Constantine Karvellas



Area of Study / Keywords

Cirrhosis Acute on chronic liver failure palliative care Molecular Adsorbent Recirculating System Albumin Dialysis Acute Liver Failure biomarkers Critical Illness Total Parenteral Nutrition Hepatic Encephalopathy critically ill intracranial hypertension acetaminophen toxicity fatty acid binding protein liver transplant


Dr. Constantine (Dean) Karvellas is a Professor of Medicine (Critical Care Medicine and Gastroenterology/Hepatology) at the University of Alberta and an Adjunct Professor in the School of Public Health Sciences. He has been an attending intensivist in the E. Garner King General Systems Intensive Care Unit since 2009 and is involved with the Liver Transplant program as a Hepatologist. Dr. Karvellas is the only Canadian co-investigator in the NIH-funded United States Acute Liver Failure study group (US ALFSG). He is an Associate Editor for the Journal of Hepatology and a Vice-chair of the Society of Critical Care Medicine (SCCM) Liver management task force. Dr. Karvellas has over 100 publications reflecting his interests in acute liver failure (ALF), acute on chronic liver failure (ACLF), liver transplantation and extracorporeal liver support.

Featured Publications

Sundaram V., Patel S., Shetty K., Lindenmeyer C.C., Rahimi R.S., Flocco G., Al-Attar A., Karvellas C.J., Challa S., Maddur H., Jou J.H., Kriss M., Stein L.L., Xiao A.H., Vyhmeister R.H., Green E.W., Campbell B., Cranford W., Mahmud N., Fortune B.E.

LIVER TRANSPLANTATION. 2022 June; 28 (6):1078-1089 10.1002/lt.26408

Kaur B., Cardenas A., Karvellas C.J.

Clinical Liver Disease. 2022 May; 19 (5):187-190 10.1002/cld.1222

Cheung K., Mailman J.F., Crawford J.J., Karvellas C.J., Sy E.

Journal of the Intensive Care Society. 2022 May; 23 (2):139-149 10.1177/1751143720985293

Hetherington A., Cardoso F.S., Lester E.L.W., Karvellas C.J.

Current Opinion in Critical Care. 2022 April; 28 (2):184-189 10.1097/MCC.0000000000000928

Opgenorth D., Baig N., Fiest K., Karvellas C., Kutsogiannis J., Lau V., Macintyre E., Senaratne J., Slemko J., Sligl W., Wang X., Bagshaw S.M., Rewa O.G.

Trials. 2022 March; 23 (1):194 10.1186/s13063-022-06115-0

MacDonald A.J., Subramanian R.M., Olson J.C., Speiser J.L., Durkalski-Mauldin V.L., Abraldes J.G., Bigam D.L., Flynn M.M., Rapaka B., Shropshire B.M., Vora R.S., Karvellas C.J.

CRITICAL CARE MEDICINE. 2022 February; 50 (2):286-295 10.1097/CCM.0000000000005194

Hefler J., Marfil-Garza B.A., Pawlick R.L., Freed D.H., Karvellas C.J., Bigam D.L., Shapiro A.M.J.

PeerJ. 2021 December; 9 (9):e12579 10.7717/peerj.12579

Dong V., Nadim M.K., Karvellas C.J.

LIVER TRANSPLANTATION. 2021 November; 27 (11):1653-1664 10.1002/lt.26094

Excellent survival but greater post-transplant complications and healthcare resource utilization for patients transplanted for acute-on-chronic liver failure.

Hepatology (AASLD 2021). 2021 October;

Osteopontin, macrophage mannose receptor and soluble PD-L1 are upregulated macrophage activation markers in patients with acute liver failure.

Hepatology (AASLD 2021). 2021 October;

Persistent acute kidney injury and not transient azotemia was associated with lower transplant free survival in patients with acute liver failure: a multicenter cohort study.

Hepatology (AASLD 2021). 2021 October;

Portal vein thrombosis is a newly identified risk factor for post-transplant mortality in grade three acute-on-chronic liver failure.

Hepatology (AASLD 2021). 2021 October;

Spontaneous survival is associated with anti-HBc IgM and immunoregulatory cytokine response in patients with Hepatitis B related acute liver failure.

