Mahesh Kate, MBBS, MD, DM, FRCPC

Associate Professor, Faculty of Medicine & Dentistry - Medicine Dept
Neurologist, Alberta Health Services

Pronouns: He/Him/His

Contact

Associate Professor, Faculty of Medicine & Dentistry - Medicine Dept
Email
mahesh@ualberta.ca
Phone
(780) 492-4137

Neurologist, Alberta Health Services
Email
mahesh.kate@albertahealthservices.ca

Overview

Area of Study / Keywords

Stroke prevention Remote Ischemic Conditioning neurophysiological assessment Clinical trials


About

Mahesh Kate is an Associate Professor with the Division of Neurology. His research focuses on secondary stroke prevention with sustainable interventions and improving stroke patients' outcomes by understanding pathophysiological mechanisms. He co-designed the first study for the Indian Stroke Clinical Trial Network (INSTRuCT). SPRINT INDIA (Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India) study enrolled 4298 patients in 31 centres. This study was recently published in Lancet Global Health and highlighted the need for education to improve compliance. 

With the help of the SMART network, he is working on the precision and comfortable delivery of remote ischemic conditioning (RIC). In a randomized clinical trial with sham controls, the group is testing, the feasibility of a novel tissue reflectance spectroscopy device to understand dermis-epidermis oxygen and hemoglobin concentration during the RIC therapy. 

Second, he is probing post-endovascular treatment recovery with the help of neurophysiological techniques including electroencephalography (QEEG) and functional near-infrared spectroscopy (fNIRS). This observational study will allow insights into novel treatment target "neurovascular coupling" in the post-stroke period. 

He runs a Young Stroke Prevention Clinic at Kaye Edmonton Clinic for vascular risk reduction and etiological assessment. This clinic will characterize stroke risk differences concerning age and sex.

https://scholar.google.com/citations?hl=en&user=eXqacgkAAAAJ&view_op=list_works&sortby=pubdate

Clinical Interests

Stroke


Research

Stroke Prevention, Remote Ischemic Conditioning, Neurovascular Coupling, QEEG, fNIRS

Featured Publications

Raviteja Kakarla, Gurpriya Bhangoo, Jeyaraj Pandian, Ashfaq Shuaib, Mahesh P. Kate

Journal of Clinical Medicine. 2024 May; 10.3390/jcm13092696


Erin F Balcom, Jennifer A McCombe, Mahesh Kate, Khanh Vu, Karen JB Martins, Sylvia Aponte-Hao, Huong Luu, Lawrence Richer, Tyler Williamson, Scott W Klarenbach, Penelope Smyth

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2024 April; 10.1017/cjn.2024.54


Radhika Nair, Jeremy Rempel, Khurshid Khan, Thomas Jeerakathil, Rene Van Dijk, Brian H. Buck, Mahesh P. Kate, Sibi Thirunavukkarasu, Kimberly Gilbertson, Sathvika Thermalingem, Ashfaq Shuaib

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2024 March; 10.1017/cjn.2023.36


Radhika Nair, Nishita Singh, Mahesh Kate, Negar Asdaghi, Robert Sarmiento, Fouzi Bala, Shelagh B Coutts, MacKenzie Horn, Alexandre Y Poppe, Heather Williams, Ayoola Ademola, Ibrahim Alhabli, Faysal Benali, Houman Khosravani, Gary Hunter, Aleksander Tkach, Herbert Alejandro Manosalva Alzate, Aleksandra Pikula, Thalia Field, Anurag Trivedi, Dar Dowlatshahi, Luciana Catanese, Ashfaq Shuaib, Andrew Demchuk, Tolulope Sajobi, Mohammed A Almekhlafi, Richard H Swartz, Bijoy Menon, Brian H Buck

Stroke and Vascular Neurology. 2024 January; 10.1136/svn-2023-002828


Naveed Akhtar, Mahesh Kate, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Uy, Blessy Babu, Shobhna Shanti, Ashfaq Shuaib

2023 October; 10.1101/2023.10.17.23297178


PS Sarma, Himani Khatter, Aneesh Dhasan, Vivek Nambiar, Sunil Narayan, Deepti Arora, Shweta Jain Verma, Meenakshi Sharma, Mahesh Pundlik Kate, Jeyaraj Durai Pandian, P.N. Sylaja

Journal of Stroke Medicine. 2023 June; 10.1177/25166085231176172


Nair R, Sarmiento R, Sheriff A, Shuaib A, Buck B, Gauthier M, Mushahwar V, Ferguson-Pell M, Kate M.

