Cloud Cao, PhD

Area of Study / Keywords

Computational Psychiatry Health Data Machine Learning Addiction Mental Disorders Precision Medicine in Mental Health Aging

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About

Trained in mathematics (BSc), psychology (MSc), computational neuroscience (PhD), neuroimaging and psychiatry (postdoc), I have a strong passion for understanding the fundamental mechanisms of how the brain works and how to cure the brain when the mechanisms are disturbed. Recently, our lab has focused on translational research of predicting and improving real-world outcomes of mental and substance use disorders and substance overdose using electronic health data and machine learning. 

As the Canada Research Chair in Computational Psychiatry (Tier 2), I am always seeking young talents to work with as graduate students (Masters and PhD) and postdoctoral fellows who are passionate about mental disorders and use their analytical, clinical and communication expertise to help patients, clinicians, policymakers and stakeholders. See one of the positions available here: https://apps.ualberta.ca/careers/posting/949.

My main research interests are:

1) Computational Psychiatry and Precision Medicine in Mental Health. The aim is to develop translational tools that can provide accurate and personalized diagnosis and treatment optimization for mental and substance use disorders. This can be achieved by identifying objective markers associated with mental disorders and their treatment outcomes through multimodal data, including electronic health records, brain imaging, genetic, biological, behavioural, cognitive and clinical measurements, and by applying advanced machine learning and statistical algorithms to these data.

2) Aging. Using large-scale data and machine learning techniques, our lab is interested in how lifestyle, environmental, social, cognitive, and genetic factors affect how we age, especially with respect to the interaction between mental and physical health during aging.

More information about our lab: https://sites.google.com/ualberta.ca/computational-psychiatry-lab/

Bo Cao, Russell Greiner, Andrew Greenshaw, Jie Sui

2024 September; 10.2196/preprints.66100

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Yipeng Song, Yang S Liu, Dan Metes, Mengzhe Wang, Bo Cao

2024 August; 10.2196/preprints.65966

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Yutong Li, Yipeng Song, Jie Sui, Russell Greiner, Xin-min Li, Andrew J. Greenshaw, Yang S. Liu, Bo Cao

Journal of Affective Disorders. 2024 July; 10.1016/j.jad.2024.04.098

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Derek V. Pierce, Yutong Li, Andrew J. Greenshaw, Tracey Bailey, Bo Cao

2024 April; 10.2196/preprints.59257

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Xiaowei Jiang, Bo Cao, Chao Li, Linna Jia, Yi Jing, Wei Cai, Wenhui Zhao, Qikun Sun, Feng Wu, Lingtao Kong, Yanqing Tang

Translational Psychiatry. 2024 January; 10.1038/s41398-023-02703-z

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SSRN. 2024 January; 10.2139/ssrn.4864825

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American Journal of Human Genetics. 2024 January; 10.1016/j.ajhg.2023.11.006

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Frontiers in Psychiatry. 2024 January; 10.3389/fpsyt.2024.1386321

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Neurobiology of Aging. 2024 January; 10.1016/j.neurobiolaging.2024.02.014

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Scientific Reports. 2024 January; 10.1038/s41598-024-56682-2

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Resilient Health: Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond. 2024 January; 10.1016/B978-0-443-18529-8.00030-5

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PLOS Digital Health. 2024 January; 10.1371/journal.pdig.0000571

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Translational Psychiatry. 2024 January; 10.1038/s41398-023-02703-z

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Journal of Clinical Psychiatry. 2024 January; 10.4088/JCP.23m14864

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International Journal of Environmental Research and Public Health. 2024 January; 10.3390/ijerph21070949

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Journal of Affective Disorders. 2024 January; 10.1016/j.jad.2024.04.098

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Schizophrenia Research: Cognition. 2024 January; 10.1016/j.scog.2024.100308

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Journal of Affective Disorders Reports. 2024 January; 10.1016/j.jadr.2024.100723

