Frank Hoentjen

Area of Study / Keywords

Ulcerative colitis Crohn's disease inflammatory bowel disease inflammation dysplasia cancer biologicals microscopic colitis

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About

Dr. Frank Hoentjen is a Gastroenterologist and Associate Professor of Medicine at the University of Alberta, specializing in inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. He earned his medical degree at the Radboud University Nijmegen, The Netherlands. After completing a 2-year research fellowship at the University of North Carolina at Chapel Hill, USA, his PhD was awarded by the Free University Medical Center, Amsterdam, The Netherlands. His research focused on immunological and microbial factors in the pathogenesis of colitis. Dr. Hoentjen completed his residencies and GI fellowship at the Free University Medical Center, Amsterdam, and completed an advanced IBD fellowship at the University of Chicago, USA. In 2011 he joined the Gastroenterology faculty at the Radboud University Medical Center Nijmegen, The Netherlands. Dr. Hoentjen joined the Faculty of Medicine at the University of Alberta in 2021. Currently he is Director of the Inflammatory Bowel Disease unit and Co-Director of the Gastroenterology Trial Unit (GastroIntestinal and Liver Disease Research Group, GILDR) at the University of Alberta. Dr. Hoentjen is Vice Chair of Clinical Research, Scientific and Medical Advisory Council (SMAC) for the Crohn's and Colitis Canada (CCC).

Clinical Interests

Dr. Hoentjen’s clinical focus is inflammatory bowel disease, including Crohn’s disease, ulcerative colitis, microscopic colitis, and inflammatory conditions associated with immune deficiencies. He specializes in the management of immunosuppressive and biological IBD therapies and the prevention of colorectal cancer in IBD patients. He runs a specialized clinic for IBD patients and provides endoscopic services at the University of Alberta Hospital in Edmonton.

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Research

Dr Hoentjen’s research focuses on IBD, a life-long inflammatory disease of the intestinal tract. His goal is to ensure that IBD patients can forget their chronic disease thanks to excellent disease management. In order to achieve this, he employs three strategies; (1) Optimizing immunosuppressive and biological or biosimilar therapies through clinical and translational studies to improve efficacy, safety, therapeutic drug monitoring and cost effectiveness. (2) Implement care pathways to improve the IBD care delivered by creating and using registries, e-health and telemonitoring at a regional level and nation-wide level. (3) Achieve a better understanding of the risk of colorectal cancer and dysplasia in IBD patients and improve surveillance strategies to prevent cancer. 

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Teaching

Dr. Hoentjen supervises clinical and research trainees and residents and provides classroom instruction for the medical students. He also participates in continuing medical education sessions for physicians and other health care providers. Students and peers at the Radboud Institute for Molecular Life Sciences at Radboud University Medical Center Nijmegen, The Netherlands voted him PhD supervisor of the year in 2020.

Sands B.E., Irving P.M., Hoops T., Izanec J.L., Gao L.L., Gasink C., Greenspan A., Allez M., Danese S., Hanauer S.B., Jairath V., Kuehbacher T., Lewis J.D., Loftus E.V., Mihály E., Panaccione R., Scherl E., Shchukina O., Sandborn W.J., Afzali A., Aitova L., Aldeguer i Mante X., Altorjay I., Argüelles Arias F., Armuzzi A., Augustyn M., Bafutto M., Barrio J., Begun J., Behrend C., Bezemer G., Bonnaud G., Brankovic M., Byung I.J., Calvet Calvo X., Chachu K., Chebli J.M.F., Cheon J.H., Cichoz-Lach H., Clark L., Cummings F., Dalal K., De Boer N., De Lourdes Ferrari M., Désilets E., Dugalic P., Duvall G., Fedorishina O., Filip R., Flores C., Fogel R., Fon J., Frankel M., Friedenberg K., Fries W., Galina V., Gietka P., Goel R., Hasselblatt P., Herfarth H., Herszényi L., Hindryckx P., Hoentjen F., Horjus Talabur Horje C., Iduru S., Irving P., Isfort R., Jones M., Kalimullina D., Katz J., Kaur M., Khurana S.K., Kim J.S., Kim Y., Kleczkowski D., Knezevic S., Knoll A., Korman L.Y., Kotzev I., Kulyapin A., Lee K.M., Leemreis D., Leszczyszyn J., Limdi J., Lissauer J., Loftus E., Malecka-Panas E., Marshall J., Mihály E., Milan L., Monteleone G., Nagorni A., Owczarek D., Palekar N., Park Y.S., Park S.H., Parra R., Patai Á., Patel K., Patel B., Pershko A., Petrova E., Pineton de Chambrun G., Randall C., Riestra Menendez S., Ritter T., Rivero M., Roblin X., Rocca R., Romatowski J., Rydzewska G., Saibeni S., Salzberg B., Sarles H., Saunders J., Savarino E.V., Serclova Z., Shchukina O., Siegel J., Soofi N., Sparrow M., Stokesberry D., Suiter D., Svorcan P., Tkachev A., Tsonev N., Tünde K., Ulbrych J., Vanasek T., Varga M., Vermeire S., Vicente Lidon R., Weiss M.L., Wesley E., Winstead N., Wojcik K., Wypych J., Zaltman C., Zdena Z.