PLoS One . 2023 May; 18 (5):e0284879 10.1371/journal.pone.0284879


Kate MP, Samuel C, Singh S, Jain M, Kamra D, Singh GB, Sharma M, Pandian JD

J Stroke Cerebrovasc Dis. 2023 March; 32 (6):107107 10.1016/j.jstrokecerebrovasdis.2023.107107


Pandian J D, Kate M P, Sylaja P N, Khurana D, P Vijaya , Ray BK et al SPRINT INDIA trial collaborators

Lancet Glob Health. 2023 March; 11 (3):e425-435 10.1016/S2214-109X(22)00544-7


Padmavathy Narayana Sylaja, Jaya Pankajakshi Raghavan Nair, Mahesh Pundlik Kate, Aneesh Dhasan, Vivek Nambiar, Sunil Narayan, Vishnu Renjith, Deepti Arora, Shweta Jain Verma, Meenakshi Sharma, Rupinder Dhaliwal, Himani Khatter, PS Sarma, Jeyaraj Durai Pandian

Cerebrovascular Diseases. 2023 January; 10.1159/000530546


Sebastian I, Kate MP, Khatter H, Singh B, Pandian JD

Ann Indian Acad Neurol. 2022 July; 25 (5):902-908 10.4103/aian.aian_289_22


Menon BK, Buck BH, Singh N, Deschaintre Y, Almekhlafi MA, Coutts SB, Thirunavukkarasu S, Khosravani H, Appireddy R, Moreau F, Gubitz G, Tkach A, Catanese L, Dowlatshahi D, Medvedev G, Mandzia J, Pikula A, Shankar J, Williams H, Field TS, Manosalva A, Siddiqui M, Zafar A, Imoukhuede O, Hunter G, Demchuk AM, Mishra S, Gioia LC, Jalini S, Cayer C, Phillips S, Elamin E, Shoamanesh A, Subramaniam S, Kate M, Jacquin G, Camden MC, Benali F, Alhabli I, Bala F, Horn M, Stotts G, Hill MD, Gladstone DJ, Poppe A, Sehgal A, Zhang Q, Lethebe BC, Doram C, Ademola A, Shamy M, Kenney C, Sajobi TT, Swartz RH; AcT Trial Investigators

Lancet. 2022 June; 400 (10347):161-169 10.1016/S0140-6736(22)01054-6


Himani Khatter, Jeyaraj D. Pandian, Mahesh Kate, Sankara Sarma, PN Sylaja, Dheeraj Khurana, Pamidimukkala Vijaya, Biman Kanti Ray, Vivek Nambiar, Sanjith Aaron, Tina George, Gaurav Mittal, Ivy Sebastian, Nagarjunakonda V. Sundarachary, Aparna R. Pai, Sankar Gorthi, Kumaravelu Somasundaram, Meenakshi Sharma, Rupinder Dhaliwal, Y. Muralidhar Reddy, Sunil Narayan, NC Borah, Rupjyoti Das, Girish B. Kulkarni, Vikram Huded, Thomas Mathew, Padma MV Srivastava, Rohit Bhatia, Pawan Ojha, Jayanta Roy, Sherly Abraham, Jemin Webster, Anand Vaishnav, Arvind Sharma, Shaik A. Jabeen, Abhishek Pathak, Sanjeev Bhoi, Sudheer Sharma, Sulena Sulena, Aralikatte Onkarappa Saroja, Neetu Ramrakhiani, Madhusudhan B. Kempegowda, Deepti Arora, Shweta J. Verma, Rahul Huilgol, Aneesh Dasan, Vishnu Renjith

Journal of Stroke Medicine. 2022 June; 10.1177/25166085221098928


Dorcas BC Gandhi, Jeyaraj D Pandian, Tony Szturm, Anuprita Kanitkar, Mahesh P Kate, Komal Bhanot

European Stroke Journal. 2021 September; 10.1177/2396987321994293


Singh S., Kate M., Samuel C., Kamra D., Kaliyaperumal A., Nandi J., Khatter H., Sharma M., Pandian J.