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Ramon E Diaz-Ramos, Isabella Noriega, Luis A Trejo, Eleni Stroulia, Bo Cao

JMIR Research Protocols. 2023 November; 10.2196/48210

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Yipeng Song, Lei Qian, Jie Sui, Russell Greiner, Xin-min Li, Andrew J. Greenshaw, Yang S. Liu, Bo Cao

Journal of Affective Disorders. 2023 October; 10.1016/j.jad.2023.06.031

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John-Jose Nunez, Yang S. Liu, Bo Cao, Benicio N. Frey, Keith Ho, Roumen Milev, Daniel J. Müller, Susan Rotzinger, Claudio N. Soares, Valerie H. Taylor, Rudolf Uher, Sidney H. Kennedy, Raymond W. Lam

Psychiatry Research. 2023 September; 10.1016/j.psychres.2023.115361

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Ramon E Diaz-Ramos, Isabella Noriega, Luis A Trejo, Eleni Stroulia, Bo Cao

2023 April; 10.2196/preprints.48210

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International Journal of Psychiatry in Clinical Practice. 2023 January; 10.1080/13651501.2022.2129067

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Schizophrenia Research. 2023 January; 10.1016/J.SCHRES.2023.02.023

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Canadian Journal of Psychiatry. 2023 January; 10.1177/07067437221114094

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Journal of Attention Disorders. 2023 January; 10.1177/10870547221136228

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Annals of Pharmacotherapy. 2023 January; 10.1177/10600280221113572

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International Journal of Clinical and Health Psychology. 2023 January; 10.1016/J.IJCHP.2023.100372

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Kevin Zhan, Yutong Li, Rafay Osmani, Xiaoyu Wang, Bo Cao

JMIR Infodemiology. 2022 September; 10.2196/38839

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Huda Al-Shamali, Amara Hussain, Liz Dennett, Bo Cao, Lisa Burback, Andrew Greenshaw, Yanbo Zhang

Journal of Affective Disorders Reports. 2022 July; 10.1016/j.jadr.2022.100356

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Psychiatry Research Day - University of Alberta . 2022 June;

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DeMaster D., Godlewska B., Liang M., Vannucci M., Bockmann T., Bo C., Selvaraj S.

JOURNAL OF AFFECTIVE DISORDERS. 2022 June; 307 10.1016/j.jad.2022.03.041

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Yang S. Liu, Jeffrey R. Hankey, Stefani Chokka, Pratap R. Chokka, Bo Cao

Scientific Reports. 2022 June; 12 (1):9599 https://doi.org/10.1038/s41598-022-13642-y

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Psychiatry Research Day - University of Alberta . 2022 June;

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Psychiatry Research Day - University of Alberta . 2022 June;

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Benoit J.R.A., Dursun S.M., Greiner R., Cao B., Brown M.R.G., Lam R.W., Greenshaw A.J.

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE. 2022 June; 67 (1):39-47 10.1177/07067437211037141

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Al-Shamali H., Hussain A., Dennett L., Cao B., Burback L., Greenshaw A., Zhang Y.

Journal of Affective Disorders Reports. 2022 May; 9 10.1016/j.jadr.2022.100356

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Obuobi-Donkor G., Eboreime E., Bond J., Phung N., Eyben S., Hayward J., Zhang Y., MacMaster F., Clelland S., Greiner R., Jones C., Cao B., Brémault-Phillips S., Wells K., Li X.M., Hilario C., Greenshaw A.J., Agyapong V.I.O.

JMIR Research Protocols. 2022 April; 11 (4) 10.2196/30680

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Yankouskaya A., Denholm-Smith T., Yi D., Greenshaw A.J., Cao B., Sui J.

