Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat2.
Author(s): Fillmore, N., Keung, W., Kelly, S.E., Proctor, S., Lopaschuk, G.D., Ussher, J.R.
Publication: Experimental Physiology
5’AMP activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes.
Author(s): Lee, C.T., Ussher, J.R., Mohammad, A., Lam, A., Lopaschuk, G.D.
Publication: Canadian Journal of Physiology and Pharmacology
Volume: 92
Issue: 4
Page Numbers: 307-314
Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole body insulin resistance in obese mice.
Author(s): Ussher, J.R., Keung, W., Fillmore N., Koves, T.R., Mori, J., Zhang, L., Lopaschuk, D.G., Ilkayeva, O.R., Wagg, C.S., Jaswal, J.S., Muoio, D.M., Lopaschuk, G.D.
Publication: Journal of Pharmacology and Experimental Therapeutics
Volume: 349
Issue: 3
Page Numbers: 487-496
The role of cardiac lipotoxicity in the pathogenesis of diabetic cardiomyopathy.
Author(s): Ussher, J.R.
Publication: Expert Reviews of Cardiovascular Therapy
Volume: 12
Issue: 3
Page Numbers: 345-358
Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.
Author(s): Masoud, W.G.T., Ussher, J.R., Wang, W., Jaswal, J.S., Wagg, C.S., Dyck, J.R.B., Lygate, C.A., Neubauer, S., Clanachan, A.S., Lopaschuk, G.D.
Publication: Cardiovascular Research
Volume: 101
Issue: 1
Page Numbers: 30-38
Gut microbiota metabolism of L-carnitine and cardiovascular risk.
Author(s): Ussher, J.R., Lopaschuk, G.D., Arduini, A.
Publication: Atherosclerosis
Volume: 231
Issue: 2
Page Numbers: 456-461
Inhibition of fatty acid oxidation as an approach to treat diastolic heart failure.
Author(s): Ussher, J.R., Jaswal, J.S.
Publication: Heart and Metabolism
Volume: 61
Page Numbers: 20-24
Cardiac insulin resistance and decreased mitochondrial energy production precede the development of systolic heart failure following pressure overload hypertrophy.
Author(s): Zhang, L., Jaswal, J.S., Ussher, J.R., Sankaralingam, S., Wagg, C.S., Zaugg, M., Lopaschuk, G.D.
Publication: Circulation Heart Failure
Volume: 6
Issue: 5
Page Numbers: 1039-1048
Cardiac Insulin Resistance: It’s Sweeter Than You Think.
Author(s): Ussher, J.R., Lopaschuk, G.D.
Publication: Endocrinology
Volume: 154
Issue: 8
Page Numbers: 2575-2578
Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.
Author(s): Keung, W., Ussher, J.R., Jaswal, J.S., Raubenheimer, M., Lam, V.H., Wagg, C.S., Lopaschuk, G.D.
Publication: Diabetes
Volume: 62
Issue: 3
Page Numbers: 711-720
Differentiating diastolic dysfunction from classic heart failure.
Author(s): Jaswal, J.S., Ussher, J.R.
Publication: Heart and Metabolism
Volume: 57
Page Numbers: 4-7
Targeting microRNAs to reduce cardiac lipotoxicity.
Author(s): Lopaschuk, G.D., Ussher, J.R.
Publication: Circulation Research
Volume: 116
Issue: 2
Page Numbers: 229-231
Inactivation of malonyl CoA decarboxylase reduces the inflammatory response associated with insulin resistance.
Author(s): Samokhvalov, V., Ussher, J.R., Fillmore N., Armstrong, I.K.G., Keung, W., Moroz, D., Lopaschuk, D.G., Seubert, J., Lopaschuk, G.D.
Publication: American Journal of Physiology: Endocrinology and Metabolism
Volume: 303
Issue: 12
Page Numbers: E1459-E1468
The impact of current and novel anti-diabetic therapies on cardiovascular risk.
Author(s): Ussher, J.R., Sutendra, G., Jaswal, J.S.
Publication: Future Cardiology
Volume: 8
Issue: 6
Page Numbers: 895-912
Something Old Holds Potential to be Something New in Heart Failure: Allopurinol Revisited.
Author(s): Jaswal, J.S., Ussher, J.R., Lopaschuk, G.D, Johnstone, D.E.
Publication: Canadian Journal of Cardiology
Volume: 28
Issue: 6
Page Numbers: 626-628
Effects of performance enhancing drugs on cardiac structure and energy substrate metabolism.
