Contact
Professor, Faculty of Medicine & Dentistry - Medicine Dept
- kmadsen@ualberta.ca
- Phone
- (780) 492-5257
- Address
-
7142K Katz Group Centre For Research
11315 - 87 Ave NWEdmonton ABT6G 2H5
Overview
Area of Study / Keywords
genetics inflammatory bowel disease gut microbes probiotics innate immunity diet microbiota bacteria-host interactions microbiome
About
Personal Statement:
Changing the gut microbiome really changes health and disease dramatically. My research looks at how microbes interact with the human host. I work with clinical colleagues to test how therapies aimed at modulating the gut microbiome can influence metabolic and inflammatory diseases.
Dr. Madsen completed a BSc (Hon) and MSc in biochemistry at the University of Manitoba followed by a PhD in the gastrointestinal physiology at the University of Calgary. She is a leading researcher in intestinal permeability and gut microbiota and their effects on disease and health.
Leadership and Collaborations:
Dr. Madsen is a lead investigator in the GEM project and the national IMAGINE Chronic Disease Network. She is a member of the Women’s & Children’s Health Research Institute in Edmonton and the Digestive Health Strategic Clinical Network. She is the University of Alberta lead for the national Microbiome Research Core (IMPACTT).
www.gemproject.ca
http://imaginespor.com
https://www.impactt-microbiome.ca
Clinical Interests
I am carrying out clinical trials using fecal microbial transplantation (FMT) to treat Crohn’s disease; FMT and fiber supplements to treat metabolic syndrome; and probiotics and fiber supplements to prevent disease recurrence in post-operative Crohn’s disease patients.
Research
The primary focus of my research is the relationships between the host and its resident microbiota, with specific interests in the role of microbes in inflammatory bowel diseases and metabolic disorders and how environmental factors and diet can modulate these interactions. My overall research goal is to gain mechanistic knowledge into these interactions in order to design effective therapeutic interventions aimed at manipulation of the gut microbiota to improve human health. My work employs a variety of complementary approaches including animal models, human tissues, cell culture models, and clinical trials.
Dr. Madsen is a highly cited author or co-author of 250 published research articles and abstracts. Her research has garnered support from many agencies including the University Hospital Foundation, the Weston Foundation, Alberta Health Services’ Digestive Health Strategic Clinical Network, Alberta Innovates, Canadian Institutes of Health Research, Canadian Association of Gastrointestinal Surgery, Calgary Center for Clinical Research, and the Society of American Gastrointestinal and Endoscopic Surgeons.
She has received awards from the Canadian Society for Clinical Investigation, the Canadian Association for Gastroenterology, Crohn's Colitis Canada and Canadian Association for Medical Education.
Teaching
Dr. Madsen supervises trainees at all levels who are pursuing research. She is an advisor and mentor to young faculty who are developing research expertise.
Featured Publications
Edward C. Deehan, Valentin Mocanu, Karen L. Madsen
Nature Reviews Gastroenterology & Hepatology. 2024 February; 10.1038/s41575-023-00891-z
Dichotomous impact of dietary fiber in pediatrics: a narrative review of the health benefits and tolerance of fiber.
Basuray N, Deehan EC, Vieira FT, Avedzi HM, Duke RL, Tun HM, Zhang Z, Wine E, Madsen KL, Field CJ, Haqq AM
Eu J Clinical Nutrition. 2024 January;
Immunometabolism and microbial metabolites at the gut barrier: lessons for therapeutic intervention in Inflammatory Bowel Disease
Michaels M and Madsen KL
Mucosal Immunology. 2023 October; 16 (1):72-85
Chemotherapy-induced weight gain in early-stage breast cancer: a prospective matched cohort study reveals associations with inflammation and gut dysbiosis
Walker J, Joy AA, Vos LJ, Mackey JR, Jovel J, Kao D, Madsen KL, Wong G.
BMC Medicine. 2023 January; 21
Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease
Armstrong H, Rahbari M, Park H, Sharon D, Thiesen A, Hotte N, Sun N, Syed H, Abofayed H, Wang W, Madsen KL, Wine E, Mason A
Microbiome. 2023 January; 11 (1)
Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis
Leibovitzh H, Lee SH, Raygoza Garay JA, Hernandez-Rocha C, Espin-Garcia O, Xue M, Neustaeter A, Goethel A, Hyuynh HQ, Griffiths A, Turner D, Madsen KL, Moayyedi P, Steinhart H, Silerberg MS, Deslandre C, Bitton A, Mack DR, Jacobson K, Cino M, Aumais G, Bernsterin CN, Panaccione R, Weiss B, Halfvarson J, Xu W, Turpin,; CCC GEM Project Research Consortium, Turpin W, Croitoru K
2023 January; 72 (8):1462-1471
Gastroenterology. 2022 May; org/10.1016/S0016-5085(22)60964-8
Turpin W, Dong M, Sasson G, Raygoza Garay JA, Espin-Garcia O, Lee SH, Neustaeter A, Smith MI, Leibovitzh H, Guttman DS, Goethel A, Griffiths AM, Huynh HQ, Dieleman LA, Panaccione R, Steinhart AH, Silverberg MS, Aumais G, Jacobson K, Mack D, Murthy SK, Marshall JK, Bernstein CN, Abreu MT, Moayyedi P, Paterson AD; Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, Xu W, Croitoru K.
