Karen Madsen

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Contact

Professor, Faculty of Medicine & Dentistry - Medicine Dept
Email
kmadsen@ualberta.ca
Phone
(780) 492-5257
Address
7142K Katz Group Centre For Research
11315 - 87 Ave NW
Edmonton AB
T6G 2H5

Overview

Area of Study / Keywords

genetics inflammatory bowel disease gut microbes probiotics innate immunity diet microbiota bacteria-host interactions microbiome


About

Personal Statement:

Changing the gut microbiome really changes health and disease dramatically. My research looks at how microbes interact with the human host.  I work with clinical colleagues to test how therapies aimed at modulating the gut microbiome can influence metabolic and inflammatory diseases.

Dr. Madsen completed a BSc (Hon) and MSc in biochemistry at the University of Manitoba followed by a PhD in the gastrointestinal physiology at the University of Calgary. She is a leading researcher in intestinal permeability and gut microbiota and their effects on disease and health.

Leadership and Collaborations:

Dr. Madsen is a lead investigator in the GEM project and the national IMAGINE Chronic Disease Network. She is a member of the Women’s & Children’s Health Research Institute in Edmonton and the Digestive Health Strategic Clinical Network.  She is the University of Alberta lead for the national Microbiome Research Core (IMPACTT).

www.gemproject.ca
http://imaginespor.com
https://www.impactt-microbiome.ca



Clinical Interests

I am carrying out clinical trials using fecal microbial transplantation (FMT) to treat Crohn’s disease; FMT and fiber supplements to treat metabolic syndrome; and probiotics and fiber supplements to prevent disease recurrence in post-operative Crohn’s disease patients. 


Research

The primary focus of my research is the relationships between the host and its resident microbiota, with specific interests in the role of microbes in inflammatory bowel diseases and metabolic disorders and how environmental factors and diet can modulate these interactions.  My overall research goal is to gain mechanistic knowledge into these interactions in order to design effective therapeutic interventions aimed at manipulation of the gut microbiota to improve human health.  My work employs a variety of complementary approaches including animal models, human tissues, cell culture models, and clinical trials.  

Dr. Madsen is a highly cited author or co-author of 250 published research articles and abstracts. Her research has garnered support from many agencies including the University Hospital Foundation, the Weston Foundation, Alberta Health Services’ Digestive Health Strategic Clinical Network, Alberta Innovates, Canadian Institutes of Health Research, Canadian Association of Gastrointestinal Surgery, Calgary Center for Clinical Research, and the Society of American Gastrointestinal and Endoscopic Surgeons.

She has received awards from the Canadian Society for Clinical Investigation, the Canadian Association for Gastroenterology, Crohn's Colitis Canada and Canadian Association for Medical Education.


Teaching

Dr. Madsen supervises trainees at all levels who are pursuing research. She is an advisor and mentor to young faculty who are developing research expertise.

Featured Publications

Gastroenterology. 2022 May; org/10.1016/S0016-5085(22)60964-8


Gastroenterology. 2022 May; doi.org/10.1053/j.gastro.2022.05.037


Turpin W, Dong M, Sasson G, Raygoza Garay JA, Espin-Garcia O, Lee SH, Neustaeter A, Smith MI, Leibovitzh H, Guttman DS, Goethel A, Griffiths AM, Huynh HQ, Dieleman LA, Panaccione R, Steinhart AH, Silverberg MS, Aumais G, Jacobson K, Mack D, Murthy SK, Marshall JK, Bernstein CN, Abreu MT, Moayyedi P, Paterson AD; Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, Xu W, Croitoru K.

GASTROENTEROLOGY. 2022 May; 10.1053/j.gastro.2022.05.037


Gastroenterology. 2022 May; doi.org/10.1053/j.gastro.2022.07.004


Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.156


Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.174


Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.170


Jovel J., Nimaga A., Jordan T., O’Keefe S., Patterson J., Thiesen A., Hotte N., Bording-Jorgensen M., Subedi S., Hamilton J., Carpenter E.J., Lauga B., Elahi S., Madsen K.L., Wong G.K.S., Mason A.L.

Frontiers in Microbiology. 2022 February; 13 10.3389/fmicb.2022.829378


Wu R.Y., Tandon P., Ambrosio L., Dunsmore G., Hotte N., Dieleman L.A., Elahi S., Madsen K., Huang V.

Digestive Diseases and Sciences. 2022 January; 10.1007/s10620-022-07430-x


Dang J.T., Mocanu V., Park H., Laffin M., Hotte N., Karmali S., Birch D.W., Madsen K.L.

Gut Microbes. 2022 January; 14 (1) 10.1080/19490976.2022.2050636


Hinchliffe T., Pauline M.L., Wizzard P.R., Jovel J., Nation P.N., Wales P.W., Madsen K.L., Turner J.M.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2022 January; 10.1002/jpen.2333


Dang J.T., Mocanu V., Park H., Laffin M., Tran C., Hotte N., Karmali S., Birch D.W., Madsen K.

Scientific Reports. 2021 December; 11 (1):23813 10.1038/s41598-021-03396-4


Tan Q., Orsso C.E., Deehan E.C., Kung J.Y., Tun H.M., Wine E., Madsen K.L., Zwaigenbaum L., Haqq A.M.

Autism Research. 2021 September; 14 (9):1820-1836 10.1002/aur.2560


Dang JT, Mocanu V, Fang B, Laffin M, Karmali S, Madsen K, Birch DW.

