Sanjay Kalra

Professor, Faculty of Medicine & Dentistry - Medicine Dept


Professor, Faculty of Medicine & Dentistry - Medicine Dept
(780) 248-1777


Area of Study / Keywords

ALS MRI biomarker neuroscience ALS Multicentre clinical trial ALS Neuroimaging Biomarkers Cognition ALS Biomarkers Clinical Trial ALS collaboration with University of Calgary Multicentre clinical drug trial. ALS fMRI High-field MRI Behavioural Impairment


Education and Training

  • BSc, University of Toronto
  • MD, University of Toronto
  • FRCPC in Neurology, McGill University
  • Research Fellowship, Montreal Neurological Institute

Academic Appointments

  • Professor, Division of Neurology, Department of Medicine
  • Adjunct Professor, Department of Computing Science
  • Adjunct Professor, Department of Biomedical Engineering


  • Neuroscience and Mental Health Institute (NMHI)
  • Neuroimaging Society in ALS (NiSALS)


Research Areas

  • Amyotrophic Lateral Sclerosis (ALS)
  • Neuroimaging
  • Biomarkers

Research Projects

  • The Canadian ALS Neuroimaging Consortium (CALSNIC) [National PI]
  • The Comprehensive Analysis Platform To Understand, Remedy, and Eliminate ALS (CAPTURE) [National PI]
  • Multimodal Neuroimaging: Magnetic Resonance Spectroscopy, Diffusion Tensor Imaging, Magnetic Resonance Volumetry, Functional MRI, Texture Analysis

Featured Publications

Mejia A.F., Koppelmans V., Jelsone-Swain L., Kalra S., Welsh R.C.

NEUROIMAGE. 2022 July; 255 10.1016/j.neuroimage.2022.119180

Bharti K., Graham S.J., Benatar M., Briemberg H., Chenji S., Dupré N., Dionne A., Frayne R., Genge A., Korngut L., Luk C., Zinman L., Kalra S.

PLoS One. 2022 June; 17 (6 June) 10.1371/journal.pone.0269154

Ishaque A., Ta D., Khan M., Zinman L., Korngut L., Genge A., Dionne A., Briemberg H., Luk C., Yang Y.H., Beaulieu C., Emery D., Eurich D.T., Frayne R., Graham S., Wilman A., Dupré N., Kalra S.

HUMAN BRAIN MAPPING. 2022 April; 43 (5):1519-1534 10.1002/hbm.25738

Kushol R., Masoumzadeh A., Huo D., Kalra S., Yang Y.H.

Proceedings - International Symposium on Biomedical Imaging. 2022 March; 2022-March 10.1109/ISBI52829.2022.9761421

Tanchip C., Guarin D.L., McKinlay S., Barnett C., Kalra S., Genge A., Korngut L., Green J.R., Berry J., Zinman L., Yadollahi A., Abrahao A., Yunusova Y.

Journal of Speech, Language, and Hearing Research. 2022 March; 65 (3):940-953 10.1044/2021_JSLHR-21-00503

Picher-Martel V., Magnussen C., Blais M., Bubela T., Das S., Dionne A., Evans A.C., Genge A., Greiner R., Iturria-Medina Y., Johnston W., Jones K., Kaneb H., Karamchandani J., Moradipoor S., Robertson J., Rogaeva E., Taylor D.M., Vande Velde C., Yunusova Y., Zinman L., Kalra S., Dupré N.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2022 January; 10.1080/21678421.2022.2041668

McMillan C.T., Wuu J., Rascovsky K., Cosentino S., Grossman M., Elman L., Quinn C., Rosario L., Stark J.H., Granit V., Briemberg H., Chenji S., Dionne A., Genge A., Johnston W., Korngut L., Shoesmith C., Zinman L., Kalra S., Benatar M.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2022 January; 10.1080/21678421.2022.2039713

Salmon K., Anoja N., Breiner A., Chum M., Dionne A., Dupré N., Fiander A., Fok D., Ghavanini A., Gosselin S., Izenberg A., Johnston W., Kalra S., Matte G., Melanson M., O’Connell C., Ritsma B., Schellenberg K., Shoesmith C., Tremblay S., Williams H., Genge A.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2022 January; 23 (3-4):305-312 10.1080/21678421.2021.1980890

Krieger C., Kalra S.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. 2022 January; 10.1017/cjn.2022.67

Cleary S., Misiaszek J.E., Wheeler S., Kalra S., Genuis S.K., Johnston W.S.

