Mahesh Kate, MBBS, MD, DM, FRCPC

Associate Professor, Faculty of Medicine & Dentistry - Medicine Dept

Neurologist, Alberta Health Services

Pronouns: He/Him/His

Contact Overview Publications

Contact

Associate Professor, Faculty of Medicine & Dentistry - Medicine Dept

Email: mahesh@ualberta.ca
Phone: (780) 492-4137

Neurologist, Alberta Health Services

Email: mahesh.kate@albertahealthservices.ca

Overview

Area of Study / Keywords

Stroke prevention Remote Ischemic Conditioning neurophysiological assessment Clinical trials

About

Mahesh Kate is an Associate Professor with the Division of Neurology. His research focuses on secondary stroke prevention with sustainable interventions and improving stroke patients' outcomes by understanding pathophysiological mechanisms. He co-designed the first study for the Indian Stroke Clinical Trial Network (INSTRuCT). SPRINT INDIA (Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India) study enrolled 4298 patients in 31 centres. This study was recently published in Lancet Global Health and highlighted the need for education to improve compliance.

With the help of the SMART network, he is working on the precision and comfortable delivery of remote ischemic conditioning (RIC). In a randomized clinical trial with sham controls, the group is testing, the feasibility of a novel tissue reflectance spectroscopy device to understand dermis-epidermis oxygen and hemoglobin concentration during the RIC therapy.

Second, he is probing post-endovascular treatment recovery with the help of neurophysiological techniques including electroencephalography (QEEG) and functional near-infrared spectroscopy (fNIRS). This observational study will allow insights into novel treatment target "neurovascular coupling" in the post-stroke period.

He runs a Young Stroke Prevention Clinic at Kaye Edmonton Clinic for vascular risk reduction and etiological assessment. This clinic will characterize stroke risk differences concerning age and sex.

https://scholar.google.com/citations?hl=en&user=eXqacgkAAAAJ&view_op=list_works&sortby=pubdate

Clinical Interests

Stroke

Research

Stroke Prevention, Remote Ischemic Conditioning, Neurovascular Coupling, QEEG, fNIRS

Featured Publications

Remote Ischemic Conditioning to Reduce Perihematoma Edema in Patients with Intracerebral Hemorrhage (RICOCHET): A Randomized Control Trial

Raviteja Kakarla, Gurpriya Bhangoo, Jeyaraj Pandian, Ashfaq Shuaib, Mahesh P. Kate

Journal of Clinical Medicine. 2024 May; 10.3390/jcm13092696

Geographical variation in medication and health resource use in multiple sclerosis

Erin F Balcom, Jennifer A McCombe, Mahesh Kate, Khanh Vu, Karen JB Martins, Sylvia Aponte-Hao, Huong Luu, Lawrence Richer, Tyler Williamson, Scott W Klarenbach, Penelope Smyth

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2024 April; 10.1017/cjn.2024.54

Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit

Radhika Nair, Jeremy Rempel, Khurshid Khan, Thomas Jeerakathil, Rene Van Dijk, Brian H. Buck, Mahesh P. Kate, Sibi Thirunavukkarasu, Kimberly Gilbertson, Sathvika Thermalingem, Ashfaq Shuaib

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2024 March; 10.1017/cjn.2023.36

Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial

Radhika Nair, Nishita Singh, Mahesh Kate, Negar Asdaghi, Robert Sarmiento, Fouzi Bala, Shelagh B Coutts, MacKenzie Horn, Alexandre Y Poppe, Heather Williams, Ayoola Ademola, Ibrahim Alhabli, Faysal Benali, Houman Khosravani, Gary Hunter, Aleksander Tkach, Herbert Alejandro Manosalva Alzate, Aleksandra Pikula, Thalia Field, Anurag Trivedi, Dar Dowlatshahi, Luciana Catanese, Ashfaq Shuaib, Andrew Demchuk, Tolulope Sajobi, Mohammed A Almekhlafi, Richard H Swartz, Bijoy Menon, Brian H Buck