GASTROENTEROLOGY. 2022 May; 10.1053/j.gastro.2022.05.037
Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease
Leibovitzh H, Lee SH, Xue M, Raygoza Garay JA, Hernandez-Rocha C, Madsen KL, Meddings JB, Guttman DS, Espin-Garcia O, Smith MI, Goethel A, Griffiths AM, Moayyedi P, Steinhart AH, Panancionne R, Huynh H, Jacobson K, Aumais G, Mack DR, Abreu M, Bernstein CN, Marshall JK, Turner D, Xu W; CCC GEM Project Research Consortium, Turpin W, Croitoru K
Gastroenterology. 2022 May; 163 (5):1364-1376
Journal of the Canadian Association of Gastroenterology . 2022 February; doi.org/10.1093/jcag/gwab049.170
Jovel J., Nimaga A., Jordan T., O’Keefe S., Patterson J., Thiesen A., Hotte N., Bording-Jorgensen M., Subedi S., Hamilton J., Carpenter E.J., Lauga B., Elahi S., Madsen K.L., Wong G.K.S., Mason A.L.
Frontiers in Microbiology. 2022 February; 13 10.3389/fmicb.2022.829378
Anti-inflammatory diet prevents subclinical colonic inflammation and alters metabolomic profile of ulcerative colitis patients in clinical remission.
Keshteli AH, Valcheva R, Nickurak C , Park H, Mandal R, Kroeker KI, Veldhuyzen van Zanten S , Halloran B , Wishart DS , Madsen KL , Dieleman LA.
Nutrients. 2022 January; 14 (16)
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice.
De Palma G, Shimbori C, Reed DE, Yu Y, Rabbia V, Lu J, Jimenez-Vargas N, Sessenwein J, Lopez-Lopez C, Pigrau M, Jaramillo-Polanco J, Zhang Y, Baerg L, Manzar A, Pujo J, Bai X, Pinto-Sanchez MI, Caminero A, Madsen K, Surette MG, Beyak M, Lomax AE, Verdu EF, Collins SM, Vanner SJ, Bercik P.
Science Translational Medicine. 2022 January; 14 (655)
Wu R.Y., Tandon P., Ambrosio L., Dunsmore G., Hotte N., Dieleman L.A., Elahi S., Madsen K., Huang V.
Digestive Diseases and Sciences. 2022 January; 10.1007/s10620-022-07430-x
Dang J.T., Mocanu V., Park H., Laffin M., Hotte N., Karmali S., Birch D.W., Madsen K.L.
Gut Microbes. 2022 January; 14 (1) 10.1080/19490976.2022.2050636
Hinchliffe T., Pauline M.L., Wizzard P.R., Jovel J., Nation P.N., Wales P.W., Madsen K.L., Turner J.M.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2022 January; 10.1002/jpen.2333
Dang J.T., Mocanu V., Park H., Laffin M., Tran C., Hotte N., Karmali S., Birch D.W., Madsen K.
Scientific Reports. 2021 December; 11 (1):23813 10.1038/s41598-021-03396-4
Tan Q., Orsso C.E., Deehan E.C., Kung J.Y., Tun H.M., Wine E., Madsen K.L., Zwaigenbaum L., Haqq A.M.
Autism Research. 2021 September; 14 (9):1820-1836 10.1002/aur.2560
Dang JT, Mocanu V, Fang B, Laffin M, Karmali S, Madsen K, Birch DW.
J Vis Exp. 2021 August; 21 (174) 10.3791/62575
Camila E. Orsso, Ye Peng, Edward C. Deehan, Qiming Tan, Catherine J. Field, Karen L. Madsen, Jens Walter, Carla M. Prado, Hein M. Tun, Andrea M. Haqq
Microorganisms. 2021 July; 10.3390/microorganisms9071490
Valentin Mocanu, Zhengxiao Zhang, Edward C. Deehan, Dina H. Kao, Naomi Hotte, Shahzeer Karmali, Daniel W. Birch, Kalutota K. Samarasinghe, Jens Walter, Karen L. Madsen
Nature Medicine. 2021 July; 10.1038/s41591-021-01399-2
Orsso C.E., Peng Y., Deehan E.C., Tan Q., Field C.J., Madsen K.L., Walter J., Prado C.M., Tun H.M., Haqq A.M.
