W Maksymowych

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Contact

Professor, Faculty of Medicine & Dentistry - Medicine Dept
Email
maksymow@ualberta.ca
Phone
(780) 407-1964

Overview

Area of Study / Keywords

ankylosing spondylitis clinical trial anti-TNF therapy osteoarthritis biologics MRI radiography inflammation biomarkers prognosis spondyloarthritis rheumatoid arthritis


About

Personal Statement:

The advances that we have made in rheumatology are due in large part to the clinical research model at the Department of Medicine where we treat patients while conducting research. Every time I see a patient, I learn something. Their questions trigger ideas which trigger the work that leads to innovation. Another factor for our success is the culture of research in Alberta built over decades by the former Alberta Heritage Foundation for Medical Research that has led to our community’s international competitiveness.

Rheumatologist and medical scientist Dr. Maksymowych was recruited from the UK to Alberta because of the province’s stellar research environment. Many of his achievements are world firsts, resulting in the advancement of the genetics of inflammatory arthritis, the novel use of imaging technologies in diagnosis and treatment, the identification of new biomarkers, and the creation of new therapeutics for several forms of arthritis.  His research network is global, involving investigators and major partners in the pharmaceutical, imaging, and biomarker industries. 

Leadership and Collaborations:

Dr. Maksymowych is co-founder and principal investigator the Spondyloarthritis Research Consortium of Canada (SPARCC) established to develop biomarkers and imaging technologies for this form of spinal arthritis. The consortium’s work includes development of a genetic screening test with collaborators in Newfoundland, where there is an increase in the disease and a related disease called psoriatic arthritis.  He is founder and chief medical officer of Canadian Research and Education (CaRE) in Arthritis Ltd. 

Dr. Maksymowych is a member of, and in many cases has chaired, committees of international associations and groups formed to advance rheumatology and arthritis related research and therapeutic development. These include the Alberta Rheumatoid Arthritis and Pharmacovigilance Program, Canadian Arthritis Network Centres of Excellence, Canadian Rheumatology Association, Outcome Measures in Rheumatology (OMERACT) Soluble Biomarker Group, Assessments in Spondyloarthritis International Society.



Clinical Interests

Dr. Maksymowych sees patients at the Kaye Edmonton Clinic. He maintains a website dedicated to patients with arthritis, and doctors and researchers in the field.


Research

The imaging technologies Dr. Maksymowych developed quantifies the degree of inflammation in the spine, hip and knee for different forms of arthritis such as spondylitis (inflammation of the vertebrae) and osteoarthritis. The methodology shows the effects a drug is having on inflammation and is the industry standard for evaluation of new therapeutics in clinical trials. 

Dr. Maksymowych co-discovered that blood protein 14-3-3n is a biomarker that indicates the presence of rheumatoid arthritis, the severity of the disease and a cause of joint inflammation. A blood test developed from the discovery was commercialized as JOINTstat™ and is used widely in North America.

Through the international RA BIODAM Study, Dr. Maksymowych integrated imaging data along with biological samples and clinical data from academic and community-based practices into the largest biorepository for rheumatoid arthritis research in North America. This resulted in an international database linking 35 academic and community-based sites in Canada and the United States, Europe and Israel in a collaborative effort to develop biomarkers and other precision technologies in rheumatoid arthritis. The University of Alberta site has been the major contributor to this initiative with respect to patient recruitment, biological samples and the systematic collection of imaging data. A spin-off benefit of the study has been the adoption of new standardized operating procedures for transporting biosamples across continents, now adopted by companies like Cryoport and FedEx. 

He has instigated numerous international collaborative networks that have culminated in the development of multiple scoring systems based on his imaging and biomarker technologies for use in both diagnostic and therapeutic settings as well as clinical trials research.

Dr. Maksymowych has more than 400 publications to his name. He has served as reviewer for such publications as The Lancet, Arthritis Rheumatology, Arthritis Research and Therapy, Journal of Rheumatology, Rheumatology (Oxford) and Annals of the Rheumatic Diseases. He is on the editorial boards for Clinical and Experimental Rheumatology and Journal of Rheumatology and is on the executive board of the Spondyloarthritis Research and Treatment Network. He is Chair of the International Biomarker Working Group for the Outcome Measures in Rheumatology Consortium . He serves as a clinical advisor at Augurex Life Sciences Corp, which has licensed the 14-3-3n biomarker discovery, and has served on numerous national and international steering committees for the pharmaceutical industry. 

Dr. Maksymowych’s research is supported by provincial, Canadian and international funding organizations and global industries including Abbvie, Novartis, and Pfizer.

Dr. Maksymowych’s honours include the Distinguished Investigator Award from the Canadian Rheumatology Association.


Teaching

Dr. Maksymowych engages in global education initiatives to communicate the latest advances in the field of rheumatology and arthritis. 

