Lawrence Richer, MD, MSc

Area of Study / Keywords

concussion health services emergency department migraine autonomic nervous system headache orthostatic intolerance real-world evidence postural orthostatic tachycardia syndrome

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About

I am a Pediatric Neurologist and Professor in the Department of Pediatrics. I serve as Associate Dean of Research for the College of Health Sciences and Center as Director of the Northern Alberta Clinical Trials and Research Center.

Clinical Interests

1. Pediatric migraine and headache disorders
2. Pediatric autonomic disorders and Postural Orthostatic Tachycardia Syndrome

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Research

My research focuses on three interrelated areas:

1. I am interested in exploring the autonomic, neuroimaging, metabolic and inflammatory underpinnings of disorders with overlapping neurological and autonomic symptoms (headache, brain fog, postural intolerance, and fatigue). By studying chronic migraine, concussion, Postural Orthostatic Tachycardia Syndrome (POTS), Long COVID, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in parallel, we aim to identify shared biological mechanisms, potential biomarkers, and novel therapeutic targets that span traditional diagnostic boundaries. 
2. Development and evaluation of new therapeutics through clinical trials. A better understanding of the pathophysiologic mechanisms of these Multi-Symptom Chronic Conditions may present novel therapeutic targets, and I am keen to lead or support clinical trials that evaluate new therapies.
3. Innovation in the conduct of clinical trials and real-world studies. The evidence gap for treatments in children may be reduced when existing health data and innovative or pragmatic study designs are employed. 

Phuong Uyen Nguyen, Huong Luu, Helen So, Khanh Vu, Karen J.B. Martins, Werner J. Becker, Farnaz Amoozegar, Thilinie Rajapakse, Lawrence Richer, Tyler Williamson, Scott W. Klarenbach

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2025 March; 10.1017/cjn.2025.40

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Rachel J. Skow, Stephen J. Foulkes, Peter Seres, Meghan A. Freer, Eric D. Mathieu, Satish R. Raj, Richard B. Thompson, Mark H. Haykowsky, Lawrence Richer

Physiological Reports. 2024 March; 10.14814/phy2.15979

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Daniel S Tsze, Nathan Kuppermann, T Charles Casper, Bradley J Barney, Lawrence P Richer, Danica B Liberman, Pamela J Okada, Claudia R Morris, Sage R Myers, Jane K Soung, Rakesh D Mistry, Lynn Babcock, Sandra P Spencer, Michael D Johnson, Eileen J Klein, Kimberly S Quayle, Dale W Steele, Andrea T Cruz, Alexander J Rogers, Danny G Thomas, Jacqueline M Grupp-Phelan, Tiffani J Johnson, Peter S Dayan

BMJ Open. 2023 November; 10.1136/bmjopen-2023-079040

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Lawrence Richer, Huong Luu, Karen J. B. Martins, Khanh Vu, Alexis Guigue, Kai On Wong, Phuong Uyen Nguyen, Thilinie Rajapakse, Tyler Williamson, Scott W. Klarenbach

Headache: The Journal of Head and Face Pain. 2023 October; 10.1111/head.14613

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Lawrence P. Richer, Qiming Tan, Merlin G. Butler, Hayford M. Avedzi, Darren S. DeLorey, Ye Peng, Hein M. Tun, Arya M. Sharma, Steven Ainsley, Camila E. Orsso, Lucila Triador, Michael Freemark, Andrea M. Haqq

International Journal of Molecular Sciences. 2023 April; 10.3390/ijms24098013

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Wong KO, Klarenbach SW, Martins KJB, Chue P, Dursun SM, Snaterse M, Guigue A, So H, Luu H, Vu K, Richer L

2022 July; 22 (1):444 10.1186/s12888-022-04075-y

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Richer LP, Ali S, Johnson DW, Rosychuk RJ, Newton AS, Rowe BH

2022 June; 62 (6):681-9 10.1111/head.14307

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Lawrence P. Richer, Samina Ali, David W. Johnson, Rhonda J. Rosychuk, Amanda S. Newton, Brian H. Rowe

Headache: The Journal of Head and Face Pain. 2022 June; 10.1111/head.14307

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Ali S, Hopkin , Poonai N, Richer L, Yaskina M, Heath A, Klassen TP, McCabe C on behalf of the KidsCAN PERC Innovative Pediatric Clinical Trials No OUCH Study Group & the KidsCAN PERC Innovative Pediatric Clinical Trials Methods Core

2021 March; 22 (206) 10.1186/s13063-021-05164-1

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Satish R. Raj, Juan C. Guzman, Paula Harvey, Lawrence Richer, Ronald Schondorf, Colette Seifer, Nicolas Thibodeau-Jarry, Robert S. Sheldon

Canadian Journal of Cardiology. 2020 March; 10.1016/j.cjca.2019.12.024

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Journal of Pediatrics. 2020 January; 10.1016/j.jpeds.2020.02.018

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Lauren E Kelly, Lawrence Richer, Samina Ali, Amy C Plint, Naveen Poonai, Stephen B Freedman, Lisa Knisley, Carolyn Shimmin, Serena Hickes, Geert W ’t Jong, Petros Pechlivanoglou, Martin Offringa, Thierry Lacaze, Terry P Klassen

BMJ Open. 2019 June; 10.1136/bmjopen-2019-029024

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PharmacoEconomics - Open. 2019 January; 10.1007/s41669-019-0137-0

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Journal of Neurotrauma. 2019 January; 10.1089/neu.2018.6009

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Neuropsychology. 2018 January; 10.1037/neu0000419

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Journal of Neurosurgery: Pediatrics. 2017 January; 10.3171/2016.10.PEDS16449

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Metabolism: Clinical and Experimental. 2017 January; 10.1016/j.metabol.2017.01.020

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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2017 January; 10.18433/J3DH0V

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Cochrane Database of Systematic Reviews. 2016 January; 10.1002/14651858.CD005220.pub2

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JAMA - Journal of the American Medical Association. 2016 January; 10.1001/jama.2016.1203

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Current Pain and Headache Reports. 2015 January; 10.1007/s11916-014-0473-9

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Cephalalgia. 2015 January; 10.1177/0333102414539056

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Lawrence Richer, William Craig, Brian Rowe

Headache: The Journal of Head and Face Pain. 2014 October; 10.1111/head.12443

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2014 January; 10.1186/1745-6215-15-271

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2008 January;

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2007 January; 10.1111/j.1526-4610.2007.00782.x

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2005 January; 10.1002/14651858.cd005220

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