Ana Klahr, PhD

Area of Study / Keywords

Neuroscience Stroke Seizures Animal Models of Stroke

About

• PhD in Neuroscience and postdoctoral fellowship in Neurology (University of Alberta), researching stroke in animals with a focus on seizures and sex differences.

• Passionate about teaching, academic excellence, and leadership.

• Intersectional feminist and Latin-American woman encouraging and endorsing of equity and diversity in the classroom, research, and work environment. 

Research

• Gunderson, M. L., Heer, S., Klahr A. C. (2023). A Pilot Systematic Review and Meta Analysis of Neuroprotective Studies in Female Rodent Models of Focal Ischemia. Translational Stroke Research (Accepted).

• Wilkinson, C. M., Kalisvaart, A. C. J., Kung, T. F. C., Maisey, D. R., Klahr, A. C., Dickson, C. T., Colbourne F. The Collagenase Model of Intracerebral Hemorrhage in Awake, Freely Moving Animals: The Effects of Isoflurane on Pathophysiology. Brain Research, 2020, 1728:146593.

• Butcher, K., Ng, K., Sheridan, P., Field, T.S., Coutts, S. B., Siddiqui, M., Gioia, L. C., Buck, B., Hill, M. D., Miller, J., Klahr, A. C., Sivakumar, L., Benavente, O. R., Hart, R. G., Sharma, M.  Dabigatran treatment of acute non-cardioembolic ischemic stroke. Stroke, 2020, 51:1190–1198.

• Klahr, A. C., Kosior, J. C., Dowlatshahi, D., Buck, B. H., Beaulieu, C., Gioia, L. C., … Butcher, K. S. Lower Blood Pressure Is Not Associated With Decreased Arterial Spin Labeling Estimates of Perfusion in Intracerebral Hemorrhage. Journal of the American Heart Association, 2019, 8, e010904.

• Klahr, A. C., Kate, M., Kosior, J., Buck, B., Shuaib, A., Emery, D., & Butcher, K. Early hematoma retraction in intracerebral hemorrhage is uncommon and does not predict outcome. PloS one, 2018, 13, e0205436. 

• Sun H., Klahr A. C., Kate M., Gioia L.C., Emery D.J., Butcher K, Wilman A. H. Quantitative Susceptibility Mapping for Staging of Intracranial Hemorrhage. Radiology, 2018, 288:830–839. 

• Gioia, L., Klahr A. C., Kate M., Buck, B., Dowlatshahi, D., Jeerakathil T., Emery D, Butcher, K. The intracerebral hemorrhage acutely decreasing arterial pressure trial II (ICH ADAPT II) protocol. BMC Neurology, 2017, 7:100.

• Klahr, A.C., Fagan, K., Aziz, J.R., John, R., Colbourne, F. Mild Contralesional Hypothermia Reduces Use of the Unimpaired Forelimb in a Skilled Reaching Task after Motor Cortex Injury in Rats. Therapeutic Hypothermia and Temperature Management, 8:90-98.

• Klahr, A. C., Nadeau, C. A., Colbourne, F. Temperature Control in Rodent Neuroprotection Studies: Methods and Challenges. Therapeutic Hypothermia and Temperature Management, 2017, 7:42-49.

• Klahr, A. C., Dietrich, K. M., Dickson, C. T., Colbourne F. Prolonged Localized Mild Hypothermia Does Not Affect Seizure Activity after Intracerebral Hemorrhage in Rats. Therapeutic Hypothermia and Temperature Management, 2016, 6: 40-47.

• Klahr, A.C., Dickson, C. T., Colbourne, F. Seizure Activity Occurs in the Collagenase but not the Blood Infusion Model of Striatal Hemorrhagic Stroke in Rats. Translational Stroke Research, 2015, 6: 29-38.

• Silasi, G., Klahr, A.C., Hackett, M. J., Auriat, A. M., Nichol, H., Colbourne, F. Prolonged therapeutic hypothermia does not adversely impact neuroplasticity after global ischemia in rats. Journal of Cerebral Blood Flow and Metabolism, 2012, 32: 1525-34. 

• Auriat, A. M., Klahr, A. C., Silasi, G., MacLellan, C. L., Penner, M., Clark, D. L., Colbourne, F. Prolonged Hypothermia in Rat: A Safety Study Using Brain-Selective and Systemic Treatments. Therapeutic Hypothermia and Temperature Management, 2012, 2:37-43.

Teaching

• AUPSY 275 An Introduction to the Brain and Nervous System
• AUPSY 375 Neuroplasticity
• AUPSY 377 Human Neuropsychology
• AUPSY 441 Emotion
• AUPSY 475 Brain Injury
• AUPSY 483 Psychological Disorders

AUPSY 103 - Introduction to Psychology

The course focuses on the basic principles underlying human behaviour. Topics include the central nervous system, cognition, development, social, and personality, and mental health. AUPSY 103 is classified as a science course.

AUPSY 269 - Principles of Learning

In-depth examination of classical and operant conditioning and social learning theory. This course provides an in-depth examination of conditioning principles and discusses how those principles can be used to modify behaviour. Topics covered may include reinforcement, extinction, punishment, schedules of reinforcement, stimulus discrimination, fading, stimulus-response chaining, generalization, modelling, Pavlovian conditioning, forgetting and concept learning. Prerequisites: AUPSY 103. Note: Credit may be obtained for only one of AUPSY 269 and 369 (2021).

AUPSY 275 - An Introduction to the Brain and Nervous System

Introduction to the structure and function of the nervous system, with a special emphasis on the brain. Prerequisite: AUPSY 103.

AUPSY 375 - Neuroplasticity

An introduction to neuroplasticity, the ability of our central nervous system to change due to the interplay between development and experience. Prerequisite: AUPSY 275.

AUPSY 377 - Human Neuropsychology

Study of changes in mood, motivation, perception, attention, memory, and cognition, as revealed by structural alterations in the human brain. Prerequisite: AUPSY 275 or consent of the instructor.

AUPSY 441 - Emotion

A survey of theory and research on affect and emotion science. Topics covered may include the history of emotion research, measurement and classification of specific emotions, neurobiology of emotions, cognitive and cultural influences, consequences of emotions/moods, and disorders of emotion. Prerequisite: AUPSY 240 or 275; third year standing.

AUPSY 483 - Psychological Disorders

Advanced-level course that focuses on the research related to the etiology, classification, assessment, and treatment of a variety of psychological disorders in children and adults (e.g., anxiety, addictions, depression, schizophrenia, and personality disorders). A student becomes acquainted with the Diagnostic Statistical Manual of Mental Disorders (DSM). Prerequisite: AUPSY 263 or 275. AUPSY 486 is highly recommended.

AUPSY 499 - Individual Study II

Fourth-year thesis research, report, and oral presentation. Prerequisite: AUPSY 497. Note: Admission to AUPSY 499 normally requires a grade point average of at least 3.5. An Application for Individual Study must be completed and approved before registration in the course.

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