Stroke and Vascular Neurology. 2024 January; 10.1136/svn-2023-002828

Short-term Functional Outcomes of Patients with acute intracerebral hemorrhage in the Native and Expatriate Population

Naveed Akhtar, Mahesh Kate, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Uy, Blessy Babu, Shobhna Shanti, Ashfaq Shuaib

2023 October; 10.1101/2023.10.17.23297178

Statistical Analysis Plan (SAP) for AyuRvedic TrEatment in the Rehabilitation of Ischemic STrOke Patients in India: A Randomized Controlled Trial (RESTORE)

PS Sarma, Himani Khatter, Aneesh Dhasan, Vivek Nambiar, Sunil Narayan, Deepti Arora, Shweta Jain Verma, Meenakshi Sharma, Mahesh Pundlik Kate, Jeyaraj Durai Pandian, P.N. Sylaja

Journal of Stroke Medicine. 2023 June; 10.1177/25166085231176172

Assessment of remote ischemic conditioning delivery with optical sensor in acute ischemic stroke: Randomised clinical trial protocol

Nair R, Sarmiento R, Sheriff A, Shuaib A, Buck B, Gauthier M, Mushahwar V, Ferguson-Pell M, Kate M.

PLoS One . 2023 May; 18 (5):e0284879 10.1371/journal.pone.0284879

Community health volunteer for blood pressure control in rural people with stroke in India: Pilot randomized trial.

Kate MP, Samuel C, Singh S, Jain M, Kamra D, Singh GB, Sharma M, Pandian JD

J Stroke Cerebrovasc Dis. 2023 March; 32 (6):107107 10.1016/j.jstrokecerebrovasdis.2023.107107

Secondary prevention with a structured semi-interactive stroke prevention package in INDIA (SPRINT INDIA): a multicentre, randomised controlled trial

Pandian J D, Kate M P, Sylaja P N, Khurana D, P Vijaya , Ray BK et al SPRINT INDIA trial collaborators

Lancet Glob Health. 2023 March; 11 (3):e425-435 10.1016/S2214-109X(22)00544-7

Ayurvedic Treatment in the Rehabilitation of Ischemic Stroke Patients in India: A Randomized Controlled Trial Study Protocol

Padmavathy Narayana Sylaja, Jaya Pankajakshi Raghavan Nair, Mahesh Pundlik Kate, Aneesh Dhasan, Vivek Nambiar, Sunil Narayan, Vishnu Renjith, Deepti Arora, Shweta Jain Verma, Meenakshi Sharma, Rupinder Dhaliwal, Himani Khatter, PS Sarma, Jeyaraj Durai Pandian

Cerebrovascular Diseases. 2023 January; 10.1159/000530546

Spectrum of Cardiovascular Autonomic Dysfunction and 24-hour Blood Pressure Variability in Idiopathic Parkinson's Disease

Sebastian I, Kate MP, Khatter H, Singh B, Pandian JD

Ann Indian Acad Neurol. 2022 July; 25 (5):902-908 10.4103/aian.aian_289_22

Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Menon BK, Buck BH, Singh N, Deschaintre Y, Almekhlafi MA, Coutts SB, Thirunavukkarasu S, Khosravani H, Appireddy R, Moreau F, Gubitz G, Tkach A, Catanese L, Dowlatshahi D, Medvedev G, Mandzia J, Pikula A, Shankar J, Williams H, Field TS, Manosalva A, Siddiqui M, Zafar A, Imoukhuede O, Hunter G, Demchuk AM, Mishra S, Gioia LC, Jalini S, Cayer C, Phillips S, Elamin E, Shoamanesh A, Subramaniam S, Kate M, Jacquin G, Camden MC, Benali F, Alhabli I, Bala F, Horn M, Stotts G, Hill MD, Gladstone DJ, Poppe A, Sehgal A, Zhang Q, Lethebe BC, Doram C, Ademola A, Shamy M, Kenney C, Sajobi TT, Swartz RH; AcT Trial Investigators

