DLJ Clive, PhD, DSc
B.Sc. Imperial College
Ph.D. Imperial College (Professor D. H. R. Barton)
Postdoctoral Fellow, Harvard (Professor R. B. Woodward)
Medal of University of Helsinki (1989)
Alfred Bader Award in Organic Chemistry (2002)
Fellow of The Chemical Institute of Canada (2002)
R. U. Lemieux Award (2010)
Fellow of the Royal Society of Chemistry (UK) (2017)
My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area are being studied in my group:
- The synthesis of structurally complex natural products that have important biochemical and medicinal properties.
- The development of new strategy and methodology for making complicated structures.
A brief formula outline of a few topics within these areas is shown below. The synthetic targets that are being examined are relevant to the treatment of heart disease (e.g., CP-225,917), or they show antitumor activity (CP-225,917, MPC1001, the otteliones), or have potential as drugs to control inflammatory diseases and metastasis (halichlorine).
The methodology program involves exploration of the flourishing area of radical cyclization, which has become an extremely useful technique in synthetic organic chemistry, and the formation of cyclic compounds by intramolecular conjugate displacements.
The correlation of structure and chemical bonding in carbon compounds with the physical properties and chemical reactivity of organic molecules. Discussion will be based on functional groups with emphasis on hydrocarbons and derivatives that contain halogens, oxygen, sulfur, and the hydroxy group. Introduction to stereochemistry, three dimensional structure, reaction mechanisms, especially addition to double bonds, nucleophilic substitution and elimination reactions. Prerequisite CHEM 101 or 103. Note: Students who have obtained credit for CHEM 264 cannot take CHEM 261 for credit. Engineering students who take this course will receive *4.5.
Continuation of the structural and chemical properties of the basic functional groups of organic compounds including alkynes, aromatic compounds, aldehydes, ketones, carboxylic acids and their derivatives and amines. Illustration of these functional groups in natural products such as carbohydrates, amino acids and proteins, nucleic acids and lipids. Discussion of the application of spectroscopic methods for the structure determination in simple organic molecules. Prerequisites: CHEM 261 or CHEM 264 and 266 or SCI 100. Students who have obtained credit for CHEM 265 cannot take CHEM 263 for credit.
A. Palanivel, S. Mubeen, T. Warner, N. Ahmed, Clive, D.L.J. Clive
J. Org. Chem.. 84
G. Yu, D.L.J. Clive
J. Org. Chem.. 81
W. Shao, D. L. J. Clive
J. Org. Chem.. 80
P. Cheng, D.L.J. Clive, S. Fernandopulle, Z. Chen
Chem. Commun.. 49
L. Wang, D.L.J. Clive
Org. Lett.. 13
D. Liu, H. P. Acharya, M. Yu, J. Wang, V.S.C. Yeh, S. Kang, C. Chiruta, S. M. Jachak, D.L.J. Clive
J. Org. Chem.. 74