Changxi Li

AAFC Professor and Chair of Bovine Genomics, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept

Contact

AAFC Professor and Chair of Bovine Genomics, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept
Email
changxi.li@ualberta.ca
Phone
(780) 492-5248
Address
2-41 General Services Building
9007 - 116 St NW
Edmonton AB
T6G 2H1

Overview

About

Degree

PhD, University of Alberta

Job/Research Area

Bovine Genomics


Research

Major Responsibilities/Research Interests

My team conducts research in bovine quantitative genetics and functional genomics. Our current research interests and activities include: (1) identification and characterization of genes for economically important traits including growth, feed efficiency, fat deposition, carcass merit traits, and fertility traits in beef cattle; (2) investigation of functions of DNA polymorphisms and elucidation of genetic mechanisms regulating growth, feed efficiency, fat deposition, meat quality, and fertility traits in beef cattle; (3) development of genomic tools to enable the beef industry to improve the above mentioned traits through genomic selection and genome assisted management.

Courses

AFNS 585 - Advanced Quantitative Genomics

Genetics and analysis of quantitative traits in farm animals and plants. Detecting, locating and measuring effects of quantitative trait loci (QTL). Recent developments in QTL mapping and discovery. The laboratory sessions include commonly used software for analyzing data from breeding and genomics experiments. Normally offered in alternate years. Prerequisite: consent of instructor.

Winter Term 2021
AN SC 485 - Animal Genetics and Breeding

Application of genetic/genomic principles and methods to the improvement of livestock and poultry. Prerequisite: AN SC 384 or consent of instructor.

