Carolyn Fitzsimmons, PhD

AAFC Asscoiate Professor, Bovine Genetics and Genomics

Pronouns: she, her, hers

Contact

AAFC Asscoiate Professor, Bovine Genetics and Genomics
Email
cfitzsim@ualberta.ca

Overview

Area of Study / Keywords

Bovine Genetics and Genomics Fetal Programming


About

Degree

PhD, Uppsala University, Sweden

Job/Research Area 

Gene Expression, Bovine Genetics 


Research

Major Responsibilities/Research Interests 

My interests lie in how biological systems influence the development of lean meat and fat tissues, specifically looking through the window of gene expression. Many new and exciting areas have now come to the forefront regarding the control of gene expression via dietary means (nutrigenomics), and the different individual responses to changes in diet (nutrigenetics). By utilizing changes in gene expression due to diet and/or other treatments, we can tease out a clearer understanding of how biological systems function and then apply this knowledge to practical situations, for example beef production. I am also interested permanent gene expression changes that can be programmed in the next generation due to nutrition and/or other factors affecting the parental generation (epigenetics). 

Courses

AFNS 574 - Applied Beef Cattle Science

Examination of current and potential future production and management practices to optimize production efficiency and animal well-being in the Canadian and international beef industry. Laboratories emphasize practical applications, field trips, and discussion. Not to be taken if credit received for AN SC 474. Prerequisite: consent of instructor.


AN SC 474 - Applied Beef Cattle Science

Examination of current and potential future production and management practices to optimize production efficiency and animal well-being in the Canadian and international beef industry. Laboratories emphasize practical applications, field trips, and discussion. Prerequisites: (AN SC 101 or 200), AN SC 260 and AN SC 310.


Browse more courses taught by Carolyn Fitzsimmons

Publications

Genetic potential for residual feed intake and diet fed during early- to mid-gestation influences post-natal DNA methylation of imprinted genes in muscle and liver tissues in beef cattle

Author(s): Devos, J., Behrouzi, A., Paradis, F., Straathof, C., Li, C., Colazo, M., Block, H. and Fitzsimmons, C.
Publication Date: 5/15/2021
Publication: Journal of Animal Science
Volume: 99
Issue: 5
External Link: https://academic.oup.com/jas/article/99/5/skab140/6276235?login=true

Impact of prenatal maternal nutrition and parental residual feed intake (RFI) on mRNA abundance of metabolic drivers of growth and development in young Angus bulls

Author(s): Foroutan, A., Devos, J., Wishart, D.S., Li, C., Colazo, M., Kastelic, J., Thundathil, J. and Fitzsimmons, C.
Publication Date: 2021
Publication: Livestock Science
Volume: 243
Page Numbers: 104365
External Link: https://www.sciencedirect.com/science/article/abs/pii/S1871141320319697

Serum Metabolite Biomarkers for Predicting Residual Feed Intake (RFI) of Young Angus Bulls

Author(s): Foroutan, A., Fitzsimmons, C., Mandal, R., Berjanskii, M. and Wishart, D.
Publication Date: 11/30/2020
Publication: Metabolites
Volume: 10
Issue: 12
Page Numbers: 491
External Link: https://www.mdpi.com/2218-1989/10/12/491

Bovine hepatic miRNAome profiling and differential miRNA expression analyses between beef steers with divergent feed efficiency phenotypes

Author(s): Mukiibi, R., Johnston, D., Vinsky, M., Fitzsimmons, C., Stothard, P., Waters, S.M. and Li, C.
Publication Date: 11/9/2020
Publication: Scientific Reports
Volume: 10
Issue: 1
Page Numbers: 19309
External Link: https://www.nature.com/articles/s41598-020-73885-5

Testis-specific changes in gene expression of post-pubertal beef bulls divergent for residual feed intake and exposure to different pre-natal diets

Author(s): Johnson, C., Fitzsimmons, C., Kovalchuk, I., Kastelic, J. and Thundathil, J.
Publication Date: 5/21/2020
Publication: Animal Production Science
Volume: 60
Issue: 12
Page Numbers: 1491-1502
External Link: https://www.publish.csiro.au/an/AN19524

