Jean Buteau, PhD

Associate Professor, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept

Contact

Associate Professor, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept
Email
jean.buteau@ualberta.ca
Phone
(780) 492-8386
Address
5-126B Li Ka Shing Centre For Research
11203 - 87 Ave NW
Edmonton AB
T6G 2H5

Overview

About

Degree

PhD in Biochemistry, University of Montreal


Awards

Canadian Institutes of Health Research, New Investigator Award, 2013-2018

Canadian Diabetes Association, Scholar Award, 2008-2013

Quebec Research Funds, Junior Investigator Award, 2008-2012



Research

Research Interests

Keywords: Diabetes, Obesity, Nutritional and hormonal regulation of beta-cell mass and function.

Our research efforts are aimed at identifying novel molecular mechanisms that govern beta-cell differentiation, proliferation, and survival. The overall goal is to harness the therapeutic potential of these newly discovered targets to stimulate the generation of new beta-cells and to expand and protect the functional beta-cells that still reside in the pancreas of patients with diabetes.

Courses

AFNS 543 - Diabetes, Cardiovascular Disease and Lifestyle

This is an advanced course examining the relationship between the role of lifestyle factors in the etiology and pathophysiology, as well as the treatment of type 2 diabetes and cardiovascular disease. Application of recent findings to our understanding of these chronic metabolic diseases will be addressed. Not to be taken if credit received for NUTR 443. Prerequisite: consent of instructor.

Fall Term 2020
NUTR 443 - Diabetes, Cardiovascular Disease and Lifestyle

This is an advanced course examining the relationship between the role of lifestyle factors in the etiology and pathophysiology, as well as the treatment of type 2 diabetes and cardiovascular disease. Application of recent findings to our understanding of these chronic metabolic diseases will be addressed. Prerequisites: (NUTR 301 or 303) and (NUTR 302 or 304).

Fall Term 2020
NUTR 450 - Undergraduate Dietetics Specialization Research Project

An independent research project on topics in nutritional science and supervised by a faculty member. Normally this is a continuation of work begun in NUTR 400. It includes implementation of a research project relevant to dietetic practice, data analysis and presentation of results orally and in writing. Prerequisite: NUTR 400.

Winter Term 2021

Browse more courses taught by Jean Buteau

Publications

Beta-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic beta INS832/13 cells.
Author(s): Talbot J, Joly E, Prentki M, Buteau J.
Publication: Mol Cell Endocrinol
Volume: 364
Issue: 1-2
Page Numbers: 65-70

GLP-1 receptor signaling: effects on pancreatic beta-cell proliferation and survival.
Author(s): Buteau J.
Publication: Diabetes Metab.
Volume: 34
Issue: Suppl. 2
Page Numbers: S.73-S.77

Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic beta-cell mass expansion.
Author(s): Bastien-Dionne PO, Valenti L, Kon N, Gu W, Buteau J.
Publication: Diabetes
Volume: 60
Issue: 12
Page Numbers: 3217-3222

Glucagon-like peptide-1 (GLP-1) diminishes neuronal degeneration and death caused by NGF deprivation by suppressing Bim induction.
Author(s): Biswas SC, Buteau J, Greene LA.
Publication: Neurochem Res.
Volume: 33
Issue: 9
Page Numbers: 1845-1851

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 beta-cells.
Author(s): El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, Pepin E, Zhao S, Iglesias J, Roche E, Prentki M.
Publication: Endocrinology
Volume: 151
Issue: 7
Page Numbers: 3061-3073

Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1.
Author(s): Buteau J, Shlien A, Foisy S, Accili D.
Publication: J Biol Chem.
Volume: 282
Issue: 1
Page Numbers: 287-293

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Author(s): Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA.
Publication: Nat Med.
Volume: 13
Issue: 10
Page Numbers: 1203-1210

Regulation of pancreatic beta-cell function by the forkhead protein FoxO1.
Author(s): Buteau J, Accili D.
Publication: Diabetes Obes Metab.
Volume: 9
Issue: Suppl 2
Page Numbers: 140-146

Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
Author(s): Buteau J, Spatz ML, Accili D.
Publication: Diabetes
Volume: 55
Issue: 5
Page Numbers: 1190-1196