LANCET. 2022 June; 399 (10342):2200-2211 10.1016/S0140-6736(22)00688-2

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Digestive Disease Week (DDW) San Diego CA May 21-24 2022. 2022 May;

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Digestive Disease Week (DDW) San Diego CA May 21-24 2022. 2022 May;

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Digestive Disease Week (DDW) San Diego CA May 21-24 2022. 2022 May;

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Digestive Disease Week (DDW) San Diego CA May 21-24 2022. 2022 May;

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Digestive Disease Week (DDW) San Diego CA May 21-24 2022. 2022 May;

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Digestive Disease Week (DDW) San Diego CA May 21-24 2022. 2022 May;

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Straatmijer T, Biemans VB, Visschedijk M, Hoentjen F, de Vries A, van Bodegraven AA, Bodelier A, de Boer NKH, Dijkstra G, Festen N, Horjus C, Jansen JM, Jharap B, Mares W, van Schaik FD, Ponsioen C, Romkens T, Srivastava N, van der Voorn MM, West R, van der Woude J, Wolvers MDJ, Pierik M, van der Meulen-de Jong AE, Duijvestein M

Clinical Gastroenterology and Hepatology. 2022 May; 10.1016/j.cgh.2022.04.038

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Digestive Disease Week (DDW) San Diego CA May 21-24 2022. 2022 May;

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Groen MT, Hoentjen F.

Clinical Gastroenterology and Hepatology. 2022 April; 10.1016/j.cgh.2022.04.002

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de Jong M.E., Nagtegaal I.D., Vos S., van der Post R.S., van Herwaarden Y., Derikx L.A.A.P., Hoentjen F.

DIGESTIVE DISEASES AND SCIENCES. 2022 April; 10.1007/s10620-022-07485-w

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Thomas P.W.A., Smits L.J.T., Groen M.T., West R.L., Russel M.G.V.M., Jansen J.M., Römkens T.E.H., Hoentjen F.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. 2022 March; 34 (5):488-495 10.1097/MEG.0000000000002336

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Savelkoul EHJ, Maas MHJ, Bourgonje AR, Crouwel F, Biemans VBC, den Broeder N, Russel MGVM, Römkens TEH, de Boer NK, Dijkstra G, Hoentjen F.

Journal of Crohns & Colitis. 2022 March; 10.1093/ecco-jcc/jjac044

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Savelkoul E.H.J., Hoentjen F.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2022 March; 55 (6):750-751 10.1111/apt.16803

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European Crohns and Colitis Organization Congress 2022. 2022 February;

