Jean Buteau, PhD

Contact

Professor, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept

Email: jbuteau@ualberta.ca
Phone: (780) 492-8386
Address: 5-126B Li Ka Shing Centre For Research
8602 112 St NW

Edmonton AB

T6G 2E1

Division Dir - Human Nutrition, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept

Email: jbuteau@ualberta.ca

Overview

About

Degree

PhD in Biochemistry, University of Montreal

Awards

Canadian Institutes of Health Research, New Investigator Award, 2013-2018

Canadian Diabetes Association, Scholar Award, 2008-2013

Quebec Research Funds, Junior Investigator Award, 2008-2012

Research

Research Interests

Keywords: Diabetes, Obesity, Nutritional and hormonal regulation of beta-cell mass and function.

Our research efforts are aimed at identifying novel molecular mechanisms that govern beta-cell differentiation, proliferation, and survival. The overall goal is to harness the therapeutic potential of these newly discovered targets to stimulate the generation of new beta-cells and to expand and protect the functional beta-cells that still reside in the pancreas of patients with diabetes.

Courses

AFNS 543 - Diabetes, Cardiovascular Disease and Lifestyle

This is an advanced course examining the relationship between the role of lifestyle factors in the etiology and pathophysiology, as well as the treatment of type 2 diabetes and cardiovascular disease. Application of recent findings to our understanding of these chronic metabolic diseases will be addressed. Not to be taken if credit received for NUTR 443. Prerequisite: consent of instructor.

Fall Term 2025

NUTR 443 - Diabetes, Cardiovascular Disease and Lifestyle

This is an advanced course examining the relationship between the role of lifestyle factors in the etiology and pathophysiology, as well as the treatment of type 2 diabetes and cardiovascular disease. Application of recent findings to our understanding of these chronic metabolic diseases will be addressed. Prerequisites: (NUTR 301 or 303) and (NUTR 302 or 304).

Fall Term 2025

NUTR 450 - Undergraduate Dietetics Specialization Research Project

An independent research project on topics in nutritional science and supervised by a faculty member. Normally this is a continuation of work begun in NUTR 400. It includes implementation of a research project relevant to dietetic practice, data analysis and presentation of results orally and in writing. Prerequisite: NUTR 400.

Winter Term 2025 Winter Term 2026

Browse more courses taught by Jean Buteau

Featured Publications

Beta-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic beta INS832/13 cells.

Talbot J, Joly E, Prentki M, Buteau J.

Mol Cell Endocrinol. 364 (1-2):65-70

GLP-1 receptor signaling: effects on pancreatic beta-cell proliferation and survival.

Buteau J.

Diabetes Metab.. 34 (Suppl. 2):S.73-S.77

Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic beta-cell mass expansion.

Bastien-Dionne PO, Valenti L, Kon N, Gu W, Buteau J.

Diabetes. 60 (12):3217-3222

Glucagon-like peptide-1 (GLP-1) diminishes neuronal degeneration and death caused by NGF deprivation by suppressing Bim induction.

Biswas SC, Buteau J, Greene LA.

Neurochem Res.. 33 (9):1845-1851

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 beta-cells.

El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, Pepin E, Zhao S, Iglesias J, Roche E, Prentki M.

Endocrinology. 151 (7):3061-3073