Karim Fouad, PhD
Professor, Faculty of Rehabilitation Medicine - Physical Therapy
- (780) 492-5971
387 Corbett (E.A.) Hall
8205 - 114 St NWEdmonton ABT6G 2G4
2018-present: Co-Director, Open Data Commons for Spinal Cord Injury
2016-2023: Canada Research Chair for Spinal Cord Injury (Tier1)
2015-2017: Co-Director, Neuroscience and Mental Health Institute
2008-present: Full Professor
2007-2014: Alberta Heritage Foundation for Medical Research, Senior Scholar
2007-2008: Associate Professor, Alberta Heritage Foundation Senior Scholar
2005-2007: Associate Professor, Alberta Heritage Foundation Scholar
2001-2005: Assistant Professor, Alberta Heritage Foundation Scholar
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
1997-2001: Research Associate, Brain Research Institute, University and ETH Zürich,
1995-1997: Post-Doctoral Researcher, University of Alberta
1995: Post-Doctoral Researcher, Faculty of Life Sciences, Ben-Gurion University, Israel
1991-1995: Ph.D. (Neuroscience), University of Konstanz, Germany
1986-1991: Diploma (Biology), University of Konstanz, Germany
2017-2022: Grant from the Canadian Institute for Health Research
2017-2018: Alberta Spinal Cord Injury Research Support Fund
2016-2019: Grant from the Heart and Stroke Foundation with Ian Winship as Co Applicant
2016-2021: Co-PI on Grant from the National Institute of Health (NIH)
2015-2016: Grant from Conquer Paralysis Now
2015-2017: Grant from Wings for Life (Austria)
2014: Equipment grant from the Alberta Paraplegic Foundation
2013-2018: Co-PI on grant from the Canadian Institutes for Health Research
2012-2015: Grant from the International Spinal Research Trust (UK)
2012-2017: Two grants from the Canadian Institutes for Health Research
2012: Equipment grant from the Canadian Foundation for Innovation
Dr. Fouad's research focuses on the promotion of functional recovery after spinal cord injuries by increasing the regenerative and plastic capabilities of the central nervous system.
Karim Fouad, PhD, is a graduate supervisor at the Faculty of Rehabilitation Medicine.
Research - Research Lab
The overall goal of our research is to promote functional recovery following spinal cord injury.
Functional recovery following injuries of the central nervous system (CNS) is limited because severed axons are unable to regrow. This inability to regenerate is caused by various factors including growth inhibitory factors in the central nervous system and intracellular properties of injured neurons. Nevertheless, moderate recovery following brain or spinal cord injuries occurs. The underlying mechanisms for this recovery lies in the ability of spared and injured CNS circuitries to rearrange, generally termed as plasticity. To promote functional recovery following spinal cord injury we are currently focusing on the following two main strategies:
- Trying to understand injury induced plasticity and attempting to enhance this naturally occurring repair mechanism.
- Promoting regeneration of lesioned axons by addressing various regeneration restricting factors in combined treatments.
The methods used in our laboratory range from various experimental approaches to promote plasticity and regeneration, to histological examinations, behavioral tests (sensory and motor), high speed kinematic and in vivo electrophysiological assessments.
Our facilities include a tissue culture area, a histology lab, a darkroom for fluorescence microscopy and a laboratory fully equipped for surgeries and physiological experiments.
Schmidt EKA, Torres-Espín A, Raposo P, Madsen KL, Kigerl KA, Popovich PG, Fenrich KK, Fouad K
Lucas-Osma AM, Li Y, Murray KC, Lin S, Black S, Stephens MJ, Ahn AH, Heckman CJ, Fenrich KK, Fouad K, Bennett DJ
Single-session cortical electrical stimulation enhances the efficacy of rehabilitative motor training after spinal cord injury in rats
Batty NJ, Torres-Espin A, Vavrek R, Raposo P, Fouad K
Neurodevelopmental and Metabolomic Responses from Prenatal Coexposure to Perfluorooctanesulfonate (PFOS) and Methylmercury (MeHg) in Sprague-Dawley Rats.
5. Reardon AJF, Karathra J, Ribbenstedt A, Benskin JP, MacDonald AM, Kinniburgh DW, Hamilton TJ, Fouad K, Martin JW
Fouad K, Bixby JL, Callahan A, Grethe JS, Jakeman LB, Lemmon VP, Magnuson DSK, Martone ME, Nielson JL, Schwab JM, Taylor-Burds C, Tetzlaff W, Torres-Espin A, Ferguson AR and the FAIR-SCI Ahead Workshop Participants.
Lin S, Li Y, Lucas-Osma AM, Hari K, Stephens MJ, Singla R, C J H, Zhang Y, Fouad K, Fenrich KK, Bennett DJ
Torres-Espin A, Forero J, Fenrich KK, Lucas-Osma AM, Krajacic A, Schmidt E, Vavrek R, Raposo P, Bennett DJ, Popovich PG, Fouad K
Extrasynaptic ∝5GABAA receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord.
