Daniel Charlebois, PhD, PPhys

Assistant Professor, Faculty of Science - Physics Admin

Contact

Assistant Professor, Faculty of Science - Physics Admin
Email
dcharleb@ualberta.ca
Phone
(780) 492-3985
Address
3-189 Centennial Ctr For Interdisciplinary SCS II
11335 Saskatchewan Drive NW
Edmonton AB
T6G 2H5

Overview

Area of Study / Keywords

Biophysics Mathematical Biology Synthetic biology Gene Regulatory Networks Nongenetic Heterogeneity Stochastic Simulations Microbial Evolution Experiments Antimicrobial Resistance


About

I am an Assistant Professor of Biophysics in the Department of Physics and an Affiliated Faculty member of the Collaborative Mathematical Biology Group at the University of Alberta.

Education & Training

NSERC Postdoctoral Fellow/Postdoctoral Associate, Laufer Center for Physical and Quantitative Biology, Stony Brook University (2014-2019) [Advisor: Prof. Gabor Balazsi]

PhD Physics (2014), University of Ottawa. Graduate researcher at the Ottawa Institute of Systems Biology [Advisor: Prof. Mads Kaern]

MSc Physics (2010), University of Ottawa. Graduate researcher at the Ottawa Institute of Systems Biology [Advisor: Prof. Mads Kaern].

BSc Physics, Applied Mathematics Minor (2008), University of Calgary. Undergraduate researcher at the Institute for Biocomplexity and Informatics [Supervisor: Dr. Stuart Kauffman].

BSc Biological Sciences (2008), University of Calgary. Undergraduate researcher at the Institute for Biocomplexity and Informatics [Supervisor: Dr. Stuart Kauffman].


Research

My research at the interface of physics and biology combines theory, computation, and experiment to make fundamental advances in our understanding of life and evolution, and applies this knowledge to study genetic networks and mitigate the growing problem of antimicrobial (drug) resistance. For more details, please visit the Charlebois Lab Website.

Announcements

I am looking to hire an experimental biophysics graduate student! There are also opportunities for undergraduate students in my group interested in an independent study course (i.e., PHYS 499, which requires a 300-level physics course and consent of the department) and/or apply for funding to participate summer research, and for postdocs with/interested in applying for fellowships. Please contact me via email and include a CV and a brief statement of research interests if you are interested in joining my group.

Publications

An algorithm for the stochastic simulation of gene expression and heterogeneous population dynamics
Author(s): Daniel A. Charlebois, Jukka Intosalmi, Dawn Fraser, Mads Kaern
Publication: Communications in Computational Physics
Volume: 9
Page Numbers: 89
External Link: https://www.cambridge.org/core/journals/communications-in-computational-physics/article/an-algorithm-for-the-stochastic-simulation-of-gene-expression-and-heterogeneous-population-dynamics/3FD3C0C7D5E6A8BA5359011E21AC7ACF#
Role of network-mediated stochasticity in mammalian drug resistance
Author(s): Kevin Farquhar, Daniel A. Charlebois, Mariola Szenk, Joseph Cohen, Dmitry Nevozhay, Gabor Balazsi
Publication: Nature Communications
Volume: 10
Page Numbers: 2766
External Link: https://www.nature.com/articles/s41467-019-10330-w
Multiscale effects of heating and cooling on genes and gene networks
Author(s): Daniel A. Charlebois, Kevin Hauser, Sylvia Marshall, Gabor Balazsi
Publication: Proceeding of the National Academy of Sciences of the United States of America
Volume: 115
Page Numbers: E10797
External Link: https://www.pnas.org/content/115/45/E10797
Coherent feedforward transcriptional regulatory motifs enhance drug resistance
Author(s): Daniel A. Charlebois, Gabor Balazsi, Mads Kaern
Publication: Physical Review E
Volume: 89
Page Numbers: 052708
External Link: https://journals.aps.org/pre/abstract/10.1103/PhysRevE.89.052708
Gene express noise facilitates adaptation and drug resistance independently of mutation
Author(s): Daniel A. Charlebois, Nezar Abdennur, Mads Kaern
Publication: Physical Review Letters
Volume: 107
Page Numbers: 218101
External Link: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.107.218101