Directory

Nadia Jahroudi

Associate Professor, Faculty of Medicine & Dentistry - Medicine Dept
Contact Overview Publications

Contact

Associate Professor, Faculty of Medicine & Dentistry - Medicine Dept
Email
jahroudi@ualberta.ca
Phone
(780) 492-7428
Address
261C Heritage Medical Research Centre
11207 - 87 Ave NW
Edmonton AB
T6G 2S2

Overview

Area of Study / Keywords

Endothelial cell biology Gene regulation

About

Dr. Jahroudi is a basic scientist currently appointed as Associate Professor in the Department of Medicine, Division of Nephrology. She has a PhD in Molecular Biology.

Research

Our main focus of research is the mechanism of endothelial cell specific gene regulation. Endothelial cells participate in many physiological and pathophysiological processes. Their specific characteristics provide the basis for their specialized function within each organ. Nonetheless, the molecular components that characterize the endothelial cell phenotype and regulate endothelial specific gene expression have not yet been identified. We aim to determine the mechanism of regulation of endothelial specific gene expression and develop gene therapy approaches to specifically target endothelial cells for expression of desired molecules. A commonly considered molecular marker for endothelial cells is von Willebrand factor (VWF) that is only expressed in endothelial cells and megakaryocytes. We are currently studying the mechanism of the regulation of VWF gene expression. The goal of our studies is to provide insight into the complex mechanism of endothelial specific gene regulation as well as offer methods to target the expression of transgenes to endothelial cells of specific organs for the purpose of gene therapy.

Current projects in our group involves:

1) Determining the mechanism of VWF transcriptional regulation during differentiation of induced pluripotent stem cells into endothelial cells

2) Determining the molecular basis of organ-specific expression of VWF and its regulation in response to hypoxia

3) Determining the mechanism and functional consequences of VWF expression by cancer cells  

Teaching

Teaching is primarily supervision of graduate students, Discovery Learning, and reading courses.

Featured Publications

DETERMINING THE ROLE OF VON WILLEBRAND FACTOR IN THROMBOTIC POST-TRANSPLANTATION COMPLICATIONS USING EX VIVO LUNG PERFUSION SYSTEM

Canadian Journal of Cardiology 37 (10), S113-S114 Supplement. 2021 October; 10.1016/j.cjca.2021.07.215

Age-associated increase in thrombogenicity and its correlation with von willebrand factor

Alavi P., Rathod A.M., Jahroudi N.

Journal of Clinical Medicine. 2021 September; 10 (18) 10.3390/jcm10184190

In silico analysis to explore lineage-independent and-dependent transcriptional programs associated with the process of endothelial and neural differentiation of human induced pluripotent stem cells

Nakhaei-Nejad M., Trinity L., Jabbari H., Pasdar M., Jahroudi N.

Journal of Clinical Medicine. 2021 September; 10 (18) 10.3390/jcm10184161