Carolyn Fitzsimmons, PhD
Pronouns: she, her, hers
Contact
- cfitzsim@ualberta.ca
Overview
Area of Study / Keywords
Bovine Genetics and Genomics Fetal Programming
About
Degree
PhD, Uppsala University, Sweden
Job/Research Area
Gene Expression, Bovine Genetics
Research
Major Responsibilities/Research Interests
My interests lie in how biological systems influence the development of lean meat and fat tissues, specifically looking through the window of gene expression. Many new and exciting areas have now come to the forefront regarding the control of gene expression via dietary means (nutrigenomics), and the different individual responses to changes in diet (nutrigenetics). By utilizing changes in gene expression due to diet and/or other treatments, we can tease out a clearer understanding of how biological systems function and then apply this knowledge to practical situations, for example beef production. I am also interested permanent gene expression changes that can be programmed in the next generation due to nutrition and/or other factors affecting the parental generation (epigenetics).
Courses
AFNS 574 - Applied Beef Cattle Science
Examination of current and potential future production and management practices to optimize production efficiency and animal well-being in the Canadian and international beef industry. Laboratories emphasize practical applications, field trips, and discussion. Not to be taken if credit received for AN SC 474. Prerequisite: consent of instructor.
AN SC 474 - Applied Beef Cattle Science
Examination of current and potential future production and management practices to optimize production efficiency and animal well-being in the Canadian and international beef industry. Laboratories emphasize practical applications, field trips, and discussion. Prerequisites: (AN SC 101 or 200), AN SC 260 and AN SC 310.
Publications
Genetic potential for residual feed intake and diet fed during early- to mid-gestation influences post-natal DNA methylation of imprinted genes in muscle and liver tissues in beef cattle
Author(s): Devos, J., Behrouzi, A., Paradis, F., Straathof, C., Li, C., Colazo, M., Block, H. and Fitzsimmons, C.
Publication Date:
5/15/2021
Publication: Journal of Animal Science
Volume: 99
Issue: 5
Impact of prenatal maternal nutrition and parental residual feed intake (RFI) on mRNA abundance of metabolic drivers of growth and development in young Angus bulls
Author(s): Foroutan, A., Devos, J., Wishart, D.S., Li, C., Colazo, M., Kastelic, J., Thundathil, J. and Fitzsimmons, C.
Publication Date:
2021
Publication: Livestock Science
Volume: 243
Page Numbers: 104365
Serum Metabolite Biomarkers for Predicting Residual Feed Intake (RFI) of Young Angus Bulls
Author(s): Foroutan, A., Fitzsimmons, C., Mandal, R., Berjanskii, M. and Wishart, D.
Publication Date:
11/30/2020
Publication: Metabolites
Volume: 10
Issue: 12
Page Numbers: 491
External Link: https://www.mdpi.com/2218-1989/10/12/491
Bovine hepatic miRNAome profiling and differential miRNA expression analyses between beef steers with divergent feed efficiency phenotypes
Author(s): Mukiibi, R., Johnston, D., Vinsky, M., Fitzsimmons, C., Stothard, P., Waters, S.M. and Li, C.
Publication Date:
11/9/2020
Publication: Scientific Reports
Volume: 10
Issue: 1
Page Numbers: 19309
External Link: https://www.nature.com/articles/s41598-020-73885-5
Testis-specific changes in gene expression of post-pubertal beef bulls divergent for residual feed intake and exposure to different pre-natal diets
Author(s): Johnson, C., Fitzsimmons, C., Kovalchuk, I., Kastelic, J. and Thundathil, J.
Publication Date:
5/21/2020
Publication: Animal Production Science
Volume: 60
Issue: 12
Page Numbers: 1491-1502
External Link: https://www.publish.csiro.au/an/AN19524
The Bovine Metabolome
Author(s): Foroutan, A., Fitzsimmons, C., Mandal, R., Piri-Moghadam, H., Zheng, J., Guo, A., Li, C., Guan, L.L. and Wishart, D.S.