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Peyrin-Biroulet L., Hart A., Bossuyt P., Long M., Allez M., Juillerat P., Armuzzi A., Loftus E.V., Ostad-Saffari E., Scalori A., Oh Y.S., Tole S., Chai A., Pulley J., Lacey S., Sandborn W.J., Aguilar H., Ahmad T., Akriviadis E., Aldeguer Mante X., Altorjay I., Ananthakrishnan A., Andersen V., Andreu Garcia M., Aumais G., Avni-Biron I., Axler J., Ayub K., Baert F., Bafutto M., Bamias G., Bassan I., Baum C., Beaugerie L., Behm B., Bekal P., Bennett M., Bermejo San Jose F., Bernstein C., Bettenworth D., Bhaskar S., Biancone L., Bilir B., Blaeker M., Bloom S., Bohman V., Bosques Padilla F.J., Bouhnik Y., Bouma G., Bourdages R., Brand S., Bressler B., Brückner M., Buening C., Carbonnel F., Caves T., Chapman J., Cheon J.H., Chiba N., Chioncel C., Christodoulou D., Clodi M., Cohen A., Corazza G.R., Corlin R., Cosintino R., Cummings F., Dalal R., Danese S., De Maeyer M., De Magalhães Francesconi C.F., De Silva A., Debinski H., Desreumaux P., Dewit O., D'Haens G., Di Felice Boratto S., Ding J.N., Dixon T., Dryden G., Du Vall G.A., Ebert M., Echarri Piudo A., Ehehalt R., Elkhashab M., Ennis C., Etzel J., Fallingborg J., Feagan B., Fejes R., Ferraz de Campos Mazo D., Ferreira de Almeida Borges V., Fischer A., Fixelle A., Fleisher M., Fowler S., Freilich B., Friedenberg K., Fries W., Fulop C., Fumery M., Fuster S., G Kiss G., Garcia Lopez S., Gassner S., Gill K., Gilletta de Saint Joseph C., Ginsburg P., Gionchetti P., Goldin E., Goldis A.E., Gomez Jaramillo H.A., Gonciarz M., Gordon G., Green D., Grimaud J.C., Guajardo Rodriguez R., Gurzo Z., Gutierrez A., Gyökeres T., Hahm K.B., Hanauer S., Hanson J., Harlan W., Hasselblatt P., Hayee B., Hebuterne X., Hendy P., Heyman M., Higgins P., Hilal R., Hindryckx P., Hoentjen F., Hoffmann P., Holtkamp-Endemann F., Holtmann G., Horvat G., Howaldt S., et al.

Lancet Gastroenterology & Hepatology. 2022 February; 7 (2):128-140 10.1016/S2468-1253(21)00298-3

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Thomas PWA, den Broeder N, Derikx M, Kievit W, West RL, Russel MGVM, Jansen JM, Römkens TEH, Hoentjen F.

INFLAMMATORY BOWEL DISEASES. 2022 February; 10.1093/ibd/izac002

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Geeven I.P.A.C., Jessurun N.T., Wasylewicz A.T.M., Drent M., Spuls P.I., Hoentjen F., van Puijenbroek E.P., Vonkeman H.E., Grootens K.P., van Doorn M.B.A., van Den Bemt B.J.F., Bekker C.L.

Expert Opinion On Drug Safety. 2022 January; 21 (5):699-706 10.1080/14740338.2022.2020756

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De Simone B., Davies J., Chouillard E., Di Saverio S., Hoentjen F., Tarasconi A., Sartelli M., Biffl W.L., Ansaloni L., Coccolini F., Chiarugi M., De’Angelis N., Moore E.E., Kluger Y., Abu-Zidan F., Sakakushev B., Coimbra R., Celentano V., Wani I., Pintar T., Sganga G., Di Carlo I., Tartaglia D., Pikoulis M., Cardi M., De Moya M.A., Leppaniemi A., Kirkpatrick A., Agnoletti V., Poggioli G., Carcoforo P., Baiocchi G.L., Catena F.

World Journal of Emergency Surgery. 2021 December; 16 (1) 10.1186/s13017-021-00362-3

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Goessens L., Colombel J.F., Outtier A., Ferrante M., Sabino J., Judge C., Saeidi R., Rabbitt L., Armuzzi A., Domenech E., Michalopoulos G., Cremer A., García-Alonso F.J., Molnar T., Karmiris K., Gecse K., Van Oostrom J., Löwenberg M., Farkas K., Atreya R., Ribaldone D.G., Selinger C., Hoentjen F., Bihin B., Sebastian S., Rahier J.F., Baert F., Horin S.B., Bossuyt P., Mas E.B., Buckley M., Byron C., Coe C., Doherty G.A., Dragoni G., Fernandes S., Gaya D.P., Gleeson S., Keogh A., Levine A., Ortega T.L., Lobo A.J., Macken E., McCarthy J., Noor N., O'Toole A., Posen A., Privitera G., Pugliese D., Raine T., Reenaers C., Resal T., Scarcelli A., Slattery E., Strubbe B., Sugrue K., Groen M.T., Vicente G.T., Truyens M., Viola A., Yanai H., Zulquernain S.A.

