Carolyn Fitzsimmons, PhD

Pronouns: she, her, hers

Contact Overview Publications

Contact

Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept

Email: cfitzsim@ualberta.ca

Overview

Area of Study / Keywords

Bovine Genetics and Genomics Fetal Programming

About

Degree

PhD, Uppsala University, Sweden

Job/Research Area

Gene Expression, Bovine Genetics

Research

Major Responsibilities/Research Interests

My interests lie in how biological systems influence the development of lean meat and fat tissues, specifically looking through the window of gene expression. Many new and exciting areas have now come to the forefront regarding the control of gene expression via dietary means (nutrigenomics), and the different individual responses to changes in diet (nutrigenetics). By utilizing changes in gene expression due to diet and/or other treatments, we can tease out a clearer understanding of how biological systems function and then apply this knowledge to practical situations, for example beef production. I am also interested permanent gene expression changes that can be programmed in the next generation due to nutrition and/or other factors affecting the parental generation (epigenetics).

Featured Publications

Genetic potential for residual feed intake and diet fed during early- to mid-gestation influences post-natal DNA methylation of imprinted genes in muscle and liver tissues in beef cattle

Devos, J., Behrouzi, A., Paradis, F., Straathof, C., Li, C., Colazo, M., Block, H. and Fitzsimmons, C.

Journal of Animal Science. 2021 May; 99 (5)

Impact of prenatal maternal nutrition and parental residual feed intake (RFI) on mRNA abundance of metabolic drivers of growth and development in young Angus bulls

Foroutan, A., Devos, J., Wishart, D.S., Li, C., Colazo, M., Kastelic, J., Thundathil, J. and Fitzsimmons, C.

Livestock Science. 2021 January; 243

Serum Metabolite Biomarkers for Predicting Residual Feed Intake (RFI) of Young Angus Bulls

Foroutan, A., Fitzsimmons, C., Mandal, R., Berjanskii, M. and Wishart, D.

Metabolites. 2020 November; 10 (12):491

Bovine hepatic miRNAome profiling and differential miRNA expression analyses between beef steers with divergent feed efficiency phenotypes

Mukiibi, R., Johnston, D., Vinsky, M., Fitzsimmons, C., Stothard, P., Waters, S.M. and Li, C.

Scientific Reports. 2020 November; 10 (1):19309

Testis-specific changes in gene expression of post-pubertal beef bulls divergent for residual feed intake and exposure to different pre-natal diets

Johnson, C., Fitzsimmons, C., Kovalchuk, I., Kastelic, J. and Thundathil, J.

Animal Production Science. 2020 May; 60 (12):1491-1502

The Bovine Metabolome

Foroutan, A., Fitzsimmons, C., Mandal, R., Piri-Moghadam, H., Zheng, J., Guo, A., Li, C., Guan, L.L. and Wishart, D.S.

Metabolites. 2020 May; 10 (6):233

Transcriptomic analysis by RNA-sequencing reveals that hepatic interferon-induced genes may be associated with feed efficiency in beef heifers

Paradis F, Yue S, Grant JR, Stothard P, Basarab J, & Fitzsimmons C

Journal of Animal Science. 2015 January; 93 (7):3331-3341

Genome-wide association for heifer reproduction and postpartum performance traits in beef cattle

Akanno EC, Plastow G, Fitzsimmons C,Akanno EC, Plastow G, Fitzsimmons C, Miller SP, Baron V, Ominski K, Basarab JA

Genome. 2015 January;

Characterization and evaluation of residual feed intake measured in mid- to late-gestation mature beef cows and relationships with circulating serum metabolites and linear body measurements

Wood KM, Montanholi YR, Fitzsimmons CF, Miller SP, McBride BW, & Swanson KC

Canadian Journal of Animal Science. 2014 January; 94 (3):499-508

Widespread Differential Maternal and Paternal Genome Effects on Fetal Bone Phenotype at Mid-Gestation

Xiang R, Lee AMC, Eindorf T, Javadmanesh A, Ghanipoor-Samami M, Gugger M, Fitzsimmons CJ, Kruk ZA, Pitchford WS, Leviton AJ, Thomsen DA, Beckman I, Anderson GI, Burns BM, Rutley DL, Xian CJ, Hiendleder S