Featured Publications

A Novel Serological Biomarker Measuring a Fragment of Cartilage Intermediate Layer Protein 1 Is Highly Upregulated in Rheumatic Diseases

Arthritis and Rheumatology. 2022 November;


ASAS Recommendations for Requesting and Reporting Imaging in Patients with Suspected Axial Spondyloarthritis

Arthritis and Rheumatology. 2022 November;


Bimekizumab Improves Signs and Symptoms, Including Inflammation, in Patients with Active Non-Radiographic Axial Spondyloarthritis: 24-Week Efficacy & Safety from a Phase 3, Multicenter, Randomized, Placebo Controlled Study

Arthritis and Rheumatology. 2022 November;


Bimekizumab Maintains Improvements in Efficacy Endpoints and Has a Consistent Safety Profile Through 52 Weeks in Patients with Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis: Results from Two Parallel Phase 3 Studies

Arthrits and Rheumatology. 2022 November;


Consensus-Driven Definition for Unequivocal Sacroiliitis on Radiographs for Classification in Juvenile Spondyloarthritis

Arthritis and Rheumatology. 2022 November;


Detection of Active Inflammatory and Structural Changes Indicative of Axial Spondyloarthritis on MRI of Sacroiliac Joint Using a Deep Learning Framework

Arthritis and Rheumatology. 2022 November;


Development of International Consensus on a Standardized Image Acquisition Protocol for Diagnostic Evaluation of the Sacroiliac Joints by MRI - an ASAS-SPARTAN Collaboration

Arthritis and Rheumatology. 2022 November;


Development, Refinement and Weighting of Candidate Criteria for Axial Disease in Juvenile Spondyloarthritis: An International Collaboration

Arthritis and Rheumatology. 2022 November;


Efficacy of Upadacitinib in Patients with Non-Radiographic Axial Spondyloarthritis Stratified by Objective Signs of Inflammation at Baseline

Arthritis and Rheumatology. 2022 November;


Identification of MRI Lesions Indicative of Spondyloarthritis Diagnosis from the Axial Spondyloarthritis International Society (ASAS) MRImagine Multi-Reader Scoring Dataset Using the Chi-Squared Automatic Interaction Detection Algorithm (CHAID)

Arthritis and Rheumatology. 2022 November;


Impact of Characteristic Inflammatory and Structural Imaging Lesions on Expert Classification of Axial Juvenile Spondyloarthritis

Arthritis and Rheumatology. 2022 November;


Increasing the Proficiency for Scoring Sacroiliac Joint Radiographs According to the Modified New York Criteria for Ankylosing Spondylitis by Using an Online Real-time Iterative Calibration (RETIC) Module

Arthritis and Rheumatology. 2022 November;


Long-Term Clinical Outcomes of Certolizumab Pegol Treatment in Patients with Active Non-Radiographic Axial Spondyloarthritis Stratified by Baseline MRI and C-Reactive Protein Status

Arthritis and Rheumatology. 2022 November;


More Meticulously Following Treat-to-target in RA Does Not Lead to Less Radiographic Progression: A Longitudinal Analysis in BIODAM

Arthritis and Rheumatology. 2022 November;


MRI Spinal Lesions in Patients Without MRI or Radiographic Lesions in the Sacroiliac Joints Typical of Axial Spondyloarthritis

Arthritis and Rheumatology. 2022 November;


Osteoarthritis of the Knee, Inflammation, and the Effect of Adalimumab: A Randomized Placebo-Controlled Trial

Arthritis and Rheumatology. 2022 November;


Putative Role of the Histidine and Tryptophan Biochemical Pathways in the Mode of Action of Upadacitinib in Patients with Ankylosing Spondylitis

Arthritis and Rheumatology. 2022 November;


Relative Frequencies of the Spectrum of MRI Lesions in the Sacroiliac Joints of Healthy Individuals and Patients with Non-Specific Back Pain: What Is the Impact of Increasing Age?

Arthritis and Rheumatology. 2022 November;


Reliability of MRI Lesions Comprising the Preliminary OMERACT Juvenile Idiopathic Arthritis MRI Score (OMERACT JAMRI-SIJ): What Is the Impact of Systematic Reader Calibration?

Arthritis and Rheumatology. 2022 November;


Time to First Remission and Prevalence of Sustained Remission After Etanercept Biosimilar (ETA-B) or Originator (ETA-O) Initiation in Rheumatoid Arthritis

Arthritis and Rheumatology. 2022 November;


Validation of the SPARCCRETIC E-Tool for Ensuring Scoring Proficiency of MRI Lesions in Axial Spondyloarthritis

Arthritis and Rheumatology. 2022 November;


Maksymowych W.P., Baraliakos X., Lambert R.G., Landewé R., Sandoval D., Carlier H., Lisse J., Li X., Hojnik M., Østergaard M.

Lancet Rheumatology. 2022 September; 4 (9):e626-e634 10.1016/S2665-9913(22)00185-0


Protopopov M, Proft F, Wichuk S, Machado PM, Lambert RG, Weber U, Juhl Pedersen S, Østergaard M, Sieper J, Rudwaleit M, Baraliakos X, Maksymowych WP, Poddubnyy D

RHEUMATOLOGY. 2022 August; 10.1093/rheumatology/keac432


Bressem KK, Adams LC, Proft F, Hermann KGA, Diekhoff T, Spiller L, Niehues SM, Makowski MR, Hamm B, Protopopov M, Rios Rodriguez V, Haibel H, Rademacher J, Torgutalp M, Lambert RG, Baraliakos X, Maksymowych WP, Vahldiek JL, Poddubnyy D

RADIOLOGY. 2022 August; 10.1148/radiol.212526


Deodhar A., Van den Bosch F., Poddubnyy D., Maksymowych W.P., van der Heijde D., Kim T.H., Kishimoto M., Blanco R., Duan Y., Li Y., Pangan A.L., Wung P., Song I.H.

