Declan Ali

Professor, Faculty of Science - Biological Sciences
Associate Dean (Research), Faculty of Science - Deans Office

Contact

Professor, Faculty of Science - Biological Sciences
Email
declan.ali@ualberta.ca
Phone
(780) 492-6094
Address
Z716 Bio Science - D.M. Ross Zoology Tower
11355 - Saskatchewan Drive
Edmonton AB
T6G 2E9

Associate Dean (Research), Faculty of Science - Deans Office
Email
sciadr@ualberta.ca
Phone
(780) 492-3169
Address
6-195 Centennial Ctr For Interdisciplinary SCS II
11335 Saskatchewan Drive NW
Edmonton AB
T6G 2H5

Overview

Research

The research program in my laboratory is designed to address two important issues in developmental neurobiology.

1) The role of postsynaptic receptor modulation, during synaptic development.

2) The role of presynaptic receptors in synaptic development.

The synapse is the site of contact between two neurons (nerve cells), or between a neuron and a target cell. Information transfer takes place between these pairs of cells via chemical or electrical synaptic transmission. The vast majority of synapses in the CNS are chemical in nature, and it is at these types of synapses that the major forms of synaptic plasticity and modulation take place. During chemical synaptic transmission, neurotransmitters, released from the presynaptic cell, cross the synaptic cleft and bind to (and activate) receptors on the postsynaptic cell membrane. We are interested in determining if the activity of presynaptic receptors is important for the release of neurotransmitters during the formation of synapses. Similarly, is the modulation of postsynaptic receptors important for the proper formation of synapses?