Andrew Waskiewicz

Professor, Faculty of Science - Biological Sciences

Contact

Professor, Faculty of Science - Biological Sciences
Email
andrew.waskiewicz@ualberta.ca
Phone
(780) 492-4403
Address
Z-316 Bio Science - D.M. Ross Zoology Tower
11355 - Saskatchewan Drive
Edmonton AB
T6G 2E9

Overview

Research

We study zebrafish development with a goal of understanding human neural disorders, retinal birth defects, and coloboma. We are also pursuing new methods of genome engineering using CRISPR nucleases.

Blindness:

More than 180 million people throughout the world are visually impaired. Of these, 45 million are blind. Our research focuses on finding the genetic causes of two blinding disorders, coloboma and Leber’s Congenital Amaurosis. We are currently generating zebrafish models for each disorder, with a focus on retinoic acid signaling in coloboma and BMP signaling in LCA.

Brain Ventricle Morphogenesis:

During embryonic development, the vertebrate brain forms a ventricle (lumen), which functions as a secondary circulatory system. We are studying the role of signaling pathways in regulating the formation of this critical neural structure.

Retinoic Acid in sensory organ development:

Retinoic acid, a derivative of vitamin A is a vitally important morphogen. Our lab is studying the role of retinoids in eye and ear development.

CRISPR Nucleases:

One of the most important methods of studying human disease is to create an animal model that has a mutation in a disease-causing locus. We are working to develop techniques to create zebrafish knockouts. We are using CRISPR technology to induce double strand breaks in genes of interest. Current efforts include developing techniques for gene replacement as a means of repairing genetic lesions.

Lab Home Page
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Courses

GENET 418 - Human Genetics

A survey of human genetic variation and mutation in a molecular genetics context. Molecular basis of diseases and applications to genetic counseling and screening, chromosomal abnormalities, genomic imprinting, cancer genetics, gene mapping, population genetics, multifactorial inheritance, gene therapy, and ethical issues. Prerequisites: any two GENET 300-level lecture courses, GENET 302 is recommended. Credit cannot be obtained for both GENET 418 and 518.

Winter Term 2021
GENET 518 - Advanced Human Genetics

A survey of human genetic variation and mutation in a molecular genetics context. Molecular basis of diseases and applications to genetic counseling and screening, chromosomal abnormalities, genomic imprinting, cancer genetics, gene mapping, population genetics, multifactorial inheritance, gene therapy, and ethical issues. Scheduled classes are the same as GENET 418, but with additional assignments and evaluation appropriate to graduate studies. Prerequisite: consent of instructor. Credit cannot be obtained for both GENET 418 and 518.

Winter Term 2021
ZOOL 303 - Animal Developmental Biology

An introduction to basic principles in animal development both in vertebrates and invertebrates. This course examines how the molecular, cellular and comparative approaches are integrated to explain the development of the egg into the embryo, and the cellular interactions that culminate in the development of organ systems. Prerequisite: BIOL 201 or CELL 201.

Fall Term 2020

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