Winter Term 2021

Browse more courses taught by Changxi Li

Publications

Genetic architecture of quantitative traits in beef cattle revealed by genome wide association studies of imputed whole genome sequence variants: II: carcass merit traits
Author(s): Yining Wang, Feng Zhang, Robert Mukiibi, Liuhong Chen, Michael Vinsky, Graham Plastow, John Basarab, Paul Stothard & Changxi Li
Publication Date: 1/13/2020
Publication: BMC Genomics
Issue: 21
Page Numbers: 38
External Link: https://doi.org/10.1186/s12864-019-6273-1
Genetic architecture of quantitative traits in beef cattle revealed by genome wide association studies of imputed whole genome sequence variants: I: feed efficiency and component traits
Author(s): Feng Zhang, Yining Wang, Robert Mukiibi, Liuhong Chen, Michael Vinsky, Graham Plastow, John Basarab, Paul Stothard & Changxi Li
Publication Date: 1/13/2020
Publication: BMC Genomics
Volume: 21
Page Numbers: 36
External Link: https://doi.org/10.1186/s12864-019-6362-1
Liver transcriptome profiling of beef steers with divergent growth rate, feed intake, or metabolic body weight phenotypes (EDITOR'S CHOICE)
Author(s): Robert Mukiibi, Michael Vinsky, Kate Keogh, Carolyn Fitzsimmons, Paul Stothard, Sinéad M Waters, Changxi Li
Publication Date: 10/4/2019
Publication: Journal of Animal Science
Volume: 97
Issue: 11
Page Numbers: 4386–4404
External Link: https://doi.org/10.1093/jas/skz315
Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle
Author(s): Fuyong Li, Changxi Li, Yanhong Chen, Junhong Liu, Chunyan Zhang, Barry Irving, Carolyn Fitzsimmons, Graham Plastow & Le Luo Guan
Publication Date: 6/13/2019
Publication: Microbiome
Volume: 7
Page Numbers: 92
External Link: https://doi.org/10.1186/s40168-019-0699-1
Evaluation of a genomic-enhanced sorting system for feeder cattle
Author(s): Everestus C. Akanno, Chinyere Ekine-Dzivenu, Liuhong Chen, Michael Vinsky, Mohammed K. Abo-Ismail, Michael D. MacNeil, Graham Plastow, John Basarab, Changxi Li, Carolyn Fitzsimmons
Publication Date: 3/1/2019
Publication: Journal of Animal Science
Volume: 97
Issue: 3
Page Numbers: 1066–1075
External Link: https://doi.org/10.1093/jas/skz026
Genome-wide association scan for heterotic quantitative trait loci in multi-breed and crossbred beef cattle
Author(s): Everestus C. Akanno, Liuhong Chen, Mohammed K. Abo-Ismail, John J. Crowley, Zhiquan Wang, Changxi Li, John A. Basarab, Michael D. MacNeil & Graham S. Plastow
Publication Date: 10/5/2018
Publication: Genetics Selection Evolution
Volume: 50
Page Numbers: 48
External Link: https://doi.org/10.1186/s12711-018-0405-y
Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle
Author(s): Robert Mukiibi, Michael Vinsky, Kate A. Keogh, Carolyn Fitzsimmons, Paul Stothard, Sinéad M. Waters & Changxi Li
Publication Date: 5/18/2018
Publication: Scientific Reports
Volume: 8
Page Numbers: 7303
External Link: https://doi.org/10.1038/s41598-018-25605-3
Modeling heterotic effects in beef cattle using genome-wide SNP-marker genotypes
Author(s): Everestus C Akanno, Mohammed K Abo-Ismail, Liuhong Chen, John J Crowley, Zhiquan Wang, Changxi Li, John A Basarab, Michael D MacNeil, Graham S Plastow
Publication Date: 1/24/2018
Publication: Journal of Animal Science
Volume: 96
Issue: 3
Page Numbers: 830–845
External Link: https://doi.org/10.1093/jas/skx002
Phenotypic and genetic correlations of fatty acid composition in subcutaneous adipose tissue with carcass merit and meat tenderness traits in Canadian beef cattle
Author(s): C. Ekine-Dzivenu, M. Vinsky, J. A. Basarab, J. L. Aalhus, M. E. R. Dugan, C. Li
Publication Date: 12/1/2017
Publication: Journal of Animal Science
Volume: 95
Issue: 12
Page Numbers: 5184–5196
External Link: https://doi.org/10.2527/jas2017.1966
Phenotypic and genetic relationships of residual feed intake measures and their component traits with fatty acid composition in subcutaneous adipose of beef cattle
Author(s): F. Zhang, C. Ekine-Dzivenu, M. Vinsky, J. A. Basarab, J. L. Aalhus, M. E. R. Dugan and C. Li
Publication Date: 7/1/2017
Publication: Journal of Animal Science
Volume: 95
Issue: 7
Page Numbers: 2813–2824
External Link: https://doi.org/10.2527/jas.2017.1451
Genotype Imputation Methods and Their Effects on Genomic Predictions in Cattle
Author(s): Yining Wang, Guohui Lin, Changxi Li & Paul Stothard
Publication Date: 2/21/2017
Publication: Springer Science Reviews
Volume: 4
Page Numbers: 79–98
External Link: https://doi.org/10.1007/s40362-017-0041-x
Accuracy of genomic predictions for feed efficiency traits of beef cattle using 50K and imputed HD genotypes
Author(s): D. Lu, E. C. Akanno, J. J. Crowley, F. Schenkel, H. Li, M. De Pauw, S. S. Moore, Z. Wang, C. Li, P. Stothard, G. Plastow, S. P. Miller, J. A. Basarab
Publication Date: 4/1/2016
Publication: Journal of Animal Science
Volume: 94
Issue: 4
Page Numbers: 1342–1353
External Link: https://doi.org/10.2527/jas.2015-0126
Genome-wide association and genomic prediction of breeding values for fatty acid composition in subcutaneous adipose and longissimus lumborum muscle of beef cattle
Author(s): Liuhong Chen, Chinyere Ekine-Dzivenu, Michael Vinsky, John Basarab, Jennifer Aalhus, Mike E. R. Dugan, Carolyn Fitzsimmons, Paul Stothard and Changxi Li
Publication Date: 11/21/2015
Publication: BMC Genetics
Volume: 16
Issue: 135
Page Numbers: 1-15
External Link: https://doi.org/10.1186/s12863-015-0290-0
Accuracy of predicting genomic breeding values for carcass merit traits in Angus and Charolais beef cattle
Author(s): Chen, L.,Vinsky, M., and Li, C
Publication Date: 2015
Publication: Animal Genetics
Volume: 46
Page Numbers: 55–59

Estimates of genetic parameters for fatty acids in brisket adipose tissue of Canadian commercial crossbred beef steers
Author(s): Ekine-Dzivenu, C., Chen, L., Vinsky, M.D., Aldai, N., Dugan, M.E.R, McAllister, T.A., Wang, Z., Okine, E., and Li, C.
Publication Date: 2014
Publication: Meat Science
Volume: 96
Issue: 4
Page Numbers: 1517-1526

Estimation of genomic breeding values for residual feed intake in a multibreed cattle population
Author(s): Khansefid, M., Pryce, J.E., Bolormaa, S., Miller, S.P., Wang, Z., Li, C., and Goddard, M.E.
Publication Date: 2014
Publication: Journal of Animal Science
Volume: 92
Issue: 8
Page Numbers: 3270-3283

Heritability estimates of conjugated linoleic acid isomers in brisket adipose tissue of Canadian crossbred beef steers
Author(s): Li, C., Ekine-Dzivenu, C., Chen, L., Vinsky, M. D., Aldai, N., Dugan, M.E.R, and McAllister, T.A.
Publication Date: 2014
Publication: Proc.10th World Congress on Genetics Applied to Livestock Production. Paper 588.