United European Gastroenterology Journal. 2021 December; 9 (10):1136-1147 10.1002/ueg2.12170

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Ten Bokkel Huinink S., Biemans V., Duijvestein M., Pierik M., Hoentjen F., West R.L., van der Woude C.J., de Vries A.C.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. 2021 December; 33 (1S Suppl 1):e783-e788 10.1097/MEG.0000000000002256

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Kosse L.J., Weits G., Vonkeman H.E., Tas S.W., Hoentjen F., Van Doorn M.B.A., Spuls P.I., D’Haens G.R., Nurmohamed M.T., van Puijenbroek E.P., Van Den Bemt B.J.F., Jessurun N.T.

Expert Opinion On Drug Safety. 2021 December; 20 (12):1565-1572 10.1080/14740338.2021.1963436

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Arkenbosch J.H.C., Mak J.W.Y., Ho J.C.L., Beelen E.M.J., Erler N.S., Hoentjen F., Bodelier A.G.L., Dijkstra G., Romberg-Camps M., de Boer N.K.H., Stassen L.P.S., van der Meulen A.E., West R., van Ruler O., van der Woude C.J., Ng S.C., de Vries A.C.

INFLAMMATORY BOWEL DISEASES. 2021 December; 28 (2):S16-S24 10.1093/ibd/izab316

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van Lint JA, van Hunsel FPAM, Tas SW, Vonkeman HE, Hoentjen F, van Doorn MBA, Hebing RCF, Nurmohamed MT, van den Bemt BJF, van Puijenbroek EP, Jessurun NT

ANNALS OF THE RHEUMATIC DISEASES. 2021 December; 10.1136/annrheumdis-2021-221840

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Derks M.E.W., Te Groen M., Hoentjen F., Derikx L.A.A.P.

BJS Open. 2021 December; 108 (12):e410 10.1093/bjs/znab284

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Mahmmod S., Schultheiss J.P.D., Van Bodegraven A.A., Dijkstra G., Gilissen L.P.L., Hoentjen F., Lutgens M.W.M.D., Mahmmod N., Van Der Meulen-De Jong A.E., Smits L.J.T., Tan A.C.I.T.L., Oldenburg B., Fidder H.H.

INFLAMMATORY BOWEL DISEASES. 2021 December; 27 (12):1954-1962 10.1093/ibd/izaa364

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Hanzel J, Dreesen E, Vermeire S, Löwenberg M, Hoentjen F, Bossuyt P, Clasquin E, Baert FJ, D'Haens GR, Mathôt R.

INFLAMMATORY BOWEL DISEASES. 2021 November; 10.1093/ibd/izab270

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Straatmijer T., Biemans V.B.C., Hoentjen F., De Boer N.K.H., Bodelier A.G.L., Dijkstra G., Van Dop W.A., Haans J.J.L., Jansen J.M., Maljaars P.W.J., Van Der Marel S., Oldenburg B., Ponsioen C.Y., Visschedijk M.C., De Vries A.C., West R.L., Van Der Woude C.J., Pierik M., Duijvestein M., Van Der Meulen-De Jong A.E.

Journal of Crohns & Colitis. 2021 November; 15 (11):1920-1930 10.1093/ecco-jcc/jjab081

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Thomas P.W.A., Römkens T.E.H., West R.L., Russel M.G.V.M., Jansen J.M., van Lint J.A., Jessurun N.T., Hoentjen F.

United European Gastroenterology Journal. 2021 October; 9 (8):919-928 10.1002/ueg2.12107

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Westdorp H., Sweep M.W.D., Gorris M.A.J., Hoentjen F., Boers-Sonderen M.J., Post R.S.v.d., Heuvel M.M.v.d., Piet B., Boleij A., Bloemendal H.J., de Vries I.J.M.

