Lorne Tyrrell, OC, AOE, MD, PhD, FRCPC, FRSC, FCAHS

Professor and Director, Li Ka Shing Institute of Virology; GSK Chair in Virology, Faculty of Medicine & Dentistry - Medical Microbiology and Immunology Dept


Professor and Director, Li Ka Shing Institute of Virology; GSK Chair in Virology, Faculty of Medicine & Dentistry - Medical Microbiology and Immunology Dept
(780) 492-8415
6010E Katz Group Centre For Research
11315 - 87 Ave NW
Edmonton AB
T6G 2H5


Area of Study / Keywords

animal models hepatitis B hepatitis C


D. Lorne Tyrrell is a Distinguished University Professor at the University of Alberta. He is the Founding Director of the Li Ka Shing Institute of Virology. He has focused his research since 1986 on viral hepatitis. His work on the development of antiviral therapy was supported by CIHR and Glaxo Canada. It resulted in the licensing of the first oral antiviral agent to treat chronic hepatitis B infection - lamivudine - in 1998. Today, lamivudine is licensed in over 200 countries worldwide for the treatment of HBV. He worked with Drs Norm Kneteman and David Mercer to establish a biotech company, KMT Hepatech Inc. based on the first non-primate animal model for HCV. This company was purchased in 2017 by PhoenixBio, but remains in Edmonton.  

Dr. Tyrrell was the Dean of the Faculty of Medicine and Dentistry from 1994-2004. Since leaving the Deanship in 2004, Dr. Tyrrell has taken on a number of important board positions in healthcare in Alberta and Canada.  These include the Chair of the Gairdner Foundation Board, and member of the Research Advisory Council for the Canadian Institute for Advanced Research.  He also has been appointed to the Science Advisory Board to Health Canada.  In 2010, he became the Founding Director of the Li Ka Shing Institute of Virology.

For his studies on viral hepatitis, Dr. Tyrrell has received numerous prestigious awards including the Gold Medal of the Canadian Liver Foundation (2000), Officer of the Order of Canada (2002), Alberta Order of Excellence (2000) and Fellow of the Royal Society of Canada (2004).  He was inducted into the Canadian Medical Hall of Fame in April 2011 and was awarded the Killam Prize Health Sciences in May 2015. 

Since the COVID-19 pandemic, he has worked on antivirals and vaccines for SARS-CoV-2.  He is a member of the COVID-19 Vaccine Task Force that advises the Federal Government on the selection of COVID-19 vaccines based on efficacy, safety, and timely availability for Canada.  

Featured Publications

Arutyunova E, Belovodskiy A, Chen P, Khan MB, Joyce M, Saffran H, Lu J, Turner Z, Bai B, Lamer T, Young HS, Vederas JC, Tyrrell DL, Lemeiux MJ, Nieman JA

ACS Biom & MNed Chem Au. 2023 November; 10.1021/acsbiomedchemau.3c00039

Shahbaz S, Bozorgmehr N, Lu J, Osman M, Sligl W, Tyrrell DL, Elahi S

Microbiol Spectr. 2023 September; 10.1128/spectrum.01256-23

de Weerd NA, Ogungbola O, Liu X, Matthews AY, Ismail A, Vivian JP, Lim SS, Tyrrell DL, Putcha N, Skawinski M, Dickensheets H, Lavoie TB, Donnelly RP, Hertzog PJ, Santer DM

J Interferon Cytokine Res. 2023 September; 43 (9):403-413 10.1089/jir.2023.0040

Liang TJ, Law JLM, Pietschmann T, Ray SC, Bukh J, Bull R, Chung RT, Tyrrell DL, Houghton M, Rice CM

Clinical Infectious Diseases. 2023 August; 77 (Supplement 3) 10.1093/cid/ciad336

Santer DM, Li D, Ghoshe Y, Zahoor MA, Prajapati D, Hansen BE, Tyrrell DLJ, Feld JJ, Gehring AJ

Nature Communications. 2022 November; 13 10.1038/s41467-022-34709-4

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van BNelkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas & Joanne Lemieux

Nature Communications. 2022 September; 10.1038/s41457-020-18096-2

Babuadze G.G., Fausther-Bovendo H., deLaVega M.A., Lillie B., Naghibosadat M., Shahhosseini N., Joyce M.A., Saffran H.A., Lorne Tyrrell D., Falzarano D., Senthilkumaran C., Christie-Holmes N., Ahn S., Gray-Owen S.D., Banerjee A., Mubareka S., Mossman K., Dupont C., Pedersen J., Lafrance M.A., Kobinger G.P., Kozak R.

npj Vaccines. 2022 April; 7 (49):1-11 10.1038/s41541-022-00461-5

Liu Y, Kumblathan T, Feng W, Pang G, Tao J, Xu J, Xiao H, Joyce MA, Tyrrell DL, Zhang H, Li XF, Le XC

ACS Measurement Science. 2022 February; 2 doi.org/10.1021/acsmeasuresciau.1c00057

Aminpour M, Miranda-Delgado W, Wacker S, Noskov S, Houghton M, Tyrrell DL, Tuszynski JA

BMC Pharmacology & Toxicology. 2021 October; 22 (61):1-20 doi.org/10.1186/s40360-021-00519-5

Feng W, Peng H, Xu J, Liu Y, Pabbaraju K, Tipples G, Joyce MA, Saffran H, Tyrrell DL, Babiuk S, Zhang H, Le XC

ANALYTICAL CHEMISTRY. 2021 September; 93 (37):12808-12816 doi.org/10.1021/acs.analchem.1c03456