J Vis Exp. 2021 August; 21 (174) 10.3791/62575


Orsso C.E., Peng Y., Deehan E.C., Tan Q., Field C.J., Madsen K.L., Walter J., Prado C.M., Tun H.M., Haqq A.M.

Microorganisms. 2021 July; 9 (7) 10.3390/microorganisms9071490


Mocanu V., Zhang Z., Deehan E.C., Kao D.H., Hotte N., Karmali S., Birch D.W., Samarasinghe K.K., Walter J., Madsen K.L.

NATURE MEDICINE. 2021 July; 27 (7):1272-1279 10.1038/s41591-021-01399-2


Mocanu V., Park H., Dang J., Hotte N., Thiesen A., Laffin M., Wang H., Birch D., Madsen K.

Nutrients. 2021 June; 13 (6):2069 10.3390/nu13062069


Schmidt E.K.A., Raposo P.J.F., Madsen K.L., Fenrich K.K., Kabarchuk G., Fouad K.

Biology. 2021 June; 10 (4) 10.3390/biology10040254


BASELINE GUT MICROBIOTA OF INDIVIDUALS WITH SEVERE OBESITY AND METABOLIC SYNDROME PREDICTS RESPONSE TO FECAL MICROBIOTA TRANSPLANTATION: A SUBGROUP ANALYSIS OF A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

Digestive Disease Week. 2021 May;


FIBER SUPPLEMENTATION DIFFERENTIALLY MODULATES RESPONSES TO FECAL MICROBIAL TRANSPLANTATION IN PATIENTS WITH METABOLIC SYNDROME AND SEVERE OBESITY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT TRIAL

Digestive Disease Week. 2021 May;


Galipeau H.J., Caminero A., Turpin W., Bermudez-Brito M., Santiago A., Libertucci J., Constante M., Raygoza Garay J.A., Rueda G., Armstrong S., Clarizio A., Smith M.I., Surette M.G., Bercik P., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Moayyedi P., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Turner D., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Huynh H., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Verdu E.F.

GASTROENTEROLOGY. 2021 April; 160 (5):1532-1545 10.1053/j.gastro.2020.12.004


Deehan E.C., Colin-Ramirez E., Triador L., Madsen K.L., Prado C.M., Field C.J., Ball G.D.C., Tan Q., Orsso C., Dinu I., Pakseresht M., Rubin D., Sharma A.M., Tun H., Walter J., Newgard C.B., Freemark M., Wine E., Haqq A.M.

Trials. 2021 February; 22 (1) 10.1186/s13063-021-05060-8


Naqvi S.A., Taylor L.M., Panaccione R., Ghosh S., Barkema H.W., Hotte N., Shommu N., Kaur S., Reimer R.A., Madsen K.L., Raman M.

Scientific Reports. 2021 January; 11 (1) 10.1038/s41598-020-80924-8


Nieuwdorp M., Madsen K.

GASTROENTEROLOGY. 2021 January; 160 (1):17-19 10.1053/j.gastro.2020.10.025


Turpin W., Lee S.H., Raygoza Garay J.A., Madsen K.L., Meddings J.B., Bedrani L., Power N., Espin-Garcia O., Xu W., Smith M.I., Griffiths A.M., Moayyedi P., Turner D., Seidman E.G., Steinhart A.H., Marshall J.K., Jacobson K., Mack D., Huynh H., Bernstein C.N., Paterson A.D., Abreu M., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Kaplan G., Krause D.O., Madsen K., Marshall J., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., McGrath J., Otley A., Panancionne R., Baldassano R., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Panaccione R., Parekh N., Plamondon S., Radford-Smith G., Rosh J., Rubin D., Schultz M., Siegel C.

GASTROENTEROLOGY. 2020 December; 159 (6):2092-2100.e5 10.1053/j.gastro.2020.08.005


Headley S.A., Chapman D.J., Germain M.J., Evans E.E., Hutchinson J., Madsen K.L., Ikizler T.A., Miele E.M., Kirton K., O’Neill E., Cornelius A., Martin B., Nindl B., Vaziri N.D.

BMC Nephrology. 2020 November; 21 (1) 10.1186/s12882-020-02177-x


Turpin W., Bedrani L., Espin-Garcia O., Xu W., Silverberg M.S., Smith M.I., Garay J.A.R., Lee S.H., Guttman D.S., Griffiths A., Moayyedi P., Panaccione R., Huynh H., Steinhart H.A., Aumais G., Dieleman L., Turner D., Abreu M., Beck P., Bernstein C., Croitoru K., Feagan B., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Seidman E., Silverberg M., Stadnyk A., Steinhart A. ., Surette M., Walters T., Vallance B., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Baldassano R., Griffiths A.M., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Parekh N., Plamondon S., Radford-Smith G., Ropeleski M., Rosh J., Rubin D., Schultz M., Siegel C., Snapper S., Paterson A.D., Croitoru K.

BMC Medical Genetics. 2020 October; 21 (1) 10.1186/s12881-020-01115-w


Moayyedi P., MacQueen G., Bernstein C.N., Vanner S., Bercik P., Madsen K.L., Surette M., Rioux J.D., DIeleman L.A., Verdú E., De Souza R.J., Otley A., Targownik L., Lavis J., Cunningham J., Marshall D.A., Zelinsky S., Fernandes A.

BMJ Open. 2020 October; 10 (10) 10.1136/bmjopen-2020-041733