Frontiers in Systems Neuroscience. 2022 April; 16 10.3389/fnsys.2022.833625

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Eboreime E., Shalaby R., Mao W., Owusu E., Vuong W., Surood S., Bales K., MacMaster F.P., McNeil D., Rittenbach K., Ohinmaa A., Bremault-Phillips S., Hilario C., Greiner R., Knox M., Chafe J., Coulombe J., Xin-Min L., McLean C., Rathwell R., Snaterse M., Spurvey P., Taylor V.H., McLean S., Urichuk L., Tzeggai B., McCabe C., Grauwiler D., Jordan S., Brown E., Fors L., Savard T., Grunau M., Kelton F., Stauffer S., Cao B., Chue P., Abba-Aji A., Silverstone P., Nwachukwu I., Greenshaw A., Agyapong V.I.O.

BMC HEALTH SERVICES RESEARCH. 2022 March; 22 (1) 10.1186/s12913-022-07510-8

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Wang Y., Zhou X., Cao B., Chen L., Wang R., Qi L., Meng L., Zeng L., Liu X., Wang W., Li C., Yang J., Gu X., Li Z., Zhou Y.

JOURNAL OF AFFECTIVE DISORDERS. 2022 February; 298 10.1016/j.jad.2021.10.130

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Lang X., Wang D., Chen D., Xiu M., Zhou H., Wang L., Cao B., Zhang X.

Neurotherapeutics. 2022 January; 19 (1):399-407 10.1007/s13311-021-01174-8

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Sämann P.G., Iglesias J.E., Gutman B., Grotegerd D., Leenings R., Flint C., Dannlowski U., Clarke-Rubright E.K., Morey R.A., van Erp T.G.M., Whelan C.D., Han L.K.M., van Velzen L.S., Cao B., Augustinack J.C., Thompson P.M., Jahanshad N., Schmaal L.

HUMAN BRAIN MAPPING. 2022 January; 43 (1):207-233 10.1002/hbm.25326

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JMIR Research Protocols. 2022 January; 10.2196/30680

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Neurotherapeutics. 2022 January; 10.1007/S13311-021-01174-8

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Journal of Affective Disorders. 2022 January; 10.1016/J.JAD.2022.04.122

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BMC Psychiatry. 2022 January; 10.1186/S12888-022-04411-2

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Journal of Affective Disorders. 2022 January; 10.1016/J.JAD.2022.03.041

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Human Brain Mapping. 2022 January; 10.1002/HBM.25326

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Scientific Reports. 2022 January; 10.1038/S41598-022-13642-Y

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CNS Spectrums. 2022 January; 10.1017/S1092852921000584

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Psychological Medicine. 2022 January; 10.1017/S0033291720004997

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BMC Health Services Research. 2022 January; 10.1186/S12913-022-07510-8

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Disaster Medicine and Public Health Preparedness. 2022 January; 10.1017/DMP.2021.27

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JMIR Human Factors. 2022 January; 10.2196/33682

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Journal of Affective Disorders. 2022 January; 10.1016/J.JAD.2021.10.130

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Canadian Journal of Psychiatry. 2022 January; 10.1177/07067437211037141

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Ella M E Forgie, Hollis Lai, Bo Cao, Eleni Stroulia, Andrew J Greenshaw, Helly Goez

Journal of Medical Internet Research. 2021 December; 10.2196/25230

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Liu Y.S., Chokka S., Cao B., Chokka P.R.

Journal of Affective Disorders Reports. 2021 December; 6 10.1016/j.jadr.2021.100215

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Forgie E.M.E., Lai H., Cao B., Stroulia E., Greenshaw A.J., Goez H.

JOURNAL OF MEDICAL INTERNET RESEARCH. 2021 December; 23 (12) 10.2196/25230

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Cao B., Liu Y.S., Selvitella A., Librenza-Garcia D., Passos I.C., Sawalha J., Ballester P., Chen J., Dong S., Wang F., Kapczinski F., Dursun S.M., Li X.M., Greiner R., Greenshaw A.

Scientific Reports. 2021 October; 11 (1) 10.1038/s41598-021-99534-z

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Sui J., Greenshaw A.J., Macrae C.N., Cao B.