Lancet Rheumatology. 2022 July; 400 (10349):369-379 10.1016/S0140-6736(22)01212-0


Van Der Heijde D., Deodhar A., Maksymowych W.P., Sieper J., Van Den Bosch F., Kim T.H., Kishimoto M., Östör A.J., Combe B., Sui Y., Duan Y., Wung P.K., Song I.H.

RMD Open. 2022 July; 8 (2) 10.1136/rmdopen-2022-002280


A deep learning framework for MRI detection of active inflammatory and structural changes in the Sacroiliac joint consistent with Axial Spondyloarthritis: An International Collaborative Study

Annals of the Rheumatic Diseases. 2022 June;


ASAS recommendations for requesting and reporting imaging examinations in patients with suspected Axial Spondyloarthritis

Annals of the Rheumatic Diseases. 2022 June;


Axial spondyloarthritis, age and male gender impact Covid vaccination AEs more than Rheumatoid Arthritis

Annals of the Rheumatic Diseases. 2022 June;


Bimekizumab in patients with active Non-radiographic Axial spondyloarthritis: 24-week efficacy & safety from be Mobile 1, A phase 3, Multicentre, Randomised, Placebo controlled study

Annals of the Rheumatic Diseases. 2022 June;


Robinson PC, Maksymowych WP, Gensler LS, Hall S, Rudwaleit M, Hoepken B, Bauer L, Kumke T, Kim M, de Peyrecave N, Deodhar A

ACR Open Rheumatology. 2022 June; 4 (9):794-801 10.1002/acr2.11469


Consensus-Driven definition for unequivocal sacroiliitis on radiographs in Juvenile spondyloarthritis

Annals of the Rheumatic Diseases. 2022 June;


Data-Driven MRI definitions for active and structural Sacroiliac joint lesions in Juvenile Spondyloarthritis typical of Axial disease.

Annals of the Rheumatic Diseases. 2022 June;


Development of International consensus on a standardized image acquisition protocol for diagnostic evaluation of the Sacroiliac joints by MRI- an ASAS-Spartan collaboration

Annals of the Rheumatic Diseases. 2022 June;


Efficacy and Safety of Upadacitinib in Patients with Active Non-Radiographic Axial Spondyloarthritis: A Double-Blind, Randomized, Placebo-Controlled Phase 3 Trial

Annals of the Rheumatic Diseases. 2022 June;


Navarro-Compán V, Boel A, Boonen A, Mease PJ, Dougados M, Kiltz U, Landewé RBM, Baraliakos X, Bautista-Molano W, Chiowchanwisawakit P, Dagfinrud H,, Fallon L, Garrido-Cumbrera M, Gensler L, ElZorkany BK, Haroon N, Heng Kwan Y, Machado PM, Maksymowych WP, Molto A, de Peyrecave N, Poddubnyy D, Protopopov M, Ramiro S, Song IH, van Weely S, van der Heijde D

ANNALS OF THE RHEUMATIC DISEASES. 2022 June; 10.1136/annrheumdis-2022-222747


Less than expected impact of Rheumatoid Arthritis and Axial spondyloarthritis disease on Covid severity

Annals of the Rheumatic Diseases. 2022 June;


Long-term clinical outcomes of Certolizumab Pegol treatment in patients with active non radiographic axial spondyloarthritis stratified by Baseline MRI and C-reactive protein status

Annals of the Rheumatic Diseases. 2022 June;


More meticulously following Treat-to-Target in RA does not lead to less Radiographic progression: A longitudinal analysis in Biodam

Annals of the Rheumatic Diseases. 2022 June;


MRI spinal lesions in patients without MRI or radiographic lesions in the Sacroiliac joints typical of Axial Spondyloarthritis

Annals of the Rheumatic Diseases. 2022 June;


Osteoarthritis of the knee, Inflammation and the effect of Adalimumab (OKINADA): A Randomized Placebo-Controlled Trial

Annals of the Rheumatic Diseases. 2022 June;


Refinement and weighting of candidate criteria for Axial disease in Juvenile Spondyloarthritis: An International Collaboration

Annals of the Rheumatic Diseases. 2022 June;


Structural outcomes in the Sacroiliac joint after Ixekizumab treatment for 16 weeks in patients with active Non radiographic Axial spondyloarthritis stratified by gender, HLA-b27, and Baseline MRI inflammation

Annals of the Rheumatic Diseases. 2022 June;


Validation of the SPARCC MRI-RETIC E-TOOL for increasing scoring proficiency of MRI lesions in axial spondyloarthritis

Annals of the Rheumatic Diseases. 2022 June;


McInnes I.B., Szekanecz Z., McGonagle D., Maksymowych W.P., Pfeil A., Lippe R., Song I.H., Lertratanakul A., Sornasse T., Biljan A., Deodhar A.

