Irwindeep Sandhu

Contact

Faculty of Medicine & Dentistry - Oncology Dept
Email
irwindee@ualberta.ca
Phone
(780) 432-8757
Address
Clinical Sciences Building
11304 83 Ave NW
Edmonton AB
T6G 2G3

Overview

Area of Study / Keywords

multiple myeloma leukemia Chimeric antigen receptor therapy cell therapy


About

Personal Statement:

Therapies for blood cancers like acute leukemia, lymphoma and multiple myeloma can have damaging effects on the heart and other organs. My work is focused on ensuring discoveries in research are validated and applied to patient care as quickly as possible. Working in collaboration with other health professionals, my goal is to see that each patient has the specific treatment needed to have the best possible outcome. 

After graduating from the University of Alberta’s medical school, Dr. Irwindeep Sandhu completed an internal medicine residency at the University of British Columbia and a hematology residency at McMaster University. He was recruited to the University of Alberta in 2009, where in addition to his position in the Division of Hematology, he has an adjunct appointment in the Department of Oncology.

Leadership and Collaborations: 

Dr. Sandhu is acting lead for the Northern Alberta Blood and Marrow Program and the medical director for the cellular apheresis program. He is a fellow in the Alberta Chapter of the American College of Physicians. He coordinates Hematologic care services for the Northwest Territories, and serves as inpatient teaching attending for the malignant hematology service at the Cross Cancer Institute.



Clinical Interests

Dr. Sandhu is a hematologist and oncologist who treats patients at the Cross Cancer Institute. He has a special interest in apheresis, leukemia, multiple myeloma and plasma cell dyscrasias, and cellular therapy. In 2016, he received a Champion of Care Award from a nomination by patient groups.


Research

Dr. Sandhu conducts translational research through collaborations with his colleagues and administers clinical trials in blood diseases such as acute leukemia and multiple myeloma. His findings have been published in several leading scientific journals including the New England Journal of Medicine, Haematologica, Blood, and Leukemia. His clinical and research contributions have helped develop the University of Alberta’s reputation as a leukemia centre and the Cross Cancer Institute’s strengths in multiple myeloma and cellular therapy. 


Teaching

Dr. Sandhu provides learning sessions for patients, family members and health care professionals on all hematology topics that include leukemia, clinical trials and multiple myeloma. He has taught, coordinated, and developed undergraduate, postgraduate and continuing medical education sessions. He has been awarded teaching awards for best ambulatory care experience and subspecialist of the year for the Department of Medicine.

Featured Publications

BLOOD. 2022 August; https://doi.org/10.1182/blood.2022016293


Presented at 2022 International Myeloma Society Meeting. Los Angeles. Aug 25-27, 2022. 2022 August; DOI:10.1016/S2152-2650(22)00326-3


Lancet Haematology. 2022 June; 6 (9):403-414 https://doi.org/10.1016/S2352-3026(22)00103-X


DREAMM-9: PHASE I STUDY OF BELANTAMAB MAFODOTIN PLUS STANDARD OF CARE IN PATIENTS WITH TRANSPLANT-INELIGIBLE NEWLY DIAGNOSED MULTIPLE MYELOMA

Presented at European Hematology Association. Poster 942.. 2022 June;


First Results From CC-92480-MM-002: A Phase 1/2 Study Of The Potent, Novel CELMoD Agent CC-92480, In Combination With Dexamethasone And Bortezomib In Patients With Relapsed/Refractory Multiple Myeloma

British J of Haematology. April 2022; 197(s1): 119-120. British Society of Haematology Meeting. April 3-5, 2022.. 2022 April;


PHASE I STUDY OF BELANTAMAB MAFODOTIN PLUS STANDARD OF CARE IN PATIENTS WITH TRANSPLANT-INELIGIBLE NEWLY DIAGNOSED MULTIPLE MYELOMA.