Impact of genotype imputation on the performance of GBLUP and Bayesian methods for genomic prediction
Author(s): Chen, L., Li, C., Sargolzaei, M., and Schenkel, F.S.
Publication Date: 2014
Publication: PLoS ONE
Volume: 9
Issue: 7
Page Numbers: e101544

Impact of reference population on accuracy of imputation from 6K to 50K single nucleotide polymorphism chips in purebred and crossbreed beef cattle
Author(s): Ventura, R., Lu, D., Schenkel, F.S., Wang, Z., Li, C., and Miller, S.P.
Publication Date: 2014
Publication: Journal of Animal Science
Volume: 92
Issue: 4
Page Numbers: 1433-1444

Multi-population genomic prediction using a multi-task Bayesian learning model
Author(s): Chen, L., Li, C., Miller, S.P., and Schenkel, F.S.
Publication Date: 2014
Publication: BMC Genetics
Volume: 15
Issue: 53

Phenotypic and genetic relationships of feeding behavior with feed intake, growth performance, feed efficiency, and carcass merit traits in Angus and Charolais steers
Author(s): Chen, L., Mao, F., Crews, Jr., D.H., Vinsky, M.D., and Li, C.
Publication Date: 2014
Publication: Journal of Animal Science
Volume: 92
Issue: 3
Page Numbers: 974-983

Plasma metabolites associated with residual feed intake and other productivity performance traits in beef cattle
Author(s): Karisa, B.K., Thomson, J., Wang, Z., Li, C., Montanholi, Y.R., Miller, S.P., Moore, S.S., and Plastow, G.
Publication Date: 2014
Publication: Livestock Science
Volume: 165
Issue: 1
Page Numbers: 200-211

Accuracy of predicting genomic breeding values for residual feed intake in Angus and Charolais beef cattle
Author(s): Chen, L., Schenkel, F.S., Vinsky, M.D., Crews, Jr., D.H., and Li, C
Publication Date: 2013
Publication: Journal of Animal Science
Volume: 91
Page Numbers: 4669-4678

Association analyses of a single nucleotide polymorphism in the promoter of OLR1 with growth, feed efficiency, fat deposition, and carcass merit traits in hybrid, Angus and Charolais beef cattle. Short Communication
Author(s): Vinsky, M.D., Islam, K.K., Chen, L., and Li, C
Publication Date: 2013
Publication: Canadian Journal of Animal Science
Volume: 93
Issue: 2
Page Numbers: 193-197

Association analyses of DNA polymorphisms in bovine SREBP-1, LXRα, FADS1 genes with fatty acid composition in Canadian commercial crossbred beef steers
Author(s): Han, C., Vinsky, M.D., Aldai, N., Dugan, M.E.R, McAllister, T.A., and Li, C
Publication Date: 2013
Publication: Meat Science
Volume: 93
Issue: 3
Page Numbers: 429-436

Association analysis for feed efficiency traits in beef cattle using preserved haplotypes
Author(s): Lu, D., Sargolzaei, M., Li, C., Abo-Ismail, M., Voort, G.V., Wang, Z., Plastow, G., Moore, S.S., and Miller, S.P.
Publication Date: 2013
Publication: Genome
Volume: 56
Page Numbers: 586-591

Phenotypic and genetic relationships of feed efficiency with growth performance, ultrasound and carcass merit traits in Angus and Charolais steers
Author(s): Mao, F., Chen, L., Vinsky, M.D., Okine, E.K., Wang, Z., Basarab, J.A., Crews, Jr., D.H., and Li, C
Publication Date: 2013
Publication: Journal of Animal Science
Volume: 91
Issue: 5
Page Numbers: 2067-2076

Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial crossbred beef steers
Author(s): Li, C., Aldai, N., Vinsky, M.D., Dugan, M.E.R, and McAllister, T.A.
Publication Date: 2012
Publication: Animal Genetics
Volume: 43
Page Numbers: 94-97

Linkage disequilibrium in Angus, Charolais, and Crossbred beef cattle
Author(s): Lu, D., Sargolzaei, M., Kelly, M., Li, C., Vander Voort, G., Wang, Z., Plastow, G., Moore, S.S., and Miller, S.P.
Publication Date: 2012
Publication: Frontiers in Genetics
Volume: 3
Page Numbers: 152

Whole genome fine mapping of QTL for ultrasound and carcass merit traits in beef cattle
Author(s): Nalaila, S.M., Stothard, P., Moore, S.S., Wang, Z., and Li, C
Publication Date: 2011
Publication: Canadian Journal of Animal Science
Volume: 91
Issue: 1
Page Numbers: 61-73

Associations of a bovine SCD1 SNP with fatty acid composition in concentrate-finished yearling bulls of different muscular hypertrophy genotypes
Author(s): Li, C., Vinsky, M.D., Aldai, N., Osoro, K., and Dugan, M.E.R.
Publication Date: 2010
Publication: Proc. 9th World Congress on Genetics Applied to Livestock Production (WCGALP). 505.

