Rachel Khadaroo

Area of Study / Keywords

Inflammatory response Cell signaling Animal models Sepsis Gastrointestinal disease Multiple organ dysfunction

---

About

I am a surgeon, critical care medicine specialized, and scientist at the University of Alberta Hospital and an assistant professor in the Division of General Surgery. My clinical interests are in Acute Care Surgery and critical illness.

I earned my Bachelor of Science and Doctor of Medicine at McMaster University in Hamilton, Ontario. My Doctor of Philosophy was achieved in the Surgical Scientist Program at the University of Toronto with my thesis in oxidant-induced lung injury following trauma.

I completed my General Surgery training at the University of Alberta and further specialized in the area of Critical Care Medicine at the University of Toronto.

Degrees & Appointments

MD (McMaster University, Hamilton, Ontario), 

PhD (Experimental Surgery/molecular/cellular biology, University of Toronto)

FRCSC (General Surgery, University of Alberta)

Critical Care Medicine Fellowship (University of Toronto)

Assistant Professor in Department of Surgery (University of Alberta)

---

Research

Intestinal Ischemia/Reperfusion injury, sepsis, lung injury, innate immunity, inflammatory cell signaling, surgical infection, acute care surgery 

Brief Summary of my Research

My major research interests relate to intestinal injury and the role the intestine has in critical illness, multiple organ dysfunction, and sepsis. To accomplish our goals my laboratory has developed clinically relevant animal and cellular models.  Specifically, my lab is working on:

1. Understand the cellular and molecular mechanisms whereby intestinal ischemia/reperfusion injury causes distant organ injury and consequent patient morbidity and mortality.
2. Discovering unique biomarkers to better diagnosis intestinal injury
3. Examining how these biomarkers act through intracellular signaling leading to an augmented inflammatory response
4. Validate these biomarkers in a clinical setting and examine the role of acute intestinal ischemia/reperfusion plays in resultant multiple organ dysfunction, acute lung injury, and sepsis
   

Khadaroo RG, Zenilman ME

Cameron and Cameron: Current Surgical Therapy, 14th ed.. 2022 December; ISBN 9780323796835

---

McIsaac D.I., Fergusson D.A., Khadaroo R., Meliambro A., Muscedere J., Gillis C., Hladkowicz E., Taljaard M.

BMJ Open. 2022 August; 12 (8):e064165 10.1136/bmjopen-2022-064165

---

CGS 2022 Annual Scientific Meeting . 2022 June;

---

Negm A.M., Lee J., Hamidian R., Jones C.A., Khadaroo R.G.

Journal of the American Medical Directors Association. 2022 May; 23 (5):707-714 10.1016/j.jamda.2022.01.057

---

Patel A., Zhang M.Q., Liao G., Karkache W., Montroy J., Fergusson D.A., Khadaroo R.G., Tran D.T.T., McIsaac D.I., Lalu M.M.

Anesthesia & Analgesia . 2022 April; 134 (4):751-764 10.1213/ANE.0000000000005832

---

Jahandideh F., Panahi S., Noble R.M.N., Gragasin F.S., Khadaroo R.G., Macala K.F., Bourque S.L.

Biomedicines . 2022 February; 10 (2):470 10.3390/biomedicines10020470

---

McIsaac D.I., Gill M., Boland L., Hutton B., Branje K., Shaw J., Grudzinski A.L., Barone N., Gillis C., Akhtar S., Atkins M., Aucoin S., Auer R., Basualdo-Hammond C., Beaule P., Brindle M., Bittner H., Bryson G., Carli F., Eskander A., Fata P., Fergusson D., Fiore J., Forster A., Gillam M., Gramlich L., Holroyd-Leduc J., Jackson T., Jacobsohn E., Khadaroo R., Lalu M., Love C., Martel G., McCartney C., McKeen D., Meliambro A., Moloo H., Moore R., Muscedere J., Nantel J., Poitras S., Scheede-Bergdahl C., Taljaard M., Wallace T., Wijeysundera D.

British Journal of Anaesthesia . 2022 February; 128 (2):244-257 10.1016/j.bja.2021.11.014

---

2021 Perioperative Care Congress . 2021 November;

---

Bhullar A.S., Rivas-Serna I.M., Anoveros-Barrera A., Dunichand-Hoedl A., Bigam D., Khadaroo R.G., McMullen T., Bathe O., Putman C.T., Baracos V., Clandinin M.T., Mazurak V.C.

Scientific Reports. 2021 November; 11 (1) 10.1038/s41598-021-02269-0

---

Saravana-Bawan B., Goplen M., Alghamdi M., Khadaroo R.G.

JOURNAL OF SURGICAL RESEARCH. 2021 November; 267 10.1016/j.jss.2021.04.034

---

European Geriatric Medicine . 2021 September;

---

Surgical Infection Society . 2021 September;

---

Finegan B, Khadaroo RG

Pre-Operative Assessment: A Case-based approach . 2021 July; Chapter 46 doi.org/10.1007/978-3-030-58842-7_46

---

Wijeysundera DN, Khadaroo RG (invited expert).

ANAESTHESIA. 2021 June; 76 (6):731-735 10.1111/anae.15490

---

Saravana-Bawan B., Warkentin L.M., Ohinmaa A., Wagg A.S., Holroyd-Leduc J., Padwal R.S., Clement F., Khadaroo R.G.

Annals of Medicine and Surgery. 2021 May; 65 10.1016/j.amsu.2021.102368