Matthias Gotte

Area of Study / Keywords

Ebola Nipah Lassa RSV Influenza viral RNA polymerase nuclease antiviral drugs mechanism of action drug discovery drug development antimicrobial resistance

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About

Dr. Götte obtained his PhD degree in 1997 at the Max-Planck-Institute for Biochemistry in Martinsried, Germany. In 2000, following his postdoctoral training at the Lady Davis Institute for Medical Research - Jewish General Hospital in Montreal, he joined the faculty at McGill University in the Department of Microbiology & Immunology. In 2014, he accepted the position as Chair of the Medical Microbiology & Immunology Department at the University of Alberta in Edmonton. 

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Research

!!! Currently Hiring Graduate Students !!!

Research in Dr. Götte's laboratory is focused on the study of viral replication, its inhibition and mechanisms associated with antimicrobial resistance (AMR). His interests cover a broad range of important human pathogens including RNA viruses with a high epidemic potential.

Baldwin E.T., Gotte M., Tchesnokov E.P., Arnold E., Hagel M., Nichols C., Dossang P., Lamers M., Wan P., Steinbacher S., Romero D.L.

Proceedings of the National Academy of Sciences of the United States of America. 2022 June; 119 (27) 10.1073/pnas.2200260119

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Feng J.Y., Pont V.D., Babusis D., Gordon C.J., Tchesnokov E.P., Perry J.K., Duong V., Vijjapurapu A., Zhao X., Chan J., Cohen C., Juneja K., Cihlar T., Götte M., Bilello J.P.

BIOMACROMOLECULES. 2022 June; 27 (13) 10.3390/molecules27134212

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Stevens L.J., Pruijssers A.J., Lee H.W., Gordon C.J., Tchesnokov E.P., Gribble J., George A.S., Hughes T.M., Lu X., Li J., Perry J.K., Porter D.P., Cihlar T., Sheahan T.P., Baric R.S., Götte M., Denison M.R.

Science Translational Medicine. 2022 April; 14 (656):eabo0718 10.1126/scitranslmed.abo0718

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Gordon C.J., Lee H.W., Tchesnokov E.P., Perry J.K., Feng J.Y., Bilello J.P., Porter D.P., Götte M.

Journal of Biological Chemistry. 2022 February; 298 (2) 10.1016/j.jbc.2021.101529

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Bader C.D., Panter F., Garcia R., Tchesnokov E.P., Haid S., Walt C., Spröer C., Kiefer A.F., Götte M., Overmann J., Pietschmann T., Müller R.

ACS Earth and Space Chemistry. 2022 February; 28 (10) 10.1002/chem.202104484

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McCubbin K.D., Anholt R.M., de Jong E., Ida J.A., Nóbrega D.B., Kastelic J.P., Conly J.M., Götte M., McAllister T.A., Orsel K., Lewis I., Jackson L., Plastow G., Wieden H.J., McCoy K., Leslie M., Robinson J.L., Hardcastle L., Hollis A., Ashbolt N.J., Checkley S., Tyrrell G.J., Buret A.G., Rennert-May E., Goddard E., Otto S.J.G., Barkema H.W.

Frontiers in Public Health. 2021 October; 9 10.3389/fpubh.2021.726484

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JOURNAL OF BIOLOGICAL CHEMISTRY. 2021 May; 10.1016/j.jbc.2021.100770.

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Matthias Götte

Current Opinion in Virology. 2021 May; 10.1016/j.coviro.2021.04.014.

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JOURNAL OF BIOLOGICAL CHEMISTRY. 2021 February; 10.1016/j.jbc.2021.100486

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Freedman H, Kundu J, Tchesnokov EP, Law JLM, Nieman JA, Schinazi RF, Tyrrell DL, Gotte M, Houghton M.

Journal of Chemical Information and Modeling. 2020 December; 10.1021/acs.jcim.0c00742.