JOURNAL OF AFFECTIVE DISORDERS. 2021 October; 293 10.1016/j.jad.2021.06.041

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Scientific Reports. 2021 October; 10.1038/s41598-021-99534-z

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Zhang Q., He H., Cao B., Gao R., Jiang L., Zhang X., Dai J.

NEUROSCIENCE LETTERS. 2021 August; 760 10.1016/j.neulet.2021.136084

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XiaoE Lang, Dongmei Wang, Dachun Chen, Mei Hong Xiu, Huixia Zhou, Li Wang, Bo Cao, Xiangyang Zhang

2021 August; 10.21203/rs.3.rs-800348/v1

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Tannous J., Cao B., Stanley J.A., Zunta-Soares G.B., Mwangi B., Sanches M., Soares J.C.

MOLECULAR PSYCHIATRY. 2021 August; 26 (8):4117-4126 10.1038/s41380-020-00927-9

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Jeffrey Sawalha, Muhammad Yousefnezhad, Alessandro M. Selvitella, Bo Cao, Andrew J. Greenshaw & Russell Greiner

Scientific Reports. 2021 August; 11 10.1038/s41598-021-98957-4

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Jonika Tannous, Bo Cao, Jeffrey A. Stanley, Giovana B. Zunta-Soares, Benson Mwangi, Marsal Sanches, Jair C. Soares

Molecular Psychiatry. 2021 August; 10.1038/s41380-020-00927-9

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Chang M., Womer F.Y., Gong X., Chen X., Tang L., Feng R., Dong S., Duan J., Chen Y., Zhang R., Wang Y., Ren S., Wang Y., Kang J., Yin Z., Wei Y., Wei S., Jiang X., Xu K., Cao B., Zhang Y., Zhang W., Tang Y., Zhang X., Wang F.

MOLECULAR PSYCHIATRY. 2021 July; 26 (7):3003 10.1038/s41380-020-00938-6

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Antonelli-Salgado T., Monteiro G.M.C., Marcon G., Roza T.H., Zimerman A., Hoffmann M.S., Cao B., Hauck S., Brunoni A.R., Passos I.C.

JOURNAL OF AFFECTIVE DISORDERS. 2021 July; 290 10.1016/j.jad.2021.04.044

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Jabbari-zadeh F., Cao B., Stanley J.A., Liu Y., Wu M.J., Tannous J., Lopez M., Sanches M., Mwangi B., Zunta-Soares G.B., Soares J.C.

JOURNAL OF AFFECTIVE DISORDERS. 2021 June; 289 10.1016/j.jad.2021.04.011

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Nunez J.J., Nguyen T.T., Zhou Y., Cao B., Ng R.T., Chen J., Frey B.N., Milev R., Müller D.J., Rotzinger S., Soares C.N., Uher R., Kennedy S.H., Lam R.W.

PLoS One. 2021 June; 16 (6 June) 10.1371/journal.pone.0253023

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Faramarz Jabbari-zadeh, Bo Cao, Jeffrey A. Stanley, Yang Liu, Mon-Ju Wu, Jonika Tannous, Mizuki Lopez, Marsal Sanches, Benson Mwangi, Giovana B. Zunta-Soares, Jair C. Soares

Journal of Affective Disorders. 2021 June; 10.1016/j.jad.2021.04.011

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Wei G.X., Ge L., Chen L.Z., Cao B., Zhang X.

HUMAN BRAIN MAPPING. 2021 April; 42 (6):1617-1625 10.1002/hbm.25315

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Reham Shalaby, Wesley Vuong, Marianne Hrabok, April Gusnowski, Kelly Mrklas, Daniel Li, Mark Snaterse, Shireen Surood, Bo Cao, Xin-Min Li, Russell Greiner, Andrew James Greenshaw, Vincent Israel Opoku Agyapong

JMIR mHealth and uHealth. 2021 April; 10.2196/24184

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Shalaby R., Vuong W., Hrabok M., Gusnowski A., Mrklas K., Li D., Snaterse M., Surood S., Cao B., Li X.M., Greiner R., Greenshaw A.J., Agyapong V.I.O.

