Lawrence Richer, MD, MSc

Area of Study / Keywords

concussion health services emergency department migraine autonomic nervous system headache orthostatic intolerance real-world evidence postural orthostatic tachycardia syndrome

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About

I am a Pediatric Neurologist and Professor in the Department of Pediatrics. I serve as Associate Dean of Research for the College of Health Sciences and Center as Director of the Northern Alberta Clinical Trials and Research Center.

Clinical Interests

1. Pediatric migraine and headache disorders
2. Pediatric autonomic disorders and Postural Orthostatic Tachycardia Syndrome

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Research

My research focusses on three interrelated areas:

1. Evaluation of functional changes in the autonomic nervous system (ANS) and brain in children with migraine, brain injury, and pediatric autonomic disorders like Postural Orthostatic Tachycardia Syndrome (POTS). The ANS is a dynamic system responsible for the maintenance of a stable internal environment and responding rapidly to external challenges or threats. Functional changes in the ANS are observed in the above disorders are initially adaptive, but these changes may become maladaptive over time - often as the disorder becomes chronic or with severe injury. Changes in the ANS may be predictive of undesirable clinical outcomes providing an early warning sign to consider earlier intervention. 
2. Development and evaluation of new therapeutics for children. A better understanding of the pathophysiologic mechanisms of disorders like migraine, concussion, or POTS may present novel therapeutic targets. Treatments intending to be used in children need to be tested in children for their efficacy and safety.
3. Innovative clinical trials and real-world studies. The evidence gap for treatments in children may be reduced when existing health data and innovative or pragmatic study designs are employed. 

Daniel S Tsze, Nathan Kuppermann, T Charles Casper, Bradley J Barney, Lawrence P Richer, Danica B Liberman, Pamela J Okada, Claudia R Morris, Sage R Myers, Jane K Soung, Rakesh D Mistry, Lynn Babcock, Sandra P Spencer, Michael D Johnson, Eileen J Klein, Kimberly S Quayle, Dale W Steele, Andrea T Cruz, Alexander J Rogers, Danny G Thomas, Jacqueline M Grupp-Phelan, Tiffani J Johnson, Peter S Dayan

BMJ Open. 2023 November; 10.1136/bmjopen-2023-079040

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Lawrence Richer, Huong Luu, Karen J. B. Martins, Khanh Vu, Alexis Guigue, Kai On Wong, Phuong Uyen Nguyen, Thilinie Rajapakse, Tyler Williamson, Scott W. Klarenbach

Headache: The Journal of Head and Face Pain. 2023 October; 10.1111/head.14613

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Lawrence P. Richer, Qiming Tan, Merlin G. Butler, Hayford M. Avedzi, Darren S. DeLorey, Ye Peng, Hein M. Tun, Arya M. Sharma, Steven Ainsley, Camila E. Orsso, Lucila Triador, Michael Freemark, Andrea M. Haqq

International Journal of Molecular Sciences. 2023 April; 10.3390/ijms24098013

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Wong KO, Klarenbach SW, Martins KJB, Chue P, Dursun SM, Snaterse M, Guigue A, So H, Luu H, Vu K, Richer L

2022 July; 22 (1):444 10.1186/s12888-022-04075-y

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Richer LP, Ali S, Johnson DW, Rosychuk RJ, Newton AS, Rowe BH

2022 June; 62 (6):681-9 10.1111/head.14307

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Ali S, Hopkin , Poonai N, Richer L, Yaskina M, Heath A, Klassen TP, McCabe C on behalf of the KidsCAN PERC Innovative Pediatric Clinical Trials No OUCH Study Group & the KidsCAN PERC Innovative Pediatric Clinical Trials Methods Core

2021 March; 22 (206) 10.1186/s13063-021-05164-1

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Satish R. Raj, Juan C. Guzman, Paula Harvey, Lawrence Richer, Ronald Schondorf, Colette Seifer, Nicolas Thibodeau-Jarry, Robert S. Sheldon

Canadian Journal of Cardiology. 2020 March; 10.1016/j.cjca.2019.12.024

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Journal of Pediatrics. 2020 January; 10.1016/j.jpeds.2020.02.018

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Lauren E Kelly, Lawrence Richer, Samina Ali, Amy C Plint, Naveen Poonai, Stephen B Freedman, Lisa Knisley, Carolyn Shimmin, Serena Hickes, Geert W ’t Jong, Petros Pechlivanoglou, Martin Offringa, Thierry Lacaze, Terry P Klassen

BMJ Open. 2019 June; 10.1136/bmjopen-2019-029024

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PharmacoEconomics - Open. 2019 January; 10.1007/s41669-019-0137-0

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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2017 January; 10.18433/J3DH0V

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JAMA - Journal of the American Medical Association. 2016 January; 10.1001/jama.2016.1203

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Cochrane Database of Systematic Reviews. 2016 January; 10.1002/14651858.CD005220.pub2

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Cephalalgia. 2015 January; 10.1177/0333102414539056

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Lawrence Richer, William Craig, Brian Rowe

Headache: The Journal of Head and Face Pain. 2014 October; 10.1111/head.12443

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