Directory

Hongquan Zhang

Associate Professor, Faculty of Medicine & Dentistry - Laboratory Medicine & Pathology Dept
Contact Overview Courses Publications

Contact

Associate Professor, Faculty of Medicine & Dentistry - Laboratory Medicine & Pathology Dept
Email
hongquan@ualberta.ca
Phone
(780) 492-1607
Address
10-102C Clinical Sciences Building
11304 83 Ave NW
Edmonton AB
T6G 2G3

Overview

Area of Study / Keywords

Point-of-care Infectious disease Aptamer Ultrasensitive assay Point-of-care testing Binding-induced DNA assembly Affinity binding Functional nucleic acids Nanomaterials Biosensing Ultrasensitive protein detection Homogeneous analysis DNAzyme

About

Ph.D.                      University of Alberta                                    2009

M.Sc.                 Northwest University, Xi’an, China           1999

B.Sc.                  Northwest University, Xi’an, China           1997


Research

  • Exploration of binding-induced DNA assembly to develop bioanalytical tools for ultrasensitive and point-of-care detection of biological targets.
  • Development of fluorescent nanosensors for real-time detection of specific biological targets under cellular environment.
  • Construction of target-triggered DNA nanomachines and nanodevices.
  • Development of novel affinity ligands by generation, modification, and manipulation of functional nucleic acids.

 

Teaching

  • LABMP 551 Laboratory Research Methods
  • LABMP 552 (NSERC CREATE Course)


Courses

LABMP 551 - Laboratory Research Methods

Theory and practice of laboratory research techniques and methods. Fundamentals and applications of quantitative analysis, separation, atomic spectrometry, mass spectrometry, PCR and cloning with laboratory experiments. For students who will perform laboratory research. This course may not be taken for credit if credit has been received in PHS 513. Prerequisite: Consent of the instructor.

Winter Term 2024

Browse more courses taught by Hongquan Zhang

Featured Publications

Construction of DNAzyme motors and logic gates using a toehold exchange translator,

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

DNA motor for imaging and modulating key molecules in living cells

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

Extraction and concentration of viral RNA from saliva and gargle samples using poly-T magnetic beads for the detection of SARS CoV-2

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for One-Tube Assay of RNA

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

Point-of-care Detection of SARS-CoV-2 Using Loop-Mediated Isothermal Amplification and CRISPR Technology

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

Recent advances in CRISPR/Cas12a: mechanistic insights guiding bioanalytical applications

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

A CRISPR/Cas12a-mediated colorimetric assay for SARS-CoV-2

Canadian Chemistry Conference and Exhibition 2022. 2022 June;

Nanoscale metal organic frameworks and their applications in disease diagnosis and therapy

Hu C., Chen J., Zhang H., Wu L., Yang P., Hou X.

MICROCHEMICAL JOURNAL. 2022 May; 180 10.1016/j.microc.2022.107595

On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads

, Liu Y, Kumblathan, T.; Fei, W.; Pang, B.; Xu, J.; Xiao, H.; Joyce, M.A.; Tyrrell, D.L.; Zhang, H.; Li, X.-F.; Le, X.C.;

ACS Meas. Sci. Au. 2022 February; 2 (3):224-232 10.1021/acsmeasuresciau.1c00057

Target-activated DNA motors and their applications to biosensing

Pacifichem 2021. 2021 December;

Split Locations and Secondary Structures of a DNAzyme Critical to Binding-Assembled Multicomponent Nucleic Acid Enzymes for Protein Detection

Cao Y., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 November; 93 (47):15712-15719 10.1021/acs.analchem.1c03617

Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA

Feng W., Peng H., Xu J., Liu Y., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Babiuk S., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 September; 93 (37):12808-12816 10.1021/acs.analchem.1c03456

CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2

Cao Y., Wu J., Pang B., Zhang H., Le X.C.

CHEMICAL COMMUNICATIONS. 2021 June; 57 (56):6871-6874 10.1039/d1cc02546e

One-pot isothermal detection of SARS-CoV-2 RNA using recombinase polymerase amplification and CRISPR technology

ACS Spring 2021. 2021 April;

CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules

Feng W., Newbigging A.M., Tao J., Cao Y., Peng H., Le C., Wu J., Pang B., Li J., Tyrrell D.L., Zhang H., Le X.C.

Chemical Science. 2021 March; 12 (13):4683-4698 10.1039/d0sc06973f

Binding-Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9

Wu J., Peng H., Lu X., Lai M., Zhang H., Le X.C.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020 December; 60 (20):11104-11109 10.1002/anie.202014162

Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology

Pang B., Xu J., Liu Y., Peng H., Feng W., Cao Y., Wu J., Xiao H., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2020 November; 92 (24):16204-16212 10.1021/acs.analchem.0c04047