JMIR mHealth and uHealth. 2021 April; 9 (4) 10.2196/24184

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Sawalha J., Cao L., Chen J., Selvitella A., Liu Y., Yang C., Li X., Zhang X., Sun J., Zhang Y., Zhao L., Cui L., Zhang Y., Sui J., Greiner R., Li X.m., Greenshaw A., Li T., Cao B.

JOURNAL OF AFFECTIVE DISORDERS. 2021 March; 282 10.1016/j.jad.2020.12.046

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Agyapong V.I.O., Shalaby R., Hrabok M., Vuong W., Noble J.M., Gusnowski A., Mrklas K., Li D., Snaterse M., Surood S., Cao B., Li X.M., Greiner R., Greenshaw A.J.

International Journal of Environmental Research and Public Health. 2021 February; 18 (4):1-13 10.3390/ijerph18042157

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Nkire N., Mrklas K., Hrabok M., Gusnowski A., Vuong W., Surood S., Abba-Aji A., Urichuk L., Cao B., Greenshaw A.J., Agyapong V.I.O.

Frontiers in Psychiatry. 2021 February; 12 10.3389/fpsyt.2021.553468

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Hong S., Liu Y.S., Cao B., Cao J., Ai M., Chen J., Greenshaw A., Kuang L.

JOURNAL OF AFFECTIVE DISORDERS. 2021 February; 280 10.1016/j.jad.2020.10.077

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Zhou H., Wang D., Wang J., Xu H., Cao B., Zhang X.

Asian Journal of Psychiatry. 2021 January; 10.1016/j.ajp.2021.102749

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Xiu M.H., Lang X., Chen D.C., Cao B., Kosten T.R., Cho R.Y., Shi H., Wei C.W., Wu A.S., Zhang X.Y.

CEREBRAL CORTEX. 2021 January; 31 (1):89-96 10.1093/cercor/bhaa208

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Camkurt M.A., Melicher T., Mwangi B., Wu M.J., Cao B., Zeni C.P., Tannous J., Zunta-Soares G., Hasan K., Sanches M., Soares J.C.

CNS SPECTRUMS. 2021 January; 10.1017/S1092852921000584

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Yang D., Chen J., Cheng X., Cao B., Chang H., Li X., Yang C., Wu Q., Sun J., Manry D., Pan Y., Dong Y., Li J., Xu T., Cao L.

DEPRESSION AND ANXIETY. 2021 January; 10.1002/da.23186

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Agyapong V.I.O., Hrabok M., Shalaby R., Vuong W., Noble J.M., Gusnowski A., Mrklas K., Li D., Urichuck L., Snaterse M., Surood S., Cao B., Li X.M., Greiner R., Greenshaw A.J.

Disaster Medicine and Public Health Preparedness. 2021 January; 10.1017/dmp.2021.27

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Benoit J.R.A., Dursun S.M., Greiner R., Cao B., Brown M.R.G., Lam R.W., Greenshaw A.J.

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE. 2021 January; 10.1177/07067437211037141

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Depression and Anxiety. 2021 January; 10.1002/DA.23186

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Neuroscience Letters. 2021 January; 10.1016/J.NEULET.2021.136084

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Asian Journal of Psychiatry. 2021 January; 10.1016/J.AJP.2021.102749

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Frontiers in Psychiatry. 2021 January; 10.3389/FPSYT.2021.553468

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Cerebral Cortex. 2021 January; 10.1093/CERCOR/BHAA208

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Journal of Affective Disorders. 2021 January; 10.1016/J.JAD.2020.10.077

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Molecular Psychiatry. 2021 January; 10.1038/S41380-020-00892-3

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Journal of Affective Disorders. 2021 January; 10.1016/J.JAD.2020.12.046

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Journal of Affective Disorders. 2021 January; 10.1016/J.JAD.2021.04.044

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International Journal of Environmental Research and Public Health. 2021 January; 10.3390/IJERPH18042157

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Journal of Affective Disorders. 2021 January; 10.1016/J.JAD.2021.06.041

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Human Brain Mapping. 2021 January; 10.1002/HBM.25315

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Agyapong V.I.O., Hrabok M., Vuong W., Shalaby R., Noble J.M., Gusnowski A., Mrklas K.J., Li D., Urichuk L., Snaterse M., Surood S., Cao B., Li X.M., Greiner R., Greenshaw A.J.

