Dominic Sauvageau

Associate Professor, Faculty of Engineering - Chemical and Materials Engineering Dept

Contact

Associate Professor, Faculty of Engineering - Chemical and Materials Engineering Dept
Email
dominic.sauvageau@ualberta.ca
Phone
(780) 492-8092
Address
13-370 Donadeo Innovation Centre For Engineering
9211-116 St
Edmonton AB
T6G 2H5

Overview

Research
  • Production in microbial expression systems
  • Bioproduction and bioconversion
  • Control of metabolism through processing strategies
  • Self-cycling fermentation
  • Genetic engineering and synthetic biology
  • Bacteriophages

Examples of projects currently in progress include:

  • smart packaging materials for the detection of pathogenic bacteria in food products;
  • conversion of methane/methanol to valuable bio-molecules using methylotrophic bacteria;
  • production of shikimic acid in synchronized populations of engineered yeast;
  • understanding the impact of cell synchronization on the metabolic activity of bacterial cells;
  • host-bacteriophage interactions: dynamics of populations, adsorption and virulence;
  • genetic modifications of bacteriophages;
  • bacteriophages as antimicrobial agents in yeast fermentations;
  • protein engineering for the improvement of biopolymer biodegradation

.

Prof. Sauvageau's research efforts focus on two main themes within the field of Bioengineering: 1) developing bioprocessing strategies for improved production and conversion in microbial systems, and 2) understanding and modifying host-bacteriophage infection mechanisms.

In the first theme, he combines tools from Metabolic Engineering and Synthetic Biology with Chemical Engineering and Processing principles to optimize the production of valuable bio-molecules. The aim is to develop engineered strains designed specifically for novel processing strategies. For example, he investigates the use of large-scale synchronization of engineered microbial populations to control metabolic activity. This mode of operation has led to significant increases in specific productivity in various microbial expression systems. Such approaches can be used in the production of biopharmaceuticals or the conversion of waste streams to platform chemicals.

In the second theme, his team looks at the interactions between bacteriophages and their host bacteria from an Engineering perspective (kinetics and mechanism of phage adsoprtion, virulence, population dynamics). The aim of the research is to control and modify these parameters for the development of novel applications and technologies.

His work is at the intersection of Chemical Engineering, Bioprocessing, Molecular Biology, Genetics and Microbiology.

Courses

CH E 445 - Chemical Reactor Analysis II

Analysis and design of non-ideal chemical reactors for industrial product synthesis. Prerequisites: CH E 314, 318 and 345.

Fall Term 2020
CME 265 - Process Analysis

Basic process principles; material and energy balances, transient processes, introduction to computer-aided balance calculations. Prerequisites: ENCMP 100, MATH 102 and CHEM 105. Corequisites: CH E 243 and MATH 209 or equivalent. Credit may not be obtained in this course if previous credit has been obtained for CH E 265.

Fall Term 2020

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