Karen Madsen

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Contact

Professor, Faculty of Medicine & Dentistry - Medicine Dept
Email
kmadsen@ualberta.ca
Phone
(780) 492-5257
Address
7142K Katz Group Centre For Research
11315 - 87 Ave NW
Edmonton AB
T6G 2H5

Overview

Area of Study / Keywords

genetics inflammatory bowel disease gut microbes probiotics innate immunity diet microbiota bacteria-host interactions microbiome


About

Personal Statement:

Changing the gut microbiome really changes health and disease dramatically. My research looks at how microbes interact with the human host.  I work with clinical colleagues to test how therapies aimed at modulating the gut microbiome can influence metabolic and inflammatory diseases.

Dr. Madsen completed a BSc (Hon) and MSc in biochemistry at the University of Manitoba followed by a PhD in the gastrointestinal physiology at the University of Calgary. She is a leading researcher in intestinal permeability and gut microbiota and their effects on disease and health.

Leadership and Collaborations:

Dr. Madsen is a lead investigator in the GEM project and the national IMAGINE Chronic Disease Network. She is a member of the Women’s & Children’s Health Research Institute in Edmonton and the Digestive Health Strategic Clinical Network.  She is the University of Alberta lead for the national Microbiome Research Core (IMPACTT).

www.gemproject.ca
http://imaginespor.com
https://www.impactt-microbiome.ca



Clinical Interests

I am carrying out clinical trials using fecal microbial transplantation (FMT) to treat Crohn’s disease; FMT and fiber supplements to treat metabolic syndrome; and probiotics and fiber supplements to prevent disease recurrence in post-operative Crohn’s disease patients. 


Research

The primary focus of my research is the relationships between the host and its resident microbiota, with specific interests in the role of microbes in inflammatory bowel diseases and metabolic disorders and how environmental factors and diet can modulate these interactions.  My overall research goal is to gain mechanistic knowledge into these interactions in order to design effective therapeutic interventions aimed at manipulation of the gut microbiota to improve human health.  My work employs a variety of complementary approaches including animal models, human tissues, cell culture models, and clinical trials.  

Dr. Madsen is a highly cited author or co-author of 250 published research articles and abstracts. Her research has garnered support from many agencies including the University Hospital Foundation, the Weston Foundation, Alberta Health Services’ Digestive Health Strategic Clinical Network, Alberta Innovates, Canadian Institutes of Health Research, Canadian Association of Gastrointestinal Surgery, Calgary Center for Clinical Research, and the Society of American Gastrointestinal and Endoscopic Surgeons.

She has received awards from the Canadian Society for Clinical Investigation, the Canadian Association for Gastroenterology, Crohn's Colitis Canada and Canadian Association for Medical Education.


Teaching

Dr. Madsen supervises trainees at all levels who are pursuing research. She is an advisor and mentor to young faculty who are developing research expertise.


Featured Publications

Edward C. Deehan, Valentin Mocanu, Karen L. Madsen

Nature Reviews Gastroenterology & Hepatology. 2024 February; 10.1038/s41575-023-00891-z


Dichotomous impact of dietary fiber in pediatrics: a narrative review of the health benefits and tolerance of fiber.

Basuray N, Deehan EC, Vieira FT, Avedzi HM, Duke RL, Tun HM, Zhang Z, Wine E, Madsen KL, Field CJ, Haqq AM

Eu J Clinical Nutrition. 2024 January;


Immunometabolism and microbial metabolites at the gut barrier: lessons for therapeutic intervention in Inflammatory Bowel Disease

Michaels M and Madsen KL

Mucosal Immunology. 2023 October; 16 (1):72-85


Chemotherapy-induced weight gain in early-stage breast cancer: a prospective matched cohort study reveals associations with inflammation and gut dysbiosis

Walker J, Joy AA, Vos LJ, Mackey JR, Jovel J, Kao D, Madsen KL, Wong G.

BMC Medicine. 2023 January; 21


Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease

Armstrong H, Rahbari M, Park H, Sharon D, Thiesen A, Hotte N, Sun N, Syed H, Abofayed H, Wang W, Madsen KL, Wine E, Mason A

Microbiome. 2023 January; 11 (1)


Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis

Leibovitzh H, Lee SH, Raygoza Garay JA, Hernandez-Rocha C, Espin-Garcia O, Xue M, Neustaeter A, Goethel A, Hyuynh HQ, Griffiths A, Turner D, Madsen KL, Moayyedi P, Steinhart H, Silerberg MS, Deslandre C, Bitton A, Mack DR, Jacobson K, Cino M, Aumais G, Bernsterin CN, Panaccione R, Weiss B, Halfvarson J, Xu W, Turpin,; CCC GEM Project Research Consortium, Turpin W, Croitoru K