Presented Poster 14 European Myeloma Network Meeting. April 6-9, 2022.. 2022 April;


CC-92480, a Potent, Novel Cereblon E3 Ligase Modulator (CELMoD) Agent, in Combination with Dexamethasone (DEX) and Bortezomib (BORT) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results from the Phase 1/2 Study CC-92480-MM-002

63rd American Society of Hematology Meeting, Atlanta, Georgia. December 11-14, 2021. Blood. . 2021 November;


Prognostic Impact of NPM1 and FLT3 Mutations at Diagnosis and Presence of Measurable Residual Disease (MRD) after Intensive Chemotherapy (IC) for Patients with Acute Myeloid Leukemia (AML) in Remission: Outcomes from the QUAZAR AML-001 Trial of Oral Azacitidine (Oral-AZA) Maintenance

63rd American Society of Hematology Meeting, Atlanta, Georgia. December 11-14, 2021 Blood. . 2021 November;


Lee A.S., Tsang R.Y., Sandhu I.

CMAJ. 2021 October; 193 (42):E1647-E1648 10.1503/CMAJ.202824-F


Lee A.S., Tsang R.Y., Sandhu I.

CMAJ. 2021 August; 193 (34):E1349 10.1503/cmaj.202824


Döhner H., Symeonidis A., Deeren D., Demeter J., Sanz M.A., Anagnostopoulos A., Esteve J., Fiedler W., Porkka K., Kim H.J., Lee J.H., Usuki K., D'Ardia S., Won Jung C., Salamero O., Horst H.A., Recher C., Rousselot P., Sandhu I., Theunissen K., Thol F., Döhner K., Teleanu V., Deangelo D.J., Naoe T., Sekeres M.A., Belsack V., Ge M., Taube T., Ottmann O.G.

HemaSphere. 2021 August; 5 (8):e617 10.1097/HS9.0000000000000617


Richardson P.G., Kumar S.K., Masszi T., Grzasko N., Bahlis N.J., Hansson M., Pour L., Sandhu I., Ganly P., Baker B.W., Jackson S.R., Stoppa A.M., Gimsing P., Garderet L., Touzeau C., Buadi F.K., Laubach J.P., Cavo M., Darif M., Labotka R., Berg D., Moreau P.

JOURNAL OF CLINICAL ONCOLOGY. 2021 August; 39 (22):2430-2442 10.1200/JCO.21.00972


Huang Y.H., Almowaled M., Li J., Venner C., Sandhu I., Peters A., Lavasanifar A., Lai R.

CURRENT ISSUES IN MOLECULAR BIOLOGY. 2021 June; 43 (1):313-323 10.3390/cimb43010026


Fenna, J., Guirguis, M., Ibrahim, C., Shirvaikar, N., Sandhu, I., Ghosh, S., Jenkins, M.

The Canadian Journal of Hospital Pharmacy. 2021 May; 74 (2):122-129. doi: 10.5737/23688076262137144.


Venner C.P., LeBlanc R., Sandhu I., White D., Belch A.R., Reece D.E., Chen C., Dolan S., Lalancette M., Louzada M., Kew A., McCurdy A., Monteith B., Reiman T., McDonald G., Sherry M., Gul E., Chen B.E., Hay A.E.

AMERICAN JOURNAL OF HEMATOLOGY. 2021 May; 96 (5):552-560 10.1002/ajh.26147


Virtual Conference 2021 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR. 8 February, 2021.. 2021 February; https://doi.org/10.1016/S2666-6367(21)00483-8


Wei A.H., Döhner H., Pocock C., Montesinos P., Afanasyev B., Dombret H., Ravandi F., Sayar H., Jang J.H., Porkka K., Selleslag D., Sandhu I., Turgut M., Giai V., Ofran Y., Çakar M.K., de Sousa A.B., Rybka J., Frairia C., Borin L., Beltrami G., Cermák J., Ossenkoppele G.J., la Torre I., Skikne B., Kumar K., Dong Q., Beach C.L., Roboz G.J.

NEW ENGLAND JOURNAL OF MEDICINE. 2020 December; 383 (26):2526-2537 10.1056/NEJMoa2004444


The QUAZAR AML-001 maintenance trial: Results of a phase III international, randomized, double-blind, placebo-controlled study of oral CC-486 in patients with Acute Myeloid Leukemia (AML) in first remission.

Oncol Res Treat 2020;43(suppl 4): 38-38. Oral Presentation, abstract 296. 2020 October;