Daniel Charlebois, PhD, PPhys

Assistant Professor, Faculty of Science - Physics Admin

Contact

Assistant Professor, Faculty of Science - Physics Admin
Email
dcharleb@ualberta.ca
Phone
(780) 492-3985
Address
3-189 Centennial Ctr For Interdisciplinary SCS II
11335 Saskatchewan Drive NW
Edmonton AB
T6G 2H5

Overview

Area of Study / Keywords

computational & experimental biophysics mathematical biology synthetic biology antimicrobial resistance bioelectromagnetics gene regulatory networks machine learning for medical diagnostics microbial evolution experiments phenotypic heterogeneity stochastic simulations


About

I am an Assistant Professor of Biophysics in the Department of Physics at the University of Alberta. I am also an Adjunct Professor in the Department of Biological Sciences and an Affiliated Faculty member of the Collaborative Mathematical Biology Group.

Education & Training

NSERC Postdoctoral Fellow/Postdoctoral Associate, Laufer Center for Physical and Quantitative Biology, Stony Brook University (2014-2019) [Advisor: Prof. Gabor Balazsi]

PhD Physics (2014), University of Ottawa. Graduate researcher at the Ottawa Institute of Systems Biology [Advisor: Prof. Mads Kaern]

MSc Physics (2010), University of Ottawa. Graduate researcher at the Ottawa Institute of Systems Biology [Advisor: Prof. Mads Kaern].

BSc Physics, Applied Mathematics Minor (2008), University of Calgary. Undergraduate researcher at the Institute for Biocomplexity and Informatics [Supervisor: Dr. Stuart Kauffman].

BSc Biological Sciences (2008), University of Calgary. Undergraduate researcher at the Institute for Biocomplexity and Informatics [Supervisor: Dr. Stuart Kauffman].


Research

My research at the interface of physics and biology combines theory, computation, and experiment to make fundamental advances in the areas of genetic networks, bioelectromagnetics, and drug resistance. For more details, please visit the Charlebois Lab Website.


Teaching

I teach introductory and advanced biophysics and first-year engineering physics courses!

Announcements

I am accepting applications from postdocs and undergraduate students that hold or are willing to apply for funding. There also be opportunities for physics and biology undergraduate students who are interested in doing a research-based independent study course (e.g., PHYS 499 or BIOL 399/499 at the University of Alberta). Send me an email including a CV, a brief statement of research interests and qualifications, and transcripts if you are interested in joining our group. Please note that only applicants selected for an interview will be contacted.

Courses

BIOPH 201 - Introduction to Biophysics

Physical principles important to the operation of biological systems. Biological applications of free energy, entropy, random walks, and diffusion; dynamics at low Reynolds number; cooperativity and 2-state systems; structural self-assembly; kinetic modeling; molecular motors and enzymes; membranes and potentials; genetic networks; sequences and evolution. Prerequisites: MATH 100/114/117/134/144, PHYS 124/144 or EN PH131. PHYS 126/130/146 recommended.


EN PH 131 - Mechanics

Kinematics and dynamics of particles; gravitation; work and energy; linear momentum; angular momentum; systems of particles; introduction to dynamics of rigid bodies. Prerequisites: MATH 100 or 117, and ENGG 130. Corequisite: MATH 101 or 118. Restricted to Engineering students. Other students who take this course will receive *3.0.


Browse more courses taught by Daniel Charlebois

Publications

Non-genetic resistance facilitates survival while hindering the evolution of drug resistance due to intraspecific competition

Author(s): Joshua D. Guthrie and Daniel A. Charlebois
Publication Date: 9/8/2022
Publication: Physical Biology
Volume: 19
Page Numbers: 066002
External Link: https://iopscience.iop.org/article/10.1088/1478-3975/ac8c17/meta

Does transcriptional heterogeneity facilitate the development of genetic drug resistance?

Author(s): Kevin S. Farquhar, Samira Rasouli Koohi, Daniel A. Charlebois
Publication Date: 6/23/2021
Publication: BioEssays
Volume: 43
Page Numbers: 2100043
External Link: https://onlinelibrary.wiley.com/doi/10.1002/bies.202100043

Role of network-mediated stochasticity in mammalian drug resistance

Author(s): Kevin Farquhar, Daniel A. Charlebois, Mariola Szenk, Joseph Cohen, Dmitry Nevozhay, Gabor Balazsi
Publication: Nature Communications
Volume: 10
Page Numbers: 2766
External Link: https://www.nature.com/articles/s41467-019-10330-w

Multiscale effects of heating and cooling on genes and gene networks

Author(s): Daniel A. Charlebois, Kevin Hauser, Sylvia Marshall, Gabor Balazsi
Publication: Proceeding of the National Academy of Sciences of the United States of America
Volume: 115
Page Numbers: E10797
External Link: https://www.pnas.org/content/115/45/E10797

Coherent feedforward transcriptional regulatory motifs enhance drug resistance

Author(s): Daniel A. Charlebois, Gabor Balazsi, Mads Kaern
Publication: Physical Review E
Volume: 89
Page Numbers: 052708
External Link: https://journals.aps.org/pre/abstract/10.1103/PhysRevE.89.052708

Gene express noise facilitates adaptation and drug resistance independently of mutation

Author(s): Daniel A. Charlebois, Nezar Abdennur, Mads Kaern
Publication: Physical Review Letters
Volume: 107
Page Numbers: 218101
External Link: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.107.218101