Frontiers in Immunology. 2021 October; 12 10.3389/fimmu.2021.768957

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van Lint J.A., Jessurun N.T., Tas S.W., van den Bemt B.J.F., Nurmohamed M.T., van Doorn M.B.A., Spuls P.I., van Tubergen A.M., ten Klooster P.M., van Puijenbroek E.P., Hoentjen F., Vonkeman H.E.

JOURNAL OF RHEUMATOLOGY. 2021 September; 48 (9):1388-1394 10.3899/jrheum.201373

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Goetgebuer R.L., Kreijne J.E., Aitken C.A., Dijkstra G., Hoentjen F., de Boer N.K., Oldenburg B., van der Meulen A.E., Ponsioen C.I.J., Pierik M.J., van Kemenade F.J., de Kok I.M.C.M., Siebers A.G., Manniën J., van der Woude C.J., de Vries A.C.

Journal of Crohns & Colitis. 2021 September; 15 (9):1464-1473 10.1093/ecco-jcc/jjab036

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Barenbrug L., Groen M.t., Hoentjen F., van Drongelen J., Reek J.M.P.A.v.d., Joosten I., de Jong E.M.G.J., van der Molen R.G.

JOURNAL OF AUTOIMMUNITY. 2021 August; 122 10.1016/j.jaut.2021.102676

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Biemans V.B.C., Straatmijer T., Hoentjen F., Pierik M.J.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2021 August; 54 (4):534-535 10.1111/apt.16505

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de Bruyn J.R., Bossuyt P., Ferrante M., West R.L., Dijkstra G., Witteman B.J., Wildenberg M., Hoentjen F., Franchimont D., Clasquin E., Van der Bilt J., Tollens T., Bemelman W.A., D'Hoore A., Duijvestein M., D'Haens G.R., Bemelman W., Buskens C., Clasquin E., De Bruyn J., D'Haens G., Duijvestein M., Van der Bilt J., Ferreira B., Mulder S., West R., Dijkstra G., Engelsman A., Lange J., Homans L., Witteman B., Eroglu-Berger A., Russel M., Jansen J., Schakel-van den Berge T., Cuppen S., Hoentjen F., Van Esch A., De Jong D.J., Mahmmod N., Hove.P. De Lange W.T., Mallant R., Houben P., Ferrante M., Vermeire S., Outtier A., Hermans T., Lefrère J., D'Hoore A., Asnong K., Bossuyt P., Van de Schoot I., Claerbout B., Lambrecht G., Boutaffala L., Guebelle C., Louis E., Franchimont D., Wambacq V., Colard A., Deflandre A.

Clinical Gastroenterology and Hepatology. 2021 August; 19 (8):1573-1582.e5 10.1016/j.cgh.2020.05.037

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Kanis S.L., Modderman S., Escher J.C., Erler N., Beukers R., De Boer N., Bodelier A., Depla A.C.T.M., Dijkstra G., Van Dijk A.B.R.M., Gilissen L., Hoentjen F., Jansen J.M., Kuyvenhoven J., Mahmmod N., Mallant-Hent R.C., Van Der Meulen-De Jong A.E., Noruzi A., Oldenburg B., Oostenbrug L.E., Ter Borg P.C.J., Pierik M., Romberg- Camps M., Thijs W., West R., De Lima A., Van Der Woude C.J.

GUT. 2021 July; 70 (7):1266-1274 10.1136/gutjnl-2019-319129

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Voskuil M.D., Spekhorst L.M., Van Der Sloot K.W.J., Jansen B.H., Dijkstra G., Van Der Woude C.J., Hoentjen F., Pierik M.J., Van Der Meulen A.E., De Boer N.K.H., Löwenberg M., Oldenburg B., Festen E.A.M., Weersma R.K.

Journal of Crohns & Colitis. 2021 June; 15 (6):930-937 10.1093/ecco-jcc/jjaa223

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Giraud E.L., Thomas P.W.A., van Lint J.A., van Puijenbroek E.P., Römkens T.E.H., West R.L., Russel M.G.V.M., Jansen J.M., Jessurun N.T., Hoentjen F.