The Bovine Metabolome

Author(s): Foroutan, A., Fitzsimmons, C., Mandal, R., Piri-Moghadam, H., Zheng, J., Guo, A., Li, C., Guan, L.L. and Wishart, D.S.
Publication Date: 5/5/2020
Publication: Metabolites
Volume: 10
Issue: 6
Page Numbers: 233
External Link: https://www.mdpi.com/2218-1989/10/6/233

Transcriptomic analysis by RNA-sequencing reveals that hepatic interferon-induced genes may be associated with feed efficiency in beef heifers

Author(s): Paradis F, Yue S, Grant JR, Stothard P, Basarab J, & Fitzsimmons C
Publication Date: 2015
Publication: Journal of Animal Science
Volume: 93
Issue: 7
Page Numbers: 3331-3341

Genome-wide association for heifer reproduction and postpartum performance traits in beef cattle

Author(s): Akanno EC, Plastow G, Fitzsimmons C,Akanno EC, Plastow G, Fitzsimmons C, Miller SP, Baron V, Ominski K, Basarab JA
Publication Date: 2015
Publication: Genome

Characterization and evaluation of residual feed intake measured in mid- to late-gestation mature beef cows and relationships with circulating serum metabolites and linear body measurements

Author(s): Wood KM, Montanholi YR, Fitzsimmons CF, Miller SP, McBride BW, & Swanson KC
Publication Date: 2014
Publication: Canadian Journal of Animal Science
Volume: 94
Issue: 3
Page Numbers: 499-508

Widespread Differential Maternal and Paternal Genome Effects on Fetal Bone Phenotype at Mid-Gestation

Author(s): Xiang R, Lee AMC, Eindorf T, Javadmanesh A, Ghanipoor-Samami M, Gugger M, Fitzsimmons CJ, Kruk ZA, Pitchford WS, Leviton AJ, Thomsen DA, Beckman I, Anderson GI, Burns BM, Rutley DL, Xian CJ, Hiendleder S
Publication Date: 2014
Publication: Journal of Bone and Mineral Research
Volume: 29
Issue: 11
Page Numbers: 2392-2404

Effect of moderate dietary restriction on visceral organ weight, hepatic oxygen consumption, and metabolic proteins associated with energy balance in mature pregnant beef cows

Author(s): Wood KM, Awda BJ, Fitzsimmons C, Miller SP, McBride BW, & Swanson KC
Publication Date: 2013
Publication: Journal of Animal Science
Volume: 91
Issue: 9
Page Numbers: 4245-4255

The influence of pregnancy in mid-to-late gestation on circulating metabolites, visceral organ mass, and abundance of proteins relating to energy metabolism mature beef cows

Author(s): Wood KM, Awda BJ, Fitzsimmons C, Miller SP, McBride BW, & Swanson KC
Publication Date: 2013
Publication: Journal of Animal Science
Volume: 91
Issue: 12
Page Numbers: 5775-5784

Maternal and Paternal Genomes Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation

Author(s): Xiang R, Ghanipoor-Samami M, Johns WH, Eindorf T, Rutley DL, Kruk ZA, Fitzsimmons C, Thomsen DA, Roberts CT, Burns BM, Anderson GI, Greenwood PL, & Hiendleder S
Publication Date: 2013
Publication: PLoS One
Volume: 8
Issue: 1
Page Numbers: e53402

INSL3 in the Ruminant: A Powerful Indicator of Gender- and Genetic-Specific Feto-Maternal Dialogue

Author(s): Anand-Ivell R., Hiendleder S., Viñoles C., Martin G.B., Fitzsimmons C., Eurich A., Hafen B. & Ivell R.
Publication Date: 2011
Publication: PLoS One
Volume: 6
Page Numbers: e19821

Extremely different behaviours in high and low body weight lines of chicken are involved in differential expression of genes involved in neuronal plasticity

Author(s): S. Ka, J. Lindberg, L. Stömstedt, C. J. Fitzsimmons, N. Lindqvist, J. Lundeberg, P.B. Siegel, L. Andersson, and F. Hallböök
Publication Date: 2009
Publication: J Neuroendocrinol
Volume: 21
Page Numbers: 208-216

A cis-acting regulatory mutation is causing premature hair greying and susceptibility to melanoma in the horse