RHEUMATOLOGY. 2022 May; 61 (5):1783-1794 10.1093/rheumatology/keab740


Kiltz U., Boonen A., van der Heijde D., Bautista-Molano W., Burgos Vargas R., Chiowchanwisawakit P., El-Zorkany B., Gaydukova I., Geher P., Gossec L., Gilio M., Grazio S., Gu J., Khan M.A., Kim T.J., Maksymowych W.P., Marzo-Ortega H., Navarro-Compán V., Ozgocmen S., Patrikos D., Pimentel-Santos F.M., Reveille J., Schirmer M., Stebbings S., Van den Bosch F., Weber U., Braun J.

RHEUMATOLOGY. 2022 May; 61 (5):2054-2062 10.1093/rheumatology/keab653


Maksymowych WP, Østergaard M, Landewé R, Barchuk W, Liu K, Gilles L, Hendrikx T, Besuyen R, Baraliakos X

RHEUMATOLOGY. 2022 May; 61 (6):2388-2397 10.1093/rheumatology/keab758


Maksymowych W.P., Østergaard M., Landewé R., Barchuk W., Liu K., Tasset C., Gilles L., Hendrikx T., Besuyen R., Baraliakos X.

RHEUMATOLOGY. 2022 May; 61 (5):2063-2071 10.1093/rheumatology/keab543


Maksymowych WP, Lambert RGW, Caplan L, van den Bosch FE, Mikkel Østergaard M

Nature Reviews Rheumatology. 2022 May; 18 (8):481-489 10.1038/s41584-022-00789-1


Baraliakos X, Østergaard M, Lambert RGW, Eshed I, Machado PM, Pedersen SJ, Weber U, de Hooge M, Sieper J, Poddubnyy D, Rudwaleit M, van der Heijde D, Landewé RBM, Maksymowych WP

ANNALS OF THE RHEUMATIC DISEASES. 2022 May; 81 (9):1243-1251 10.1136/annrheumdis-2021-222081


van der Heijde D., Østergaard M., Reveille J.D., Baraliakos X., Kronbergs A., Sandoval D.M., Li X., Carlier H., Adams D.H., Maksymowych W.P.

JOURNAL OF RHEUMATOLOGY. 2022 March; 49 (3):265-273 10.3899/jrheum.210471


Maksymowych WP, Østergaard M

JOURNAL OF RHEUMATOLOGY. 2022 March; 49 (6):72-74 10.3899/jrheum.211340


Maksymowych WP, Bolce R, Gallo G, Seem E, Geneus VJ, Sandoval DM, Østergaard M, Tada K, Baraliakos X, Deodhar A, Gensler LS

RHEUMATOLOGY. 2022 February; 10.1093/rheumatology/keac104


van der Heijde D, Dougados M, Maksymowych WP, Bergman G, Curtis S, Tzontcheva A, Huyck S, Phillip G, Sieper J

RHEUMATOLOGY. 2022 February; 61 (2):617-627 10.1093/rheumatology/keab346


Antony A, Holland R, Mathew AJ, D'Agostino M, Maksymowych WP, Mease PJ, Goel N, Ogdie A, Coates LC, Strand V, Christensen R, Gladman DD, Orbai A, Ying Leung Y, Tillett W

JOURNAL OF RHEUMATOLOGY. 2022 February; 49 (6):20-25 10.3899/jrheum.211322


Buch MH, Maksymowych WP, Boers M

ANNALS OF THE RHEUMATIC DISEASES. 2022 January; 81 (5):741-742 10.1136/annrheumdis-2021-221775


Poddubnyy D., Baraliakos X., Van den Bosch F., Braun J., Coates L.C., Chandran V., Diekhoff T., van Gaalen F.A., Gensler L.S., Goel N., Gottlieb A.B., van der Heijde D., Helliwell P.S., Hermann K.G.A., Jadon D., Lambert R.G., Maksymowych W.P., Mease P., Nash P., Proft F., Protopopov M., Sieper J., Torgutalp M., Gladman D.D.

Therapeutic Advances in Musculoskeletal Disease. 2021 December; 13 10.1177/1759720X211057975


Data-driven Definitions Based on Inflammatory Lesions for a Positive MRI of the Spine Consistent with Axial Spondyloarthritis

Arthritis and Rheumatology. 2021 November;


Data-driven MRI Definitions for Active and Structural Sacroiliac Joint Lesions in Juvenile Spondyloarthritis Typical of Axial Disease

Arthritis and Rheumatology. 2021 November;


Development of Candidate Criteria for Axial Disease in Juvenile Spondyloarthritis: An International Collaboration

Arthritis and Rheumatology. 2021 November;


Does Imaging of the Sacroiliac Joint and Spine Differ in Patients Presenting with Undiagnosed Back Pain and Psoriasis, Acute Anterior Uveitis, and Colitis: An Inception Cohort Study

Arthritis and Rheumatology. 2021 November;


Effect of Tofacitinib on Spinal Vertebral Body and Posterolateral Element Inflammation and Structural Lesions Using the Canada-Denmark MRI Scoring System in Patients with Ankylosing Spondylitis: Results from a Phase 2 Study Arthritis

Arthritis and Rheumatology. 2021 November;


Effects of Ixekizumab Treatment on Structural Changes in the Sacroiliac Joints Based on MRI Assessments at 16 Weeks in Patients with Non-Radiographic Axial Spondyloarthritis