Association analyses of a SNP in the promoter of IGF1 with fat deposition and carcass merit traits in hybrid, Angus and Charolais beef cattle
Author(s): Islam, K. K., Vinsk, M., Crews, R., Okine, E., Moore, S. S., Crews Jr. D. H., and Li, C
Publication Date: 2009
Publication: Animal Genetics
Volume: 40
Page Numbers: 766-769

Fine mapping quantitative trait loci for feed intake and feed efficiency in beef cattle
Author(s): Sherman, E. L., J. D. Nkrumah, C. Li, R. Bartusiak, B. Murdoch, and S. S. Moore
Publication Date: 2009
Publication: J. Anim Sci.
Volume: 87
Page Numbers: 37-45

Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle
Author(s): Sherman, E. L., Nkrumah, J. D., Murdoch, B. M., Li, C., Wang, Z., Fu, A., and Moore, S. S.
Publication Date: 2008
Publication: J. Anim. Sci.
Volume: 86
Page Numbers: 1-16

Primary genome scan to identify putative quantitative trait loci for feedlot growth rate, feed intake, and feed efficiency of beef cattle
Author(s): Nkrumah, J. D., Sherman, E. L., Li, C., Marques, E., Crews, D. H., Bartusiak, R., Murdoch, B., Wang, Z., Basarab, J. A., and Moore. S. S.
Publication Date: 2007
Publication: J. Anim. Sci.
Volume: 85
Page Numbers: 3170-3181

A genome-wise scan for quantitative trait affecting ultrasound and carcass backfat thickness in beef cattle
Author(s): Li, C., J.D. Nkrumah, R. Bartusiak, A. Fu, B.M. Murdoch, E.L. Sherman, S.D. McKay, Z. Wang, D.H. Crews, Jr., and S.S. Moore
Publication Date: 2006
Publication: Proc. 8th World Congress on Genetics Applied to Animal Production. Communication 03-53

Polymorphisms in the bovine leptin promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit
Author(s): Nkrumah, J.D., C. Li, J. Yu, C. Hansen, D.H. Keisler, and S.S. Moore
Publication Date: 2005
Publication: Journal of Animal Science
Volume: 83
Page Numbers: 20-28

Assessment of positional candidate genes MYF5 and IGF1 for growth on bovine chromosome 5 in commercial lines of Bos taurus
Author(s): Li, C., J. Basarab, W.M. Snelling, B. Benkel, B. Murdoch, C. Hansen, and S.S. Moore
Publication Date: 2004
Publication: Journal of Animal Science
Volume: 82
Page Numbers: 1-7

Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition
Author(s): Nkrumah, J.D., C. Li, J.B. Basarab, S. Guercio, Y. Meng, B. Murdoch, C. Hansen, and S.S. Moore
Publication Date: 2004
Publication: Canadian Journal of Animal Science
Volume: 84
Page Numbers: 211-219

Identification and fine mapping of QTL for backfat on bovine chromosome 2, 5, 6, 19, 21 and 23 in a commercial line of Bos taurus
Author(s): Li, C., J. Basarab, W.M. Snelling, B. Benkel, J. Kneeland, B. Murdoch, C. Hansen, and S.S. Moore
Publication Date: 2004
Publication: Journal of Animal Science
Volume: 82
Page Numbers: 967-972

Identification and fine mapping of quantitative trait loci for growth traits on bovine chromosome 2, 6, 14, 19, 21 and 23 within one commercial line of Bos taurus
Author(s): Kneeland, J., C. Li., J. Basarab, W.M. Snelling, B. Benkel, B. Murdoch, C. Hansen, and S.S. Moore
Publication Date: 2004
Publication: Journal of Animal Science
Volume: 82
Page Numbers: 3405-3414

Fine mapping of QTL and assessment of positional candidate genes for backfat on bovine chromosome 14 in a commercial line of Bos taurus
Author(s): Moore, S.S., C. Li, J. Basarab, W.M. Snelling, J. Kneeland, B. Murdoch, C. Hansen, and B. Benkel
Publication Date: 2003
Publication: Journal of Animal Science
Volume: 81
Page Numbers: 1919-1925

The identification of common haplotypes on bovine chromosome 5 within commercial lines of Bos taurus and their associations with growth traits
Author(s): Li. C., J. Basarab, W.M. Snelling, B. Benkel, B. Murdoch, and S.S. Moore
Publication Date: 2002
Publication: Journal of Animal Science
Volume: 80
Page Numbers: 1187-1194