James Shapiro

Area of Study / Keywords

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About

Training
Born in Leeds, England, Professor James Shapiro obtained his MD at the University of Newcastle-upon-Tyne and trained in Surgery at the University of Bristol UK. James came to Canada in 1993 and completed a surgical fellowship in hepatobiliary oncology and multiorgan transplantation. He completed further surgical fellowships at the University of Maryland, Vancouver BC and in Kyoto Japan, and joined the faculty in 1998. 

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Research

Research Interests
Hepatobiliary oncology
Transplantation
 
Research Synopsis
Professor Shapiro led the clinical team with the "Edmonton Protocol" islet transplant and was author on the 2000 NEJM study. He was PI on an international trial that replicated the Edmonton success, published in NEJM 2006. As principal investigator on several international islet transplant trial grants, Shapiro has brought in more than $65 million in grant and philanthropic support through the U of A for work on islet transplantation. He has been the recipient of multiple awards, including the Hunterian Medal from the Royal College of Surgeons of England, the Gold Medal in Surgery from the Governor General of Canada, Physician of the Century, and was recently named one of Nature Biotechnology's most remarkable and influential personalities. He was elected Fellow of the Royal Society of Canada in and was recently appointed as the Department of Surgery's first Canada Research Council's Chair in Transplantation Surgery and Regenerative Medicine.
 
Professor Shapiro is a busy clinical hepatobiliary and pancreatic oncology and transplant surgeon, and also maintains an active /transplant research laboratory. His group is actively researching personalized medicine approaches to pancreatic and other hepatobiliary cancers, with of human transplantation in immunodeficient mouse models, using a novel pre-vascularized subcutaneous implantation site model.

Barbetta A., Meeberg G., Rocque B., Barhouma S., Weaver C., Gilmour S., Faytrouni F., Guttman O., Zielsdorf S., Etesami K., Kwon Y., Yanni G., Campbell P., Shapiro J., Emamaullee J.

Pediatric Transplantation. 2022 May; 26 (3) 10.1111/petr.14197

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Tom Williams Surgical Research Day 2022. 2022 May;

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Tom Williams Surgical Research Day 2022. 2022 May; n/a

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Tom Williams Surgical Research Day 2022. 2022 May;

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Tom Williams Surgical Research Day 2022. 2022 May;

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Verhoeff K., Cuesta-Gomez N., Jasra I., Marfil-Garza B., Dadheech N., Shapiro A.M.J.

Stem Cell Reviews and Reports. 2022 May; 10.1007/s12015-022-10391-3

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Tom Williams Surgical Research Day 2022. 2022 May;

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Marfil-Garza B.A., Imes S., Verhoeff K., Hefler J., Lam A., Dajani K., Anderson B., O'Gorman D., Kin T., Bigam D., Senior P.A., Shapiro A.M.J.

The Lancet Diabetes and Endocrinology. 2022 May; 10 (7):519-532 10.1016/S2213-8587(22)00114-0

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Tom Williams Surgical Research Day 2022. 2022 May;

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Purich K., Verhoeff K., Miles A., Kung J.Y., James Shapiro A.M., Bigam D.

Canadian Journal of Surgery. 2022 May; 65 (3):E372-E380 10.1503/cjs.010121

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Kin T., Shapiro A.J.

Pancreatology. 2022 April; 22 (3):446-447 10.1016/j.pan.2022.03.004

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Marfil-Garza B.A., Pawlick R.L., Szeto J., Kroger C., Tahiliani V., Hefler J., Dadheech N., Seavey M.M., Wolf J., Jasuja R.R., James Shapiro A.M.

American Journal of Transplantation. 2022 April; 22 (4):1101-1114 10.1111/ajt.16940

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Ebadi M, Dunichand-Hoedl AR, Rider E, Kneteman N, Shapiro AMJ, Bigam DL, Dajani K, Mazurak VC, Baracos VE, Montano-Loza AJ

JHEP Rep. 2022 April; 4 (7):100495 10.1016/j.jhepr.2022.100495.

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Verhoeff K., Marfil-Garza B.A., Cuesta-Gomez N., Jasra I., Dadheech N., Shapiro A.M.J.

