Examples of projects currently in progress include:
Prof. Sauvageau's research efforts focus on two main themes within the field of Bioengineering: 1) developing bioprocessing strategies for improved production and conversion in microbial systems, and 2) understanding and modifying host-bacteriophage infection mechanisms.
In the first theme, he combines tools from Metabolic Engineering and Synthetic Biology with Chemical Engineering and Processing principles to optimize the production of valuable bio-molecules. The aim is to develop engineered strains designed specifically for novel processing strategies. For example, he investigates the use of large-scale synchronization of engineered microbial populations to control metabolic activity. This mode of operation has led to significant increases in specific productivity in various microbial expression systems. Such approaches can be used in the production of biopharmaceuticals or the conversion of waste streams to platform chemicals.
In the second theme, his team looks at the interactions between bacteriophages and their host bacteria from an Engineering perspective (kinetics and mechanism of phage adsoprtion, virulence, population dynamics). The aim of the research is to control and modify these parameters for the development of novel applications and technologies.
His work is at the intersection of Chemical Engineering, Bioprocessing, Molecular Biology, Genetics and Microbiology.
Analysis and design of non-ideal chemical reactors for industrial product synthesis. Prerequisites: CH E 314, 318 and 345.Fall Term 2020
Basic process principles; material and energy balances, transient processes, introduction to computer-aided balance calculations. Prerequisites: ENCMP 100, MATH 102 and CHEM 105. Corequisites: CH E 243 and MATH 209 or equivalent. Credit may not be obtained in this course if previous credit has been obtained for CH E 265.Fall Term 2020