Author(s): Ussher, J.R., Jaswal, J.S.
Publication: Heart and Metabolism
Volume: 56
Page Numbers: 34-37
Pyridine Nucleotide Regulation of Cardiac Intermediary Metabolism.
Author(s): Ussher, J.R., Jaswal, J.S., Lopaschuk, G.D.
Publication: Circulation Research
Volume: 111
Issue: 5
Page Numbers: 628-641
Inhibition Of Serine Palmitoyl Transferase I Reduces Cardiac Ceramide Levels And Increases Glycolysis Rates Following Diet-Induced Insulin Resistance.
Author(s): Ussher, J.R., Folmes, C.D.L., Keung, W., Fillmore N., Jaswal, J.S., Cadete, V.J.J., Beker, D.L., Lam, V.H., Zhang, L., Lopaschuk, G.D.
Publication: PLoS ONE
Volume: 7
Issue: 5
Page Numbers: e37703
An ACE Up Your Sleeve: 2 Is Better Than 1.
Author(s): Ussher, J.R., Lopaschuk, G.D.
Publication: Circulation Research
Volume: 110
Issue: 10
Page Numbers: 1270-1272
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.
Author(s): Ussher, J.R., Wang, W., Gandhi, M., Keung, W., Samokhvalov, V., Oka, T., Wagg, C.S., Jaswal, J.S., Harris, R.A., Clanachan A.S., Dyck, J.R.B., Lopaschuk, G.D.
Publication: Cardiovascular Research
Volume: 94
Issue: 2
Page Numbers: 359-369
Cardiac hypertrophy in the newborn delays the maturation of fatty acid β-oxidation and compromises post-ischemic functional recovery.
Author(s): Oka, T., Lam, V.H., Zhang L., Keung, W., Cadete, V.J.J, Samokhvalov, V., Tanner B.A., Beker, D.L., Ussher, J.R., Huqi, A., Jaswal, J.S., Rebeyka, I.M., Lopaschuk, G.D.
Publication: American Journal of Physiology: Heart and Circulatory Physiology
Volume: 302
Issue: 9
Page Numbers: H1784-H1794
Cardiovascular Biology of the Incretin System.
Author(s): Ussher, J.R., Drucker, D.J.
Publication: Endocrine Reviews
Volume: 33
Issue: 2
Page Numbers: 187-215
Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.
Author(s): Ali, S., Ussher, J.R., Baggio, L.L., Kabir, M.G., Charron, M.J., Ilkayeva, O.R., Newgard, C.B., Drucker, D.J.
Publication: Molecular Metabolism
Volume: 4
Issue: 2
Page Numbers: 132-143
The Gipr is Essential for Adrenocortical Steroidogenesis However Corticosterone Deficiency Does Not Mediate the Favourable Metabolic Phenotype of Gipr-/- Mice.
Author(s): Bates, H.E., Campbell, J.E., Ussher, J.R., Baggio, L.L., Maida, A.M., Seino, Y., Drucker, D.J.
Publication: Diabetes
Volume: 61
Issue: 1
Page Numbers: 40-48
Targeting fatty acid and carbohydrate oxidation – a novel therapeutic intervention in the ischemic and failing heart.
Author(s): Jaswal, J.S., Keung, W., Wang, W., Ussher, J.R., Lopaschuk, G.D.
Publication: Biochimica et Biophysica Acta
Volume: 1813
Issue: 7
Page Numbers: 1333-1350
Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation.
Author(s): Zhang, L., Ussher, J.R., Oka, T., Cadete, V.J., Wagg, C.S., Lopaschuk, G.D.
Publication: Cardiovascular Research
Volume: 89
Issue: 1
Page Numbers: 148-156
Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole Body Oxygen Consumption.
Author(s): Ussher, J.R., Koves, T.R., Cadete, V.J.J., Zhang, L., Jaswal, J.S., Swyrd, S.J., Lopaschuk, D.G., Proctor, S.D., Keung, W., Muoio, D.M., Lopaschuk, G.D.
Publication: Diabetes
Volume: 59
Issue: 10
Page Numbers: 2453-2464
Targeting Intermediary Metabolism in the Hypothalamus as a Mechanism to Regulate Appetite.
Author(s): Lopaschuk, G.D., Ussher, J.R., Jaswal, J.S.
Publication: Pharmacological Reviews
Volume: 62
Issue: 2
Page Numbers: 237-264
Myocardial Fatty Acid Metabolism in Health and Disease.