Neuroepidemiology. 2021 May; 55 (4):297-305 10.1159/000515636


Kate M., Gioia L., Asdaghi N., Jeerakathil T., Shuaib A., Buck B., Emery D., Beaulieu C., Butcher K.

Canadian Journal of Neurological Sciences. 2021 May; 48 (3):349-357 10.1017/cjn.2020.179


Kate MP, Jeerakathil T, Buck BH, Khan K, Nomani AZ, Butt A, Thirunavukkarasu S, Nowacki T, Kalashyan H, Lloret-Villas MI, D'Souza A, Mishra S, McCombe J, Butcher K, Jickling G, Saqqur M, Shuaib A

Sci Rep. 2021 March; 11 (1):4988 10.1038/s41598-021-84441-0


Kate MP, Verma SJ, Arora D, Sylaja PN, Padma MV, Bhatia R, Khurana D, Sharma A, Ojha PK, Renjith V, Kulkarni GB, Sadiq M, Jabeen S, Borah NC, Ray BK, Sharma M, Pandian JD

Ann Indian Acad Neurol. 2020 October; 23 (5):681-686 10.4103/aian.AIAN_639_19


Akhtar N, Kate M, Kamran S, Singh R, Bhutta Z, Saqqur M, Elzouki AN, Babu B, Bourke P, Morgan D, Joseph S, Jose N, Francis R, Imam Y, Amir N, Own A, Shuaib A

Eur Neurol. 2020 May; 83 (2):154-161 10.1159/000507193


Hiremath N, Kate M, Mohimen A, Kesavadas C, Sylaja PN

Neuroradiology. 2020 May; 62 (10):1279-1284 10.1007/s00234-020-02429-5


Mahesh Pundlik Kate, Deepti Arora, Shweta Jain Verma, PN Sylaja, Vishnu Renjith, Meenakshi Sharma, Jeyaraj Durai Pandian

International Journal of Stroke. 2020 January; 10.1177/1747493019895653


Mahesh Kate, Sumair Brar, Uttam George, Shubhra Rathore, Kenneth Butcher, Jeyaraj Pandian, David Hess

Wellcome Open Research. 2019 October; 10.12688/wellcomeopenres.15490.1


Mahesh Kate, Negar Asdaghi, Laura C Gioia, Brian Buck, Sumit R Majumdar, Thomas Jeerakathil, Ashfaq Shuaib, Derek Emery, Christian Beaulieu, Kenneth Butcher

Journal of Cerebral Blood Flow & Metabolism. 2019 September; 10.1177/0271678X18774708


Jeyaraj D Pandian, Seana L Gall, Mahesh P Kate, Gisele S Silva, Rufus O Akinyemi, Bruce I Ovbiagele, Pablo M Lavados, Dorcas B C Gandhi, Amanda G Thrift

Lancet (London, England). 2018 October; 10.1016/s0140-6736(18)31269-8


Journal of stroke. 2018 August; 10.5853/jos.2017.00178.e1


The Lancet. Neurology. 2018 August; 10.1016/S1474-4422(18)30253-9


Neuroepidemiology. 2017 August; 10.1159/000479518


International journal of stroke : official journal of the International Stroke Society. 2016 October; 10.1177/1747493016676612


Journal of Cerebral Blood Flow and Metabolism. 2013 January; 10.1038/jcbfm.2013.164


The Lancet Neurology. 2012 January; 10.1016/S1474-4422(12)70019-4


Seizure. 2012 January; 10.1016/j.seizure.2012.04.011


Neurology India. 2012 January; 10.4103/0028-3886.96393


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