Advances in Experimental Medicine and Biology. 2022 April; 1387 10.1007/5584_2022_711

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D’Addio F., Maestroni A., Assi E., Ben Nasr M., Amabile G., Usuelli V., Loretelli C., Bertuzzi F., Antonioli B., Cardarelli F., El Essawy B., Solini A., Gerling I.C., Bianchi C., Becchi G., Mazzucchelli S., Corradi D., Fadini G.P., Foschi D., Markmann J.F., Orsi E., �krha J., Camboni M.G., Abdi R., James Shapiro A.M., Folli F., Ludvigsson J., Del Prato S., Zuccotti G., Fiorina P.

NAt Comm. 2022 February; 13 (1) 10.1038/s41467-022-28360-2

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Babu B.I., James Shapiro A.M.

Pancreas. 2022 February; 51 (2):117-120 10.1097/MPA.0000000000001974

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Shapiro AMJ

Endocrine Today. 2021 December; n/a

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IPITA Congress 2021. 2021 December;

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Shapiro A.M.J., Thompson D., Donner T.W., Bellin M.D., Hsueh W., Pettus J., Wilensky J., Daniels M., Wang R.M., Brandon E.P., Jaiman M.S., Kroon E.J., D'Amour K.A., Foyt H.L.

Cell Reports Medicine. 2021 December; 2 (12) 10.1016/j.xcrm.2021.100466

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Hefler J., Marfil-Garza B.A., Pawlick R.L., Freed D.H., Karvellas C.J., Bigam D.L., Shapiro A.M.J.

PeerJ. 2021 December; 9 10.7717/peerj.12579

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Marfil-Garza B.A., Hefler J., Dajani K., Kin T., James Shapiro A.M.

American Journal of Transplantation. 2021 November; 21 (11):3790-3793 10.1111/ajt.16723

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Alberta Diabetes Institute Research Day 2021. 2021 November;

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Alberta Diabetes Institute Research Day 2021. 2021 November;

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Alberta Diabetes Institute Research Day 2021. 2021 November;

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Fu A., van Rooyen L., Evans L., Armstrong N., Avizonis D., Kin T., Bird G.H., Reddy A., Chouchani E.T., Liesa-Roig M., Walensky L.D., Shapiro A.M.J., Danial N.N.

Cell Reports. 2021 November; 37 (8) 10.1016/j.celrep.2021.110037

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Alberta Diabetes Institute Research Day 2021. 2021 November;

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Canadian Associaion of General Surgeons Meeting 2021. 2021 November;

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Alberta Diabetes Institute Research Day 2021. 2021 November;

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Alberta Diabetes Institute Research Day 2021. 2021 November;

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Lau H.H., Gan S.U., Lickert H., Shapiro A.M.J., Lee K.O., Teo A.K.K.

Cell Reports. 2021 October; 2 (10):1138-1162 10.1016/j.medj.2021.09.001

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Li J., Inoue R., Togashi Y., Okuyama T., Satoh A., Kyohara M., Nishiyama K., Tsuno T., Miyashita D., Kin T., Shapiro A.M.J., Chew R.S.E., Teo A.K.K., Oyadomari S., Terauchi Y., Shirakawa J.

Diabetes. 2021 September; 71 (3):424-439 10.2337/db21-0123

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Barbetta A., Butler C., Barhouma S., Hogen R., Rocque B., Goldbeck C., Schilperoort H., Meeberg G., Shapiro J., Kwon Y.K., Kohli R., Emamaullee J.

Transplantation Direct. 2021 September; 10.1097/TXD.0000000000001219

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Webb A.N., Lester E.L.W., Shapiro A.M.J., Eurich D.T., Bigam D.L.

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 August; 10.1111/ajt.16797

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Nickel K.J., Staples J., Meeberg G., Kwan P.O., Gilmour S., Bigam D.L., Dajani K., Shapiro A.M.J., Kneteman N.M., Ladak A.

Plastic and Reconstructive Surgery. 2021 August; 10.1097/PRS.0000000000008169

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Verhoeff K, Marfil-Garza BA, Shapiro AMJ

Current Opinion in Organ Transplantation. 2021 August; 26 (4):397-404 10.1097/MOT.0000000000000891

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Fox D.E., Quinn R.R., Ronksley P.E., Harrison T.G., Quan H., Bigam D., Shapiro A.M.J., Jeong R., Lam N.N.

