Lynne Sigler

Contact

Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept
Email
lynne.sigler@ualberta.ca

Overview

About
Major Responsibilities and Research Interests:
I curated the University of Alberta Microfungus Collection and Herbarium (UAMH) from 1969 to 2013, negotiated its transfer to the Dalla Lana School of Public Health, University of Toronto, in 2015 and continue to provide ad hoc assistance to the Collection now renamed as UAMH Centre for Global Microfungal Biodiversity. See links to UAMH  activities.
My research in fungal systematics is concerned with fungi that cause human and animal disease, produce toxins or metabolites of medicinal importance and occupy vertebrate-associated habitats. See current research areas and featured publications and Google scholar citations.

Research

Fungi causing cutaneous disease in reptiles. In recent research, we have described new genera Nannizziopsis, Paranannizziopsis and Ophidiomyces and species of pathogenic fungi that cause cutaneous and invasive diseases in captive and free-ranging reptiles. Nannizziopsis guarroi is the cause of skin infections in captive bearded dragons known as yellow fungus disease that impacts the commercial bearded dragon pet trade. Infections caused by Paranannizziopsis species are frequently fatal in aquatic snakes in zoological environments and they also pose a threat to captive tuataras. These reptiles of ancient lineage are being closely monitored in New Zealand and elsewhere (e.g. London Zoo) to ensure their health and conservation. Ophidiomyces ophiodiicola is the cause of snake fungal disease (SFD) in captive and free-ranging snakes and is an emergent global threat to populations of endangered wild snakes. The US National Wildlife Health Center now recognizes that, in laboratory and molecular evaluations, O. ophiodiicola is consistently associated with free ranging snakes with fungal dermatitis. Similarly, the Canadian Wildlife Health Cooperative (CWHC) identifies SFD is an emerging disease caused by O. ophiodiicola affecting wild snakes in eastern North America. In 2015, I confirmed for CWHC the first case in a sick snake in eastern Canada.

Systematics of dimorphic pathogens (Ajellomycetaceae). The study of Emmonsia species began in Alberta in the late 1940’s when fungal isolates were obtained from lungs of rodents. Many isolates from animals and human clinical sources were subsequently deposited in the UAMH Centre for Global Microfungal Diversity (see link). The two originally-described species, E. parva and E. crescens, do not cause disseminated disease, but rather a granulomatous lung disease in animals (and occasionally in humans) caused by inhalation of spores that inflate to form large spherules. Emmonsia species are closely related to the dimorphic fungi Blastomyces and Histoplasma species and together belong to a distinct lineage of the ascomycetes, the Ajellomycetaceae. Recent reports have identified Emmonsia-like fungi associated with many cases of mycoses among HIV+ individuals in South Africa and with infections in animals and humans in western North America. I am working with a consortium of scientists and clinicians to investigate the systematics of these unclassified isolates.

Publications

An overview of reptile fungal pathogens in the genera Nannizziopsis, Paranannizziopsis, and Ophidiomyces
Author(s): Paré J and Sigler L
Publication Date: 2016
Publication: Journal of Herpetological Medicine and Surgery
Volume: 26
Page Numbers: 46-53
External Link: http://dx.doi.org/10.1139/cjb-2016-0086
Dermatomycosis caused by Paranannizziopsis australasiensis in five tuatara (Sphenodon punctatus) and a coastal bearded dragon (Pogona barbata) in a zoological collection in New Zealand
Author(s): Masters NJ, Alexander S, Jackson B, Sigler L, Chatteron J, Harvey C, Gibson R, Humphrey S, RawdonTG, Spence RP, Ha HJ, McInnes K, Jakob-Hoff R
Publication Date: 2016
Publication: New Zealand Veterinary Journal (Clinical Communication)
Volume: 64
Page Numbers: 301-307
External Link: http://dx.doi.org/10.1080/00480169.2016.1177473
Fungi associated with hibernating bats in New Brunswick caves: the genus Leuconeurospora
Author(s): Malloch D, Sigler L, Hambleton S, Vanderwolf KA, Gibas CFC, McAlpine DF
Publication Date: 2016
Publication: Botany
Volume: 94
Issue: 12
Page Numbers: 1171–1181
External Link: http://dx.doi.org/10.1139/cjb-2016-0086
Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)
Author(s): 1. Dukik K, Muñoz JF, Jiang J, Feng P, Sigler L, Stielow JB, Freeke J, Jamalian A, van den Ende BG, McEwen JG, Clay OK, Schwartz IS, Govender NP, Maphanga TG, Cuomo CA, Moreno L, Kenyon C, Borman AM, de Hoog S
Publication Date: 2016
Publication: Mycoses
Volume: in press (acc 30 Dec 2016)
External Link: doi:10.1111/myc.12601
50 years of Emmonsia disease in humans: emergence of a cluster of novel fungal pathogens
Author(s): Schwartz, IS, Kenyon C, Feng P, Govender NP, Dukik K, Sigler L, Jiang Y, Stielow JB, Muñoz JF, Cuomo CA, Botha A, Stchigel AM, de Hoog GS
Publication Date: 2015
Publication: PLoS Pathogens
Volume: 11
Issue: 11
Page Numbers: e1005198
External Link: http://dx.doi.org/10.1371%2Fjournal.ppat.1005198
Molecular characterization of reptile pathogens currently known as members of the Chrysosporium anamorph of Nannizziopsis vriesii (CANV) complex and relationship with some human-associated isolates
Author(s): Sigler L, Hambleton S, Paré JA
Publication Date: 2013
Publication: Journal of Clinical Microbiology
Volume: 51
Page Numbers: 3338-3357
External Link: 10.1128/JCM.01465-13