Svetlana Komarova

Area of Study / Keywords

Mechanobiology Bone physiology Space physiology Mathematical modeling Knowledge synthesis Digital twins Biomedical engineering

About

Dr. Komarova earned an undergraduate degree in physics (Moscow State University) and PhD in biophysics (Institute for Theoretical and Experimental Biophysics) and underwent postdoctoral training at NASA Ames Research Center, University of Cincinnati and University of Western Ontario. Prior to coming to the University of Alberta, she worked for almost 20 years at the Faculty of Dental Medicine and Oral Health Sciences, McGill University.

Research

Dr. Komarova’s research interest is in biomedical engineering relevant to mineralized tissues, including bone, teeth and eggshell. She studies the interactions of mechanical, chemical, and biological stimuli in cell, tissue and body function in the context of health (from growth to healthy aging), disease (arthritis, genetic disorders such as osteogenesis imperfecta) and extreme environment (space travel). She uses a variety of experimental approaches and develops computational support for her projects, including “digital twins”, computational representations of physiological systems for experiment troubleshooting and optimization.

Selected publications:

Patron M, M Neset, M Mielkozorova, DG Bisson, M Vigouroux, J P Cata, PM Ingelmo, JA Ouellet, L Haglund, SV Komarova (2024) Markers of tissue deterioration and pain on Earth and in Space. J Pain Research, 17, 1683-1692

Dsouza C and SV Komarova (2024) Mechanosensitivity and mechanotransductive properties of osteoclasts. Am J Physiol Cell Physiol 326(1):C95-C106.

Moussa MS, D Bachour, SV Komarova (2024) Adverse effect of botulinum toxin-A injections on mandibular bone: a systematic review and meta-analysis. J Oral Rehabil, 51, 2, 404-415. 

Poorhemati H, SV Komarova (2023) Mathematical model of physicochemical regulation of precipitation of bone hydroxyapatite. Front. Appl. Math. Stat., 9:1294540.

Poorhemati H, M Ghaly, G Sadvakassova, SV Komarova (2023) FGF23 level in poultry chicken, a systematic review and meta-analysis. Front Physiol Oct 16:14:1279204.

Bertin H, MS Moussa, SV Komarova (2023) Efficacy of antiresorptive agents in fibrous dysplasia and McCune Albright syndrome, a systematic review and meta-analysis. Rev Endocr Metab Disord. 24(6):1103-1119.

Moussa MS, Goldsmith M, Komarova SV (2023) Craniofacial bones and teeth in spacefarers: systematic review and meta-analysis. JDR Clin Trans Res. 8(2):113-122.

Tiedemann K, ML Muthu, DP Reinhardt, SV Komarova (2022) Male mice with fibrillin-1 deficiency are predisposed to high fat diet induced obesity, diabetes, and fatty liver. Am J Physiol Cell Physiol. 323(2):C354-C366. 

Muthu ML, K Tiedemann, J Fradette, SV Komarova, DP Reinhardt (2022) Fibrillin-1 is a key regulator of white adipose tissue development, homeostasis, and function. Matrix Biol 110, 106-128

Goldsmith M, SD Crooks, SF Condon, B Willie, SV Komarova (2022) Bone strength and composition in spacefaring rodents: systematic review and meta-analysis. npg Microgravity 8 (1), 1-14.

Mikolajewicz N, D Smith, SV Komarova, A Khadra (2021) High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts. PLoS Comp Biol 17(6):e1008872 

Fu J, M Goldsmith, SD Crooks, SF Condon, M Morris, SV Komarova (2021) Bone health in spacefaring rodents and primates: systematic review and meta-analysis. npg Microgravity 7(1):19.

Tauer JT, I Boraschi-Diaz, O Al Rifai, F Rauch, M Ferron, SV Komarova (2021) Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity. Mol Genet Metab 133(2):211-221

Sadvakassova G, K Tiedemann, KJD Steer, N Mikolajewicz, M Stavnichuk, I In-Kyung Lee, Z Sabirova, M Schranzhofer, SV Komarova (2021) Active hematopoiesis triggers exosomal release of PRDX2 promoting osteoclast formation Physiol Rep 9(3):e14745. 

Stavnichuk M, JT Tauer, Z Nagy, A Mazharian, M Welman, M Lordkipanidzé, YA Senis, SV Komarova (2021) Severity of megakaryocyte-driven osteosclerosis in Mpig6b-deficient mice is sex-linked. J Bone Min Res 36(4):803-813 

Corlett T, M Stavnichuk, SV Komarova (2020) Population analysis of space travelers. Life Sci Space Res, 27, 1-5

Stavnichuk M, N Mikolajewicz, T Corlett, M Morris, SV Komarova (2020) Bone loss in space travelers: systematic review and meta-analysis. npg Microgravity 6 (1), 1-9

Mikolajewicz N, N Bishop, AJ Burghardt, L Folkestad, A Hall, KM Kozloff, P Lukey, M Molloy-Bland, S Morin, AC Offiah, J Shapiro, B van Rietbergen, K Wager, BM Willie, SV Komarova, FH Glorieux (2020) HR-pQCT Measures of Bone Microarchitecture Predict Fracture. J Bone Miner Res. 35(3):446-459.

McKee TJ, G Perlman, M Morris, SV Komarova (2019) Extracellular matrix composition of connective tissues: systematic review and meta-analysis Scientific Reports 9(1):10542.

Mikolajewicz N, S Sehayek, PW Wiseman, SV Komarova (2019) Transmission of mechanical information by purinergic signalling. Biophys J, 116(10):2009-2022.

Tiedemann K, Sadvakassova G, Mikolajewicz N, Juhasa M, Sabirova Z, Tabaries S, Gettemans J, Siegel PM, Komarova SV (2019) Exosomal release of L-plastin by breast cancer cells facilitates metastatic bone osteolysis. Trans Oncol, 12(3):462-474. 

Mikolajewicz N, SV Komarova (2019) Meta-analytic methodology for basic research. Front Physiol, section Computational Physiology and Medicine. 10:203. (NSERC)

Mikolajewicz N, A Mohammed, M. Morris and SV Komarova (2018) Mechanically stimulated ATP release from mammalian cells: systematic review and meta-analysis. J Cell Science; 131(22).

Mikolajewicz N, EA Zimmermann, BM Willie, SV Komarova (2018) Mechanically-stimulated ATP release in bone cells: a balance of injury and repair. Elife. Oct 16;7. pii: e37812.

Boraschi-Diaz I, JS Mort, D Bromme, YA Senis, A Mazharian, SV Komarova (2018) Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation. Bone 117:23-30