B.Sc. Imperial College
Ph.D. Imperial College (Professor D. H. R. Barton)
Postdoctoral Fellow, Harvard (Professor R. B. Woodward)
Medal of University of Helsinki (1989)
Alfred Bader Award in Organic Chemistry (2002)
Fellow of The Chemical Institute of Canada (2002)
R. U. Lemieux Award (2010)
Fellow of the Royal Society of Chemistry (UK) (2017)
My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area are being studied in my group:
A brief formula outline of a few topics within these areas is shown below. The synthetic targets that are being examined are relevant to the treatment of heart disease (e.g., CP-225,917), or they show antitumor activity (CP-225,917, MPC1001, the otteliones), or have potential as drugs to control inflammatory diseases and metastasis (halichlorine).
The methodology program involves exploration of the flourishing area of radical cyclization, which has become an extremely useful technique in synthetic organic chemistry, and the formation of cyclic compounds by intramolecular conjugate displacements.
The correlation of structure and chemical bonding in carbon compounds with the physical properties and chemical reactivity of organic molecules. Discussion will be based on functional groups with emphasis on hydrocarbons and derivatives that contain halogens, oxygen, sulfur, and the hydroxy group. Introduction to stereochemistry, three dimensional structure, reaction mechanisms, especially addition to double bonds, nucleophilic substitution and elimination reactions. Prerequisite CHEM 101 or 103. Note: Students who have obtained credit for CHEM 161 or 164 cannot take CHEM 261 for credit. Engineering students who take this course will receive *4.5.Winter Term 2022