Mahesh Kate, MBBS, MD, DM, FRCPC
Pronouns: He/Him/His
Contact
Associate Professor, Faculty of Medicine & Dentistry - Medicine Dept
- mahesh@ualberta.ca
- Phone
- (780) 492-4137
Neurologist, Alberta Health Services
Overview
Area of Study / Keywords
Stroke prevention Remote Ischemic Conditioning neurophysiological assessment Clinical trials
About
Mahesh Kate is an Associate Professor with the Division of Neurology. His research focuses on secondary stroke prevention with sustainable interventions and improving stroke patients' outcomes by understanding pathophysiological mechanisms. He co-designed the first study for the Indian Stroke Clinical Trial Network (INSTRuCT). SPRINT INDIA (Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India) study enrolled 4298 patients in 31 centres. This study was recently published in Lancet Global Health and highlighted the need for education to improve compliance.
With the help of the SMART network, he is working on the precision and comfortable delivery of remote ischemic conditioning (RIC). In a randomized clinical trial with sham controls, the group is testing, the feasibility of a novel tissue reflectance spectroscopy device to understand dermis-epidermis oxygen and hemoglobin concentration during the RIC therapy.
Second, he is probing post-endovascular treatment recovery with the help of neurophysiological techniques including electroencephalography (QEEG) and functional near-infrared spectroscopy (fNIRS). This observational study will allow insights into novel treatment target "neurovascular coupling" in the post-stroke period.
He runs a Young Stroke Prevention Clinic at Kaye Edmonton Clinic for vascular risk reduction and etiological assessment. This clinic will characterize stroke risk differences concerning age and sex.
https://scholar.google.com/citations?hl=en&user=eXqacgkAAAAJ&view_op=list_works&sortby=pubdate
Clinical Interests
Stroke
Research
Stroke Prevention, Remote Ischemic Conditioning, Neurovascular Coupling, QEEG, fNIRS
Featured Publications
Raviteja Kakarla, Gurpriya Bhangoo, Jeyaraj Pandian, Ashfaq Shuaib, Mahesh P. Kate
Journal of Clinical Medicine. 2024 May; 10.3390/jcm13092696
Erin F Balcom, Jennifer A McCombe, Mahesh Kate, Khanh Vu, Karen JB Martins, Sylvia Aponte-Hao, Huong Luu, Lawrence Richer, Tyler Williamson, Scott W Klarenbach, Penelope Smyth
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2024 April; 10.1017/cjn.2024.54
Radhika Nair, Jeremy Rempel, Khurshid Khan, Thomas Jeerakathil, Rene Van Dijk, Brian H. Buck, Mahesh P. Kate, Sibi Thirunavukkarasu, Kimberly Gilbertson, Sathvika Thermalingem, Ashfaq Shuaib
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2024 March; 10.1017/cjn.2023.36
Radhika Nair, Nishita Singh, Mahesh Kate, Negar Asdaghi, Robert Sarmiento, Fouzi Bala, Shelagh B Coutts, MacKenzie Horn, Alexandre Y Poppe, Heather Williams, Ayoola Ademola, Ibrahim Alhabli, Faysal Benali, Houman Khosravani, Gary Hunter, Aleksander Tkach, Herbert Alejandro Manosalva Alzate, Aleksandra Pikula, Thalia Field, Anurag Trivedi, Dar Dowlatshahi, Luciana Catanese, Ashfaq Shuaib, Andrew Demchuk, Tolulope Sajobi, Mohammed A Almekhlafi, Richard H Swartz, Bijoy Menon, Brian H Buck
Stroke and Vascular Neurology. 2024 January; 10.1136/svn-2023-002828
Naveed Akhtar, Mahesh Kate, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Uy, Blessy Babu, Shobhna Shanti, Ashfaq Shuaib
2023 October; 10.1101/2023.10.17.23297178
PS Sarma, Himani Khatter, Aneesh Dhasan, Vivek Nambiar, Sunil Narayan, Deepti Arora, Shweta Jain Verma, Meenakshi Sharma, Mahesh Pundlik Kate, Jeyaraj Durai Pandian, P.N. Sylaja
Journal of Stroke Medicine. 2023 June; 10.1177/25166085231176172
Nair R, Sarmiento R, Sheriff A, Shuaib A, Buck B, Gauthier M, Mushahwar V, Ferguson-Pell M, Kate M.
