Matthias Gotte
Contact
Professor, Faculty of Medicine & Dentistry - Medical Microbiology and Immunology Dept
- gotte@ualberta.ca
Chair, Faculty of Medicine & Dentistry - Medical Microbiology and Immunology Dept
- gotte@ualberta.ca
Overview
Area of Study / Keywords
Ebola Nipah Lassa RSV Influenza viral RNA polymerase nuclease antiviral drugs mechanism of action drug discovery drug development antimicrobial resistance
About
Dr. Götte obtained his PhD degree in 1997 at the Max-Planck-Institute for Biochemistry in Martinsried, Germany. In 2000, following his postdoctoral training at the Lady Davis Institute for Medical Research - Jewish General Hospital in Montreal, he joined the faculty at McGill University in the Department of Microbiology & Immunology. In 2014, he accepted the position as Chair of the Medical Microbiology & Immunology Department at the University of Alberta in Edmonton.Research
!!! Currently Hiring Graduate Students !!!
Research in Dr. Götte's laboratory is focused on the study of viral replication, its inhibition and mechanisms associated with antimicrobial resistance (AMR). His interests cover a broad range of important human pathogens including RNA viruses with a high epidemic potential.
Featured Publications
Baldwin E.T., Gotte M., Tchesnokov E.P., Arnold E., Hagel M., Nichols C., Dossang P., Lamers M., Wan P., Steinbacher S., Romero D.L.
Proceedings of the National Academy of Sciences of the United States of America. 2022 June; 119 (27) 10.1073/pnas.2200260119
Feng J.Y., Pont V.D., Babusis D., Gordon C.J., Tchesnokov E.P., Perry J.K., Duong V., Vijjapurapu A., Zhao X., Chan J., Cohen C., Juneja K., Cihlar T., Götte M., Bilello J.P.
BIOMACROMOLECULES. 2022 June; 27 (13) 10.3390/molecules27134212
Stevens L.J., Pruijssers A.J., Lee H.W., Gordon C.J., Tchesnokov E.P., Gribble J., George A.S., Hughes T.M., Lu X., Li J., Perry J.K., Porter D.P., Cihlar T., Sheahan T.P., Baric R.S., Götte M., Denison M.R.
Science Translational Medicine. 2022 April; 14 (656):eabo0718 10.1126/scitranslmed.abo0718
Gordon C.J., Lee H.W., Tchesnokov E.P., Perry J.K., Feng J.Y., Bilello J.P., Porter D.P., Götte M.
Journal of Biological Chemistry. 2022 February; 298 (2) 10.1016/j.jbc.2021.101529
Bader C.D., Panter F., Garcia R., Tchesnokov E.P., Haid S., Walt C., Spröer C., Kiefer A.F., Götte M., Overmann J., Pietschmann T., Müller R.
ACS Earth and Space Chemistry. 2022 February; 28 (10) 10.1002/chem.202104484
McCubbin K.D., Anholt R.M., de Jong E., Ida J.A., Nóbrega D.B., Kastelic J.P., Conly J.M., Götte M., McAllister T.A., Orsel K., Lewis I., Jackson L., Plastow G., Wieden H.J., McCoy K., Leslie M., Robinson J.L., Hardcastle L., Hollis A., Ashbolt N.J., Checkley S., Tyrrell G.J., Buret A.G., Rennert-May E., Goddard E., Otto S.J.G., Barkema H.W.
Frontiers in Public Health. 2021 October; 9 10.3389/fpubh.2021.726484
JOURNAL OF BIOLOGICAL CHEMISTRY. 2021 May; 10.1016/j.jbc.2021.100770.
Matthias Götte
Current Opinion in Virology. 2021 May; 10.1016/j.coviro.2021.04.014.
JOURNAL OF BIOLOGICAL CHEMISTRY. 2021 February; 10.1016/j.jbc.2021.100486
Freedman H, Kundu J, Tchesnokov EP, Law JLM, Nieman JA, Schinazi RF, Tyrrell DL, Gotte M, Houghton M.
Journal of Chemical Information and Modeling. 2020 December; 10.1021/acs.jcim.0c00742.