2023 January; 72 (8):1462-1471


Gastroenterology. 2022 May; org/10.1016/S0016-5085(22)60964-8


Turpin W, Dong M, Sasson G, Raygoza Garay JA, Espin-Garcia O, Lee SH, Neustaeter A, Smith MI, Leibovitzh H, Guttman DS, Goethel A, Griffiths AM, Huynh HQ, Dieleman LA, Panaccione R, Steinhart AH, Silverberg MS, Aumais G, Jacobson K, Mack D, Murthy SK, Marshall JK, Bernstein CN, Abreu MT, Moayyedi P, Paterson AD; Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, Xu W, Croitoru K.

GASTROENTEROLOGY. 2022 May; 10.1053/j.gastro.2022.05.037


Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease

Leibovitzh H, Lee SH, Xue M, Raygoza Garay JA, Hernandez-Rocha C, Madsen KL, Meddings JB, Guttman DS, Espin-Garcia O, Smith MI, Goethel A, Griffiths AM, Moayyedi P, Steinhart AH, Panancionne R, Huynh H, Jacobson K, Aumais G, Mack DR, Abreu M, Bernstein CN, Marshall JK, Turner D, Xu W; CCC GEM Project Research Consortium, Turpin W, Croitoru K

Gastroenterology. 2022 May; 163 (5):1364-1376


Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.170


Jovel J., Nimaga A., Jordan T., O’Keefe S., Patterson J., Thiesen A., Hotte N., Bording-Jorgensen M., Subedi S., Hamilton J., Carpenter E.J., Lauga B., Elahi S., Madsen K.L., Wong G.K.S., Mason A.L.

Frontiers in Microbiology. 2022 February; 13 10.3389/fmicb.2022.829378


Anti-inflammatory diet prevents subclinical colonic inflammation and alters metabolomic profile of ulcerative colitis patients in clinical remission.

Keshteli AH, Valcheva R, Nickurak C , Park H, Mandal R, Kroeker KI, Veldhuyzen van Zanten S , Halloran B , Wishart DS , Madsen KL , Dieleman LA.

Nutrients. 2022 January; 14 (16)


Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice.

De Palma G, Shimbori C, Reed DE, Yu Y, Rabbia V, Lu J, Jimenez-Vargas N, Sessenwein J, Lopez-Lopez C, Pigrau M, Jaramillo-Polanco J, Zhang Y, Baerg L, Manzar A, Pujo J, Bai X, Pinto-Sanchez MI, Caminero A, Madsen K, Surette MG, Beyak M, Lomax AE, Verdu EF, Collins SM, Vanner SJ, Bercik P.

Science Translational Medicine. 2022 January; 14 (655)


Wu R.Y., Tandon P., Ambrosio L., Dunsmore G., Hotte N., Dieleman L.A., Elahi S., Madsen K., Huang V.

Digestive Diseases and Sciences. 2022 January; 10.1007/s10620-022-07430-x


Dang J.T., Mocanu V., Park H., Laffin M., Hotte N., Karmali S., Birch D.W., Madsen K.L.

Gut Microbes. 2022 January; 14 (1) 10.1080/19490976.2022.2050636


Hinchliffe T., Pauline M.L., Wizzard P.R., Jovel J., Nation P.N., Wales P.W., Madsen K.L., Turner J.M.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2022 January; 10.1002/jpen.2333


Dang J.T., Mocanu V., Park H., Laffin M., Tran C., Hotte N., Karmali S., Birch D.W., Madsen K.

Scientific Reports. 2021 December; 11 (1):23813 10.1038/s41598-021-03396-4


Tan Q., Orsso C.E., Deehan E.C., Kung J.Y., Tun H.M., Wine E., Madsen K.L., Zwaigenbaum L., Haqq A.M.

Autism Research. 2021 September; 14 (9):1820-1836 10.1002/aur.2560


Dang JT, Mocanu V, Fang B, Laffin M, Karmali S, Madsen K, Birch DW.

J Vis Exp. 2021 August; 21 (174) 10.3791/62575


Camila E. Orsso, Ye Peng, Edward C. Deehan, Qiming Tan, Catherine J. Field, Karen L. Madsen, Jens Walter, Carla M. Prado, Hein M. Tun, Andrea M. Haqq

Microorganisms. 2021 July; 10.3390/microorganisms9071490


Valentin Mocanu, Zhengxiao Zhang, Edward C. Deehan, Dina H. Kao, Naomi Hotte, Shahzeer Karmali, Daniel W. Birch, Kalutota K. Samarasinghe, Jens Walter, Karen L. Madsen

Nature Medicine. 2021 July; 10.1038/s41591-021-01399-2


Orsso C.E., Peng Y., Deehan E.C., Tan Q., Field C.J., Madsen K.L., Walter J., Prado C.M., Tun H.M., Haqq A.M.