Microorganisms. 2021 July; 9 (7) 10.3390/microorganisms9071490
Mocanu V., Park H., Dang J., Hotte N., Thiesen A., Laffin M., Wang H., Birch D., Madsen K.
Nutrients. 2021 June; 13 (6):2069 10.3390/nu13062069
Schmidt E.K.A., Raposo P.J.F., Madsen K.L., Fenrich K.K., Kabarchuk G., Fouad K.
Biology. 2021 June; 10 (4) 10.3390/biology10040254
Galipeau H.J., Caminero A., Turpin W., Bermudez-Brito M., Santiago A., Libertucci J., Constante M., Raygoza Garay J.A., Rueda G., Armstrong S., Clarizio A., Smith M.I., Surette M.G., Bercik P., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Moayyedi P., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Turner D., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Huynh H., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Verdu E.F.
GASTROENTEROLOGY. 2021 April; 160 (5):1532-1545 10.1053/j.gastro.2020.12.004
Deehan E.C., Colin-Ramirez E., Triador L., Madsen K.L., Prado C.M., Field C.J., Ball G.D.C., Tan Q., Orsso C., Dinu I., Pakseresht M., Rubin D., Sharma A.M., Tun H., Walter J., Newgard C.B., Freemark M., Wine E., Haqq A.M.
Trials. 2021 February; 22 (1) 10.1186/s13063-021-05060-8
Nieuwdorp M., Madsen K.
GASTROENTEROLOGY. 2021 January; 160 (1):17-19 10.1053/j.gastro.2020.10.025
Naqvi S.A., Taylor L.M., Panaccione R., Ghosh S., Barkema H.W., Hotte N., Shommu N., Kaur S., Reimer R.A., Madsen K.L., Raman M.
Scientific Reports. 2021 January; 11 (1) 10.1038/s41598-020-80924-8
Turpin W., Lee S.H., Raygoza Garay J.A., Madsen K.L., Meddings J.B., Bedrani L., Power N., Espin-Garcia O., Xu W., Smith M.I., Griffiths A.M., Moayyedi P., Turner D., Seidman E.G., Steinhart A.H., Marshall J.K., Jacobson K., Mack D., Huynh H., Bernstein C.N., Paterson A.D., Abreu M., Beck P., Bernstein C., Croitoru K., Dieleman L., Feagan B., Griffiths A., Guttman D., Kaplan G., Krause D.O., Madsen K., Marshall J., Ropeleski M., Seidman E., Silverberg M., Snapper S., Stadnyk A., Steinhart H., Surette M., Walters T., Vallance B., Aumais G., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., McGrath J., Otley A., Panancionne R., Baldassano R., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Panaccione R., Parekh N., Plamondon S., Radford-Smith G., Rosh J., Rubin D., Schultz M., Siegel C.
GASTROENTEROLOGY. 2020 December; 159 (6):2092-2100.e5 10.1053/j.gastro.2020.08.005
Headley S.A., Chapman D.J., Germain M.J., Evans E.E., Hutchinson J., Madsen K.L., Ikizler T.A., Miele E.M., Kirton K., O’Neill E., Cornelius A., Martin B., Nindl B., Vaziri N.D.
BMC Nephrology. 2020 November; 21 (1) 10.1186/s12882-020-02177-x
Moayyedi P., MacQueen G., Bernstein C.N., Vanner S., Bercik P., Madsen K.L., Surette M., Rioux J.D., DIeleman L.A., Verdú E., De Souza R.J., Otley A., Targownik L., Lavis J., Cunningham J., Marshall D.A., Zelinsky S., Fernandes A.
BMJ Open. 2020 October; 10 (10) 10.1136/bmjopen-2020-041733
Turpin W., Bedrani L., Espin-Garcia O., Xu W., Silverberg M.S., Smith M.I., Garay J.A.R., Lee S.H., Guttman D.S., Griffiths A., Moayyedi P., Panaccione R., Huynh H., Steinhart H.A., Aumais G., Dieleman L., Turner D., Abreu M., Beck P., Bernstein C., Croitoru K., Feagan B., Guttman D., Jacobson K., Kaplan G., Krause D.O., Madsen K., Marshall J., Seidman E., Silverberg M., Stadnyk A., Steinhart A. ., Surette M., Walters T., Vallance B., Bitton A., Cino M., Critch J., Denson L., Deslandres C., El-Matary W., Herfarth H., Higgins P., Hyams J., Mack D., McGrath J., Otley A., Panancionne R., Baldassano R., Griffiths A.M., Hedin C., Hussey S., Hyams H., Keljo D., Kevans D., Lees C., Murthy S., Parekh N., Plamondon S., Radford-Smith G., Ropeleski M., Rosh J., Rubin D., Schultz M., Siegel C., Snapper S., Paterson A.D., Croitoru K.
BMC Medical Genetics. 2020 October; 21 (1) 10.1186/s12881-020-01115-w
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