Hongquan Zhang

Associate Professor, Faculty of Medicine & Dentistry - Laboratory Medicine & Pathology Dept

Contact

Associate Professor, Faculty of Medicine & Dentistry - Laboratory Medicine & Pathology Dept
Email
hongquan@ualberta.ca
Phone
(780) 492-1607
Address
10-102C Clinical Sciences Building
11304 83 Ave NW
Edmonton AB
T6G 2G3

Overview

Area of Study / Keywords

Point-of-care Infectious disease Aptamer Ultrasensitive assay Point-of-care testing Binding-induced DNA assembly Affinity binding Functional nucleic acids Nanomaterials Biosensing Ultrasensitive protein detection Homogeneous analysis DNAzyme


About

Ph.D.                      University of Alberta                                    2009

M.Sc.                 Northwest University, Xi’an, China           1999

B.Sc.                  Northwest University, Xi’an, China           1997



Research

  • Exploration of binding-induced DNA assembly to develop bioanalytical tools for ultrasensitive and point-of-care detection of biological targets.
  • Development of fluorescent nanosensors for real-time detection of specific biological targets under cellular environment.
  • Construction of target-triggered DNA nanomachines and nanodevices.
  • Development of novel affinity ligands by generation, modification, and manipulation of functional nucleic acids.

 

Teaching

  • LABMP 551 Laboratory Research Methods
  • LABMP 552 (NSERC CREATE Course)


Featured Publications

Construction of DNAzyme motors and logic gates using a toehold exchange translator,

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


DNA motor for imaging and modulating key molecules in living cells

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


Extraction and concentration of viral RNA from saliva and gargle samples using poly-T magnetic beads for the detection of SARS CoV-2

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for One-Tube Assay of RNA

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


Point-of-care Detection of SARS-CoV-2 Using Loop-Mediated Isothermal Amplification and CRISPR Technology

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


Recent advances in CRISPR/Cas12a: mechanistic insights guiding bioanalytical applications

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


A CRISPR/Cas12a-mediated colorimetric assay for SARS-CoV-2

Canadian Chemistry Conference and Exhibition 2022. 2022 June;


Hu C., Chen J., Zhang H., Wu L., Yang P., Hou X.

MICROCHEMICAL JOURNAL. 2022 May; 180 10.1016/j.microc.2022.107595


, Liu Y, Kumblathan, T.; Fei, W.; Pang, B.; Xu, J.; Xiao, H.; Joyce, M.A.; Tyrrell, D.L.; Zhang, H.; Li, X.-F.; Le, X.C.;

ACS Meas. Sci. Au. 2022 February; 2 (3):224-232 10.1021/acsmeasuresciau.1c00057


Target-activated DNA motors and their applications to biosensing

Pacifichem 2021. 2021 December;


Cao Y., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 November; 93 (47):15712-15719 10.1021/acs.analchem.1c03617


Feng W., Peng H., Xu J., Liu Y., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Babiuk S., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 September; 93 (37):12808-12816 10.1021/acs.analchem.1c03456


Cao Y., Wu J., Pang B., Zhang H., Le X.C.

CHEMICAL COMMUNICATIONS. 2021 June; 57 (56):6871-6874 10.1039/d1cc02546e


One-pot isothermal detection of SARS-CoV-2 RNA using recombinase polymerase amplification and CRISPR technology

ACS Spring 2021. 2021 April;


Feng W., Newbigging A.M., Tao J., Cao Y., Peng H., Le C., Wu J., Pang B., Li J., Tyrrell D.L., Zhang H., Le X.C.

Chemical Science. 2021 March; 12 (13):4683-4698 10.1039/d0sc06973f


Wu J., Peng H., Lu X., Lai M., Zhang H., Le X.C.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020 December; 60 (20):11104-11109 10.1002/anie.202014162


Pang B., Xu J., Liu Y., Peng H., Feng W., Cao Y., Wu J., Xiao H., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2020 November; 92 (24):16204-16212 10.1021/acs.analchem.0c04047