Author(s): G. Rosengren-Pielberg, A. Golovko, E. Sundström, I. Curik, J. Lennartsson, M. H. Seltenhammer, T. Druml, M. Binns, C. Fitzsimmons, G. Lindgren, K. Sandberg, R. Baumung, M. Vetterlein, S. Strömberg, M. Grabherr, C. Wade, K. Lindblad-Toh1, F. Pontén, C. Heldin, J. Sölkner and L. Andersson
Publication Date: 2008
Publication: Nature Genetics
Volume: 40
Page Numbers: 1004-1009

Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traits

Author(s): C-J. Rubin, J. Lindberg, C. J. Fitzsimmons, P. Savolainen, P. Jensen, J. Lundeberg, L. Andersson, A. Kindmark
Publication Date: 2007
Publication: BMC Genomics
Volume: 8
Page Numbers: 208

Expression analysis of growth and energy regulation-associated genes in two divergent chicken strains

Author(s): S. Ka, C. J. Fitzsimmons, L. Jacobsson, P. Savolainen, J. Lundeberg, P.B. Siegel, L. Andersson, and F. Hallböök
Publication Date: 2005
Publication: Ann. N Y Acad. Sci.
Volume: 1040
Page Numbers: 357-359

ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels

Author(s): P. Savolainen, C. J. Fitzsimmons, L. Arvestad, L. Andersson, and J. Lundeberg
Publication Date: 2005
Publication: Cytogenet. Genome Res.
Volume: 111
Page Numbers: 79-87

Detection of sequence polymorphisms in red junglefowl and White Leghorn ESTs

Author(s): C. J. Fitzsimmons, P. Savolainen, B. Amini, G. Hjälm, J. Lundeberg, and L. Andersson
Publication Date: 2004
Publication: Anim. Genet.
Volume: 35
Page Numbers: 391-396

EST-Based Gene Discovery in Pig: Virtual Expression Patterns and Comparative Mapping to Human

Author(s): C. K. Tuggle, J. A. Green, C. Fitzsimmons, R. Woods, R. S. Prather, S. Malchenko, M. B. Soares, T. Kucaba, K. Crouch, C. Smith, D. Tack, N. Robinson, B. O'Leary, T. Scheetz, T. Casavant, D. Pomp, J. B. Edeal, Y. Zhang, M. F. Rothschild, and K. G. Beavis
Publication Date: 2003
Publication: Mamm. Genome
Volume: 14
Page Numbers: 565-579

Complementary DNA macroarray analyses of differential gene expression in porcine fetal and postnatal muscle

Author(s): S-H. Zhao, D. Nettleton, W. Liu, C. Fitzsimmons, C. W. Ernst, N. E. Raney, and C. K. Tuggle
Publication Date: 2003
Publication: J. Anim. Sci.
Volume: 81
Page Numbers: 2179-2188

Precise mapping of breakpoints in conserved synteny between human chromosome 1 and pig chromosomes 4, 6 and 9

Author(s): H. S. Sun, C. K. Tuggle, A. Goureau, C. J. Fitzsimmons, P. Pinton, P. Chardon and M. Yerle
Publication Date: 2002
Publication: Anim. Genet.
Volume: 33
Page Numbers: 91-96

Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels

Author(s): F. C. Buchanan, C. J. Fitzsimmons, A. G. Van Kessel, T. D. Thue, D.C. Winkelmen-Sim and S. M. Schmutz
Publication Date: 2002
Publication: Genet. Sel. Evol.
Volume: 34
Page Numbers: 105-116

Radiation hybrid comparative mapping between human chromosome 17 and porcine chromosome 12 demonstrates conservation of gene order

Author(s): X-W. Shi, C. J. Fitzsimmons, C. Genêt, R. Prather, K. Whitworth, J. A. Green, and C. K. Tuggle
Publication Date: 2001
Publication: Anim. Genet.
Volume: 32
Page Numbers: 205-209

A potential association between the BM 1500 microsatellite and fat deposition in cattle

Author(s): C. J. Fitzsimmons, S. M. Schmutz, R. D. Bergen, and J. J. McKinnon
Publication Date: 1998
Publication: Mamm. Genome
Volume: 9
Page Numbers: 432-434