Canadian Journal of Kidney Health and Disease. 2021 July; 8 10.1177/20543581211029389

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Webb A.N., Izquierdo D.L., Eurich D.T., Shapiro A.M.J., Bigam D.L.

PharmacoEconomics. Open. 2021 June; 5 (2):311-318 10.1007/s41669-020-00241-8

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Witkowski P., Wijkstrom M., Bachul P.J., Morgan K.A., Levy M., Onaca N., Chaidarun S.S., Gardner T., Shapiro A.M.J., Posselt A., Ahmad S.A., Daffonchio L., Ruffini P.A., Bellin M.D.

American Journal of Transplantation. 2021 May; 10.1111/ajt.16695

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ILTS Annual Congress 2022. 2021 May;

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Tom Williams Surgical Research Day. 2021 May;

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Tom Williams Surgical Research Day. 2021 May;

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General Surgery Research Day. 2021 April;

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Markmann JF, Rickels MR, Eggerman TL, Bridges ND, Lafontant DE, Qidwai J, Foster E, Clarke WR, Kamoun M, Alejandro R, Bellin M, Chaloner K, Czarniecki CW, Goldstein JS, Hering BJ, Hunsicker LG, Kaufman DB, Korsgren O, Larsen CP, Luo X, Naji A, Oberholzer J, Posselt AM, Ricordi C, Senior PA, Shapiro AMJ, Stock PG, Turgeon NA, Clinical Islet Transplant Consortium

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 April; 21 (4):1477 - 1492 doi: 10.1111/ajt/16174

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Desai C.S., Szempruch K.R., Vonderau J.S., Chetboun M., Pattou F., Coates T., De Paep D.L., Hawthorne W.J., Khan K.M., de Koning E.J.P., Naziruddin B., Posselt A., Schrope B.A., Wijkstrom M., Witkowski P., Shapiro A.M.J.

TRANSPLANT INTERNATIONAL. 2021 March; 34 (3):593-595 10.1111/tri.13821

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Marfil-Garza B.A., Shapiro A.M.J., Kin T.

Journal of Hepato-Biliary-Pancreatic Sciences. 2021 March; 28 (3):243-254 10.1002/jhbp.891

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Raza M.H., Jackson W.E., Dell A., Ding L., Shapiro J., Pomfret E.A., Genyk Y., Sher L., Emamaullee J.

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 March; 21 (3):1056-1067 10.1111/ajt.16229

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Marfil-Garza B.A., Hefler J., Bermudez De Leon M., Pawlick R., Dadheech N., Shapiro A.M.J.

ENDOCRINE REVIEWS. 2021 March; 42 (2):198-218 10.1210/endrev/bnaa028

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Shapiro AMJ

Endocrine Today. 2021 January; (January 2022) n/a

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Nickel K.J., Staples J., Meeberg G., Kwan P.O., Gilmour S., Bigam D.L., Dajani K., Shapiro A.M.J., Kneteman N.M., Ladak A.

Plastic and Reconstructive Surgery. 2021 January; 10.1097/PRS.0000000000008169

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Fox D.E., Quinn R.R., Ronksley P.E., Harrison T.G., Quan H., Bigam D., Shapiro A.M.J., Jeong R., Lam N.N.

Can J Kidney Health Dis. 2021 January; 8 10.1177/20543581211029389

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Babu B.I., Bigam D.L., Gilmour S.M., Dajani K.Z., Shapiro A.M.J., Kneteman N.M.

Transplantation Direct. 2021 January; 7 (1):e654 10.1097/TXD.0000000000001106

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Verhoeff K., Henschke S.J., Marfil-Garza B.A., Dadheech N., Shapiro A.M.J.

Cells. 2021 January; 10 (2) 10.3390/cells10020278

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Marfil-Garza B.A., Kim R., Shapiro A.M.J., Kin T.

DIGESTIVE DISEASES AND SCIENCES. 2021 January; 66 (1):218 - 223 10.1007/s10620-020-06145-1

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Alberta Diabetes Institute Research Day. 2020 November;

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Emamaullee J., Tenorio L., Khan S., Butler C., Kim S., Tucker-Seeley R., Kwon Y., Shapiro J., Saigal S., Sher L., Genyk Y.

CLINICAL TRANSPLANTATION. 2020 November; 34 (11) 10.1111/ctr.14073

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Till and McCulloch Meeting. 2020 October;