Gregory D Funk

Professor, Faculty of Medicine & Dentistry - Physiology Dept

Chair, Faculty of Medicine & Dentistry - Physiology Dept

Contact Overview Publications

Contact

Professor, Faculty of Medicine & Dentistry - Physiology Dept

Email: gf@ualberta.ca
Phone: (780) 492-8330
Address: 3020G Katz Group Centre For Research
11315 - 87 Ave NW

Edmonton AB

T6G 2H5

Chair, Faculty of Medicine & Dentistry - Physiology Dept

Email: gf@ualberta.ca

Overview

Area of Study / Keywords

Simulation

About

Dr. Gregory D Funk is currently appointed as Professor and Chair in the Department of Physiology in the Faculty of Medicine & Dentistry.

Featured Publications

Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats

Biancardi V., Patrone L.G.A., Vicente M.C., Marques D.A., Bícego K.C., Funk G.D., Gargaglioni L.H.

Journal of Applied Physiology. 2022 June; 133 (2):371-389 10.1152/japplphysiol.00020.2022

Respiration

Greer, J.J., Funk, G.D.

Neuroscience in the 21st Century. 2022 June; doi.org/10.1007/978-1-4614-6434-1_49-3

Reklow RJ, Zoccal DB, Alvares TS, Toohey AW, Hansen MA, Frangos SM, Boison D, Funk GD. Limited capacity for clearance of adenosine from the preBötzinger Complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

29th Annual Physiology Research Day, Edmonton, AB.. 2022 May;

1. Reklow, R, Sinnatamby T, Zoccal D, Qiu S, Toohey A, Hansen M, Frangos S, Boison D, Funk GD. (2022). Postnatal Development of the Purinergic Signaling System in the preBötzinger Complex; Implications for the Hypoxic Ventilatory Response

The FASEB Journal 36. 2022 April;

Release your inhibitions: The role of post-inhibitory rebound and synaptic inhibition in the generation of expiratory activity

Huckstepp R.T.R., Funk G.D.

Journal of Physiology. 2021 December; 599 (24):5331-5332 10.1113/JP282482

Sinnatamby T, Reklow RJ, van Baarle S, Funk GD. Does the immature hypoxic ventilatory response of newborn mammals and their vulnerability to hypoxia reflect an inability to increase ventilation or decrease metabolic rate?

WCHRI Research Day Proceedings. 2021 November;

Sinnatamby T, Reklow RJ, van Baarle S, Funk GD. (2021). Inability of premature mammals to produce a sustained breathing response to hypoxia may reflect postnatal maturation of adenosine kinase.

54th Annual FoMD Summer Student Research Day. 2021 October;

Reklow RJ, Zoccal DB, Alvares TS, Toohey AW, Hansen MA, Frangos SM, Boison D, Funk GD. Limited capacity for clearance of adenosine from the preBötzinger Complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

28th Annual Department of Physiology Research Day, May 13, 2021, Edmonton, AB.. 2021 May;

KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal Rats in vitro

Revill A.L., Katzell A., Del Negro C.A., Milsom W.K., Funk G.D.

Frontiers in Physiology. 2021 April; 12 10.3389/fphys.2021.626470

Biancardi V, Zhang Y, Zoccal DB, Alvares TS, Scarpellini C, Pagliardini S, Montandon G, Funk GD. 2021. P2Y1 receptor modulation of Ih in the preBötzinger inspiratory rhythm generator may underlie the ATP-mediated attenuation of the hypoxic respiratory depression.

Experimental Biology, Virtual Meeting. April 27- 30, 2021.. 2021 April;

Miranda Tapia AP, Reklow R, Zhang Y, Biancardi V, Rancic V, Alvares T, Gosgnach S, Krügel U, Pagliardini S, Kam K, Funk GD. Neuronal mediators of the frequency increase evoked by activation of P2Y1 receptors in the preBötzinger Complex inspiratory rhythm generating network in vitro.

Experimental Biology, Virtual Meeting. April 27- 30, 2021.. 2021 April;

Reklow RJ, Zoccal DB, Alvares TS, Toohey, AW, Hansen MA, Frangos SM, Alvares TS, Funk GD. Limited capacity for clearance of adenosine from the preBötzinger complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

Experimental Biology, Virtual Meeting. April 27- 30, 2021.. 2021 April;

Mapping of the excitatory, inhibitory, and modulatory afferent projections to the anatomically defined active expiratory oscillator in adult male rats

Biancardi V., Saini J., Pageni A., Prashaad M. H., Funk G.D., Pagliardini S.

Journal of Comparative Neurology. 2021 March; 529 (4):853-884 10.1002/cne.24984

A brainstem peptide system activated at birth protects postnatal breathing

Shi Y., Stornetta D.S., Reklow R.J., Sahu A., Wabara Y., Nguyen A., Li K., Zhang Y., Perez-Reyes E., Ross R.A., Lowell B.B., Stornetta R.L., Funk G.D., Guyenet P.G., Bayliss D.A.

Nature. 2021 January; 589 (7842):426-430 10.1038/s41586-020-2991-4

Qiu S, Reklow RJ, Alvares T, Funk GD. Enzymes that produce inhibitory transmitters implicated in apnea of prematurity are unevenly distributed in the brainstem network that controls breathing.