MUSCLE & NERVE. 2021 December; 64 (6):676-682 10.1002/mus.27417

Ta D., Ishaque A., Srivastava O., Hanstock C., Seres P., Eurich D.T., Luk C., Briemberg H., Frayne R., Genge A.L., Graham S.J., Korngut L., Zinman L., Kalra S.

NEUROLOGY. 2021 August; 97 (8):e803-e813 10.1212/WNL.0000000000012367

Mapping cerebral abnormalities using texture analysis in ALS with T2-FLAIR MRI: a multicenter study

Organization for Human Brain Mapping. 2021 June;

MRI texture analysis for the prediction of survival in amyotrophic lateral sclerosis

Organization for Human Brain Mapping. 2021 June;

Texture analysis reveals cerebral degeneration in amyotrophic lateral sclerosis: a multicenter study

Organization for Human Brain Mapping. 2021 June;

Progressive neurochemical abnormalities in cognitive and motor subgroups of ALS: a multicenter study

Neurology. 2021 April;

The Comprehensive Analysis Platform To Understand, Remedy, and Eliminate ALS (CAPTURE ALS)

Neurology. 2021 April;

Dai Z., Kalra S., Mah D., Seres P., Sun H., Wu R., Wilman A.H.

EUROPEAN RADIOLOGY. 2021 March; 31 (3):1401-1409 10.1007/s00330-020-07243-4

Danyluk H., Ishaque A., Ta D., Yang Y.H., Wheatley B.M., Kalra S., Sankar T.

Frontiers in Neurology. 2021 February; 12 10.3389/fneur.2021.626504

Dey A., Assaedi E., Johnston W., Kalra S., Das S.

FOLIA NEUROPATHOLOGICA. 2021 January; 59 (4):403-408 10.5114/fn.2021.111486

Hodgkinson V., Lounsberry J., M'Dahoma S., Russell A., Jewett G., Benstead T., Brais B., Campbell C., Johnston W., Lochmuller H., McCormick A., Nguyen C.T., O'Ferrall E., Oskoui M., Abrahao A., Briemberg H., Bourque P.R., Botez S., Cashman N., Chapman K., Chrestian N., Crone M., Dobrowolski P., Dojeiji S., Dowling J.J., Dupre N., Genge A., Gonorazky H., Grant I., Hasal S., Izenberg A., Kalra S., Katzberg H., Krieger C., Leung E., Linassi G., Mackenzie A., Mah J.K., Marrero A., Massie R., Matte G., McAdam L., McMillan H., Melanson M., Mezei M.M., O'Connell C., Pfeffer G., Phan C., Plamondon S., Poulin C., Rodrigue X., Schellenberg K., Selby K., Sheriko J., Shoesmith C., Smith R.G., Taillon M., Taylor S., Venance S., Warman-Chardon J., Worley S., Zinman L., Korngut L.

Journal of Neuromuscular Diseases. 2021 January; 8 (1):53-61 10.3233/JND-200538

Canadian Best Practice Recommendations for the Management of ALS

ALS. 2020 December;

Clinical Characteristics of SOD1 and c9ORF72 positive ALS: Findings from the Canadian Neuromuscular Disease Registry

ALS. 2020 December;

Dentate nucleus structural and functional connectivity changes in Amyotrophic lateral sclerosis: A multicenter and multi-modal neuroimaging study

ALS. 2020 December;

Genetic testing for ALS in Canada - An assessment of current practices

ALS. 2020 December;

Impaired functional connectivity of the primary motor cortex is associated with underlying structural and neurochemical deficits: A multicentre-multimodal imaging approach to investigating ALS pathology

ALS. 2020 December;

The Comprehensive Analysis Platform To Understand, Remedy, and Eliminate ALS (CAPTURE ALS)

ALS. 2020 December;

Shoesmith C., Abrahao A., Benstead T., Chum M., Dupre N., Izenberg A., Johnston W., Kalra S., Leddin D., O’Connell C., Schellenberg K., Tandon A., Zinman L.

CANADIAN MEDICAL ASSOCIATION JOURNAL. 2020 November; 192 (46):E1453-E1468 10.1503/cmaj.191721

Chenji S., Ishaque A., Mah D., Fujiwara E., Beaulieu C., Seres P., Graham S.J., Frayne R., Zinman L., Genge A., Korngut L., Johnston W., Kalra S.

Brain Imaging and Behavior. 2020 November; 15 (3):1641-1654 10.1007/s11682-020-00359-7