James Shapiro

Professor, Faculty of Medicine & Dentistry - Surgery Dept

Contact

Professor, Faculty of Medicine & Dentistry - Surgery Dept
Email
jshapiro@ualberta.ca
Phone
(780) 492-3974
Address
1-002 Li Ka Shing Centre For Research
8602 112 St NW
Edmonton AB
T6G 2E1

Overview

Area of Study / Keywords


About

Training
Born in Leeds, England, Professor James Shapiro obtained his MD at the University of Newcastle-upon-Tyne and trained in Surgery at the University of Bristol UK. James came to Canada in 1993 and completed a surgical fellowship in hepatobiliary oncology and multiorgan transplantation. He completed further surgical fellowships at the University of Maryland, Vancouver BC and in Kyoto Japan, and joined the faculty in 1998. 

Research

Research Interests
Hepatobiliary oncology
Transplantation
 
Research Synopsis
Professor Shapiro led the clinical team with the "Edmonton Protocol" islet transplant success, and was lead author on the 2000 NEJM study. He was PI on an international trial that replicated the Edmonton success, published in NEJM 2006. As principal investigator on several international islet transplant trial grants, Shapiro has brought in more than $65 million in grant and philanthropic support through the U of A for work on islet transplantation. He has been the recipient of multiple awards, including the Hunterian Medal from the Royal College of Surgeons of England, the Gold Medal in Surgery from the Governor General of Canada, Physician of the Century, and was recently named one of Nature Biotechnology's most remarkable and influential personalities. He was elected Fellow of the Royal Society of Canada in 2012, and was recently appointed as the Department of Surgery's first Canada Research Council's Chair in Transplantation Surgery and Regenerative Medicine.
 
Professor Shapiro is a busy clinical hepatobiliary and pancreatic oncology and transplant surgeon, and also maintains an active immunology/transplant research laboratory. His group is actively researching personalized medicine approaches to pancreatic and other hepatobiliary cancers, with generation of human tumor transplantation in immunodeficient mouse models, using a novel pre-vascularized subcutaneous implantation site model.

Featured Publications

Barbetta A., Meeberg G., Rocque B., Barhouma S., Weaver C., Gilmour S., Faytrouni F., Guttman O., Zielsdorf S., Etesami K., Kwon Y., Yanni G., Campbell P., Shapiro J., Emamaullee J.

Pediatric Transplantation. 2022 May; 26 (3) 10.1111/petr.14197


Impact of LNWH selection on the rate of prophylactic anti-Xa achievement and venous thromboembolism following hepato-pancreatico-biliary surgery; A prospective cohort study

Tom Williams Surgical Research Day 2022. 2022 May;


Tom Williams Surgical Research Day 2022. 2022 May; n/a


Normothermic machine perfusion in liver transplantation - seven year experience at a single North American centre

Tom Williams Surgical Research Day 2022. 2022 May;


Optimization of the differentiation protocol for the generation of safe and effective iPSC derived beta-like cells for the treatment of diabetes

Tom Williams Surgical Research Day 2022. 2022 May;


Verhoeff K., Cuesta-Gomez N., Jasra I., Marfil-Garza B., Dadheech N., Shapiro A.M.J.

Stem Cell Reviews and Reports. 2022 May; 10.1007/s12015-022-10391-3


Outcomes following extrahepatic and intraportal pancreatic islet transplantation: A comparative cohort study

Tom Williams Surgical Research Day 2022. 2022 May;


Marfil-Garza B.A., Imes S., Verhoeff K., Hefler J., Lam A., Dajani K., Anderson B., O'Gorman D., Kin T., Bigam D., Senior P.A., Shapiro A.M.J.

The Lancet Diabetes and Endocrinology. 2022 May; 10 (7):519-532 10.1016/S2213-8587(22)00114-0


Trends in graduate degree types and research output for Canadian academic general surgeons

Tom Williams Surgical Research Day 2022. 2022 May;


Purich K., Verhoeff K., Miles A., Kung J.Y., James Shapiro A.M., Bigam D.

Canadian Journal of Surgery. 2022 May; 65 (3):E372-E380 10.1503/cjs.010121


Kin T., Shapiro A.J.

Pancreatology. 2022 April; 22 (3):446-447 10.1016/j.pan.2022.03.004


Marfil-Garza B.A., Pawlick R.L., Szeto J., Kroger C., Tahiliani V., Hefler J., Dadheech N., Seavey M.M., Wolf J., Jasuja R.R., James Shapiro A.M.

American Journal of Transplantation. 2022 April; 22 (4):1101-1114 10.1111/ajt.16940


Ebadi M, Dunichand-Hoedl AR, Rider E, Kneteman N, Shapiro AMJ, Bigam DL, Dajani K, Mazurak VC, Baracos VE, Montano-Loza AJ

JHEP Rep. 2022 April; 4 (7):100495 10.1016/j.jhepr.2022.100495.


Verhoeff K., Marfil-Garza B.A., Cuesta-Gomez N., Jasra I., Dadheech N., Shapiro A.M.J.