DRUG SAFETY. 2021 May; 44 (5):581-588 10.1007/s40264-021-01045-3

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Brand E.C., Klaassen M.A.Y., Gacesa R., Vich Vila A., Ghosh H., de Zoete M.R., Boomsma D.I., Hoentjen F., Horjus Talabur Horje C.S., van de Meeberg P.C., Willemsen G., Fu J., Wijmenga C., van Wijk F., Zhernakova A., Oldenburg B., Weersma R.K., Honkoop P., Jacobs R.J., Ponsioen C.Y., de Boer N.K.H., Alderlieste Y.A., van Herwaarden M.A., van Tuyl S.A.C., Lutgens M.W., Janneke van der Woude C., Mares W.G.M., de Koning D.B., Bosman J.H., Vecht J., de Schryver A.M.P., van der Meulen-de Jong A.E., Pierik M.J., Boekema P.J., Verburg R.J., Jharap B., Jansen J.M., Stokkers P.C.F., Quispel R., Mahmmod N., West R.L., Willems M., Minderhoud I.M., Fidder H.H., van Schaik F.D.M., Hirdes M.M.C., Boontje N.A., Müskens B.L.M., Romberg-Camps M.J.L.

GASTROENTEROLOGY. 2021 May; 160 (6):1970-1985 10.1053/j.gastro.2021.01.030

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Derikx L.A.A.P., Lantinga M.A., De Jong D.J., Van Dop W.A., Creemers R.H., Römkens T.E.H., Jansen J.M., Mahmmod N., West R.L., Tan A.C.I.T.L., Bodelier A.G.L., Gorter M.H.P., Boekema P.J., Halet E.R.C., Horjus C.S., Van Dijk M.A., Hirdes M.M.C., Epping Stippel L.S.M., Jharap B., Lutgens M.W.M.D., Russel M.G., Gilissen L.P.L., Nauta S., Van Bodegraven A.A., Hoentjen F.

Journal of Crohns & Colitis. 2021 April; 15 (4):529-539 10.1093/ecco-jcc/jjaa215

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Thomas P.W.A., West R.L., Russel M.G.V.M., Jansen J.M., Kosse L.J., Jessurun N.T., Römkens T.E.H., Hoentjen F.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2021 April; 30 (4):520-524 10.1002/pds.5175

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Wijnands A.M., de Jong M.E., Lutgens M.W.M.D., Hoentjen F., Elias S.G., Oldenburg B.

GASTROENTEROLOGY. 2021 April; 160 (5):1584-1598 10.1053/j.gastro.2020.12.036

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Beelen E.M.J., van der Woude C.J., Pierik M.J., Hoentjen F., de Boer N.K., Oldenburg B., van der Meulen A.E., Ponsioen C.I.J., Dijkstra G., Bruggink A.H., Erler N.S., Schouten W.R., de Vries A.C.

ANNALS OF SURGERY. 2021 March; 273 (3):557-563 10.1097/SLA.0000000000003395

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te Groen M., Derks M.E.W., Kuijpers C.C.H.J., Nagtegaal I.D., Hoentjen F.

GASTROENTEROLOGY. 2021 February; 160 (3):935-937.e1 10.1053/j.gastro.2020.10.032

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de Jong M.E., Taal E., Thomas P.W.A., Römkens T.E.H., Jansen J.M., West R.L., Slotman E., Hoentjen F., Russel M.G.V.M.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2021 January; 56 (2):155-161 10.1080/00365521.2020.1857430

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Thomas P.W.A., Ferwerda G., West R.L., Hoentjen F.

Journal of Crohns & Colitis. 2021 January; 15 (1):162-164 10.1093/ecco-jcc/jjaa115

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Kosse L.J., Weits G., Vonkeman H.E., Tas S.W., Hoentjen F., Van Doorn M.B.A., Spuls P.I., D’Haens G.R., Nurmohamed M.T., van Puijenbroek E.P., Van Den Bemt B.J.F., Jessurun N.T.

Expert Opinion On Drug Safety. 2021 January; 20 (12):1565-1572 10.1080/14740338.2021.1963436