Jan Willem Cohen Tervaert

Area of Study / Keywords

vascular immunology auto-immunity to myeloid lysosomal enzymes pathophysiology of vasculitis accelerated atherosclerosis in rheumatic diseases ASIA syndrome role of vitamin D in auto-immune diseases inflammation translational research rheumatology clinical immunology

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About

Personal Statement:

My expertise is rheumatic diseases with a focus on vasculitis, a category of severe, autoimmune diseases that cause inflammation of the blood vessels. My goal is to develop a translational research laboratory to study (vascular) immunology here in our Department of Medicine so that we can take immunological findings in the lab, into much-needed patient care.

Dr. Cohen Tervaert was recruited from Maastricht University in 2017 as professor and director of the Department of Medicine’s Division of Rheumatology. He trained in internal medicine, nephrology and immunology in the Netherlands and was a visiting researcher in vascular biology at Harvard Medical School. 

In 1993, he returned to Groningen (as a recipient of a fellowship of the Royal Netherlands Academy of Sciences), where he was a staff member at the Department of Clinical Immunology at the University Medical Center Groningen. In 2000, he was appointed Professor of Medicine and Immunology at the Maastricht University. Until 2012, he was the chairman of the Division of Clinical and Experimental Immunology of the Department of Internal Medicine and head of the Immunology Laboratory at the Maastricht University Medical Center. From 2012-2015, he was research director of the Sint Franciscus Vlietland Group in Rotterdam.

A specialist in immunology, he is establishing a laboratory in vascular immunology at the University of Alberta to accelerate research discoveries into new therapies for patients with systemic autoimmune diseases such as vasculitis, systemic sclerosis and dermatomyositis. 

Leadership and Collaborations
Dr. Cohen Tervaert is a founding member of the Autoimmunity Consortium, the North American Vascular Biology Organization and the Dutch Vasculitis Study Group. 

He served in several national medical leadership roles in the Netherlands. He is a former chair of the scientific advisory board of the Dutch Arthritis Foundation (“Reumafonds”) and of the Dutch Scientific Section of Nephrology. He was a board member of the Dutch Federation of Nephrology and the Dutch Society of Immunology, and a member of the scientific advisory board of The National Health Care Institute that advises the Dutch Minister of Health, Welfare, and Sports on health care coverage and medications in the Netherlands. 

Dr. Cohen Tervaert was an expert member of a WHO committee assessing autoimmunity associated with exposure to chemicals and of the Netherlands National Institute for Public Health and the Environment Committee on Chromium-VI. He was also a member of the Health Council of the Netherlands committee on myalgic encephalomyelitis/chronic fatigue syndrome.

He has served on the editorial board of several journals including Clinical and Experimental Immunology.

See also: Presentation to FDA (USA) – March 25, 2019

Clinical Interests

Dr. Cohen Tervaert is a rheumatologist, clinical immunologist and internal medicine specialist with a focus on vasculitis and rheumatic diseases developing after foreign body implantation such as polypropylene mesh, hip and knee implants and/or breast implants. He treats patients at the Kaye Edmonton Clinic. 

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Research

Dr. Cohen Tervaert is a leading researcher in the fields of inflammation and autoimmunity of vascular disorders, such as atherosclerosis and vasculitis. His research has a special focus on genes and the interplay with environmental factors such as vitamin D, S. aureus, silica, and foreign body implantation such as silicones and polypropylene mesh in the development of autoimmunity. In 2018, he was the first scientist to publish a study of autoimmune responses in people who had polypropylene mesh implantation. The study contributed to the US and Canada banning polypropylene meshes. 

He is lead author and coauthor of more than 430 scientific articles that are cited in more than 27,000 publications. He is a member of the editorial boards of three scientific journals. His Hirsch factor as of September 2019 is 83. 

Major Grant
Fatigue in patients with vasculitis and/or other systemic autoimmune diseases.  Dutch Kidney Foundation: 2019-2023

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Teaching

Dr. Cohen Tervaert is an experienced teacher about the role of the immune system in cardiovascular diseases such as atherosclerosis and vasculitis. In addition, the interaction between the immune system and the development of malignancies is one of his favorite subjects to explain how the immune system works. Furthermore, with multiple case studies as examples, he loves to teach about common and rare rheumatic diseases.

Cohen Tervaert J.W., van Eeden C., Osman M.

Expert Review of Clinical Immunology. 2022 August; 18 (8):777-778 10.1080/1744666X.2022.2090340

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Gniadecki R., Iyer A., Hennessey D., Khan L., O'Keefe S., Redmond D., Storek J., Durand C., Cohen-Tervaert J.W., Osman M.

JOURNAL OF AUTOIMMUNITY. 2022 July; 131 10.1016/j.jaut.2022.102847

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13th International Congress on Autoimmunity 2022 . 2022 June;

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13th International Congress on Autoimmunity 2022 . 2022 June;

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13th International Congress on Autoimmunity 2022 . 2022 June;