Lucas-Osma AM, Li Y, Lin S, Black S, Singla R, Fouad K, Fenrich KK, Bennett DJ
Batty NJ, Fenrich KK, Fouad K.
Single pellet grasping following cervical spinal cord injury in adult rat using an automated full-time training robot.
Fenrich KK, May Z, Torres-Espín A, Forero J, Bennett DJ, Fouad K.
Li Y, Lucas-Osma AM, Black S, Bandet MV, Stephens MJ, Vavrek R, Sanelli L, Fenrich KK, Di Narzo AF, Dracheva S, Winship IR, Fouad K, Bennett DJ.
Inhibiting cortical protein kinase A in spinal cord injured rats enhances efficacy of rehabilitative training.
Wei D, Hurd C, Galleguillos D, Singh J, Fenrich KK, Webber CA, Sipione S, Fouad K.
Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery.
May Z, Fenrich KK, Dahlby J, Batty NJ, Torres-Espín A, Fouad K.
Enhancing Spinal Plasticity Amplifies the Benefits of Rehabilitative Training and Improves Recovery from Stroke.
Wiersma AM, Fouad K, Winship IR.
Alpaugh M, Galleguillos D, Forero J, Morales LC, Lackey SW, Kar P, Di Pardo A, Holt A, Kerr BJ, Todd KG, Baker GB, Fouad K, Sipione S.
Callahan A, Anderson KD, Beattie MS, Bixby JL, Ferguson AR, Fouad K, Jakeman LB, Nielson JL, Popovich PG, Schwab JM, Lemmon VP; FAIR Share Workshop Participants.
Depolarization and electrical stimulation enhance in vitro and in vivo sensory axon growth after spinal cord injury.
Goganau I, Sandner B, Weidner N, Fouad K, Blesch A.
Cyclosporine-immunosuppression does not affect survival of transplanted skin-derived precursor Schwann cells in the injured rat spinal cord.
May Z, Torres-Espín A, Lucas-Osma AM, Batty NJ, Raposo P, Fenrich KK, Stykel MG, Führmann T, Shoichet M, Biernaskie J, Fouad K.
Cortical electrical stimulation in female rats with a cervical spinal cord injury to promote axonal outgrowth.
Jack AS, Hurd C, Forero J, Nataraj A, Fenrich K, Blesch A, Fouad K.
Adult skin-derived precursor Schwann cell grafts form growths in the injured spinal cord of Fischer rats.
May Z, Kumar R, Führmann T, Tam R, Vulic K, Forero J, Lucas-Osma AM, Fenrich K, Assinck P, Lee MJ, Moulson A, Shoichet MS, Tetzlaff W, Biernaskie J, Fouad K.
A motorized pellet dispenser to deliver high intensity training of the single pellet reaching and grasping task in rats.
Torres-Espín A, Forero J, Schmidt EKA, Fouad K, Fenrich KK.
Improved single pellet grasping using automated ad libitum full-time training robot. Behav Brain Res. 2015 Mar 15;281:137-48. doi: 10.1016/j.bbr.2014.11.048.
Fenrich KK, May Z, Hurd C, Boychuk CE, Kowalczewski J, Bennett DJ, Whishaw IQ, Fouad K
Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling. Dev Biol. 2015 Mar 1;399(1):2-14. doi: 10.1016/j.ydbio.2014.11.024.
Helmbrecht MS, Soellner H, Truckenbrodt AM, Sundermeier J, Cohrs C, Hans W, de Angelis MH, Feuchtinger A, Aichler M, Fouad K, Huber AB
Challenges of animal models in SCI research: Effects of pre-injury task-specific training in adult rats before lesion. Behav Brain Res. 2015 Sep 15;291:26-35. doi: 10.1016/j.bbr.2015.04.058.
May Z, Fouad K, Shum-Siu A, Magnuson DS
A critical period for postnatal adaptive plasticity in a model of motor axon miswiring. PLoS One. 2015 Apr 13;10(4):e0123643. doi: 10.1371/journal.pone.0123643.
Helmbrecht MS, Soellner H, Castiblanco-Urbina MA, Winzeck S, Sundermeier J, Theis FJ, Fouad K, Huber AB
Repairing the injured spinal cord: sprouting versus regeneration. Is this a realistic match? Neural Regen Res. 2014 Mar 1;9(5):462. doi: 10.4103/1673-5374.130059.
Fouad K, Hurd C
Training following unilateral cervical spinal cord injury in rats affects the contralesional forelimb. Neurosci Lett, 28;539:77-81
Weishaupt N, Vavrek R, Fouad K
Reticulospinal plasticity after cervical spinal cord injury in the rat involves withdrawal of projections below the injury. Exp Neurol, 2013 Sep;247:241-9. doi: 10.1016/j.expneurol.2013.05.003.
Weishaupt N, Hurd C, Wei DZ, Fouad K
Anatomical correlates of recovery in single pellet reaching in spinal cord injured rats. Exp Neurol, 2013 Sep;247:605-14. doi: 10.1016/j.expneurol.2013.02.013
Hurd C, Weishaupt N, Fouad K.