WCHRI Research Day, November 4, 2020, Edmonton, AB.. 2020 November;

Reklow RJ, Alvares TS, Zoccal DB, Toohey AW, Hansen MA, Frangos SM, Funk GD. The life-threatening inhibition of breathing by hypoxia in premature mammals may reflect limited adenosine clearance from the central network that generates breathing.

WCHRI Research Day, November 4, 2020, Edmonton, AB.. 2020 November;

Gregory D Funk

Contact

Professor, Faculty of Medicine & Dentistry - Physiology Dept

Chair, Faculty of Medicine & Dentistry - Physiology Dept

Overview

Area of Study / Keywords

About

Featured Publications

Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats

Respiration

Reklow RJ, Zoccal DB, Alvares TS, Toohey AW, Hansen MA, Frangos SM, Boison D, Funk GD. Limited capacity for clearance of adenosine from the preB&#246;tzinger Complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

1. Reklow, R, Sinnatamby T, Zoccal D, Qiu S, Toohey A, Hansen M, Frangos S, Boison D, Funk GD. (2022). Postnatal Development of the Purinergic Signaling System in the preB&#246;tzinger Complex; Implications for the Hypoxic Ventilatory Response

Release your inhibitions: The role of post-inhibitory rebound and synaptic inhibition in the generation of expiratory activity

Sinnatamby T, Reklow RJ, van Baarle S, Funk GD. Does the immature hypoxic ventilatory response of newborn mammals and their vulnerability to hypoxia reflect an inability to increase ventilation or decrease metabolic rate?

Sinnatamby T, Reklow RJ, van Baarle S, Funk GD. (2021). Inability of premature mammals to produce a sustained breathing response to hypoxia may reflect postnatal maturation of adenosine kinase.

Reklow RJ, Zoccal DB, Alvares TS, Toohey AW, Hansen MA, Frangos SM, Boison D, Funk GD. Limited capacity for clearance of adenosine from the preB&#246;tzinger Complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-B&#246;tzinger Complex of Neonatal Rats in vitro

Biancardi V, Zhang Y, Zoccal DB, Alvares TS, Scarpellini C, Pagliardini S, Montandon G, Funk GD. 2021. P2Y1 receptor modulation of Ih in the preB&#246;tzinger inspiratory rhythm generator may underlie the ATP-mediated attenuation of the hypoxic respiratory depression.

Miranda Tapia AP, Reklow R, Zhang Y, Biancardi V, Rancic V, Alvares T, Gosgnach S, Kr&#252;gel U, Pagliardini S, Kam K, Funk GD. Neuronal mediators of the frequency increase evoked by activation of P2Y1 receptors in the preB&#246;tzinger Complex inspiratory rhythm generating network in vitro.

Reklow RJ, Zoccal DB, Alvares TS, Toohey, AW, Hansen MA, Frangos SM, Alvares TS, Funk GD. Limited capacity for clearance of adenosine from the preB&#246;tzinger complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

Mapping of the excitatory, inhibitory, and modulatory afferent projections to the anatomically defined active expiratory oscillator in adult male rats

A brainstem peptide system activated at birth protects postnatal breathing

Qiu S, Reklow RJ, Alvares T, Funk GD. Enzymes that produce inhibitory transmitters implicated in apnea of prematurity are unevenly distributed in the brainstem network that controls breathing.

Reklow RJ, Alvares TS, Zoccal DB, Toohey AW, Hansen MA, Frangos SM, Funk GD. The life-threatening inhibition of breathing by hypoxia in premature mammals may reflect limited adenosine clearance from the central network that generates breathing.

Reklow RJ, Zoccal DB, Alvares TS, Toohey AW, Hansen MA, Frangos SM, Boison D, Funk GD. Limited capacity for clearance of adenosine from the preBötzinger Complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

1. Reklow, R, Sinnatamby T, Zoccal D, Qiu S, Toohey A, Hansen M, Frangos S, Boison D, Funk GD. (2022). Postnatal Development of the Purinergic Signaling System in the preBötzinger Complex; Implications for the Hypoxic Ventilatory Response

Reklow RJ, Zoccal DB, Alvares TS, Toohey AW, Hansen MA, Frangos SM, Boison D, Funk GD. Limited capacity for clearance of adenosine from the preBötzinger Complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.

KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal Rats in vitro

Biancardi V, Zhang Y, Zoccal DB, Alvares TS, Scarpellini C, Pagliardini S, Montandon G, Funk GD. 2021. P2Y1 receptor modulation of Ih in the preBötzinger inspiratory rhythm generator may underlie the ATP-mediated attenuation of the hypoxic respiratory depression.

Miranda Tapia AP, Reklow R, Zhang Y, Biancardi V, Rancic V, Alvares T, Gosgnach S, Krügel U, Pagliardini S, Kam K, Funk GD. Neuronal mediators of the frequency increase evoked by activation of P2Y1 receptors in the preBötzinger Complex inspiratory rhythm generating network in vitro.

Reklow RJ, Zoccal DB, Alvares TS, Toohey, AW, Hansen MA, Frangos SM, Alvares TS, Funk GD. Limited capacity for clearance of adenosine from the preBötzinger complex inspiratory network contributes to the profound depression of breathing by hypoxia in the very young.