Publication Date:
5/5/2020
Publication: Metabolites
Volume: 10
Issue: 6
Page Numbers: 233
External Link: https://www.mdpi.com/2218-1989/10/6/233
Transcriptomic analysis by RNA-sequencing reveals that hepatic interferon-induced genes may be associated with feed efficiency in beef heifers
Author(s): Paradis F, Yue S, Grant JR, Stothard P, Basarab J, & Fitzsimmons C
Publication Date:
2015
Publication: Journal of Animal Science
Volume: 93
Issue: 7
Page Numbers: 3331-3341
Genome-wide association for heifer reproduction and postpartum performance traits in beef cattle
Author(s): Akanno EC, Plastow G, Fitzsimmons C,Akanno EC, Plastow G, Fitzsimmons C, Miller SP, Baron V, Ominski K, Basarab JA
Publication Date:
2015
Publication: Genome
Characterization and evaluation of residual feed intake measured in mid- to late-gestation mature beef cows and relationships with circulating serum metabolites and linear body measurements
Author(s): Wood KM, Montanholi YR, Fitzsimmons CF, Miller SP, McBride BW, & Swanson KC
Publication Date:
2014
Publication: Canadian Journal of Animal Science
Volume: 94
Issue: 3
Page Numbers: 499-508
Widespread Differential Maternal and Paternal Genome Effects on Fetal Bone Phenotype at Mid-Gestation
Author(s): Xiang R, Lee AMC, Eindorf T, Javadmanesh A, Ghanipoor-Samami M, Gugger M, Fitzsimmons CJ, Kruk ZA, Pitchford WS, Leviton AJ, Thomsen DA, Beckman I, Anderson GI, Burns BM, Rutley DL, Xian CJ, Hiendleder S
Publication Date:
2014
Publication: Journal of Bone and Mineral Research
Volume: 29
Issue: 11
Page Numbers: 2392-2404
Effect of moderate dietary restriction on visceral organ weight, hepatic oxygen consumption, and metabolic proteins associated with energy balance in mature pregnant beef cows
Author(s): Wood KM, Awda BJ, Fitzsimmons C, Miller SP, McBride BW, & Swanson KC
Publication Date:
2013
Publication: Journal of Animal Science
Volume: 91
Issue: 9
Page Numbers: 4245-4255
The influence of pregnancy in mid-to-late gestation on circulating metabolites, visceral organ mass, and abundance of proteins relating to energy metabolism mature beef cows
Author(s): Wood KM, Awda BJ, Fitzsimmons C, Miller SP, McBride BW, & Swanson KC
Publication Date:
2013
Publication: Journal of Animal Science
Volume: 91
Issue: 12
Page Numbers: 5775-5784
Maternal and Paternal Genomes Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation
Author(s): Xiang R, Ghanipoor-Samami M, Johns WH, Eindorf T, Rutley DL, Kruk ZA, Fitzsimmons C, Thomsen DA, Roberts CT, Burns BM, Anderson GI, Greenwood PL, & Hiendleder S
Publication Date:
2013
Publication: PLoS One
Volume: 8
Issue: 1
Page Numbers: e53402
INSL3 in the Ruminant: A Powerful Indicator of Gender- and Genetic-Specific Feto-Maternal Dialogue
Author(s): Anand-Ivell R., Hiendleder S., Viñoles C., Martin G.B., Fitzsimmons C., Eurich A., Hafen B. & Ivell R.
