James Shapiro

Professor, Faculty of Medicine & Dentistry - Surgery Dept

Contact Overview Publications

Contact

Professor, Faculty of Medicine & Dentistry - Surgery Dept

Email: jshapiro@ualberta.ca
Phone: (780) 492-3974
Address: 1-002 Li Ka Shing Centre For Research
8602 112 Street NW

Edmonton AB

T6G 2E1

Overview

Area of Study / Keywords

About

Training
Born in Leeds, England, Professor James Shapiro obtained his MD at the University of Newcastle-upon-Tyne and trained in Surgery at the University of Bristol UK. James came to Canada in 1993 and completed a surgical fellowship in hepatobiliary oncology and multiorgan transplantation. He completed further surgical fellowships at the University of Maryland, Vancouver BC and in Kyoto Japan, and joined the faculty in 1998.

Research

Research Interests
Hepatobiliary oncology
Transplantation

Research Synopsis
Professor Shapiro led the clinical team with the "Edmonton Protocol" islet transplant success, and was lead author on the 2000 NEJM study. He was PI on an international trial that replicated the Edmonton success, published in NEJM 2006. As principal investigator on several international islet transplant trial grants, Shapiro has brought in more than $65 million in grant and philanthropic support through the U of A for work on islet transplantation. He has been the recipient of multiple awards, including the Hunterian Medal from the Royal College of Surgeons of England, the Gold Medal in Surgery from the Governor General of Canada, Physician of the Century, and was recently named one of Nature Biotechnology's most remarkable and influential personalities. He was elected Fellow of the Royal Society of Canada in 2012, and was recently appointed as the Department of Surgery's first Canada Research Council's Chair in Transplantation Surgery and Regenerative Medicine.

Professor Shapiro is a busy clinical hepatobiliary and pancreatic oncology and transplant surgeon, and also maintains an active immunology/transplant research laboratory. His group is actively researching personalized medicine approaches to pancreatic and other hepatobiliary cancers, with generation of human tumor transplantation in immunodeficient mouse models, using a novel pre-vascularized subcutaneous implantation site model.

Featured Publications

Immunologic benefits of maternal living donor allografts in pediatric liver transplantation: fewer rejection episodes and no evidence of de novo allosensitization

Barbetta A., Meeberg G., Rocque B., Barhouma S., Weaver C., Gilmour S., Faytrouni F., Guttman O., Zielsdorf S., Etesami K., Kwon Y., Yanni G., Campbell P., Shapiro J., Emamaullee J.

Pediatric Transplantation. 2022 May; 26 (3) 10.1111/petr.14197

Impact of LNWH selection on the rate of prophylactic anti-Xa achievement and venous thromboembolism following hepato-pancreatico-biliary surgery; A prospective cohort study

Tom Williams Surgical Research Day 2022. 2022 May;

Impact of LNWH selection on the rate of prophylactic anti-Xa achievement and venous thromboembolism following hepato-pancreatico-biliary surgery; A prospective cohort study

Tom Williams Surgical Research Day 2022. 2022 May; n/a

Normothermic machine perfusion in liver transplantation - seven year experience at a single North American centre

Tom Williams Surgical Research Day 2022. 2022 May;

Optimization of the differentiation protocol for the generation of safe and effective iPSC derived beta-like cells for the treatment of diabetes

Tom Williams Surgical Research Day 2022. 2022 May;

Optimizing Generation of Stem Cell-Derived Islet Cells

Verhoeff K., Cuesta-Gomez N., Jasra I., Marfil-Garza B., Dadheech N., Shapiro A.M.J.

Stem Cell Reviews and Reports. 2022 May; 10.1007/s12015-022-10391-3

Outcomes following extrahepatic and intraportal pancreatic islet transplantation: A comparative cohort study

Tom Williams Surgical Research Day 2022. 2022 May;

Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada

Marfil-Garza B.A., Imes S., Verhoeff K., Hefler J., Lam A., Dajani K., Anderson B., O'Gorman D., Kin T., Bigam D., Senior P.A., Shapiro A.M.J.