Law J, Logan M, Joyce MA, Landi A, Hockman D, Crawford K, Johnson J, LaChance G, Saffran HA, Shields J, Hobart E, Brassard R, Arutyunova E, Pabbaraju K, Croxen M, Tipples G, Lemieux MJ, Tyrrell DL, Houghton M

VACCINE. 2021 September; 39 (40):5769-5779 doi.org/10.1016/j.vaccine.2021.08.081

Bai B, Arutyunova E, Khan MB, Lu J, Joyce MA, Saffran H, Shields JA, Kandadai AS, Belovodskiy A, Hena M, Vuong W, Lamer T, Young H, Vederas J, Tyrrell DL, Lemieux J and Nieman J

RSC Medicinal Chemistry. 2021 August; 12 (10):1722-1730 doi: 10.1039/D1MD00247C

Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce M, Saffran H, Shields J, Khan M, Arutyunova E, Lu J, Bajwa S, Hockman D, Fischer C, Lamer T, Vuong W, Van Belkum M, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young H, Vederas J, Tyrrell DL, Lemieux MJ, Nieman J

JOURNAL OF MEDICINAL CHEMISTRY. 2021 July; 65 (4):2905-2925 doi: 10.1021/acs.jmedchem.1c00616

Le C, Liu Y, López-Orozc J, Joyce MA, Le XC, Tyrrell DL

ANALYTICAL CHEMISTRY. 2021 July; 93 (31):10756-10761 doi.org/10.1021/acs.analchem.1c02227

Arutyunova E, Khan MB, Fischer C, Lu J, Lamer T, Vuong W, van Belkum MJ, McKay R, Tyrrell DL, Vederas JC, Young HS, Lemieux MJ.

JOURNAL OF MOLECULAR BIOLOGY. 2021 June; 433 (13):167003 doi.org/10.1016/j.jmb.2021.167003

Feld J*, Kandel C*, Biondi NP*, Kozak RA, Lemieux C, Borgia S, Boggild A, Powis J, McCready J, Tan D, Chan T, Coburn B, Kumar D, Humar A, Chan A, O’Neil B, Noureldin S, Booth J, Hong R, Smookler D, Aleyadeh W, Patel A, Barber B, Casey J. Zahoor A, Hiebert R, Mistry H, Santer D, Tyrrell DLJ, Gleen JS, Gehring AJ, Janssen HLA, Hansen B. *Contributed equally to the work

The Lancet Respiratory Medicine. 2021 May; 9 (5):498-510 doi.org/10.1016/S2213-2600(20)30566-X

Vuong W, Fischer C, Khan MB, van Belkum M, Lamer T, Willoughby K, Lu J, Arutyunova E, Joyce MA, Saffran H, Shields J, Young H, Nieman J, Tyrrell DL, Lemieux MJ, Vederas J

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2021 May; 222 doi.org/10.1016/j.ejmech.2021.113584

Shahbaz S, Xu L, Osman M, Sligl W, Shields J, Joyce MA, Tyrrell DLJ, Oyegbami O, and Elahi S.

Stem Cell Reports. 2021 May; 16 10.1101.2020.08.18.255927

Pandey M, Ozberk V, Eskandari S, Shalash A, Joyce MA, Saffran HA, Day CJ, Lepletier A, Spillings BL, Mills J-L, Calcutt A, Fan F, Williams JT, Stanisic DI, Hattingh L, Gerrard J, Skwarczynski M, Mak J, Jennings MP, Toth I, Tyrrell DL, Good MF

Clinical & Translational Immunology. 2021 March; doi: 10.1002/cti2.1260

Stone D, Long KR, De Silva Feelixge HS, Kenkel EJ, Liley RM, Rapp S, Roychoudhury P, Nguyen T, Stensland L, Loprieno M, Weber ND, Le C, Wagoner J, Goecker EA, Tyrrell DLJ, Greninger AL, Huang ML, Polyak SJ, Aubert M, Sagartz JE, Jerome KR

Molecular Therapy-Methods & Clinical Development. 2021 March; 20 doi.org/10.1016/j.omtm.2020.11.014

Feng W, Newbigging A, Tao J, Cao Y, Peng H, Le C, Wu J, Pag B, Li J, Tyrrell DL, Zhang, H, Le X.

Chemical Science. 2021 February; 12 doi: 10.1039/d0sc06973f

Le C, Sirajee R, Steenbergen R, Joyce MA, Addison WR, Tyrrell DL

Viruses-Basel. 2021 January; 13 (97) doi.org/10.3390/v13010097

Freedman H, Kundu J, Tchesnokov E, Law J, Nieman J, Schinzai R, Tyrrell DL, Götte M, Houghton M.

Journal of Chemical Information and Modeling. 2020 December; 60 (12):6566-6578 doi: 10.1021/acs.jcim.0c00742

Pang B, Xu J, Liu Y, Peng H, Feng W, Cao Y, Wu J, Xiao H, Pabbaraju K, Tipples G, Joyce MA, Bandi H. Tyrrell DL, Zhang H, Le XC

ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2020 December; 92 doi: 10.1021/acs.analchem.0c04047

Onabajo OO, Banday AR, Stanifer ML, Yan W, Obajemu A, Santer DM, Florez-Vargas O, Piontkivska H, Vargas JM, Ring TJ, Kee C, Doldan P, Tyrrell DL, Mendoza JL, Boulant S, and Prokunina-Olsson L

NATURE GENETICS. 2020 October; 52 https://doi.org/10.1038/s41588-020-00731-9

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