Continuation of the structural and chemical properties of the basic functional groups of organic compounds including alkynes, aromatic compounds, aldehydes, ketones, carboxylic acids and their derivatives and amines. Illustration of these functional groups in natural products such as carbohydrates, amino acids and proteins, nucleic acids and lipids. Discussion of the application of spectroscopic methods for the structure determination in simple organic molecules. Prerequisites: CHEM 261 or CHEM 264 and 266 or SCI 100. Students who have obtained credit for CHEM 265 cannot take CHEM 263 for credit.
Modern organic reactions and reactive intermediates. Cations, free radicals, radical ions, carbenes, metallocarbenes, arynes, and transition-metal catalysis. Mechanisms, transition-state conformational analysis and stereoelectronic effects. Diastereoselectivity. The laboratory is focused on multistep organic synthesis, featuring reactions drawn from the lecture topics. Prerequisites: Chem 361 or consent of instructor. Students with credit for Chem 363 cannot take Chem 460 for credit.