Karen Madsen

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Contact Overview Publications

Contact

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Email: kmadsen@ualberta.ca
Phone: (780) 492-5257
Address: 7142K Katz Group Centre For Research
11315 - 87 Ave NW

Edmonton AB

T6G 2H5

Overview

Area of Study / Keywords

genetics inflammatory bowel disease gut microbes probiotics innate immunity diet microbiota bacteria-host interactions microbiome

About

Personal Statement:

Changing the gut microbiome really changes health and disease dramatically. My research looks at how microbes interact with the human host. I work with clinical colleagues to test how therapies aimed at modulating the gut microbiome can influence metabolic and inflammatory diseases.

Dr. Madsen completed a BSc (Hon) and MSc in biochemistry at the University of Manitoba followed by a PhD in the gastrointestinal physiology at the University of Calgary. She is a leading researcher in intestinal permeability and gut microbiota and their effects on disease and health.

Leadership and Collaborations:

Dr. Madsen is a lead investigator in the GEM project and the national IMAGINE Chronic Disease Network. She is a member of the Women’s & Children’s Health Research Institute in Edmonton and the Digestive Health Strategic Clinical Network. She is the University of Alberta lead for the national Microbiome Research Core (IMPACTT).

www.gemproject.ca
http://imaginespor.com
https://www.impactt-microbiome.ca

Clinical Interests

I am carrying out clinical trials using fecal microbial transplantation (FMT) to treat Crohn’s disease; FMT and fiber supplements to treat metabolic syndrome; and probiotics and fiber supplements to prevent disease recurrence in post-operative Crohn’s disease patients.

Research

The primary focus of my research is the relationships between the host and its resident microbiota, with specific interests in the role of microbes in inflammatory bowel diseases and metabolic disorders and how environmental factors and diet can modulate these interactions. My overall research goal is to gain mechanistic knowledge into these interactions in order to design effective therapeutic interventions aimed at manipulation of the gut microbiota to improve human health. My work employs a variety of complementary approaches including animal models, human tissues, cell culture models, and clinical trials.

Dr. Madsen is a highly cited author or co-author of 250 published research articles and abstracts. Her research has garnered support from many agencies including the University Hospital Foundation, the Weston Foundation, Alberta Health Services’ Digestive Health Strategic Clinical Network, Alberta Innovates, Canadian Institutes of Health Research, Canadian Association of Gastrointestinal Surgery, Calgary Center for Clinical Research, and the Society of American Gastrointestinal and Endoscopic Surgeons.

She has received awards from the Canadian Society for Clinical Investigation, the Canadian Association for Gastroenterology, Crohn's Colitis Canada and Canadian Association for Medical Education.

Teaching

Dr. Madsen supervises trainees at all levels who are pursuing research. She is an advisor and mentor to young faculty who are developing research expertise.

Featured Publications

Empaglifozin improves gastrointestinal inflammation in a mouse model of colitis independent of changes to gut microbial composition

Gastroenterology. 2022 May; org/10.1016/S0016-5085(22)60964-8

Mediterranean -like dietary pattern associations with gut microbiome composition and subclinical gastrointestinal inflammation

Gastroenterology. 2022 May; doi.org/10.1053/j.gastro.2022.05.037

Mediterranean-like dietary pattern associations with gut microbiome composition and subclinical gastrointestinal inflammation

Turpin W, Dong M, Sasson G, Raygoza Garay JA, Espin-Garcia O, Lee SH, Neustaeter A, Smith MI, Leibovitzh H, Guttman DS, Goethel A, Griffiths AM, Huynh HQ, Dieleman LA, Panaccione R, Steinhart AH, Silverberg MS, Aumais G, Jacobson K, Mack D, Murthy SK, Marshall JK, Bernstein CN, Abreu MT, Moayyedi P, Paterson AD; Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, Xu W, Croitoru K.

GASTROENTEROLOGY. 2022 May; 10.1053/j.gastro.2022.05.037

Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of Crohn’s disease patients

Gastroenterology. 2022 May; doi.org/10.1053/j.gastro.2022.07.004

Definitions of Mediterranean Diet inconsistently associate with markers of gut barrier function or subclinical inflammation in a population -based cohort

Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.156

Disease activity in first trimester is associated wit reduced growth in infnts born to women with inflammatory bowel disease.

Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.174

Exploring patients perspectives on a 12-week online stress reduction intervention in inflammatory bowel disease

Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.170

Metagenomics Versus Metatranscriptomics of the Murine Gut Microbiome for Assessing Microbial Metabolism During Inflammation

Jovel J., Nimaga A., Jordan T., O’Keefe S., Patterson J., Thiesen A., Hotte N., Bording-Jorgensen M., Subedi S., Hamilton J., Carpenter E.J., Lauga B., Elahi S., Madsen K.L., Wong G.K.S., Mason A.L.

Frontiers in Microbiology. 2022 February; 13 10.3389/fmicb.2022.829378

Post-neonatal Outcomes of Infants Born to Women with Active Trimester One Inflammatory Bowel Disease: A Pilot Study

Wu R.Y., Tandon P., Ambrosio L., Dunsmore G., Hotte N., Dieleman L.A., Elahi S., Madsen K., Huang V.

Digestive Diseases and Sciences. 2022 January; 10.1007/s10620-022-07430-x

Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways

Dang J.T., Mocanu V., Park H., Laffin M., Hotte N., Karmali S., Birch D.W., Madsen K.L.

Gut Microbes. 2022 January; 14 (1) 10.1080/19490976.2022.2050636

The effect of fecal microbial transplant on intestinal microbial composition in short-bowel neonatal piglets

Hinchliffe T., Pauline M.L., Wizzard P.R., Jovel J., Nation P.N., Wales P.W., Madsen K.L., Turner J.M.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2022 January; 10.1002/jpen.2333

Ileal microbial shifts after Roux-en-Y gastric bypass orchestrate changes in glucose metabolism through modulation of bile acids and L-cell adaptation

Dang J.T., Mocanu V., Park H., Laffin M., Tran C., Hotte N., Karmali S., Birch D.W., Madsen K.

Scientific Reports. 2021 December; 11 (1):23813 10.1038/s41598-021-03396-4

Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review

Tan Q., Orsso C.E., Deehan E.C., Kung J.Y., Tun H.M., Wine E., Madsen K.L., Zwaigenbaum L., Haqq A.M.

Autism Research. 2021 September; 14 (9):1820-1836 10.1002/aur.2560

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Dang JT, Mocanu V, Fang B, Laffin M, Karmali S, Madsen K, Birch DW.

J Vis Exp. 2021 August; 21 (174) 10.3791/62575

Composition and functions of the gut microbiome in pediatric obesity: Relationships with markers of insulin resistance

Orsso C.E., Peng Y., Deehan E.C., Tan Q., Field C.J., Madsen K.L., Walter J., Prado C.M., Tun H.M., Haqq A.M.

Microorganisms. 2021 July; 9 (7) 10.3390/microorganisms9071490

Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial

Mocanu V., Zhang Z., Deehan E.C., Kao D.H., Hotte N., Karmali S., Birch D.W., Samarasinghe K.K., Walter J., Madsen K.L.

NATURE MEDICINE. 2021 July; 27 (7):1272-1279 10.1038/s41591-021-01399-2

Timing of tributyrin supplementation differentially modulates gastrointestinal inflammation and gut microbial recolonization following murine ileocecal resection

Mocanu V., Park H., Dang J., Hotte N., Thiesen A., Laffin M., Wang H., Birch D., Madsen K.

Nutrients. 2021 June; 13 (6):2069 10.3390/nu13062069

What makes a successful donor? Fecal transplant from anxious-like rats does not prevent spinal cord injury-induced dysbiosis

Schmidt E.K.A., Raposo P.J.F., Madsen K.L., Fenrich K.K., Kabarchuk G., Fouad K.

Biology. 2021 June; 10 (4) 10.3390/biology10040254

BASELINE GUT MICROBIOTA OF INDIVIDUALS WITH SEVERE OBESITY AND METABOLIC SYNDROME PREDICTS RESPONSE TO FECAL MICROBIOTA TRANSPLANTATION: A SUBGROUP ANALYSIS OF A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

Digestive Disease Week. 2021 May;

FIBER SUPPLEMENTATION DIFFERENTIALLY MODULATES RESPONSES TO FECAL MICROBIAL TRANSPLANTATION IN PATIENTS WITH METABOLIC SYNDROME AND SEVERE OBESITY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT TRIAL

Digestive Disease Week. 2021 May;

Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis

Galipeau H.J., Caminero A., Turpin W., Bermudez-Brito M., Santiago A., Libertucci J., Constante M., Raygoza Garay J.A., Rueda G., Armstrong S., Clarizio A., Smith M.I., Surette M.G., Bercik P., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Moayyedi P., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Turner D., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Huynh H., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Verdu E.F.