The Lancet Diabetes and Endocrinology. 2022 May; 10 (7):519-532 10.1016/S2213-8587(22)00114-0

Trends in graduate degree types and research output for Canadian academic general surgeons

Tom Williams Surgical Research Day 2022. 2022 May;

Association between academic degrees and research productivity: an assessment of Canadian academic general surgeons

Purich K., Verhoeff K., Miles A., Kung J.Y., James Shapiro A.M., Bigam D.

Canadian Journal of Surgery. 2022 May; 65 (3):E372-E380 10.1503/cjs.010121

Reassessment of the embryonic fusion plane between the ventral and dorsal pancreases in human donors for transplantation

Kin T., Shapiro A.J.

Pancreatology. 2022 April; 22 (3):446-447 10.1016/j.pan.2022.03.004

Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonists in islet transplantation: Endogenous in vivo regulatory T cell expansion promotes prolonged allograft survival

Marfil-Garza B.A., Pawlick R.L., Szeto J., Kroger C., Tahiliani V., Hefler J., Dadheech N., Seavey M.M., Wolf J., Jasuja R.R., James Shapiro A.M.

American Journal of Transplantation. 2022 April; 22 (4):1101-1114 10.1111/ajt.16940

Higher subcutaneous adipose tissue radiodensity is associated with increased mortality in patients with cirrhosis

Ebadi M, Dunichand-Hoedl AR, Rider E, Kneteman N, Shapiro AMJ, Bigam DL, Dajani K, Mazurak VC, Baracos VE, Montano-Loza AJ

JHEP Rep. 2022 April; 4 (7):100495 10.1016/j.jhepr.2022.100495.

Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell-Based Islet Cell Transplant

Verhoeff K., Marfil-Garza B.A., Cuesta-Gomez N., Jasra I., Dadheech N., Shapiro A.M.J.

Advances in Experimental Medicine and Biology. 2022 April; 1387 10.1007/5584_2022_711

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

D’Addio F., Maestroni A., Assi E., Ben Nasr M., Amabile G., Usuelli V., Loretelli C., Bertuzzi F., Antonioli B., Cardarelli F., El Essawy B., Solini A., Gerling I.C., Bianchi C., Becchi G., Mazzucchelli S., Corradi D., Fadini G.P., Foschi D., Markmann J.F., Orsi E., �krha J., Camboni M.G., Abdi R., James Shapiro A.M., Folli F., Ludvigsson J., Del Prato S., Zuccotti G., Fiorina P.

NAt Comm. 2022 February; 13 (1) 10.1038/s41467-022-28360-2

Current Evidence in the Management of Premalignant Cystic Lesions of the Pancreas in Patients Undergoing Liver Transplantation

Babu B.I., James Shapiro A.M.

Pancreas. 2022 February; 51 (2):117-120 10.1097/MPA.0000000000001974

Cell replacement therapy holds promise for precision control in diabetes.

Shapiro AMJ

Endocrine Today. 2021 December; n/a

Evaluation of a low dose recombinant collagenase and BP protease for clinical islet transplantation

IPITA Congress 2021. 2021 December;

Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device

Shapiro A.M.J., Thompson D., Donner T.W., Bellin M.D., Hsueh W., Pettus J., Wilensky J., Daniels M., Wang R.M., Brandon E.P., Jaiman M.S., Kroon E.J., D'Amour K.A., Foyt H.L.

Cell Reports Medicine. 2021 December; 2 (12) 10.1016/j.xcrm.2021.100466

Preclinical models of acute liver failure: A comprehensive review

Hefler J., Marfil-Garza B.A., Pawlick R.L., Freed D.H., Karvellas C.J., Bigam D.L., Shapiro A.M.J.

PeerJ. 2021 December; 9 10.7717/peerj.12579