Mark Kreutzberger

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Availability

Cryo-EM, structural biology, bacterial pathogenesis, extracellular matrix structure, innate immunity, filamentous assemblies.

About

As a PhD student at the University of Virginia, Dr. Mark Kreutzberger became interested in using the powerful and revolutionary technique of cryo-EM to study the details of protein machineries that allow bacteria to better survive in their ecological niches. At the time the 2017 Nobel Prize had just been awarded to three of leading developers of  cryo-EM (Dubochet, Frank, and Henderson) and Dr. Kreutzberger was excited about the potential of the methodology. As a result, he joined the lab of Dr. Ed Egelman, a pioneer in cryo-EM structural determination of large filamentous protein assemblies. Dr. Kreutzberger discovered new structural and functional details regarding species-specific structural adaptations of bacterial flagellar filaments - motor driven propellers that allow bacteria to swim. This included the flagella from several well-known pathogens. Dr. Kreutzberger remained in the Egelman lab at UVA as a postdoctoral researcher where he solved the first near atomic resolution cryo-EM structure of a collagen assembly – a “defense collagen” peptide assembly based on the immune system assembly known as C1q. Dr. Kreutzberger has had a number of publications in respected journals such as Cell, Nature Communications, PNAS, and ACS Central Science.

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Research

The Kreutzberger lab uses cryo-electron microscopy and other complementary techniques to study the atomic structures of macromolecular assemblies from a wide range of biological systems. One major interest includes understanding the structural details of protein assemblies on the surface of bacterial pathogens. We are also interested in the structural and details of these assemblies’ interactions with host immune and extracellular proteins as well as the atomistic and molecular organization of mammalian extracellular assemblies relevant to immunity and diseases such as fibrosis.

Carson C. Cole, Mark A. B. Kreutzberger, Kevin Klein, Kiana A. Cahue, Brett H. Pogostin, Adam C. Farsheed, Joseph W. R. Swain, Thi H. Bui, Arghadip Dey, Jonathan T. Makhoul, Marija Dubackic, Antara Pal, Ulf Olsson, Anđela Šarić, Edward H. Egelman, Jeffrey D. Hartgerink

Biomacromolecules. 2026 April; 10.1021/acs.biomac.6c00345

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Kudryashova E, Kreutzberger MAB, Niedzialkowska E, Dong S, Kudryashov DS, Egelman EH

Proceedings of the National Academy of Sciences of the United States of America. 2025 November; 10.1073/pnas.2523856122

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Kreutzberger MAB, Yu LT, Bui TH, Hancu MC, Purdy MD, Osinski T, Kasson PM, Egelman EH, Hartgerink JD

ACS central science. 2025 February; 10.1021/acscentsci.5c00018

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Yu LT, Kreutzberger MAB, Bui TH, Hancu MC, Farsheed AC, Egelman EH, Hartgerink JD

Nature communications. 2024 November; 10.1038/s41467-024-54560-z

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Cheng Y, Kreutzberger MAB, Han J, Egelman EH, Cao Q

Nature communications. 2024 September; 10.1038/s41467-024-52422-2

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Sonani RR, Palmer LK, Esteves NC, Horton AA, Sebastian AL, Kelly RJ, Wang F, Kreutzberger MAB, Russell WK, Leiman PG, Scharf BE, Egelman EH

Nature communications. 2024 January; 10.1038/s41467-024-44959-z

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Mark A.B. Kreutzberger, Ravi R. Sonani, Edward H. Egelman

Quarterly Reviews of Biophysics. 2024 January; 10.1017/S0033583524000155

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Marko Nedeljković, Mark A. B. Kreutzberger, Sandra Postel, Daniel Bonsor, Yingying Xing, Neil Jacob, William J. Schuler, Edward H. Egelman, Eric J. Sundberg

PLOS Pathogens. 2023 May; 10.1371/journal.ppat.1010979

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Mark A.B. Kreutzberger, Ravi R. Sonani, Junfeng Liu, Sharanya Chatterjee, Fengbin Wang, Amanda L. Sebastian, Priyanka Biswas, Cheryl Ewing, Weili Zheng, Frédéric Poly, Gad Frankel, B.F. Luisi, Chris R. Calladine, Mart Krupovic, Birgit E. Scharf, Edward H. Egelman

Cell. 2022 September; 10.1016/j.cell.2022.08.009

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Mark A. B. Kreutzberger, Shengyuan Wang, Leticia C. Beltran, Abraham Tuachi, Xiaobing Zuo, Edward H. Egelman, Vincent P. Conticello

Proceedings of the National Academy of Sciences. 2022 May; 10.1073/pnas.2121586119

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Mark A. B. Kreutzberger, Richard C. Sobe, Amber B. Sauder, Sharanya Chatterjee, Alejandro Peña, Fengbin Wang, Jorge A. Giron, Volker Kiessling, Tiago R. D. Costa, Vincent P. Conticello, Gad Frankel, Melissa M. Kendall, Birgit E. Scharf, Edward H. Egelman

Nature Communications. 2022 March; 10.1038/s41467-022-29069-y

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Mark A. B. Kreutzberger, Cheryl Ewing, Frederic Poly, Fengbin Wang, Edward H. Egelman

Proceedings of the National Academy of Sciences. 2020 July; 10.1073/pnas.2010996117

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