Kalyan Das, PhD

Area of Study / Keywords

Structural biology cryo-EM macromolecular assembly transcription structure-based drug design

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About

 Investigating and targeting molecular machines and macromolecule assemblies using biophysical and structural biology techniques such as single-particle cryo-EM.

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Research

Research projects

(i) to understand mechanisms of viral and bacterial drug resistance, (ii) to elucidate molecular mechanisms such as – transcription initiation, elongation and regulation, mitochondrial DNA transcription, DNA and RNA polymerization, RNA degradation, and ribosome – ER translocon complex, (iii) to study and target protein-protein and protein-nucleic acid interactions, (iv) targeting viral polymerases, (v) fragment screening to generate hits and to identify new druggable sites, and (vi) hit-to-lead optimization

Quinten Goovaerts, Jiayu Shen, Brent De Wijngaert, Urmimala Basu, Smita S. Patel, Kalyan Das

Nature. 2023 October; 10.1038/s41586-023-06643-y

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Pauwels, Eva; Shewakramani, Neesha R; De Wijngaert, Brent; Camps, Anita; Provinciael, Becky; Stroobants, Joren; Kalies, Kai-Uwe; Hartmann, Enno; Maes, Piet; Vermeire, Kurt; Das, Kalyan

Science Advances. 2023 March; 9 (9) 10.1126/sciadv.adf079

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Abhimanyu K Singh, Brent De Wijngaert, Marc Bijnens, Kris Uyttersprot, Hoai Nguyen, Sergio E Martinez, Dominique Schols, Piet Herdewijn, Christophe Pannecouque, Eddy Arnold, Kalyan Das

Proceedings of the National Academy of Sciences. 2022 July; 119 (30):e2203660119 10.1073/pnas.2203660119

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Abhimanyu K. Singh, Sergio E. Martinez, Weijie Gu, Hoai Nguyen, Dominique Schols, Piet Herdewijn, Steven De Jonghe, Kalyan Das

Nature Communications. 2021 December; 10.1038/s41467-021-27409-y

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Brent De Wijngaert, Shemaila Sultana, Anupam Singh, Chhaya Dharia, Hans Vanbuel, Jiayu Shen, Daniel Vasilchuk, Sergio E Martinez, Eaazhisai Kandiah, Smita S Patel, Kalyan Das

Molecular Cell. 2021 January; 81 (2):268-280. e5 10.1016/j.molcel.2020.11.016

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