Lorne Tyrrell, OC, AOE, MD, PhD, FRCPC, FRSC, FCAHS

Area of Study / Keywords

animal models hepatitis B hepatitis C

---

About

D. Lorne Tyrrell is a Distinguished University Professor at the University of Alberta. He is the Founding Director of the Li Ka Shing Institute of Virology. He has focused his research since 1986 on viral hepatitis. His work on the development of antiviral therapy was supported by CIHR and Glaxo Canada. It resulted in the licensing of the first oral antiviral agent to treat chronic hepatitis B infection - lamivudine - in 1998. Today, lamivudine is licensed in over 200 countries worldwide for the treatment of HBV. He worked with Drs Norm Kneteman and David Mercer to establish a biotech company, KMT Hepatech Inc. based on the first non-primate animal model for HCV. This company was purchased in 2017 by PhoenixBio, but remains in Edmonton.  

Dr. Tyrrell was the Dean of the Faculty of Medicine and Dentistry from 1994-2004. Since leaving the Deanship in 2004, Dr. Tyrrell has taken on a number of important board positions in healthcare in Alberta and Canada.  These include the Chair of the Gairdner Foundation Board, and member of the Research Advisory Council for the Canadian Institute for Advanced Research.  He also has been appointed to the Science Advisory Board to Health Canada.  In 2010, he became the Founding Director of the Li Ka Shing Institute of Virology.

For his studies on viral hepatitis, Dr. Tyrrell has received numerous prestigious awards including the Gold Medal of the Canadian Liver Foundation (2000), Officer of the Order of Canada (2002), Alberta Order of Excellence (2000) and Fellow of the Royal Society of Canada (2004).  He was inducted into the Canadian Medical Hall of Fame in April 2011 and was awarded the Killam Prize Health Sciences in May 2015. 

Since the COVID-19 pandemic, he has worked on antivirals and vaccines for SARS-CoV-2.  He is a member of the COVID-19 Vaccine Task Force that advises the Federal Government on the selection of COVID-19 vaccines based on efficacy, safety, and timely availability for Canada.  

IMIN 324 - Basic Virology

An introduction to the structure, replication, and taxonomy of bacteriophages, plant, insect, and animal viruses. Their role in disease and methods of control and detection is also discussed. Prerequisites: BIOL 207, IMIN 200 and BIOCH 200 or 205. May not be taken for credit if credit already obtained in INT D 224. (Offered jointly by the Departments of Biological Sciences and of Medical Microbiology and Immunology.) [Biological Sciences]

---

Browse more courses taught by Lorne Tyrrell

Arutyunova E, Belovodskiy A, Chen P, Khan MB, Joyce M, Saffran H, Lu J, Turner Z, Bai B, Lamer T, Young HS, Vederas JC, Tyrrell DL, Lemeiux MJ, Nieman JA

ACS Biom & MNed Chem Au. 2023 November; 10.1021/acsbiomedchemau.3c00039

---

Shahbaz S, Bozorgmehr N, Lu J, Osman M, Sligl W, Tyrrell DL, Elahi S

Microbiol Spectr. 2023 September; 10.1128/spectrum.01256-23

---

de Weerd NA, Ogungbola O, Liu X, Matthews AY, Ismail A, Vivian JP, Lim SS, Tyrrell DL, Putcha N, Skawinski M, Dickensheets H, Lavoie TB, Donnelly RP, Hertzog PJ, Santer DM

J Interferon Cytokine Res. 2023 September; 43 (9):403-413 10.1089/jir.2023.0040

---

Liang TJ, Law JLM, Pietschmann T, Ray SC, Bukh J, Bull R, Chung RT, Tyrrell DL, Houghton M, Rice CM

Clinical Infectious Diseases. 2023 August; 77 (Supplement 3) 10.1093/cid/ciad336

---

Santer DM, Li D, Ghoshe Y, Zahoor MA, Prajapati D, Hansen BE, Tyrrell DLJ, Feld JJ, Gehring AJ

Nature Communications. 2022 November; 13 10.1038/s41467-022-34709-4

---

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van BNelkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas & Joanne Lemieux

Nature Communications. 2022 September; 10.1038/s41457-020-18096-2

---

Babuadze G.G., Fausther-Bovendo H., deLaVega M.A., Lillie B., Naghibosadat M., Shahhosseini N., Joyce M.A., Saffran H.A., Lorne Tyrrell D., Falzarano D., Senthilkumaran C., Christie-Holmes N., Ahn S., Gray-Owen S.D., Banerjee A., Mubareka S., Mossman K., Dupont C., Pedersen J., Lafrance M.A., Kobinger G.P., Kozak R.

npj Vaccines. 2022 April; 7 (49):1-11 10.1038/s41541-022-00461-5

---

Liu Y, Kumblathan T, Feng W, Pang G, Tao J, Xu J, Xiao H, Joyce MA, Tyrrell DL, Zhang H, Li XF, Le XC

ACS Measurement Science. 2022 February; 2 doi.org/10.1021/acsmeasuresciau.1c00057

---

Aminpour M, Miranda-Delgado W, Wacker S, Noskov S, Houghton M, Tyrrell DL, Tuszynski JA

BMC Pharmacology & Toxicology. 2021 October; 22 (61):1-20 doi.org/10.1186/s40360-021-00519-5

---

Feng W, Peng H, Xu J, Liu Y, Pabbaraju K, Tipples G, Joyce MA, Saffran H, Tyrrell DL, Babiuk S, Zhang H, Le XC

ANALYTICAL CHEMISTRY. 2021 September; 93 (37):12808-12816 doi.org/10.1021/acs.analchem.1c03456