Advances in Experimental Medicine and Biology. 2022 April; 1387 10.1007/5584_2022_711


D’Addio F., Maestroni A., Assi E., Ben Nasr M., Amabile G., Usuelli V., Loretelli C., Bertuzzi F., Antonioli B., Cardarelli F., El Essawy B., Solini A., Gerling I.C., Bianchi C., Becchi G., Mazzucchelli S., Corradi D., Fadini G.P., Foschi D., Markmann J.F., Orsi E., �krha J., Camboni M.G., Abdi R., James Shapiro A.M., Folli F., Ludvigsson J., Del Prato S., Zuccotti G., Fiorina P.

NAt Comm. 2022 February; 13 (1) 10.1038/s41467-022-28360-2


Babu B.I., James Shapiro A.M.

Pancreas. 2022 February; 51 (2):117-120 10.1097/MPA.0000000000001974


Shapiro AMJ

Endocrine Today. 2021 December; n/a


Evaluation of a low dose recombinant collagenase and BP protease for clinical islet transplantation

IPITA Congress 2021. 2021 December;


Shapiro A.M.J., Thompson D., Donner T.W., Bellin M.D., Hsueh W., Pettus J., Wilensky J., Daniels M., Wang R.M., Brandon E.P., Jaiman M.S., Kroon E.J., D'Amour K.A., Foyt H.L.

Cell Reports Medicine. 2021 December; 2 (12) 10.1016/j.xcrm.2021.100466


Hefler J., Marfil-Garza B.A., Pawlick R.L., Freed D.H., Karvellas C.J., Bigam D.L., Shapiro A.M.J.

PeerJ. 2021 December; 9 10.7717/peerj.12579


Marfil-Garza B.A., Hefler J., Dajani K., Kin T., James Shapiro A.M.

American Journal of Transplantation. 2021 November; 21 (11):3790-3793 10.1111/ajt.16723


Replication fork stalling in human autologous iPSC-derived B-cells enhance maturation but change mitochondrial respiration and function

Alberta Diabetes Institute Research Day 2021. 2021 November;


Pancreatic islet transplantation: 20 year outcomes at the University of Alberta

Alberta Diabetes Institute Research Day 2021. 2021 November;


Modelling human pleuripotent stem cells physiological benefits in 3D scale-up microenvironment vs 2D planar platform

Alberta Diabetes Institute Research Day 2021. 2021 November;


Fu A., van Rooyen L., Evans L., Armstrong N., Avizonis D., Kin T., Bird G.H., Reddy A., Chouchani E.T., Liesa-Roig M., Walensky L.D., Shapiro A.M.J., Danial N.N.

Cell Reports. 2021 November; 37 (8) 10.1016/j.celrep.2021.110037


Comparative evaluation of outcomes following extrahepatic and intaportal pancreatic islet transplantation

Alberta Diabetes Institute Research Day 2021. 2021 November;


Association between academic degrees and research productivity: an assessment of academic general surgeons in Canada

Canadian Associaion of General Surgeons Meeting 2021. 2021 November;


Acquiring machine learning approach to identify and select human pleuripotent stem cells during reprogramming

Alberta Diabetes Institute Research Day 2021. 2021 November;


Method optimization to manufacture off-target cell free human iPSC-derived islets

Alberta Diabetes Institute Research Day 2021. 2021 November;


Lau H.H., Gan S.U., Lickert H., Shapiro A.M.J., Lee K.O., Teo A.K.K.

Cell Reports. 2021 October; 2 (10):1138-1162 10.1016/j.medj.2021.09.001


Li J., Inoue R., Togashi Y., Okuyama T., Satoh A., Kyohara M., Nishiyama K., Tsuno T., Miyashita D., Kin T., Shapiro A.M.J., Chew R.S.E., Teo A.K.K., Oyadomari S., Terauchi Y., Shirakawa J.

Diabetes. 2021 September; 71 (3):424-439 10.2337/db21-0123


Barbetta A., Butler C., Barhouma S., Hogen R., Rocque B., Goldbeck C., Schilperoort H., Meeberg G., Shapiro J., Kwon Y.K., Kohli R., Emamaullee J.

Transplantation Direct. 2021 September; 10.1097/TXD.0000000000001219


Webb A.N., Lester E.L.W., Shapiro A.M.J., Eurich D.T., Bigam D.L.

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 August; 10.1111/ajt.16797


Nickel K.J., Staples J., Meeberg G., Kwan P.O., Gilmour S., Bigam D.L., Dajani K., Shapiro A.M.J., Kneteman N.M., Ladak A.

Plastic and Reconstructive Surgery. 2021 August; 10.1097/PRS.0000000000008169


Verhoeff K, Marfil-Garza BA, Shapiro AMJ

Current Opinion in Organ Transplantation. 2021 August; 26 (4):397-404 10.1097/MOT.0000000000000891


Fox D.E., Quinn R.R., Ronksley P.E., Harrison T.G., Quan H., Bigam D., Shapiro A.M.J., Jeong R., Lam N.N.

