Kirst King-Jones, PhD

Professor, Faculty of Science - Biological Sciences


Professor, Faculty of Science - Biological Sciences
(780) 492-8605
G-504 Bio Science - Genetics Wing
11355 - Saskatchewan Drive
Edmonton AB
T6G 2E9



Steroid hormones are ancient signaling molecules that play fundamental roles in development and disease. For instance, steroid hormones are critical regulators of reproductive tissues in humans, and are a key determinant of insect development. In addition, steroid hormones play crucial roles in maintaining mineral salt concentrations, and control stress as well as inflammatory responses in humans. Steroid hormones are usually released as pulses, thereby generating a systemic timing signal that functions to coordinate multiple physiological and developmental changes throughout the body. In Drosophila, pulses of the steroid hormone ecdysone govern all major developmental transitions, including the larval molts, the transformation of a larva to a pupa and metamorphosis. While we have a relatively good understanding of the enzymatic steps that synthesize the hormone, comparatively little is known about the complex signaling pathways that control these pulses. Currently, we are modeling the function of rare human disease genes in Drosophila by exploring their unexpected relationships to the cellular signaling pathways that control the regulation and production of steroid hormones pulses.

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2017: Interested in joining our lab? We have opportunities for PhD students and BIOL498/499!

September 1. Welcome to our new lab member, Song Wang!

August 25. Pendleton Cox Master's Thesis defence.

August 18. Check out our latest paper on circadian rhythms: 

U of A press release

Publisher site.

August 15: Dr. Qiuxiang Ou leaves our lab (congrats on the new job!!)

Featured Publications

E. Thomas Danielsen, Morten E. Moeller, Naoki Yamanaka, Qiuxiang Ou, Janne M. Laursen, Caecilie Soenderholm, Ran Zhuo, Brian Phelps, Kevin Tang, Jie Zeng, Shu Kondo, Christian H. Nielsen, Eva B. Harvald,6 Nils J. Faergeman,6 Macy J. Haley, Kyle A. O’Connor, Kirst King-Jones, Michael B. O’Connor, and Kim F. Rewitz

Developmental Cell. 37

Qiuxiang Ou, Adam Magico, Kirst King-Jones*

PLoS Biology. 9 (9):1-19

Francesca Di Cara and Kirst King-Jones

Current Biology. 26

F Di Cara, TM Maile, BD Parsons, A Magico, S Basu, N Tapon and K King-Jones

Cell Death and Differentiation. 22

Qiuxiang Ou, Jie Zeng, Naoki Yamanaka, Christina Brakken-Thal, Michael B. O’Connor, Kirst King-Jones

Cell Reports. 16