Publication Date:
2011
Publication: PLoS One
Volume: 6
Page Numbers: e19821
Extremely different behaviours in high and low body weight lines of chicken are involved in differential expression of genes involved in neuronal plasticity
Author(s): S. Ka, J. Lindberg, L. Stömstedt, C. J. Fitzsimmons, N. Lindqvist, J. Lundeberg, P.B. Siegel, L. Andersson, and F. Hallböök
Publication Date:
2009
Publication: J Neuroendocrinol
Volume: 21
Page Numbers: 208-216
A cis-acting regulatory mutation is causing premature hair greying and susceptibility to melanoma in the horse
Author(s): G. Rosengren-Pielberg, A. Golovko, E. Sundström, I. Curik, J. Lennartsson, M. H. Seltenhammer, T. Druml, M. Binns, C. Fitzsimmons, G. Lindgren, K. Sandberg, R. Baumung, M. Vetterlein, S. Strömberg, M. Grabherr, C. Wade, K. Lindblad-Toh1, F. Pontén, C. Heldin, J. Sölkner and L. Andersson
Publication Date:
2008
Publication: Nature Genetics
Volume: 40
Page Numbers: 1004-1009
Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traits
Author(s): C-J. Rubin, J. Lindberg, C. J. Fitzsimmons, P. Savolainen, P. Jensen, J. Lundeberg, L. Andersson, A. Kindmark
Publication Date:
2007
Publication: BMC Genomics
Volume: 8
Page Numbers: 208
Expression analysis of growth and energy regulation-associated genes in two divergent chicken strains
Author(s): S. Ka, C. J. Fitzsimmons, L. Jacobsson, P. Savolainen, J. Lundeberg, P.B. Siegel, L. Andersson, and F. Hallböök
Publication Date:
2005
Publication: Ann. N Y Acad. Sci.
Volume: 1040
Page Numbers: 357-359
ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels
Author(s): P. Savolainen, C. J. Fitzsimmons, L. Arvestad, L. Andersson, and J. Lundeberg
Publication Date:
2005
Publication: Cytogenet. Genome Res.
Volume: 111
Page Numbers: 79-87
Detection of sequence polymorphisms in red junglefowl and White Leghorn ESTs
Author(s): C. J. Fitzsimmons, P. Savolainen, B. Amini, G. Hjälm, J. Lundeberg, and L. Andersson
Publication Date:
2004
Publication: Anim. Genet.
Volume: 35
Page Numbers: 391-396
EST-Based Gene Discovery in Pig: Virtual Expression Patterns and Comparative Mapping to Human
Author(s): C. K. Tuggle, J. A. Green, C. Fitzsimmons, R. Woods, R. S. Prather, S. Malchenko, M. B. Soares, T. Kucaba, K. Crouch, C. Smith, D. Tack, N. Robinson, B. O'Leary, T. Scheetz, T. Casavant, D. Pomp, J. B. Edeal, Y. Zhang, M. F. Rothschild, and K. G. Beavis
Publication Date:
2003
Publication: Mamm. Genome
Volume: 14
Page Numbers: 565-579
Complementary DNA macroarray analyses of differential gene expression in porcine fetal and postnatal muscle
Author(s): S-H. Zhao, D. Nettleton, W. Liu, C. Fitzsimmons, C. W. Ernst, N. E. Raney, and C. K. Tuggle
Publication Date:
2003
Publication: J. Anim. Sci.
Volume: 81
Page Numbers: 2179-2188
Precise mapping of breakpoints in conserved synteny between human chromosome 1 and pig chromosomes 4, 6 and 9
Author(s): H. S. Sun, C. K. Tuggle, A. Goureau, C. J. Fitzsimmons, P. Pinton, P. Chardon and M. Yerle
Publication Date:
2002
Publication: Anim. Genet.
Volume: 33
Page Numbers: 91-96
Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
Author(s): F. C. Buchanan, C. J. Fitzsimmons, A. G. Van Kessel, T. D. Thue, D.C. Winkelmen-Sim and S. M. Schmutz
Publication Date:
2002
Publication: Genet. Sel. Evol.
Volume: 34
Page Numbers: 105-116
Radiation hybrid comparative mapping between human chromosome 17 and porcine chromosome 12 demonstrates conservation of gene order
Author(s): X-W. Shi, C. J. Fitzsimmons, C. Genêt, R. Prather, K. Whitworth, J. A. Green, and C. K. Tuggle
Publication Date:
2001
Publication: Anim. Genet.
Volume: 32
Page Numbers: 205-209
A potential association between the BM 1500 microsatellite and fat deposition in cattle
Author(s): C. J. Fitzsimmons, S. M. Schmutz, R. D. Bergen, and J. J. McKinnon
Publication Date:
1998
Publication: Mamm. Genome
Volume: 9
Page Numbers: 432-434