---

Law J, Logan M, Joyce MA, Landi A, Hockman D, Crawford K, Johnson J, LaChance G, Saffran HA, Shields J, Hobart E, Brassard R, Arutyunova E, Pabbaraju K, Croxen M, Tipples G, Lemieux MJ, Tyrrell DL, Houghton M

VACCINE. 2021 September; 39 (40):5769-5779 doi.org/10.1016/j.vaccine.2021.08.081

---

Bai B, Arutyunova E, Khan MB, Lu J, Joyce MA, Saffran H, Shields JA, Kandadai AS, Belovodskiy A, Hena M, Vuong W, Lamer T, Young H, Vederas J, Tyrrell DL, Lemieux J and Nieman J

RSC Medicinal Chemistry. 2021 August; 12 (10):1722-1730 doi: 10.1039/D1MD00247C

---

Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce M, Saffran H, Shields J, Khan M, Arutyunova E, Lu J, Bajwa S, Hockman D, Fischer C, Lamer T, Vuong W, Van Belkum M, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young H, Vederas J, Tyrrell DL, Lemieux MJ, Nieman J

JOURNAL OF MEDICINAL CHEMISTRY. 2021 July; 65 (4):2905-2925 doi: 10.1021/acs.jmedchem.1c00616

---

Le C, Liu Y, López-Orozc J, Joyce MA, Le XC, Tyrrell DL

ANALYTICAL CHEMISTRY. 2021 July; 93 (31):10756-10761 doi.org/10.1021/acs.analchem.1c02227

---

Arutyunova E, Khan MB, Fischer C, Lu J, Lamer T, Vuong W, van Belkum MJ, McKay R, Tyrrell DL, Vederas JC, Young HS, Lemieux MJ.

JOURNAL OF MOLECULAR BIOLOGY. 2021 June; 433 (13):167003 doi.org/10.1016/j.jmb.2021.167003

---

Feld J*, Kandel C*, Biondi NP*, Kozak RA, Lemieux C, Borgia S, Boggild A, Powis J, McCready J, Tan D, Chan T, Coburn B, Kumar D, Humar A, Chan A, O’Neil B, Noureldin S, Booth J, Hong R, Smookler D, Aleyadeh W, Patel A, Barber B, Casey J. Zahoor A, Hiebert R, Mistry H, Santer D, Tyrrell DLJ, Gleen JS, Gehring AJ, Janssen HLA, Hansen B. *Contributed equally to the work

The Lancet Respiratory Medicine. 2021 May; 9 (5):498-510 doi.org/10.1016/S2213-2600(20)30566-X

---

Vuong W, Fischer C, Khan MB, van Belkum M, Lamer T, Willoughby K, Lu J, Arutyunova E, Joyce MA, Saffran H, Shields J, Young H, Nieman J, Tyrrell DL, Lemieux MJ, Vederas J

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2021 May; 222 doi.org/10.1016/j.ejmech.2021.113584

---

Shahbaz S, Xu L, Osman M, Sligl W, Shields J, Joyce MA, Tyrrell DLJ, Oyegbami O, and Elahi S.

Stem Cell Reports. 2021 May; 16 10.1101.2020.08.18.255927

---

Pandey M, Ozberk V, Eskandari S, Shalash A, Joyce MA, Saffran HA, Day CJ, Lepletier A, Spillings BL, Mills J-L, Calcutt A, Fan F, Williams JT, Stanisic DI, Hattingh L, Gerrard J, Skwarczynski M, Mak J, Jennings MP, Toth I, Tyrrell DL, Good MF

Clinical & Translational Immunology. 2021 March; doi: 10.1002/cti2.1260

---

Stone D, Long KR, De Silva Feelixge HS, Kenkel EJ, Liley RM, Rapp S, Roychoudhury P, Nguyen T, Stensland L, Loprieno M, Weber ND, Le C, Wagoner J, Goecker EA, Tyrrell DLJ, Greninger AL, Huang ML, Polyak SJ, Aubert M, Sagartz JE, Jerome KR

Molecular Therapy-Methods & Clinical Development. 2021 March; 20 doi.org/10.1016/j.omtm.2020.11.014

---

Feng W, Newbigging A, Tao J, Cao Y, Peng H, Le C, Wu J, Pag B, Li J, Tyrrell DL, Zhang, H, Le X.

Chemical Science. 2021 February; 12 doi: 10.1039/d0sc06973f

---

Le C, Sirajee R, Steenbergen R, Joyce MA, Addison WR, Tyrrell DL

Viruses-Basel. 2021 January; 13 (97) doi.org/10.3390/v13010097

---

Freedman H, Kundu J, Tchesnokov E, Law J, Nieman J, Schinzai R, Tyrrell DL, Götte M, Houghton M.

Journal of Chemical Information and Modeling. 2020 December; 60 (12):6566-6578 doi: 10.1021/acs.jcim.0c00742

---

Pang B, Xu J, Liu Y, Peng H, Feng W, Cao Y, Wu J, Xiao H, Pabbaraju K, Tipples G, Joyce MA, Bandi H. Tyrrell DL, Zhang H, Le XC

ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2020 December; 92 doi: 10.1021/acs.analchem.0c04047

---

Onabajo OO, Banday AR, Stanifer ML, Yan W, Obajemu A, Santer DM, Florez-Vargas O, Piontkivska H, Vargas JM, Ring TJ, Kee C, Doldan P, Tyrrell DL, Mendoza JL, Boulant S, and Prokunina-Olsson L

NATURE GENETICS. 2020 October; 52 https://doi.org/10.1038/s41588-020-00731-9

---

View additional publications