Journal of Bone and Mineral Research. 2014 January; 29 (11):2392-2404

Effect of moderate dietary restriction on visceral organ weight, hepatic oxygen consumption, and metabolic proteins associated with energy balance in mature pregnant beef cows

Wood KM, Awda BJ, Fitzsimmons C, Miller SP, McBride BW, & Swanson KC

Journal of Animal Science. 2013 January; 91 (9):4245-4255

The influence of pregnancy in mid-to-late gestation on circulating metabolites, visceral organ mass, and abundance of proteins relating to energy metabolism mature beef cows

Wood KM, Awda BJ, Fitzsimmons C, Miller SP, McBride BW, & Swanson KC

Journal of Animal Science. 2013 January; 91 (12):5775-5784

Maternal and Paternal Genomes Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation

Xiang R, Ghanipoor-Samami M, Johns WH, Eindorf T, Rutley DL, Kruk ZA, Fitzsimmons C, Thomsen DA, Roberts CT, Burns BM, Anderson GI, Greenwood PL, & Hiendleder S

PLoS One. 2013 January; 8 (1):e53402

INSL3 in the Ruminant: A Powerful Indicator of Gender- and Genetic-Specific Feto-Maternal Dialogue

Anand-Ivell R., Hiendleder S., Viñoles C., Martin G.B., Fitzsimmons C., Eurich A., Hafen B. & Ivell R.

PLoS One. 2011 January; 6

Extremely different behaviours in high and low body weight lines of chicken are involved in differential expression of genes involved in neuronal plasticity

S. Ka, J. Lindberg, L. Stömstedt, C. J. Fitzsimmons, N. Lindqvist, J. Lundeberg, P.B. Siegel, L. Andersson, and F. Hallböök

J Neuroendocrinol. 2009 January; 21

A cis-acting regulatory mutation is causing premature hair greying and susceptibility to melanoma in the horse

G. Rosengren-Pielberg, A. Golovko, E. Sundström, I. Curik, J. Lennartsson, M. H. Seltenhammer, T. Druml, M. Binns, C. Fitzsimmons, G. Lindgren, K. Sandberg, R. Baumung, M. Vetterlein, S. Strömberg, M. Grabherr, C. Wade, K. Lindblad-Toh1, F. Pontén, C. Heldin, J. Sölkner and L. Andersson

Nature Genetics. 2008 January; 40

Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traits

C-J. Rubin, J. Lindberg, C. J. Fitzsimmons, P. Savolainen, P. Jensen, J. Lundeberg, L. Andersson, A. Kindmark

BMC Genomics. 2007 January; 8

Expression analysis of growth and energy regulation-associated genes in two divergent chicken strains

S. Ka, C. J. Fitzsimmons, L. Jacobsson, P. Savolainen, J. Lundeberg, P.B. Siegel, L. Andersson, and F. Hallböök

Ann. N Y Acad. Sci.. 2005 January; 1040

ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels

P. Savolainen, C. J. Fitzsimmons, L. Arvestad, L. Andersson, and J. Lundeberg

Cytogenet. Genome Res.. 2005 January; 111

Detection of sequence polymorphisms in red junglefowl and White Leghorn ESTs

C. J. Fitzsimmons, P. Savolainen, B. Amini, G. Hjälm, J. Lundeberg, and L. Andersson

Anim. Genet.. 2004 January; 35

EST-Based Gene Discovery in Pig: Virtual Expression Patterns and Comparative Mapping to Human

C. K. Tuggle, J. A. Green, C. Fitzsimmons, R. Woods, R. S. Prather, S. Malchenko, M. B. Soares, T. Kucaba, K. Crouch, C. Smith, D. Tack, N. Robinson, B. O'Leary, T. Scheetz, T. Casavant, D. Pomp, J. B. Edeal, Y. Zhang, M. F. Rothschild, and K. G. Beavis

Mamm. Genome. 2003 January; 14

Radiation hybrid comparative mapping between human chromosome 17 and porcine chromosome 12 demonstrates conservation of gene order

X-W. Shi, C. J. Fitzsimmons, C. Genêt, R. Prather, K. Whitworth, J. A. Green, and C. K. Tuggle

Anim. Genet.. 2001 January; 32

A potential association between the BM 1500 microsatellite and fat deposition in cattle

C. J. Fitzsimmons, S. M. Schmutz, R. D. Bergen, and J. J. McKinnon

Mamm. Genome. 1998 January; 9