DLJ Clive, PhD, DSc

Professor, Faculty of Science - Chemistry

Contact

Professor, Faculty of Science - Chemistry
Email
derrick.clive@ualberta.ca
Phone
(780) 492-3251
Address
W5-03B Chemistry Centre - West
11227 Saskatchewan Drive NW
Edmonton AB
T6G 2G2

Overview

About
B.Sc. Imperial College
Ph.D. Imperial College (Professor D. H. R. Barton)
Postdoctoral Fellow, Harvard (Professor R. B. Woodward)
Medal of University of Helsinki (1989)
Alfred Bader Award in Organic Chemistry (2002)
Fellow of The Chemical Institute of Canada (2002)
R. U. Lemieux Award (2010)
Fellow of the Royal Society of Chemistry (UK) (2017)

Research

My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area are being studied in my group:

  • The synthesis of structurally complex natural products that have important biochemical and medicinal properties.
  • The development of new strategy and methodology for making complicated structures.

A brief formula outline of a few topics within these areas is shown below. The synthetic targets that are being examined are relevant to the treatment of heart disease (e.g., CP-225,917), or they show antitumor activity (CP-225,917, MPC1001, the otteliones), or have potential as drugs to control inflammatory diseases and metastasis (halichlorine).

The methodology program involves exploration of the flourishing area of radical cyclization, which has become an extremely useful technique in synthetic organic chemistry, and the formation of cyclic compounds by intramolecular conjugate displacements.

Synthetic Targets:



Methodology:




Courses

CHEM 463 - Organic Synthesis

Discussion of the different concepts of chemoselective, regioselective and stereoselective reactions of organic compounds. Main classes of reactions described are oxidations, reductions, functional group protection, and carbon-carbon bond formation methods for single, double, and triple bonds. Emphasis on modern methodology for organic synthesis, including asymmetric catalysis and transition-metal catalyzed methods such as cross-coupling chemistry. Prerequisite: CHEM 363 or consent of Instructor.

Winter Term 2021
CHEM 563 - Organic Synthesis

Graduate-level discussion of the different concepts of chemoselective, regioselective and stereoselective reactions of organic compounds. Main classes of reactions described are oxidations, reductions, functional group protection, and carbon-carbon bond formation methods for single, double, and triple bonds. Emphasis on modern methodology for organic synthesis, including asymmetric catalysis and transition-metal catalyzed methods such as cross-coupling chemistry. Not open to students with credit in CHEM 463 or 467.

Winter Term 2021

Publications

Formation of Enol Ethers by Radical Decarboxylation of α-Alkoxy β-Phenylthio Acids
Author(s): A. Palanivel, S. Mubeen, T. Warner, N. Ahmed, Clive, D.L.J. Clive
Publication: J. Org. Chem.
Volume: 84
Page Numbers: 12542–12552
External Link: https://pubs.acs.org/doi/10.1021/acs.joc.9b02042
Formation of meta-Substituted Phenols by Transition Metal-Free Aromatization: Use of 2-Bromocyclohex-2-en-1-ones.
Author(s): G. Yu, D.L.J. Clive
Publication: J. Org. Chem.
Volume: 81
Page Numbers: 8470–8484
External Link: https://pubs.acs.org/doi/10.1021/acs.joc.6b01653
Synthesis of substituted resorcinol monomethyl ethers from 2-bromo-3-methoxycyclohex-2-en-1-ones
Author(s): W. Shao, D. L. J. Clive
Publication: J. Org. Chem.
Volume: 80
Page Numbers: 3211-3216
External Link: http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b00192
Racemic Marinopyrrole B by Total Synthesis
Author(s): P. Cheng, D.L.J. Clive, S. Fernandopulle, Z. Chen
Publication: Chem. Commun.
Volume: 49
Page Numbers: 558-560
External Link: http://pubs.rsc.org/en/content/articlelanding/2013/cc/c2cc37110c
The [[(tert-Butyl)dimethylsilyl]oxy]methyl Group for Sulfur Protection
Author(s): L. Wang, D.L.J. Clive
Publication: Org. Lett.
Volume: 13
Page Numbers: 1734-1737
External Link: http://pubs.acs.org/doi/abs/10.1021/ol2002573
Total Synthesis of the Marine Alkaloid Halichlorine — Development and Use of a General Route to Chiral Piperidines
Author(s): D. Liu, H. P. Acharya, M. Yu, J. Wang, V.S.C. Yeh, S. Kang, C. Chiruta, S. M. Jachak, D.L.J. Clive
Publication: J. Org. Chem.
Volume: 74
Page Numbers: 7417-7428
External Link: http://pubs.acs.org/doi/abs/10.1021/jo901481n