Arthritis and Rheumatology. 2021 November;


Efficacy and Safety of Upadacitinib in Patients with Active Ankylosing Spondylitis: 2-Year Results from a Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Extension

Arthritis and Rheumatology. 2021 November;


Filgotinib Treatment Results in Reduction of Inflammatory and Matrix Remodeling Biomarkers Associated with Disease in Patients with Ankylosing Spondylitis

Arthritis and Rheumatology. 2021 November;


López-Medina C., Chevret S., Molto A., Sieper J., Duruöz T., Kiltz U., Elzorkany B., Hajjaj-Hassouni N., Burgos-Vargas R., Maldonado-Cocco J., Ziade N., Gavali M., Navarro-Compan V., Luo S.F., Biglia A., Tae-Jong K., Kishimoto M., Pimentel-Santos F.M., Gu J., Muntean L., Van Gaalen F.A., Geher P., Magrey M., Ibáñez-Vodnizza S.E., Bautista-Molano W., Maksymowych W., MacHado P.M., Landewé R., Van Der Heijde D., Dougados M.

RMD Open. 2021 November; 7 (3) 10.1136/rmdopen-2021-001728


Ixekizumab Shows a Distinct Pattern of Pain Improvement Beyond Measurable Inflammation as Assessed by MRI or CRP or BASDAI Questions 5 & 6 in Patients with Ankylosing Spondylitis

Arthritis and Rheumatology. 2021 November;


Long-Term Safety and Efficacy of Certolizumab Pegol in Patients with Active Non Radiographic Axial Spondyloarthritis: 3-Year Results from a Phase 3 Multicenter Study

Arthritis and Rheumatology. 2021 November;


Quantitative Assessment of Volumetric Change in Hip Effusion Using Artificial Intelligence in Patients with Osteoarthritis of the Hip

Arthritis and Rheumatology. 2021 November;


Scoring MRI Structural Lesions in Sacroiliac Joints of Patients with Axial Spondyloarthritis: How Many Slices Are Optimal?

Arthritis and Rheumatology. 2021 November;


Sustained Functional Remission in Axial Spondyloarthritis (axSpA): Which Are the Primary Outcomes That Should Be Targeted to Achieve This?

Arthritis and Rheumatology. 2021 November;


Switching Biologics and Failure to Attain Remission in the First Year Predicts bDMARD Refractory Disease in Rheumatoid Arthritis: A 15-year Follow up of the Alberta Biologics Pharmacovigilance Cohort

Arthritis and Rheumatology. 2021 November;


The OMERACT Knee Inflammation MRI Scoring System: Validation of Quantitative Methodologies and Tri-compartmental Overlays by Comparison with the MRI Osteoarthritis Knee Score

Arthritis and Rheumatology. 2021 November;


Maksymowych WP, Kumke T, Auteri SE, Hoepken B, Bauer L, Rudwaleit M

ARTHRITIS RESEARCH & THERAPY. 2021 October; 23 (274) 10.1186/s13075-021-02650-4


Consensus definitions for MRI lesions in the spine of patients with axial spondyloarthritis: First analysis from the assessments in spondyloarthritis international society classification cohort

Clinical and Experimental Rheumatology. 2021 September;


Diagnostic utility of IBP criteria in an inception cohort of patients with psoriasis, iritis, or colitis presenting with undiagnosed back pain

Clinical and Experimental Rheumatology. 2021 September;


Does imaging of the sacroiliac joint differ in patients presenting with undiagnosed back pain and psoriasis, acute anterior uveitis, and colitis: an inception cohort study

Clinical and Experimental Rheumatology. 2021 September;


Effects of Filgotinib on spinal lesions in patients with ankylosing spondylitis: Magnetic Resonance Imaging data from the placebo-controlled, double-blind, randomized Tortuga Trial

Clinical and Experimental Rheumatology. 2021 September;


Effects of Ixekizumab treatment on structural changes in the sacroiliac joints based on MRI assessments at 16 weeks in patients with Non-radiographic Axial spondyloarthritis.

Clinical and Experimental Rheumatology. 2021 September;


Evaluation of spinal radiographic progression in patients with radiographic axial spondyloarthritis receiving Ixekizumab Therapy over 2 years

Clinical and Experimental Rheumatology. 2021 September;


Impact of filgotinib on structural lesions in the sacroiliac joints at 12 weeks in patients with active ankylosing spondylitis: correlation with clinical endpoints

Clinical and Experimental Rheumatology. 2021 September;


Metabolomics profiling of serum for biomarker discovery to identify Psoriatic Arthritis and Ankylosing Spondylitis

Clinical and Experimental Rheumatology. 2021 September;


Performance of three referral algorithms for diagnosing axial spondyloarthritis

Clinical and Experimental Rheumatology. 2021 September;


Otobo T.M., Herregods N., Jaremko J.L., Sudol-szopinska I., Maksymowych W.P., Meyers A.B., Weiss P., Tse S., Paschke J., Moineddin R., Haroon N., Tzaribachev N., Appenzeller S., Papakonstantinou O., Kirkhus E., van Rossum M.A.J., Carrino J., Conaghan P.G., Tolend M., Stimec J., Jans L., Lambert R.G., Rumsey D., Doria A.S.