Author(s): Lopaschuk, G.D., Ussher, J.R., Folmes, C.D.L., Jaswal, J.S., Stanley, W.C.
Publication: Physiological Reviews
Volume: 90
Issue: 1
Page Numbers: 207-258
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.
Author(s): Basu, R., Oudit, G.Y., Wang, X., Zhang, L., Ussher, J.R., Lopaschuk, G.D., Kassiri, Z.
Publication: American Journal of Physiology: Heart and Circulatory Physiology
Volume: 297
Issue: 6
Page Numbers: H2096-H2108
The role of the atypical protein kinase C zeta in the regulation of 5’AMP activated protein kinase in cardiac and skeletal muscle.
Author(s): Ussher, J.R., Jaswal, J.S., Wagg, C.S., Armstrong, H.E., Lopaschuk, D.G., Keung, W., Lopaschuk, G.D.
Publication: American Journal of Physiology: Endocrinology and Metabolism
Volume: 297
Issue: 2
Page Numbers: E349-E357
Insulin-Stimulated Cardiac Glucose Oxidation is Increased in Hearts from High Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase.
Author(s): Ussher, J.R., Koves, T.R., Jaswal, J.S., Zhang, L., Ilkayeva, O., Dyck, J.R., Muoio, D.M., Lopaschuk, G.D.
Publication: Diabetes
Volume: 58
Issue: 8
Page Numbers: 1766-1775
Myocardial fatty acid utilization as a determinant of cardiac efficiency and function.
Author(s): Jaswal, J.S., Ussher, J.R., Lopaschuk, G.D.
Publication: Clinical Lipidology
Volume: 4
Issue: 3
Page Numbers: 379-389
MicroRNAs as therapeutics for heart disease.
Author(s): Ussher, J.R.
Publication: Heart and Metabolism
Volume: 65
Page Numbers: 37-39
Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia.
Author(s): Ussher, J.R., Lopaschuk, G.D.
Publication: Basic Research in Cardiology
Volume: 104
Issue: 2
Page Numbers: 203-210
The malonyl CoA Axis as a potential target for the treatment of ischemic heart disease.
Author(s): Ussher, J.R., Lopaschuk, G.D.
Publication: Cardiovascular Research.
Volume: 79
Issue: 2
Page Numbers: 259-268
Entry exclusion in the IncHI1 plasmid R27 is mediated by EexA and EexB.
Author(s): Gunton, J.E., Ussher, J.E.R., Rooker, M.M., Wetsch N.M., Alonso, G., Taylor, D.E.
Publication: Plasmid
Volume: 59
Issue: 2
Page Numbers: 86-101
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance.
Author(s): Koves, T.R., Ussher, J.R., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J., Newgard, C.B., Lopaschuk, G., Muoio D.M.
Publication: Cell Metabolism
Volume: 7
Issue: 1
Page Numbers: 45-56
Clinical implications of energetic problems in cardiovascular disease.
Author(s): Ussher, J.R., Lopaschuk, G.D.
Publication: Heart and Metabolism
Volume: 32
Page Numbers: 9-17
Sweet as sugar: Excessive glucose metabolism in the failing heart.
Author(s): Ussher, J.R.
Publication: Future Cardiology
Volume: 10
Issue: 4
Page Numbers: 465-468
Deciphering ventricular GLP-1 action: time for a change of heart.
Author(s): Ussher, J.R.
Publication: American Journal of Physiology: Heart and Circulatory Physiology
Volume: 307
Issue: 10
Page Numbers: H1390-H1392
Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice.
Author(s): Ussher, J.R., Fillmore, N., Keung, W., Mori, J., Beker, D.L., Wagg, C.S., Jaswal, J.S., Lopaschuk, G.D.
Publication: Canadian Journal of Cardiology
Volume: 30
Issue: 8
Page Numbers: 940-944
Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection.
Author(s): Ussher, J.R., Baggio, L.L., Campbell, J.E., Mulvihill, E.E., Kim, M.S., Kabir, M.G., Cao, X., Baranek, J., Stoffers, D.A., Seeley, R.J., Drucker, D.J.
Publication: Molecular Metabolism
Volume: 3
Issue: 5
Page Numbers: 507-517
Cardiovascular actions of incretin-based therapies.
Author(s): Ussher, J.R., Drucker, D.J.
Publication: Circulation Research
Volume: 114
Issue: 11
Page Numbers: 1788-1803