14 (6):1-14 10.3390/polym14061120


Transplantation. 2021 December; 10.1097/01.tp.0000804688.45982.65


THE ROLE OF NECROPTOSIS IN ?-CELL LOSS FOLLOWING ISLET TRANSPLANTATION

3rd Annual Joint Symposium Helmhotlz Research School of Diabetes. 2021 December;


Transplantation. 2021 December; 10.1097/01.tp.0000804536.23741.ad


Transplantation. 2021 December; 10.1097/01.tp.0000804416.62388.b4


Transplantation. 2021 December; 10.1097/01.tp.0000804340.34071.ab


UPREGULATION OF CYTOSOLIC REDUCING SIGNALING THROUGH SENP1 IS REQUIRED FOR �-CELL FUNCTIONAL COMPENSATION TO SHORT-TERM HIGH FAT DIET

Alberta Diabetes Institute Research Day . 2021 November;


Cytoprotective Properties of Thioketals Against Oxidative Stress Damage to Islets

Canadian Biomaterials Society. 2021 May;


The Role of Necroptosis in �-Cell Loss Following Islet Transplantation

Tom Williams Research Day. 2021 May;


Pepper A.R., Korbutt G.S.

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 April; 21 (9):2927-2928 10.1111/ajt.16587


Upregulation of cytosolic reducing signaling through SENP1 is required for beta-cell functional compensation to short-term HFD

Insulin 100: Scientific Symposium. 2021 April;


TRANSPLANTATION. 2021 March; 10.1097/TP.0000000000003746


LAYER BY LAYER COATING PRESERVES HUMAN AND MOUSE ISLETS IN VITRO AND IN VIVO FUNCTIONAL POTENCY

Alberta Diabetes Institute Research Day . 2020 November;


THE ROLE OF NECROPTOSIS IN ?-CELL LOSS FOLLOWING ISLET CELL TRANSPLANTATION

Alberta Diabetes Institute Research Day . 2020 November;