Journal of Clinical Medicine. 2021 September; 10 (19):4564 10.3390/jcm10194564


Scoring MRI structural lesions in sacroiliac joints of patients with axial spondyloarthritis: How many slices are optimal?

Clinical and Experimental Rheumatology.. 2021 September;


Wang R., Maksymowych W.P.

Frontiers in Immunology. 2021 September; 12 10.3389/fimmu.2021.715510


Wetterslev M., Lambert R.G., Maksymowych W.P., Eshed I., Pedersen S.J., Bird P., Stoenoiu M.S., Krabbe S., Mathew A.J., Foltz V., Gandjbakhch F., Paschke J., De Marco G., Marzo-Ortega H., Carron P., Poulsen A.E., Jaremko J.L., Conaghan P.G., Østergaard M.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 August; 51 (4):940-945 10.1016/j.semarthrit.2021.05.006


D'Agostino M.A., Beaton D.E., Maxwell L.J., Cembalo S.M., Hoens A.M., Hofstetter C., Zabalan C., Bird P., Christensen R., de Wit M., Doria A.S., Maksymowych W.P., Oo W.M., Østergaard M., Serban T., Sloan V.S., Terslev L., van Rossum M.A., Conaghan P.G., Boers M.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 August; 51 (5):1125-1133 10.1016/j.semarthrit.2021.08.004


Wetterslev M., Maksymowych W.P., Lambert R.G., Eshed I., Pedersen S.J., Stoenoiu M.S., Krabbe S., Bird P., Foltz V., Mathew A.J., Gandjbakhch F., Paschke J., Carron P., De Marco G., Marzo-Ortega H., Poulsen A.E., Jaremko J.L., Conaghan P.G., Østergaard M.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 August; 51 (4):933-939 10.1016/j.semarthrit.2021.05.013


Navarro-Compán V., Boel A., Boonen A., Mease P., Landewé R., Kiltz U., Dougados M., Baraliakos X., Bautista-Molano W., Carlier H., Chiowchanwisawakit P., Dagfinrud H., de Peyrecave N., El-Zorkany B., Fallon L., Gaffney K., Garrido-Cumbrera M., Gensler L.S., Haroon N., Kwan Y.H., Machado P.M., Maksymowych W.P., Poddubnyy D., Protopopov M., Ramiro S., Shea B., Song I.H., van Weely S., van der Heijde D.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 August; 51 (6):1342-1349 10.1016/j.semarthrit.2021.07.021


Maksymowych W.P., McReynolds A., Pedersen S.J., Weber U., Paschke J., Wichuk S., Jaremko J.L., Lambert R.G.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 August; 51 (4):925-928 10.1016/j.semarthrit.2021.05.014


Arthritis and Enthesitis in the Hip and Pelvis Region in Spondyloarthritis - Validation of Two Whole-Body MRI Methods

Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Herregods N., Maksymowych W.P., Jans L.B.O., Otobo T.M., Sudol-Szopinska I., Meyers A.B., Van Rossum M.A.J., Kirkhus E., Panwar J., Appenzeller S., Weiss P., Tse S.M.L., Doria A.S., Lambert R.G.W., Jaremko J.L.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 June; 51 (5):1089-1098 10.1016/j.semarthrit.2021.07.003


Herregods N., Maksymowych W.P., Jans L.B.O., Otobo T.M., Sudol-Szopinska I., Meyers A.B., Van Rossum M.A.J., Kirkhus E., Panwar J., Appenzeller S., Weiss P., Tse S.M.L., Doria A.S., Lambert R.G.W., Jaremko J.L.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 June; 51 (5):1099-1107 10.1016/j.semarthrit.2021.07.009


Data-Driven Definitions Based on Inflammatory Lesions for a Positive MRI of the Spine consistent with Axial Spondyloarthritis

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Does Imaging of the Sacroiliac Joint differ in patients presenting with Undiagnosed Back Pain and Psoriasis, Acute Anterior Uveitis, and Colitis: An Inception Cohort Study

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Effects of Filgotinib on Spinal Lesions in Ankylosing Spondylitis: Magnetic Resonance Imaging Data from the Tortuga Trial

Annals of Rheumatic Diseases. 2021 June;


Efficacy and Safety of Upadacitinib in Patients with Active Ankylosing Spondylitis: 1-year Results from a Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Extensión

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Evaluation of Spinal Radiographic Progression in Patients with Radiographic Axial Spondyloarthritis Receiving Ixekizumab Therapy over 2 years

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Identification of Clinical Phenotypes in patients with Axial Spondyloarthritis, Peripheral Spondyloarthritis and Psoriatic Arthritis according to Peripheral Musculoskeletal Manifestations: A Cluster Analysis in the International ASAS-perSpA Study

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Weber U., Jurik A.G., Lambert R.G.W., Maksymowych W.P.

Current Rheumatology Reports. 2021 June; 23 (8) 10.1007/s11926-021-01030-w


Improving Osteoarthritis Care by Automatic Measurement of Hip Effusion using AI

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Keeling S., Maksymowych W.P.