Lancet. 2022 June; 400 (10347):161-169 10.1016/S0140-6736(22)01054-6

Statistical Analysis Plan for the Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in INDIA (SPRINT INDIA): A Randomized Controlled Trial

Himani Khatter, Jeyaraj D. Pandian, Mahesh Kate, Sankara Sarma, PN Sylaja, Dheeraj Khurana, Pamidimukkala Vijaya, Biman Kanti Ray, Vivek Nambiar, Sanjith Aaron, Tina George, Gaurav Mittal, Ivy Sebastian, Nagarjunakonda V. Sundarachary, Aparna R. Pai, Sankar Gorthi, Kumaravelu Somasundaram, Meenakshi Sharma, Rupinder Dhaliwal, Y. Muralidhar Reddy, Sunil Narayan, NC Borah, Rupjyoti Das, Girish B. Kulkarni, Vikram Huded, Thomas Mathew, Padma MV Srivastava, Rohit Bhatia, Pawan Ojha, Jayanta Roy, Sherly Abraham, Jemin Webster, Anand Vaishnav, Arvind Sharma, Shaik A. Jabeen, Abhishek Pathak, Sanjeev Bhoi, Sudheer Sharma, Sulena Sulena, Aralikatte Onkarappa Saroja, Neetu Ramrakhiani, Madhusudhan B. Kempegowda, Deepti Arora, Shweta J. Verma, Rahul Huilgol, Aneesh Dasan, Vishnu Renjith

Journal of Stroke Medicine. 2022 June; 10.1177/25166085221098928

A computer-game-based rehabilitation platform for individuals with fine and gross motor upper extremity deficits post-stroke (CARE fOR U) – Protocol for a randomized controlled trial

Dorcas BC Gandhi, Jeyaraj D Pandian, Tony Szturm, Anuprita Kanitkar, Mahesh P Kate, Komal Bhanot

European Stroke Journal. 2021 September; 10.1177/2396987321994293

Rural Stroke Surveillance and Establishment of Acute Stroke Care Pathway Using Frontline Health Workers in Rural Northwest India: The Ludhiana Experience

Singh S., Kate M., Samuel C., Kamra D., Kaliyaperumal A., Nandi J., Khatter H., Sharma M., Pandian J.

Neuroepidemiology. 2021 May; 55 (4):297-305 10.1159/000515636

Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke

Kate M., Gioia L., Asdaghi N., Jeerakathil T., Shuaib A., Buck B., Emery D., Beaulieu C., Butcher K.

Canadian Journal of Neurological Sciences. 2021 May; 48 (3):349-357 10.1017/cjn.2020.179

Pre-hospital triage of suspected acute stroke patients in a mobile stroke unit in the rural Alberta

Kate MP, Jeerakathil T, Buck BH, Khan K, Nomani AZ, Butt A, Thirunavukkarasu S, Nowacki T, Kalashyan H, Lloret-Villas MI, D'Souza A, Mishra S, McCombe J, Butcher K, Jickling G, Saqqur M, Shuaib A

Sci Rep. 2021 March; 11 (1):4988 10.1038/s41598-021-84441-0

Systematic Development of Structured Semi-interactive Stroke Prevention Package for Secondary Stroke Prevention

Kate MP, Verma SJ, Arora D, Sylaja PN, Padma MV, Bhatia R, Khurana D, Sharma A, Ojha PK, Renjith V, Kulkarni GB, Sadiq M, Jabeen S, Borah NC, Ray BK, Sharma M, Pandian JD

Ann Indian Acad Neurol. 2020 October; 23 (5):681-686 10.4103/aian.AIAN_639_19

Sex-Specific Differences in Short-Term and Long-Term Outcomes in Acute Stroke Patients from Qatar

Akhtar N, Kate M, Kamran S, Singh R, Bhutta Z, Saqqur M, Elzouki AN, Babu B, Bourke P, Morgan D, Joseph S, Jose N, Francis R, Imam Y, Amir N, Own A, Shuaib A

Eur Neurol. 2020 May; 83 (2):154-161 10.1159/000507193