Canadian Journal of Kidney Health and Disease. 2021 July; 8 10.1177/20543581211029389


Webb A.N., Izquierdo D.L., Eurich D.T., Shapiro A.M.J., Bigam D.L.

PharmacoEconomics. Open. 2021 June; 5 (2):311-318 10.1007/s41669-020-00241-8


Witkowski P., Wijkstrom M., Bachul P.J., Morgan K.A., Levy M., Onaca N., Chaidarun S.S., Gardner T., Shapiro A.M.J., Posselt A., Ahmad S.A., Daffonchio L., Ruffini P.A., Bellin M.D.

American Journal of Transplantation. 2021 May; 10.1111/ajt.16695


Management of premalignant cystic lesions of the pancreas in patients undergoing liver transplantation

ILTS Annual Congress 2022. 2021 May;


Combination of an alginate-based islet encapsulation device with a prevascularization strategy to enable immunosuppression=free subcutaneous islet transplantation

Tom Williams Surgical Research Day. 2021 May;


Effect of cyclosporine A on liver ischemia-reperfusion injury in a mouse mode

Tom Williams Surgical Research Day. 2021 May;


Association between academic degrees and research productivity: an assessment of academic general surgeons in Canada

General Surgery Research Day. 2021 April;


Markmann JF, Rickels MR, Eggerman TL, Bridges ND, Lafontant DE, Qidwai J, Foster E, Clarke WR, Kamoun M, Alejandro R, Bellin M, Chaloner K, Czarniecki CW, Goldstein JS, Hering BJ, Hunsicker LG, Kaufman DB, Korsgren O, Larsen CP, Luo X, Naji A, Oberholzer J, Posselt AM, Ricordi C, Senior PA, Shapiro AMJ, Stock PG, Turgeon NA, Clinical Islet Transplant Consortium

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 April; 21 (4):1477 - 1492 doi: 10.1111/ajt/16174


Desai C.S., Szempruch K.R., Vonderau J.S., Chetboun M., Pattou F., Coates T., De Paep D.L., Hawthorne W.J., Khan K.M., de Koning E.J.P., Naziruddin B., Posselt A., Schrope B.A., Wijkstrom M., Witkowski P., Shapiro A.M.J.

TRANSPLANT INTERNATIONAL. 2021 March; 34 (3):593-595 10.1111/tri.13821


Marfil-Garza B.A., Shapiro A.M.J., Kin T.

Journal of Hepato-Biliary-Pancreatic Sciences. 2021 March; 28 (3):243-254 10.1002/jhbp.891


Raza M.H., Jackson W.E., Dell A., Ding L., Shapiro J., Pomfret E.A., Genyk Y., Sher L., Emamaullee J.

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 March; 21 (3):1056-1067 10.1111/ajt.16229


Marfil-Garza B.A., Hefler J., Bermudez De Leon M., Pawlick R., Dadheech N., Shapiro A.M.J.

ENDOCRINE REVIEWS. 2021 March; 42 (2):198-218 10.1210/endrev/bnaa028


Shapiro AMJ

Endocrine Today. 2021 January; (January 2022) n/a


Nickel K.J., Staples J., Meeberg G., Kwan P.O., Gilmour S., Bigam D.L., Dajani K., Shapiro A.M.J., Kneteman N.M., Ladak A.

Plastic and Reconstructive Surgery. 2021 January; 10.1097/PRS.0000000000008169


Fox D.E., Quinn R.R., Ronksley P.E., Harrison T.G., Quan H., Bigam D., Shapiro A.M.J., Jeong R., Lam N.N.

Can J Kidney Health Dis. 2021 January; 8 10.1177/20543581211029389


Babu B.I., Bigam D.L., Gilmour S.M., Dajani K.Z., Shapiro A.M.J., Kneteman N.M.

Transplantation Direct. 2021 January; 7 (1):e654 10.1097/TXD.0000000000001106


Verhoeff K., Henschke S.J., Marfil-Garza B.A., Dadheech N., Shapiro A.M.J.

Cells. 2021 January; 10 (2) 10.3390/cells10020278


Marfil-Garza B.A., Kim R., Shapiro A.M.J., Kin T.

DIGESTIVE DISEASES AND SCIENCES. 2021 January; 66 (1):218 - 223 10.1007/s10620-020-06145-1


Combination of an alginate-based islet encapsulation device with a prevacularization strategy to enable immunosuppression-free subcutaneous islet transplantation

Alberta Diabetes Institute Research Day. 2020 November;


Emamaullee J., Tenorio L., Khan S., Butler C., Kim S., Tucker-Seeley R., Kwon Y., Shapiro J., Saigal S., Sher L., Genyk Y.

CLINICAL TRANSPLANTATION. 2020 November; 34 (11) 10.1111/ctr.14073


Bioreactor-based scale-up of human iPSC-derived islet-like cells restores normoglycemia and reverses diabetes

Till and McCulloch Meeting. 2020 October;