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Alessandra Bettiol 1, Maria Letizia Urban 1, Lorenzo Dagna 2, Vincent Cottin 3, Franco Franceschini 4 5, Stefano Del Giacco 6, Franco Schiavon 7, Thomas Neumann 8 9, Giuseppe Lopalco 10, Pavel Novikov 11, Chiara Baldini 12, Carlo Lombardi 13, Alvise Berti 14, Federico Alberici 15 16, Marco Folci 17 18, Simone Negrini 19 20, Renato Alberto Sinico 21, Luca Quartuccio 22, Claudio Lunardi 23, Paola Parronchi 1, Frank Moosig 24, Georgina Espígol-Frigolé 25 26, Jan Schroeder 27, Anna Luise Kernder 28, Sara Monti 29, Ettore Silvagni 30, Claudia Crimi 31, Francesco Cinetto 32, Paolo Fraticelli 33, Dario Roccatello 34, Angelo Vacca 35, Aladdin J Mohammad 36 37, Bernhard Hellmich 38, Maxime Samson 39, Elena Bargagli 40, Jan Willem Cohen Tervaert 41 42, Camillo Ribi 43, Davide Fiori 1, Federica Bello 1, Filippo Fagni 1, Luca Moroni 2, Giuseppe Alvise Ramirez 2, Mouhamad Nasser 3, Chiara Marvisi 44 45, Paola Toniati 4, Davide Firinu 6, Roberto Padoan 7, Allyson Egan 37, Benjamin Seeliger 46, Florenzo Iannone 10, Carlo Salvarani 44 45, David Jayne 37, Domenico Prisco 1, Augusto Vaglio 47 48, Giacomo Emmi 1, European EGPA Study Group

Arthritis & Rheumatology. 2022 February; 74 (2):295-306 doi: 10.1002/art.41943.

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Cohen Tervaert J.W., Mohazab N., Redmond D., van Eeden C., Osman M.

Expert Review of Clinical Immunology. 2022 January; 18 (1):15-29 10.1080/1744666X.2022.2010546

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Tariq S., Tervaert J.W.C., Osman M.

MICROVASCULAR RESEARCH. 2022 January; 139 10.1016/j.mvr.2021.104267

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Utkarsh Chauhan, Brett Cassidy, Jan Willem Cohen Tervaert

AUTOIMMUNITY REVIEWS. 2021 December; 20 (12):102979 10.1016/j.autrev.2021.102979

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Dylan Johnson Charmaine van Eeden Naima Moazab1 Desiree Redmond Cecile Phan Stephanie Keeling Robert Gniadecki Jan Willem Cohen Tervaert Mohammed Osman

Frontiers in Medicine. 2021 August; 8 doi.org/10.3389/fmed.2021.708432

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JOURNAL OF RHEUMATOLOGY. 2021 July;

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JOURNAL OF RHEUMATOLOGY. 2021 July;

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JOURNAL OF RHEUMATOLOGY. 2021 July;

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Mohammed Osman, Desiree Redmond 1, Jan Willem Cohen Tervaert 1

RHEUMATOLOGY. 2021 July; 60 (11):e407-e409 10.1093/rheumatology/keab525.

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Journal of Rheumatology. 2021 July; 10.3899/jrheum.210406

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Osman M., Cohen Tervaert J.W., Pagnoux C.

Expert Review of Clinical Immunology. 2021 July; 17 (7):717-726 10.1080/1744666X.2021.1932466

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Renée M L Miseré, MD, Maartje J L Colaris, MD, Jan W Cohen Tervaert, MD, PhD, René R W J van der Hulst, MD, PhD

Aesthetic Surgery Journal. 2021 June; 41 (6):661-668 https://doi.org/10.1093/asj/sjaa207

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Autoimmunity 2021 (online meeting). 2021 May;

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Autoimmunity 2021 (online meeting). 2021 May;

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Autoimmunity 2021 (online meeting). 2021 May;

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Clifford A.H., Cohen Tervaert J.W.

Atherosclerosis. 2021 May; 325 10.1016/j.atherosclerosis.2021.03.032

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Subburayalu J., Dolff S., Xu S., Sun M., Lindemann M., Heinold A., Heinemann F.M., Tervaert J.W.C., Eisenberger U., Korth J., Brinkhoff A., Kribben A., Witzke O., Wilde B.

Clinical Immunology. 2021 May; 226 10.1016/j.clim.2021.108698

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Gill N., Tervaert J.W.C., Yacyshyn E.

Clinical Rheumatology. 2021 May; 40 (5):1697-1708 10.1007/s10067-020-05398-5

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Mendel A., Ennis D., Go E., Bakowsky V., Baldwin C., Benseler S.M., Cabral D.A., Carette S., Clements-Baker M., Clifford A.H., Tervaert J.W.C., Cox G., Dehghan N., Dipchand C., Dhindsa N., Famorca L., Fifi-Mah A., Garner S., Girard L.P., Lessard C., Liang P., Noone D., Makhzoum J.P., Milman N., Pineau C.A., Reich H.N., Rhéaume M., Robinson D.B., Rumsey D.G., Towheed T.E., Trudeau J., Twilt M., Yacyshyn E., Yeung R.S.M., Barra L.B., Khalidi N., Pagnoux C.

Journal of Rheumatology. 2021 April; 48 (4):555-566 10.3899/JRHEUM.200721

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Chu R., van Eeden C., Suresh S., Sligl W.I., Osman M., Tervaert J.W.C.

International Journal of Molecular Sciences. 2021 March; 22 (6):1-16 10.3390/ijms22062967

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Tariq S., Van Eeden C., Tervaert J.W.C., Osman M.S.

Clinical Rheumatology. 2021 February; 40 (2):433-442 10.1007/s10067-020-05529-y

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Colaris M.J.L., Cohen Tervaert J.W., Ponds R.W.H.M., Wilmink J., Van Der Hulst R.R.W.J.

Plastic and Reconstructive Surgery - Global Open. 2021 February; 10.1097/GOX.0000000000003394