Microorganisms. 2021 July; 9 (7) 10.3390/microorganisms9071490


Mocanu V., Park H., Dang J., Hotte N., Thiesen A., Laffin M., Wang H., Birch D., Madsen K.

Nutrients. 2021 June; 13 (6):2069 10.3390/nu13062069


Schmidt E.K.A., Raposo P.J.F., Madsen K.L., Fenrich K.K., Kabarchuk G., Fouad K.

Biology. 2021 June; 10 (4) 10.3390/biology10040254


Galipeau H.J., Caminero A., Turpin W., Bermudez-Brito M., Santiago A., Libertucci J., Constante M., Raygoza Garay J.A., Rueda G., Armstrong S., Clarizio A., Smith M.I., Surette M.G., Bercik P., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Moayyedi P., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Turner D., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Huynh H., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Verdu E.F.

GASTROENTEROLOGY. 2021 April; 160 (5):1532-1545 10.1053/j.gastro.2020.12.004


Deehan E.C., Colin-Ramirez E., Triador L., Madsen K.L., Prado C.M., Field C.J., Ball G.D.C., Tan Q., Orsso C., Dinu I., Pakseresht M., Rubin D., Sharma A.M., Tun H., Walter J., Newgard C.B., Freemark M., Wine E., Haqq A.M.

Trials. 2021 February; 22 (1) 10.1186/s13063-021-05060-8


Nieuwdorp M., Madsen K.

GASTROENTEROLOGY. 2021 January; 160 (1):17-19 10.1053/j.gastro.2020.10.025


Naqvi S.A., Taylor L.M., Panaccione R., Ghosh S., Barkema H.W., Hotte N., Shommu N., Kaur S., Reimer R.A., Madsen K.L., Raman M.

Scientific Reports. 2021 January; 11 (1) 10.1038/s41598-020-80924-8


Turpin W., Lee S.H., Raygoza Garay J.A., Madsen K.L., Meddings J.B., Bedrani L., Power N., Espin-Garcia O., Xu W., Smith M.I., Griffiths A.M., Moayyedi P., Turner D., Seidman E.G., Steinhart A.H., Marshall J.K., Jacobson K., Mack D., Huynh H., Bernstein C.N., Paterson A.D., Abreu M., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Kaplan G., Krause D.O., Madsen K., Marshall J., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., McGrath J., Otley A., Panancionne R., Baldassano R., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Panaccione R., Parekh N., Plamondon S., Radford-Smith G., Rosh J., Rubin D., Schultz M., Siegel C.

GASTROENTEROLOGY. 2020 December; 159 (6):2092-2100.e5 10.1053/j.gastro.2020.08.005


Headley S.A., Chapman D.J., Germain M.J., Evans E.E., Hutchinson J., Madsen K.L., Ikizler T.A., Miele E.M., Kirton K., O’Neill E., Cornelius A., Martin B., Nindl B., Vaziri N.D.

BMC Nephrology. 2020 November; 21 (1) 10.1186/s12882-020-02177-x


Moayyedi P., MacQueen G., Bernstein C.N., Vanner S., Bercik P., Madsen K.L., Surette M., Rioux J.D., DIeleman L.A., Verdú E., De Souza R.J., Otley A., Targownik L., Lavis J., Cunningham J., Marshall D.A., Zelinsky S., Fernandes A.

BMJ Open. 2020 October; 10 (10) 10.1136/bmjopen-2020-041733


Turpin W., Bedrani L., Espin-Garcia O., Xu W., Silverberg M.S., Smith M.I., Garay J.A.R., Lee S.H., Guttman D.S., Griffiths A., Moayyedi P., Panaccione R., Huynh H., Steinhart H.A., Aumais G., Dieleman L., Turner D., Abreu M., Beck P., Bernstein C., Croitoru K., Feagan B., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Seidman E., Silverberg M., Stadnyk A., Steinhart A. ., Surette M., Walters T., Vallance B., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Baldassano R., Griffiths A.M., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Parekh N., Plamondon S., Radford-Smith G., Ropeleski M., Rosh J., Rubin D., Schultz M., Siegel C., Snapper S., Paterson A.D., Croitoru K.

BMC Medical Genetics. 2020 October; 21 (1) 10.1186/s12881-020-01115-w


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