PLoS One . 2023 May; 18 (5):e0284879 10.1371/journal.pone.0284879
Kate MP, Samuel C, Singh S, Jain M, Kamra D, Singh GB, Sharma M, Pandian JD
J Stroke Cerebrovasc Dis. 2023 March; 32 (6):107107 10.1016/j.jstrokecerebrovasdis.2023.107107
Pandian J D, Kate M P, Sylaja P N, Khurana D, P Vijaya , Ray BK et al SPRINT INDIA trial collaborators
Lancet Glob Health. 2023 March; 11 (3):e425-435 10.1016/S2214-109X(22)00544-7
Padmavathy Narayana Sylaja, Jaya Pankajakshi Raghavan Nair, Mahesh Pundlik Kate, Aneesh Dhasan, Vivek Nambiar, Sunil Narayan, Vishnu Renjith, Deepti Arora, Shweta Jain Verma, Meenakshi Sharma, Rupinder Dhaliwal, Himani Khatter, PS Sarma, Jeyaraj Durai Pandian
Cerebrovascular Diseases. 2023 January; 10.1159/000530546
Sebastian I, Kate MP, Khatter H, Singh B, Pandian JD
Ann Indian Acad Neurol. 2022 July; 25 (5):902-908 10.4103/aian.aian_289_22
Menon BK, Buck BH, Singh N, Deschaintre Y, Almekhlafi MA, Coutts SB, Thirunavukkarasu S, Khosravani H, Appireddy R, Moreau F, Gubitz G, Tkach A, Catanese L, Dowlatshahi D, Medvedev G, Mandzia J, Pikula A, Shankar J, Williams H, Field TS, Manosalva A, Siddiqui M, Zafar A, Imoukhuede O, Hunter G, Demchuk AM, Mishra S, Gioia LC, Jalini S, Cayer C, Phillips S, Elamin E, Shoamanesh A, Subramaniam S, Kate M, Jacquin G, Camden MC, Benali F, Alhabli I, Bala F, Horn M, Stotts G, Hill MD, Gladstone DJ, Poppe A, Sehgal A, Zhang Q, Lethebe BC, Doram C, Ademola A, Shamy M, Kenney C, Sajobi TT, Swartz RH; AcT Trial Investigators
Lancet. 2022 June; 400 (10347):161-169 10.1016/S0140-6736(22)01054-6
Himani Khatter, Jeyaraj D. Pandian, Mahesh Kate, Sankara Sarma, PN Sylaja, Dheeraj Khurana, Pamidimukkala Vijaya, Biman Kanti Ray, Vivek Nambiar, Sanjith Aaron, Tina George, Gaurav Mittal, Ivy Sebastian, Nagarjunakonda V. Sundarachary, Aparna R. Pai, Sankar Gorthi, Kumaravelu Somasundaram, Meenakshi Sharma, Rupinder Dhaliwal, Y. Muralidhar Reddy, Sunil Narayan, NC Borah, Rupjyoti Das, Girish B. Kulkarni, Vikram Huded, Thomas Mathew, Padma MV Srivastava, Rohit Bhatia, Pawan Ojha, Jayanta Roy, Sherly Abraham, Jemin Webster, Anand Vaishnav, Arvind Sharma, Shaik A. Jabeen, Abhishek Pathak, Sanjeev Bhoi, Sudheer Sharma, Sulena Sulena, Aralikatte Onkarappa Saroja, Neetu Ramrakhiani, Madhusudhan B. Kempegowda, Deepti Arora, Shweta J. Verma, Rahul Huilgol, Aneesh Dasan, Vishnu Renjith
Journal of Stroke Medicine. 2022 June; 10.1177/25166085221098928
Dorcas BC Gandhi, Jeyaraj D Pandian, Tony Szturm, Anuprita Kanitkar, Mahesh P Kate, Komal Bhanot
European Stroke Journal. 2021 September; 10.1177/2396987321994293
Singh S., Kate M., Samuel C., Kamra D., Kaliyaperumal A., Nandi J., Khatter H., Sharma M., Pandian J.
