DLJ Clive, PhD, DSc

Professor, Faculty of Science - Chemistry

Contact

Professor, Faculty of Science - Chemistry
Email
derrick.clive@ualberta.ca
Phone
(780) 492-3251
Address
W5-03B Chemistry Centre - West
11227 Saskatchewan Drive NW
Edmonton AB
T6G 2G2

Overview

About

B.Sc. Imperial College

Ph.D. Imperial College (Professor D. H. R. Barton)

Postdoctoral Fellow, Harvard (Professor R. B. Woodward)

Medal of University of Helsinki (1989)

Alfred Bader Award in Organic Chemistry (2002)

Fellow of The Chemical Institute of Canada (2002)

R. U. Lemieux Award (2010)

Fellow of the Royal Society of Chemistry (UK) (2017)


Research

My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area are being studied in my group:

  • The synthesis of structurally complex natural products that have important biochemical and medicinal properties.
  • The development of new strategy and methodology for making complicated structures.

A brief formula outline of a few topics within these areas is shown below. The synthetic targets that are being examined are relevant to the treatment of heart disease (e.g., CP-225,917), or they show antitumor activity (CP-225,917, MPC1001, the otteliones), or have potential as drugs to control inflammatory diseases and metastasis (halichlorine).

The methodology program involves exploration of the flourishing area of radical cyclization, which has become an extremely useful technique in synthetic organic chemistry, and the formation of cyclic compounds by intramolecular conjugate displacements.


Synthetic Targets:

Methodology:

Courses

CHEM 261 - Organic Chemistry I

The correlation of structure and chemical bonding in carbon compounds with the physical properties and chemical reactivity of organic molecules. Discussion will be based on functional groups with emphasis on hydrocarbons and derivatives that contain halogens, oxygen, sulfur, and the hydroxy group. Introduction to stereochemistry, three dimensional structure, reaction mechanisms, especially addition to double bonds, nucleophilic substitution and elimination reactions. Prerequisite CHEM 101 or 103. Note: Students who have obtained credit for CHEM 161 or 164 cannot take CHEM 261 for credit. Engineering students who take this course will receive *4.5.

Winter Term 2022

Browse more courses taught by DLJ Clive

Publications

Formation of Enol Ethers by Radical Decarboxylation of α-Alkoxy β-Phenylthio Acids

Author(s): A. Palanivel, S. Mubeen, T. Warner, N. Ahmed, Clive, D.L.J. Clive
Publication: J. Org. Chem.
Volume: 84
Page Numbers: 12542–12552
External Link: https://pubs.acs.org/doi/10.1021/acs.joc.9b02042

Formation of meta-Substituted Phenols by Transition Metal-Free Aromatization: Use of 2-Bromocyclohex-2-en-1-ones.

Author(s): G. Yu, D.L.J. Clive
Publication: J. Org. Chem.
Volume: 81
Page Numbers: 8470–8484
External Link: https://pubs.acs.org/doi/10.1021/acs.joc.6b01653

Synthesis of substituted resorcinol monomethyl ethers from 2-bromo-3-methoxycyclohex-2-en-1-ones

Author(s): W. Shao, D. L. J. Clive
Publication: J. Org. Chem.
Volume: 80
Page Numbers: 3211-3216
External Link: http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b00192

Racemic Marinopyrrole B by Total Synthesis

Author(s): P. Cheng, D.L.J. Clive, S. Fernandopulle, Z. Chen
Publication: Chem. Commun.
Volume: 49
Page Numbers: 558-560
External Link: http://pubs.rsc.org/en/content/articlelanding/2013/cc/c2cc37110c

The [[(tert-Butyl)dimethylsilyl]oxy]methyl Group for Sulfur Protection

Author(s): L. Wang, D.L.J. Clive
Publication: Org. Lett.
Volume: 13
Page Numbers: 1734-1737
External Link: http://pubs.acs.org/doi/abs/10.1021/ol2002573

Total Synthesis of the Marine Alkaloid Halichlorine — Development and Use of a General Route to Chiral Piperidines

Author(s): D. Liu, H. P. Acharya, M. Yu, J. Wang, V.S.C. Yeh, S. Kang, C. Chiruta, S. M. Jachak, D.L.J. Clive
Publication: J. Org. Chem.
Volume: 74
Page Numbers: 7417-7428
External Link: http://pubs.acs.org/doi/abs/10.1021/jo901481n