Michelle Graham

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Contact Overview Publications

Contact

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Email: mmg2@ualberta.ca
Phone: (780) 407-1590
Address: Mackenzie Health Science Centre
8440 - 112 St

Edmonton AB

T6G 2B7

Overview

Area of Study / Keywords

Outcomes cardiac care in the elderly interventional cardiology acute coronary syndromes contrast-induced acute kidney injury

About

Personal Statement:

The exciting thing about research is its potential to have profound impacts on peoples’ lives. My areas of research focus are informed by my patients, who have taught me the value of not only living longer, but living better.

Dr. Graham obtained her MD at the University of Ottawa, trained in Internal Medicine at Western University, Cardiology at Dalhousie University and Interventional Cardiology at the University of Calgary.

Leadership and Collaborations:

Dr. Graham is former Chair of both the Canadian Cardiovascular Society’s Scientific Program Committee and Guidelines Committee. She is Associate Editor of the Canadian Journal of Cardiology, and the Inaugural Editor in Chief of CJC Open, which published its first issue in January 2019. She has extensive experience with peer review agencies, including Chair or Scientific Officer duties for committees of the Canadian Institutes of Health Research. She also Chairs the Quality Management Committee at the Alberta Strategic Clinical Network for Cardiovascular Health and Stroke.

Clinical Interests

Dr. Graham is an interventionalist cardiologist who treats patients at the University Hospital.

Research

Dr. Graham spends 50 percent of her time conducting outcomes research. Dr. Graham’s primary research interests are varied and include perioperative medicine, cardiac care in the elderly, processes of care, and precision medicine. She currently holds funding from the Canadian Institutes of Health Research and Alberta Innovates/Health Solutions and has over 100 peer review articles to date, including a 2018 publication in Annals of Internal Medicine. The study reviewed the 2014 POISE-2 clinical trial data to show a reduced risk of heart attack when patients with previous percutaneous coronary intervention took low-dose aspirin around the time of noncardiac surgery. This was a Late-Breaking Clinical Trials presentation at the American Heart Association Scientific Sessions in 2017.

Dr. Graham is also co-author of the Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery. She is a member of the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) team which created one of the most comprehensive registries of cardiac catheterization patients used to track long-term outcomes. The APPROACH team’s work was named one of the top six health research achievements in Canada in 2011 by the Canadian Institutes of Health Research and the Canadian Medical Association Journal. Dr. Graham was awarded the Department of Medicine’s Paul W. Armstrong Research Award in 2017.

Mentorship is an important area to Dr. Graham. She has received mentoring awards from trainees in the Core Internal Medicine program, as well as those from the Division of Cardiology. She received a Tier II Clinical Mentoring Award in 2011 from the Faculty of Medicine & Dentistry, and in 2017 was the recipient of the Thomas J. Marrie Mentorship Award from the Department of Medicine.

Featured Publications

P2Y12inhibitor adherence trajectories in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prognostic implications

Turgeon R.D., Koshman S.L., Dong Y., Graham M.M.

EUROPEAN HEART JOURNAL. 2022 June; 43 (24):2303-2313 10.1093/eurheartj/ehac116

Anemia, Cardiovascular Disease, and Frailty in the Older Adult

O'Neill D.E., Graham M.M.

CANADIAN JOURNAL OF CARDIOLOGY. 2022 June; 38 (6):715-717 10.1016/j.cjca.2022.03.001

Missing the Goal With the 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization

Ruel M., Williams A., Ouzounian M., Sun L., Légaré J.F., Poirier P., Malas T., Farkouh M.E., Chedrawy E., Hassan A., Higgins J., Connelly K., McClure R.S., Bewick D., Whitlock R., Graham M., Arora R.C.

CANADIAN JOURNAL OF CARDIOLOGY. 2022 June; 38 (6):705-708 10.1016/j.cjca.2022.03.013

A Practical Approach to Invasive Testing in Ischemia With No Obstructive Coronary Arteries (INOCA)

Bastiany A., Pacheco C., Sedlak T., Saw J., Miner S.E.S., Liu S., Lavoie A., Kim D.H., Gulati M., Graham M.M.

CJC Open. 2022 May; 4 (8):709-720 10.1016/j.cjco.2022.04.009

Physical Activity in Renal Disease and the Effect on Hypertension: A Randomized Controlled Trial

Thompson S., Wiebe N., Stickland M.K., Gyenes G.T., Davies R., Vallance J., Graham M.

Kidney Blood PRess Res. 2022 April; 47 (7):475-485 10.1159/000524518

Effect of New Evidence on Antithrombotic Therapies in Atrial Fibrillation Patients Who Undergo Percutaneous Coronary Intervention in Alberta, Canada

Eberhardt T.E., Bungard T.J., Graham M.M., Picard M., Wang G.T., Ackman M.L.

CJC Open. 2022 April; 4 (4):378-382 10.1016/j.cjco.2021.12.007

Development and Evaluation of an Audit and Feedback Process for Prevention of Acute Kidney Injury During Coronary Angiography and Intervention

Ma B., Faris P., Har B.J., Tyrrell B., Benterud E., Spertus J.A., Pannu N., Manns B.J., Graham M.M., James M.T.

CJC Open. 2022 March; 4 (3):271-281 10.1016/j.cjco.2021.10.006

In-Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology

Wu P., Sharma G.V., Mehta L.S., Chew-Graham C.A., Lundberg G.P., Nerenberg K.A., Graham M.M., Chappell L.C., Kadam U.T., Jordan K.P., Mamas M.A.

