Muhammad Khan, MSc, PhD

Contact Overview Publications

Contact

Faculty of Medicine & Dentistry - Biochemistry Dept

Email: mbk@ualberta.ca

Overview

Area of Study / Keywords

Biochemistry Molecular Biology X-rays cryo-EM Membrane protein Molecular level Structure Biology

About

Muhammad Khan is currently appointed in the Department of Biochemistry in the Faculty of Medicine & Dentistry.

Research

I study membrane protein (P-type ATPases) at molecular level using X-rays and cryo-EM to explore their mechanism of action.

Featured Publications

Pediatric Functional Constipation: A New Challenge

Samina Khan Bashir, Muhammad Bashir Khan

Advanced Gut & Microbiome Research. 2024 January; 10.1155/2024/5569563

Overview of Helicobacter pylori Infection, Prevalence, Risk Factors, and Its Prevention

Samina Khan Bashir, Muhammad Bashir Khan

Advanced Gut & Microbiome Research. 2023 May; 10.1155/2023/9747027

SARS-CoV-2 Mproprotease variants of concern display altered viral and host target processing but retain potency towards antivirals

Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A. Nieman, John C. Vederas, Olivier Julien, Marcin Drag, Shokrollah Elahi, Howard S. Young, M. Joanne Lemieux

2023 January; 10.1101/2023.01.28.525917

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

Wayne Vuong, Conrad Fischer, Muhammad Bashir Khan, Marco J van Belkum, Tess Lamer, Kurtis D Willoughby, Jimmy Lu, Elena Arutyunova, Michael A Joyce, Holly A Saffran, Justin A Shields, Howard S Young, James A Nieman, D Lorne Tyrrell, M Joanne Lemieux, John C Vederas

European Journal of Medicinal Chemistry. 2021 October; 222

N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro

Elena Arutyunova, Muhammad Bashir Khan, Conrad Fischer, Jimmy Lu, Tess Lamer, Wayne Vuong, Marco J. van Belkum, Ryan T. McKay, D. Lorne Tyrrell, John C. Vederas, Howard S. Young, M. Joanne Lemieux

2021 February; 10.1101/2021.02.16.431021

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux

Nature Communications. 2020 October; 10.1038/s41467-020-19339-y

Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin

Nikos Pinotsis, Karolina Zielinska, Mrigya Babuta, Joan L. Arolas, Julius Kostan, Muhammad Bashir Khan, Claudia Schreiner, Anita Salmazo, Luciano Ciccarelli, Martin Puchinger, Eirini A. Gkougkoulia, Euripedes de Almeida Ribeiro, Jr, Thomas C. Marlovits, Alok Bhattacharya, Kristina Djinovic-Carugo

Proceedings of the National Academy of Sciences. 2020 September; 10.1073/pnas.1917269117

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Nature Communications. 2020 August; 10.1038/s41467-020-18096-2

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux

2020 May; 10.1101/2020.05.03.073080

Fluorescence enhancement strategy for evaluation of the minor groove binder DAPI to complementary ssDNA sequence including telomere mimics in (ssDNA@DAPI/LDH) ultrathin films

Muhammad Sohail Haroone, Yuehua Hu, Ping Zhang, Ruili Ma, Xiaorang Zhang, Qari Muhammad Kaleem, Muhammad Bashir Khan, Jun Lu

Dyes and Pigments. 2019 July; 10.1016/j.dyepig.2019.03.007

Purification and biochemical properties of SDS-stable low molecular weight alkaline serine protease from Citrullus colocynthis.

Natural product research. 2015 September; 10.1080/14786419.2015.1079909

Structural and functional characterization of the N-terminal domain of the yeast Mg2+ channel Mrs2.

Acta crystallographica. Section D, Biological crystallography. 2013 August; 10.1107/s0907444913011712

The G-M-N motif determines ion selectivity in the yeast magnesium channel Mrs2p.

Metallomics : integrated biometal science. 2013 June; 10.1039/c3mt20201a

Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2, a magnesium ion transporter from yeast inner mitochondrial membrane.

Acta crystallographica. Section F, Structural biology and crystallization communications. 2010 May; 10.1107/S1744309110012212

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