Expert Review of Clinical Immunology. 2021 June; 17 (7):701-715 10.1080/1744666X.2021.1925541


Predictors of Response in Patients with Non-Radiographic Axial Spondyloarthritis Receiving Certolizumab Pegol in the C-Axspand Study

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Reliability and Responsiveness of Two Omeract Whole-Body MRI Scores of Entheseal and Joint Inflammation in the Knee Region in Spondyloarthritis

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Sacroiliac Joint MRI abnormalities in Juvenile Spondyloarthritis: An Update of Definitions and Scoring of the Omeract Juvenile Idiopathic Arthritis MRI Score

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Scoring MRI Structural Lesions in Sacroiliac Joints of Patients with Axial Spondyloarthritis: How Many Slices are Optimal?

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


The Omeract Knee Inflammation MRI Scoring System: Validation of Quantitative Methodologies and Tri-Compartmental Overlays by Comparison with the MRI Osteoarthritis Knee Score

Annals of Rheumatic Diseases, Annals of Rheumatic Diseases, European Congress of Rheumatology Annual Meeting. 2021 June;


Deodhar, Atul; van der Heijde, Desiree; Sieper, Joachim; Van den Bosch, Filip; Maksymowych, Walter P; Kim, Tae-Hwan; Kishimoto, Mitsumasa; Ostor, Andrew; Combe, Bernard; Sui, Yunxia; Chu, Alvina D; Song, In-Ho.

Arthritis & Rheumatology. 2021 June; 10.1002/art.41911


Jaremko J.L., Felfeliyan B., Hareendranathan A., Thejeel B., Vanessa Q.L., Østergaard M., Conaghan P.G., Lambert R.G.W., Ronsky J.L., Maksymowych W.P.

Seminars in Arthritis and Rheumatism. 2021 June; 51 (3):623-626 10.1016/j.semarthrit.2021.03.009


Antony A., Holland R., D'Agostino M.A., Maksymowych W.P., Bertheussen H., Schick L., Goel N., Ogdie A., Orbai A.M., Højgaard P., Coates L.C., Strand V., Gladman D.D., Christensen R., Leung Y.Y., Mease P., Tillett W.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 April; 51 (2):367-386 10.1016/j.semarthrit.2021.01.008


Malik F., Scherl E., Weber U., Carrino J.A., Epsten M., Wichuk S., Pedersen S.J., Paschke J., Schwartzman S., Kroeber G., Maksymowych W.P., Longman R., Mandl L.A.

International Journal of Rheumatic Diseases. 2021 April; 24 (4):582-590 10.1111/1756-185X.14081


Maksymowych WP, Lambert RG, Østergaard M, Baraliakos X

ANNALS OF THE RHEUMATIC DISEASES. 2021 March; 10.1136/annrheumdis-2021-220078


Jaremko J, Banafshe F, Abhilash H, Bashiar T, Quinn-Laurin V, Østergaard M, Conaghan PG, Lambert RG, Ronsky JL, Maksymowych WP

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 March; 10.1016/j.semarthrit.2021.03.009


Maksymowych WP, Lambert RG, Baraliakos X, Weber U, Machado PM, Pedersen SJ, de Hooge M, Sieper J, Wichuk S, Poddubnyy D, Rudwaleit M, van der Heijde D, Landewe R, Eshed I, Ostergaard M

RHEUMATOLOGY. 2021 February; 10.1093/rheumatology/keab099


Maksymowych W.P., Østergaard M.

JOURNAL OF RHEUMATOLOGY. 2021 February; 97 10.3899/jrheum.201676


Antony A., Holland R., D'Agostino M.A., Maksymowych W.P., Bertheussen H., Schick L., Goel N., Ogdie A., Orbai A.M., Højgaard P., Coates L.C., Strand V., Gladman D.D., Christensen R., Leung Y.Y., Mease P., Tillett W.

SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021 February; 51 (2):367-386 10.1016/j.semarthrit.2021.01.008


Protopopov M, Proft F, Sepriano A, Landewé R, van der Heijde D, Maksymowych WP, Baraliakos X, Sieper J, Rudwaleit M, Poddubnyy D

RHEUMATOLOGY. 2021 February; 10.1093/rheumatology/keab091


Sepriano A., Ramiro S., Wichuk S., Chiowchanwisawakit P., Paschke J., van der Heijde D., Landewé R., Maksymowych W.P.

Arthritis & Rheumatology. 2021 February; 73 (7):1211-1219 10.1002/art.41667


Sepriano A., Ramiro S., Wichuk S., Chiowchanwisawakit P., Paschke J., Van Der Heijde D., Landewé R., Maksymowych W.P.

RHEUMATOLOGY. 2021 January; 60 (1):461-462 10.1093/rheumatology/keaa564


Nash P., Kerschbaumer A., Dörner T., Dougados M., Fleischmann R.M., Geissler K., McInnes I., Pope J.E., Van Der Heijde D., Stoffer-Marx M., Takeuchi T., Trauner M., Winthrop K.L., De Wit M., Aletaha D., Baraliakos X., Boehncke W.H., Emery P., Isaacs J.D., Kremer J., Lee E.B., Maksymowych W.P., Voshaar M., Tam L.S., Tanaka Y., Van Den Bosch F., Westhovens R., Xavier R., Smolen J.S.