Neuroepidemiology. 2021 May; 55 (4):297-305 10.1159/000515636
Kate M., Gioia L., Asdaghi N., Jeerakathil T., Shuaib A., Buck B., Emery D., Beaulieu C., Butcher K.
Canadian Journal of Neurological Sciences. 2021 May; 48 (3):349-357 10.1017/cjn.2020.179
Kate MP, Jeerakathil T, Buck BH, Khan K, Nomani AZ, Butt A, Thirunavukkarasu S, Nowacki T, Kalashyan H, Lloret-Villas MI, D'Souza A, Mishra S, McCombe J, Butcher K, Jickling G, Saqqur M, Shuaib A
Sci Rep. 2021 March; 11 (1):4988 10.1038/s41598-021-84441-0
Kate MP, Verma SJ, Arora D, Sylaja PN, Padma MV, Bhatia R, Khurana D, Sharma A, Ojha PK, Renjith V, Kulkarni GB, Sadiq M, Jabeen S, Borah NC, Ray BK, Sharma M, Pandian JD
Ann Indian Acad Neurol. 2020 October; 23 (5):681-686 10.4103/aian.AIAN_639_19
Akhtar N, Kate M, Kamran S, Singh R, Bhutta Z, Saqqur M, Elzouki AN, Babu B, Bourke P, Morgan D, Joseph S, Jose N, Francis R, Imam Y, Amir N, Own A, Shuaib A
Eur Neurol. 2020 May; 83 (2):154-161 10.1159/000507193
Hiremath N, Kate M, Mohimen A, Kesavadas C, Sylaja PN
Neuroradiology. 2020 May; 62 (10):1279-1284 10.1007/s00234-020-02429-5
Mahesh Pundlik Kate, Deepti Arora, Shweta Jain Verma, PN Sylaja, Vishnu Renjith, Meenakshi Sharma, Jeyaraj Durai Pandian
International Journal of Stroke. 2020 January; 10.1177/1747493019895653
Mahesh Kate, Sumair Brar, Uttam George, Shubhra Rathore, Kenneth Butcher, Jeyaraj Pandian, David Hess
Wellcome Open Research. 2019 October; 10.12688/wellcomeopenres.15490.1
Mahesh Kate, Negar Asdaghi, Laura C Gioia, Brian Buck, Sumit R Majumdar, Thomas Jeerakathil, Ashfaq Shuaib, Derek Emery, Christian Beaulieu, Kenneth Butcher
Journal of Cerebral Blood Flow & Metabolism. 2019 September; 10.1177/0271678X18774708
Jeyaraj D Pandian, Seana L Gall, Mahesh P Kate, Gisele S Silva, Rufus O Akinyemi, Bruce I Ovbiagele, Pablo M Lavados, Dorcas B C Gandhi, Amanda G Thrift
Lancet (London, England). 2018 October; 10.1016/s0140-6736(18)31269-8
Journal of stroke. 2018 August; 10.5853/jos.2017.00178.e1
The Lancet. Neurology. 2018 August; 10.1016/S1474-4422(18)30253-9
Strategies to Improve Stroke Care Services in Low- and Middle-Income Countries: A Systematic Review.
Neuroepidemiology. 2017 August; 10.1159/000479518
International journal of stroke : official journal of the International Stroke Society. 2016 October; 10.1177/1747493016676612
Journal of Cerebral Blood Flow and Metabolism. 2013 January; 10.1038/jcbfm.2013.164
The Lancet Neurology. 2012 January; 10.1016/S1474-4422(12)70019-4
Seizure. 2012 January; 10.1016/j.seizure.2012.04.011
Neurology India. 2012 January; 10.4103/0028-3886.96393
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