JMIR Mental Health. 2020 December; 7 (12) 10.2196/22423

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Song Y., Talarico F., Greenshaw A., Cao B.

JOURNAL OF AFFECTIVE DISORDERS. 2020 December; 277 10.1016/j.jad.2020.09.048

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Yipeng Song, Fernanda Talarico, Andrew Greenshaw, Bo Cao

Journal of Affective Disorders. 2020 December; 10.1016/j.jad.2020.09.048

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Ella M E Forgie, Hollis Lai, Bo Cao, Eleni Stroulia, Andrew J Greenshaw, Helly Goez

2020 October; 10.2196/preprints.25230

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Chelsea Jones, Antonio Miguel-Cruz, Lorraine Smith-MacDonald, Emily Cruikshank, Delaram Baghoori, Avneet Kaur Chohan, Alexa Laidlaw, Allison White, Bo Cao, Vincent Agyapong, Lisa Burback, Olga Winkler, Phillip R Sevigny, Liz Dennett, Martin Ferguson-Pell, Andrew Greenshaw, Suzette Brémault-Phillips

JMIR mHealth and uHealth. 2020 September; 10.2196/22079

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Reham Shalaby, Wesley Vuong, Marianne Hrabok, April Gusnowski, Kelly Mrklas, Daniel Li, Mark Snaterse, Shireen Surood, Bo Cao, Xin-Min Li, Russell Greiner, Andrew James Greenshaw, Vincent Israel Opoku Agyapong

2020 September; 10.2196/preprints.24184

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Chelsea Jones, Antonio Miguel-Cruz, Lorraine Smith-MacDonald, Emily Cruikshank, Delaram Baghoori, Avneet Kaur Chohan, Alexa Laidlaw, Allison White, Bo Cao, Vincent Agyapong, Lisa Burback, Olga Winkler, Phillip R Sevigny, Liz Dennett, Martin Ferguson-Pell, Andrew Greenshaw, Suzette Brémault-Phillips

2020 July; 10.2196/preprints.22079

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Journal of Affective Disorders. 2020 January;

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JMIR Mental Health. 2020 January; 10.2196/22423

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JMIR Research Protocols. 2020 January; 10.2196/19292

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Behavioural Brain Research. 2020 January; 10.1016/J.BBR.2020.112544

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Molecular Psychiatry. 2020 January; 10.1038/s41380-018-0106-5

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Journal of affective disorders. 2019 January;

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Molecular psychiatry. 2019 January;

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Personalized Psychiatry. 2019 January;

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Journal of Clinical Densitometry. 2018 January; 10.1016/j.jocd.2017.05.016

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Schizophrenia Research. 2018 January; 10.1016/j.schres.2017.08.063

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International Journal of Eating Disorders. 2018 January;

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Neuropsychopharmacology. 2018 January; 10.1038/npp.2017.166

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PeerJ. 2018 January; 10.7717/peerj.5442

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Schizophrenia Bulletin. 2018 January; 10.1093/schbul/sbx108

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Journal of psychiatric research. 2018 January;

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Current Psychiatry Reviews. 2018 January;

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Bipolar disorders. 2018 January;

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Brazilian Journal of Psychiatry. 2018 January;

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Scientific reports. 2018 January;

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Translational psychiatry. 2018 January;

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Molecular psychiatry. 2018 January;

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Acta Psychiatrica Scandinavica. 2017 January;

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