ANNALS OF THE RHEUMATIC DISEASES. 2021 January; 80 (1):71-87 10.1136/annrheumdis-2020-218398


López-Medina C., Molto A., Sieper J., Duruöz T., Kiltz U., Elzorkany B., Hajjaj-Hassouni N., Burgos-Vargas R., Maldonado-Cocco J., Ziade N., Gavali M., Navarro-Compan V., Luo S.F., Monti S., Tae-Jong K., Kishimoto M., Pimentel-Santos F.M., Gu J., Schiotis R., Van Gaalen F.A., Geher P., Magrey M., Ibáñez Vodnizza S.E., Bautista-Molano W., Maksymowych W., Machado P.M., Landewé R., Van Der Heijde D., Dougados M.

RMD Open. 2021 January; 7 (1) 10.1136/rmdopen-2020-001450


Maksymowych W.P., Claudepierre P., de Hooge M., Lambert R.G., Landewé R., Molto A., van der Heijde D., Bukowski J.F., Jones H., Pedersen R., Szumski A., Vlahos B., Dougados M.

ARTHRITIS RESEARCH & THERAPY. 2021 January; 23 (1) 10.1186/s13075-021-02428-8


Maksymowych W.P.

CLINICAL RHEUMATOLOGY. 2021 January; 40 10.1007/s10067-020-05527-0


Aouad K., Maksymowych W.P., Baraliakos X., Ziade N.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY. 2020 December; 34 (6) 10.1016/j.berh.2020.101628


Bone Marrow Lesion Scores in Patients with Knee Osteoarthritis Undergoing Tibial Osteotomy: Reliability and Concurrent Validity of the Knee Inflammation MRI Scoring System (KIMRISS)

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Certolizumab Pegol Efficacy in Patients with Non-Radiographic Axial Spondyloarthritis Stratified by Baseline MRI and CReactive Protein Status

Arthritis and Rheumatology, Certolizumab Pegol Efficacy in Patients with Non-Radiographic Axial Spondyloarthritis Stratified by Baseline MRI and CReactive Protein Status. 2020 November;


Certolizumab Pegol Efficacy in Patients with Non-Radiographic Axial Spondyloarthritis Stratified by Baseline MRI and C-Reactive Protein Status

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Consensus Definitions for MRI Lesions in the Spine of Patients with Axial Spondyloarthritis: First Analysis from the Assessments in SpondyloArthritis International Society Classification Cohort

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Diagnosis of Axial Spondyloarthritis: A Primary Unmet Educational Need for Rheumatologists Is Interpretation of MRI

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Effects of Filgotinib on Spinal Lesions in Patients with Ankylosing Spondylitis: Magnetic Resonance Imaging Data from the Placebo-Controlled, Double Blind, Randomized TORTUGA Trial

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Efficacy and Safety of Upadacitinib in Patients with Active Ankylosing Spondylitis: 1-Year Results from a Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Extension

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Efficacy of Ixekizumab on Disease Activity and Quality of Life in Patients with Active Nonradiographic Axial Spondyloarthritis and Objective Signs of Inflammation, Stratified by Baseline CRP/Sacroiliac Joint MRI Status

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Identification of Clinical Phenotypes in Patients with Axial Spondyloarthritis, Peripheral Spondyloarthritis and Psoriatic Arthritis According to Peripheral Musculoskeletal Manifestations: A Cluster Analysis in the International ASAS-PerSpA Study

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Impact of Filgotinib on Structural Lesions in the Sacroiliac Joints at 12 Weeks in Patients with Active Ankylosing Spondylitis: Correlation with Clinical Endpoints

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Isotope-Labeling-LC-MS-based Metabolic Profiling of Multiple Serum Sample Sets for the Discovery of High-confidence Rheumatoid Arthritis Biomarkers

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Metabolomics Profiling of Human Serum for Discovering Biomarkers to Diagnose Psoriatic Arthritis and Ankylosing Spondylitis with High Specificity

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Performance of Three Referral Algorithms for Diagnosing Axial Spondyloarthritis: Results from the Screening in Axial Spondyloarthritis for Psoriasis, Iritis, and Colitis Cohort

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Predictors of Response in Patients with Non-Radiographic Axial Spondyloarthritis Receiving Certolizumab Pegol in the C-axSpAnd Study

Arthritis and Rheumatology. 2020 November;


Preliminary Definition of a Positive MRI for Active Lesions in the Sacroiliac Joints Typical of Axial Spondyloarthritis

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Preliminary Definition of a Positive MRI for Structural Lesions in the Sacroiliac Joints in Axial Spondyloarthritis

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Prevalence and Distribution of Peripheral Musculoskeletal Manifestations in Axial Spondyloarthritis, Peripheral Spondyloarthritis and Psoriatic Arthritis: Results of the International, Cross-sectional ASAS-PerSpA Study

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


Recent Use, Missed Doses and Discontinuation of Infliximab in New-users: Comparisons of Biosimilar and Originator Exposures

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;


The Relative Diagnostic Utility of Inflammatory Back Pain Criteria in an Inception Cohort of Patients with Psoriasis, Iritis, and Colitis Presenting with Undiagnosed Back Pain

Arthritis and Rheumatology, American College of Rheumatology Annual Meeting. 2020 November;