Daniel Charlebois, PhD, PPhys

Assistant Professor, Faculty of Science - Physics Admin

Contact

Assistant Professor, Faculty of Science - Physics Admin
Email
dcharleb@ualberta.ca
Phone
(780) 492-3985
Address
3-189 Centennial Ctr For Interdisciplinary SCS II
11335 Saskatchewan Drive NW
Edmonton AB
T6G 2H5

Overview

Area of Study / Keywords

computational & experimental biophysics mathematical biology synthetic biology antimicrobial resistance bioelectromagnetics gene regulatory networks machine learning for medical diagnostics microbial evolution experiments phenotypic heterogeneity stochastic simulations


About

I am an Assistant Professor of Biophysics in the Department of Physics at the University of Alberta. I am also an Adjunct Professor in the Department of Biological Sciences and an Affiliated Faculty member of the Collaborative Mathematical Biology Group.

Education & Training

NSERC Postdoctoral Fellow/Postdoctoral Associate, Laufer Center for Physical and Quantitative Biology, Stony Brook University (2014-2019) [Advisor: Prof. Gabor Balazsi]

PhD Physics (2014), University of Ottawa. Graduate researcher at the Ottawa Institute of Systems Biology [Advisor: Prof. Mads Kaern]

MSc Physics (2010), University of Ottawa. Graduate researcher at the Ottawa Institute of Systems Biology [Advisor: Prof. Mads Kaern].

BSc Physics, Applied Mathematics Minor (2008), University of Calgary. Undergraduate researcher at the Institute for Biocomplexity and Informatics [Supervisor: Dr. Stuart Kauffman].

BSc Biological Sciences (2008), University of Calgary. Undergraduate researcher at the Institute for Biocomplexity and Informatics [Supervisor: Dr. Stuart Kauffman].


Research

My research at the interface of physics and biology combines theory, computation, and experiment to make fundamental advances in the areas of genetic networks, bioelectromagnetics, and drug resistance. For more details, please visit the Charlebois Lab Website.

Announcements

There may be opportunities postdoctoral fellows with their own funding and a biology graduate student to join my research program. There may also be opportunities for undergraduate students who are interested in doing a research-based independent study course (i.e., PHYS 499 or BIOL 499 at the University of Alberta) and/or summer research. Send me an email including a CV, a brief statement of research interests and qualifications, and a copy of your transcripts (for potential undergraduate and graduate students) if you are interested in joining my group. Please note that only suitable applicants for available positions will be contacted for an interview.

Courses

BIOPH 401 - Advanced Biophysics

Physical properties of biological macromolecules and macromolecular assemblies; biopolymer folding; ligand binding and allostery; lipid membranes; cellular electricity and nerve conduction; models of molecular motors; stochasticity in biology; numerical and experimental techniques in biophysics; synthetic biology. Prerequisites: MATH 209/215/317, MATH 201/334/336, BIOPH 201, PHYS 234, PHYS 230/281, PHYS 310.

Winter Term 2022
BIOPH 501 - Advanced Biophysics

Physical properties of biological macromolecules and macromolecular assemblies; biopolymer folding; ligand binding and allostery; lipid membranes; cellular electricity and nerve conduction; models of molecular motors; stochasticity in biology; numerical and experimental techniques in biophysics; synthetic biology. Prerequisites: MATH 209/215/317, MATH 201/334/336, BIOPH 201, PHYS 234, PHYS 230/281, PHYS 310.

Winter Term 2022
EN PH 131 - Mechanics

Kinematics and dynamics of particles; gravitation; work and energy; linear momentum; angular momentum; systems of particles; introduction to dynamics of rigid bodies. Prerequisites: MATH 100 or 117, and ENGG 130. Corequisite: MATH 101 or 118. Restricted to Engineering students. Other students who take this course will receive *3.0.

Winter Term 2022

Browse more courses taught by Daniel Charlebois

Publications

Does transcriptional heterogeneity facilitate the development of genetic drug resistance?
Author(s): Kevin S. Farquhar, Samira Rasouli Koohi, Daniel A. Charlebois
Publication Date: 6/23/2021
Publication: BioEssays
Volume: 43
Page Numbers: 2100043
External Link: https://onlinelibrary.wiley.com/doi/10.1002/bies.202100043
Advancing antimicrobial resistance research through quantitative modeling and synthetic biology
Author(s): Kevin S. Farquhar, Harold Flohr, Daniel Charlebois
Publication Date: 9/18/2020
Publication: Frontiers in Biotechnology and Bioengineering
Volume: 8
Page Numbers: 583415
External Link: https://www.frontiersin.org/articles/10.3389/fbioe.2020.583415/full
Role of network-mediated stochasticity in mammalian drug resistance
Author(s): Kevin Farquhar, Daniel A. Charlebois, Mariola Szenk, Joseph Cohen, Dmitry Nevozhay, Gabor Balazsi
Publication: Nature Communications
Volume: 10
Page Numbers: 2766
External Link: https://www.nature.com/articles/s41467-019-10330-w
Multiscale effects of heating and cooling on genes and gene networks
Author(s): Daniel A. Charlebois, Kevin Hauser, Sylvia Marshall, Gabor Balazsi
Publication: Proceeding of the National Academy of Sciences of the United States of America
Volume: 115
Page Numbers: E10797
External Link: https://www.pnas.org/content/115/45/E10797
Coherent feedforward transcriptional regulatory motifs enhance drug resistance
Author(s): Daniel A. Charlebois, Gabor Balazsi, Mads Kaern
Publication: Physical Review E
Volume: 89
Page Numbers: 052708
External Link: https://journals.aps.org/pre/abstract/10.1103/PhysRevE.89.052708
Gene express noise facilitates adaptation and drug resistance independently of mutation
Author(s): Daniel A. Charlebois, Nezar Abdennur, Mads Kaern
Publication: Physical Review Letters
Volume: 107
Page Numbers: 218101
External Link: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.107.218101