Jean Buteau, PhD

Contact

Professor, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept

Email: jbuteau@ualberta.ca
Phone: (780) 492-8386
Address: 5-126B Li Ka Shing Centre For Research
8602 112 St NW

Edmonton AB

T6G 2E1

Overview

About

Degree

PhD in Biochemistry, University of Montreal

Awards

Canadian Institutes of Health Research, New Investigator Award, 2013-2018

Canadian Diabetes Association, Scholar Award, 2008-2013

Quebec Research Funds, Junior Investigator Award, 2008-2012

Research

Research Interests

Keywords: Diabetes, Obesity, Nutritional and hormonal regulation of beta-cell mass and function.

Our research efforts are aimed at identifying novel molecular mechanisms that govern beta-cell differentiation, proliferation, and survival. The overall goal is to harness the therapeutic potential of these newly discovered targets to stimulate the generation of new beta-cells and to expand and protect the functional beta-cells that still reside in the pancreas of patients with diabetes.

Courses

AFNS 543 - Diabetes, Cardiovascular Disease and Lifestyle

This is an advanced course examining the relationship between the role of lifestyle factors in the etiology and pathophysiology, as well as the treatment of type 2 diabetes and cardiovascular disease. Application of recent findings to our understanding of these chronic metabolic diseases will be addressed. Not to be taken if credit received for NUTR 443. Prerequisite: consent of instructor.

Fall Term 2024

NUTR 443 - Diabetes, Cardiovascular Disease and Lifestyle

This is an advanced course examining the relationship between the role of lifestyle factors in the etiology and pathophysiology, as well as the treatment of type 2 diabetes and cardiovascular disease. Application of recent findings to our understanding of these chronic metabolic diseases will be addressed. Prerequisites: (NUTR 301 or 303) and (NUTR 302 or 304).

Fall Term 2024

NUTR 450 - Undergraduate Dietetics Specialization Research Project

An independent research project on topics in nutritional science and supervised by a faculty member. Normally this is a continuation of work begun in NUTR 400. It includes implementation of a research project relevant to dietetic practice, data analysis and presentation of results orally and in writing. Prerequisite: NUTR 400.

Winter Term 2025

Browse more courses taught by Jean Buteau

Featured Publications

Beta-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic beta INS832/13 cells.

Talbot J, Joly E, Prentki M, Buteau J.

Mol Cell Endocrinol. 364 (1-2):65-70

GLP-1 receptor signaling: effects on pancreatic beta-cell proliferation and survival.

Buteau J.

Diabetes Metab.. 34 (Suppl. 2):S.73-S.77

Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic beta-cell mass expansion.

Bastien-Dionne PO, Valenti L, Kon N, Gu W, Buteau J.

Diabetes. 60 (12):3217-3222

Glucagon-like peptide-1 (GLP-1) diminishes neuronal degeneration and death caused by NGF deprivation by suppressing Bim induction.

Biswas SC, Buteau J, Greene LA.

Neurochem Res.. 33 (9):1845-1851

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 beta-cells.

El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, Pepin E, Zhao S, Iglesias J, Roche E, Prentki M.

Endocrinology. 151 (7):3061-3073