Area of Study / Keywords

Chemical Biology

CHEM 261 - Organic Chemistry I

The correlation of structure and chemical bonding in carbon compounds with the physical properties and chemical reactivity of organic molecules. Discussion will be based on functional groups with emphasis on hydrocarbons and derivatives that contain halogens, oxygen, sulfur, and the hydroxy group. Introduction to stereochemistry, three dimensional structure, reaction mechanisms, especially addition to double bonds, nucleophilic substitution and elimination reactions. Prerequisite CHEM 101 or 103. Note: Students who have obtained credit for CHEM 161 or 164 cannot take CHEM 261 for credit. Engineering students who take this course will receive *4.5.

Winter Term 2022

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Browse more courses taught by Matthew Macauley

Mass Spectrometry-Based Shotgun Glycomics for Discovery of Natural Ligands of Glycan-Binding Proteins

Author(s): Heajin Park, Jaesoo Jung, Emily Rodrigues, Elena N Kitova, Matthew S Macauley, John S Klassen
Publication Date: 10/20/2020
Publication: Analytical Chemistry
Volume: 92
Issue: 20
Page Numbers: 14012-14020
External Link: https://pubmed.ncbi.nlm.nih.gov/32936606/

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A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

Author(s): Emily Rodrigues, Jaesoo Jung, Heajin Park, Caleb Loo, Sepideh Soukhtehzari, Elena N Kitova, Fahima Mozaneh, Gour Daskhan, Edward N Schmidt, Vivian Aghanya, Susmita Sarkar, Laura Streith, Chris D St Laurent, Linh Nguyen, Jean-Philippe Julien, Lori J West, Karla C Williams, John S Klassen, Matthew S Macauley
Publication Date: 10/9/2020
Publication: Nature Communications
Volume: 11
Issue: 1
Page Numbers: 5091
External Link: https://pubmed.ncbi.nlm.nih.gov/33037195/

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Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

Author(s): Levon D Movsisyan, Matthew S Macauley
Publication Date: 8/5/2020
Publication: Organic & Biomolecular Chemistry
Volume: 18
Issue: 30
Page Numbers: 5784-5797
External Link: https://pubmed.ncbi.nlm.nih.gov/32756649/

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Repression of phagocytosis by human CD33 is not conserved with mouse CD33

Author(s): Abhishek Bhattacherjee, Emily Rodrigues, Jaesoo Jung, Matthew Luzentales-Simpson, Jhon R Enterina, Danny Galleguillos, Chris D St Laurent, Maryam Nakhaei-Nejad, Felix F Fuchsberger, Laura Streith, Qian Wang, Norihito Kawasaki, Shiteng Duan, Arjun Bains, James C Paulson, Christoph Rademacher, Fabrizio Giuliani, Simonetta Sipione, Matthew S Macauley
Publication Date: 12/3/2019
Publication: Communications Biology
Volume: 2
Page Numbers: 450
External Link: https://pubmed.ncbi.nlm.nih.gov/31815204/

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A quantitative, high-throughput method identifies protein-glycan interactions via mass spectrometry

Author(s): Pavel I Kitov, Elena N Kitova, Ling Han, Zhixiong Li, Jaesoo Jung, Emily Rodrigues, Carmanah D Hunter, Christopher W Cairo, Matthew S Macauley, John S Klassen
Publication Date: 7/22/2019
Publication: Communications Biology
Volume: 2
Page Numbers: 268
External Link: https://pubmed.ncbi.nlm.nih.gov/31341967/