Hepatology (AASLD 2021). 2021 October;

Tavabie O.D., Karvellas C.J., Salehi S., Speiser J.L., Rose C.F., Menon K., Prachalias A., Heneghan M.A., Agarwal K., Lee W.M., McPhail M.J.W., Aluvihare V.R.

JOURNAL OF HEPATOLOGY. 2021 August; 75 (2):424-434 10.1016/j.jhep.2021.03.013

Bernal W., Karvellas C., Saliba F., Saner F.H., Meersseman P.

JOURNAL OF HEPATOLOGY. 2021 July; 75 (Suppl1):S163-S177 10.1016/j.jhep.2020.10.024

Karvellas C.J., Francoz C., Weiss E.

TRANSPLANTATION. 2021 July; 105 (7):1471-1481 10.1097/TP.0000000000003550

Cardoso F.S., Pereira R., Laranjo A., Gamelas V., Bagulho L., Germano N., Karvellas C.J.

JOURNAL OF CRITICAL CARE. 2021 June; 63 10.1016/j.jcrc.2020.09.012

Cardoso F., Mcphail M., Karvellas C., Fuhrmann V., Germano N., Auzinger G.

GE Portuguese Journal of Gastroenterology. 2021 May; 29 (1):22-30 10.1159/000516672

Khemichian S., Francoz C., Durand F., Karvellas C.J., Nadim M.K.

CRITICAL CARE CLINICS. 2021 April; 37 (2):321-334 10.1016/j.ccc.2020.11.011

Cardoso F.S., Pereira R., Moreno R., Karvellas C.J., Germano N.

GE Portuguese Journal of Gastroenterology. 2021 April; 28 (3):170-178 10.1159/000511646

Dong V., Karvellas C.J.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2021 March; 24 (2):189-194 10.1097/MCO.0000000000000721

Weiss E., Saner F., Asrani S.K., Biancofiore G., Blasi A., Lerut J., Durand F., Fernandez J., Findlay J.Y., Fondevila C., Francoz C., Gustot T., Jaber S., Karvellas C., Kronish K., Laleman W., Laterre P.F., Levesque E., Mandell M.S., Mc Phail M., Muiesan P., Olson J.C., Olthoff K., Daniele Pinna A., Reiberger T., Reyntjens K., Saliba F., Scatton O., Simpson K.J., Soubrane O., Subramanian R.M., Tacke F., Tomescu D., Xia V., Wagener G., Paugam-Burtz C.

TRANSPLANTATION. 2021 March; 105 (3):561-568 10.1097/TP.0000000000003364

R T Stravitz, R J Fontana, C Meinzer, V Durkalski, A J Hanje, J Olson, D Koch, B Hamid, M L Schilsky, B McGuire, D Ganger, I Liou, C J Karvellas, J A Rule, T Lisman, K Clasen, A Reuben, M W Cripps, W M Lee, ALF Study Group

HEPATOLOGY. 2021 February; 74 (2):937-949 10.1002/hep.31767

Sundaram V., Mahmud N., Perricone G., Katarey D., Wong R.J., Karvellas C.J., Fortune B.E., Rahimi R.S., Maddur H., Jou J.H., Kriss M., Stein L.L., Lee M., Jalan R.

LIVER TRANSPLANTATION. 2020 December; 26 (12):1594-1602 10.1002/lt.25831

Bleeding, thrombosis and outcome according to rotational thromboelastometry (ROTEM) parameters in patients with acute liver injury /failure.

Hepatology (AASLD Liver Meeting). 2020 November;

Cost-utility of n-acetyl cysteine in acute liver failure.

Hepatology (AASLD Liver Meeting). 2020 November;

Improved transplant-free survival following molecular adsorbent recirculating system therapy in acute liver failure: a multicenter propensity score-matched study.

Hepatology. 2020 November;

Surviving acute liver failure: an analysis of ALFSG and SRTR data.

Hepatology (AASLD Liver Meeting). 2020 November;

Upregulation of macrophage activation markers is associated with poor outcome in patients with acute liver failure.

Hepatology (AASLD Liver Meeting). 2020 November;