GASTROENTEROLOGY. 2021 April; 160 (5):1532-1545 10.1053/j.gastro.2020.12.004

Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial

Deehan E.C., Colin-Ramirez E., Triador L., Madsen K.L., Prado C.M., Field C.J., Ball G.D.C., Tan Q., Orsso C., Dinu I., Pakseresht M., Rubin D., Sharma A.M., Tun H., Walter J., Newgard C.B., Freemark M., Wine E., Haqq A.M.

Trials. 2021 February; 22 (1) 10.1186/s13063-021-05060-8

Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation

Naqvi S.A., Taylor L.M., Panaccione R., Ghosh S., Barkema H.W., Hotte N., Shommu N., Kaur S., Reimer R.A., Madsen K.L., Raman M.

Scientific Reports. 2021 January; 11 (1) 10.1038/s41598-020-80924-8

The Promise of Maintaining Diet-Induced Weight Loss by Swallowing One's Own Feces: Time to Provide a Do-It-Yourself Manual?

Nieuwdorp M., Madsen K.

GASTROENTEROLOGY. 2021 January; 160 (1):17-19 10.1053/j.gastro.2020.10.025

Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease

Turpin W., Lee S.H., Raygoza Garay J.A., Madsen K.L., Meddings J.B., Bedrani L., Power N., Espin-Garcia O., Xu W., Smith M.I., Griffiths A.M., Moayyedi P., Turner D., Seidman E.G., Steinhart A.H., Marshall J.K., Jacobson K., Mack D., Huynh H., Bernstein C.N., Paterson A.D., Abreu M., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Kaplan G., Krause D.O., Madsen K., Marshall J., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., McGrath J., Otley A., Panancionne R., Baldassano R., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Panaccione R., Parekh N., Plamondon S., Radford-Smith G., Rosh J., Rubin D., Schultz M., Siegel C.

GASTROENTEROLOGY. 2020 December; 159 (6):2092-2100.e5 10.1053/j.gastro.2020.08.005

The effects of 16-weeks of prebiotic supplementation and aerobic exercise training on inflammatory markers, oxidative stress, uremic toxins, and the microbiota in pre-dialysis kidney patients: a randomized controlled trial-protocol paper

Headley S.A., Chapman D.J., Germain M.J., Evans E.E., Hutchinson J., Madsen K.L., Ikizler T.A., Miele E.M., Kirton K., O’Neill E., Cornelius A., Martin B., Nindl B., Vaziri N.D.

BMC Nephrology. 2020 November; 21 (1) 10.1186/s12882-020-02177-x

Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn’s disease subjects

Turpin W., Bedrani L., Espin-Garcia O., Xu W., Silverberg M.S., Smith M.I., Garay J.A.R., Lee S.H., Guttman D.S., Griffiths A., Moayyedi P., Panaccione R., Huynh H., Steinhart H.A., Aumais G., Dieleman L., Turner D., Abreu M., Beck P., Bernstein C., Croitoru K., Feagan B., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Seidman E., Silverberg M., Stadnyk A., Steinhart A. ., Surette M., Walters T., Vallance B., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Baldassano R., Griffiths A.M., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Parekh N., Plamondon S., Radford-Smith G., Ropeleski M., Rosh J., Rubin D., Schultz M., Siegel C., Snapper S., Paterson A.D., Croitoru K.

BMC Medical Genetics. 2020 October; 21 (1) 10.1186/s12881-020-01115-w

IMAGINE Network's M ind A nd G ut i nteractions C ohort (MAGIC) Study: A protocol for a prospective observational multicentre cohort study in inflammatory bowel disease and irritable bowel syndrome

Moayyedi P., MacQueen G., Bernstein C.N., Vanner S., Bercik P., Madsen K.L., Surette M., Rioux J.D., DIeleman L.A., Verdú E., De Souza R.J., Otley A., Targownik L., Lavis J., Cunningham J., Marshall D.A., Zelinsky S., Fernandes A.

BMJ Open. 2020 October; 10 (10) 10.1136/bmjopen-2020-041733