L Li, PhD

Professor, Faculty of Science - Chemistry


Professor, Faculty of Science - Chemistry
(780) 492-3250
W3-39C Chemistry Centre - West
11227 Saskatchewan Drive NW
Edmonton AB
T6G 2G2



Please visit the Li Group Website: http://liweb.chem.ualberta.ca/.


Dr. Li's research is in the area of analytical mass spectrometry (MS). The major objectives of the research are to develop advanced methods and strategies, primarily based on MS, for the detection and characterization of biological molecules including proteins (proteomics) and metabolites (metabolomics), and to apply these methods to study real-world biological systems. The latter is being accomplished through active collaboration with researchers at the forefront of their disciplines.

For students who are interested in Analytical Chemistry, Dr. Li's lab provides a good learning environment for state-of-the-art analytical techniques and methods, including biological and pharmaceutical sample handling methods, chemical separation techniques (e.g., multi-dimensional liquid chromatography), mass spectrometry (e.g., TOF MS, Ion trap MS, FT-MS, and tandem MS), and data processing/bioinformatics tools.

For students with strong biology background (e.g., an undergraduate degree in biological sciences or biochemistry) who are interested in Chemical Biology, Dr. Li's group offers the unique opportunity for training in both chemistry and biology, with the assistance of collaborators in biosciences such as faculty members in Biological Sciences, Biochemistry, Cell Biology, Oncology, and Computational Biology. Joint supervision of a chemical biology research project can also be arranged. We are particularly interested in applying analytical techniques and methods in solving biological problems. These include metabolomics and proteomics applications in systems biology and disease biomarker discovery research.


    Chem 425/518 Analytical Mass Spectrometry

    Chem 618 Advanced Analytical Mass Spectrometry

    Chem 623 Special Topics in Analytical Chemistry: Omics Technologies

    Chem 211/213 Introduction to Analytical Chemistry


    CHEM 425 - Separations and Mass Spectrometry

    Concepts and techniques in chromatography, mass spectrometry, and chromatography/MS combinations. Examples of modern instrumentation as well as applications to chemical, biochemical, and biomedical analysis. Prerequisite: CHEM 313.

    CHEM 516 - Separations

    Six week course on separations with topics that may include LC, GC, intermolecular forces, retention mechanisms, gradient elution, separation optimization, band broadening, HPLC modes-reversed phase, size exclusion, ion exchange, HILIC. Not open to students with credit in CHEM 425.

    CHEM 518 - Mass Spectrometry

    Six week course on mass spectrometry with topics that may include mass analyzers, sample introduction techniques, ionization techniques, ion detection and data systems, applications. Not open to students with credit in CHEM 425.

    CHEM 623 - Special Topics in Advanced Analytical Chemistry

    Course may be repeated for credit, provided there is no duplication of specific topic.

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