Journal of the American Heart Association. 2022 March; 11 (5) 10.1161/JAHA.121.022658

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study

Kontopantelis E., Mamas M.A., Webb R.T., Castro A., Rutter M.K., Gale C.P., Ashcroft D.M., Pierce M., Abel K.M., Price G., Faivre-Finn C., van Spall H.G.C., Graham M.M., Morciano M., Martin G.P., Sutton M., Doran T.

PLOS MEDICINE. 2022 February; 19 (2) 10.1371/journal.pmed.1003904

Continuous Noninvasive Remote Automated Blood Pressure Monitoring With Novel Wearable Technology: A Preliminary Validation Study

McGillion M.H., Dvirnik N., Yang S., Belley-Côté E., Lamy A., Whitlock R., Marcucci M., Borges F.K., Duceppe E., Ouellette C., Bird M., Carroll S.L., Conen D., Tarride J.E., Harsha P., Scott T., Good A., Gregus K., Sanchez K., Benoit P., Owen J., Harvey V., Peter E., Petch J., Vincent J., Graham M., Devereaux P.J.

JMIR mHealth and uHealth. 2022 February; 10 (2) 10.2196/24916

Beyond Wellness Monitoring: Continuous Multiparameter Remote Automated Monitoring of Patients

McGillion M.H., Allan K., Ross-Howe S., Jiang W., Graham M., Marcucci M., Johnson A., Scott T., Ouellette C., Kocetkov D., Lounsbury J., Bird M., Harsha P., Sanchez K., Harvey V., Vincent J., Borges F.K., Carroll S.L., Peter E., Patel A., Bergh S., Devereaux P.J.

CANADIAN JOURNAL OF CARDIOLOGY. 2022 February; 38 (2):267-278 10.1016/j.cjca.2021.10.011

Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery

Gouda P., Wang X., Youngson E., McGillion M., Mamas M.A., Graham M.M.

PLoS One. 2022 January; 17 (1 January) 10.1371/journal.pone.0262322

Sex and Medium-term Outcomes of ST-Segment Elevation Myocardial Infarction in Kerala, India: A Propensity Score-Matched Analysis

Mathew A., Hong Y., Yogasundaram H., Nagendran J., Punnoose E., Ashraf S.M., Fischer L., Abdullakutty J., Pisharody S., Bainey K., Graham M.

CJC Open. 2021 December; 3 (12):S71-S80 10.1016/j.cjco.2021.09.023

The incidence of stroke in patients with early echocardiography after acute myocardial infarction

Zhang P.(., Becher H., Jeerakathil T., Graham M.M., Shanks M.

INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING. 2021 December; 37 10.1007/s10554-021-02333-w

Trends in cardiovascular mortality of cancer patients in the US over two decades 1999-2019

Kobo O., Khattak S., Lopez-Mattei J., Van Spall H.G.C., Graham M., Cheng R.K., Osman M., Sun L., Ullah W., Fischman D.L., Roguin A., Mohamed M.O., Mamas M.A.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE. 2021 November; 75 (11) 10.1111/ijcp.14841

Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions

Matetic A., Mohamed M., Miller R.J.H., Kolman L., Lopez-Mattei J., Cheung W.Y., Brenner D.R., Van Spall H.G.C., Graham M., Bianco C., Mamas M.A.

INTERNATIONAL JOURNAL OF CARDIOLOGY. 2021 October; 341 10.1016/j.ijcard.2021.07.054

Racial Disparities in Management and Outcomes of Out-of-Hospital Cardiac Arrest Complicating Myocardial Infarction: A National Study From England and Wales

Dafaalla M., Rashid M., Bond R.M., Smith T., Parwani P., Thamman R., Moledina S.M., Graham M.M., Mamas M.A.

CJC Open. 2021 October; 3 (12):S81-S88 10.1016/j.cjco.2021.09.026

The Indirect Impact of COVID-19 on Cardiac Care and Outcomes: Lessons From a Stretched System

Graham M.M., Simpson C.S.

CANADIAN JOURNAL OF CARDIOLOGY. 2021 October; 37 (10):1502-1503 10.1016/j.cjca.2021.06.002

Post-discharge after surgery Virtual Care with Remote Automated Monitoring-1 (PVC-RAM-1) technology versus standard care: Randomised controlled trial

McGillion M.H., Parlow J., Borges F.K., Marcucci M., Jacka M., Adili A., Lalu M.M., Ouellette C., Bird M., Ofori S., Roshanov P.S., Patel A., Yang H., O'Leary S., Tandon V., Hamilton G.M., Mrkobrada M., Conen D., Harvey V., Lounsbury J., Mian R., Bangdiwala S.I., Arellano R., Scott T., Guyatt G.H., Gao P., Graham M., Nenshi R., Forster A.J., Nagappa M., Levesque K., Marosi K., Chaudhry S., Haider S., Deuchar L., Leblanc B., McCartney C.J.L., Schemitsch E.H., Vincent J., Pettit S.M., Dumerton D., Paulin A.D., Simunovic M., Williams D.C., Halman S., Harlock J., Meyer R.M., Taylor D.A., Shanthanna H., Schlachta C.M., Parry N., Pichora D.R., Yousuf H., Peter E., Lamy A., Petch J., Moloo H., Sehmbi H., Waggott M., Shelley J., Belley-Cote E.P., Devereaux P.J.

BMJ-British Medical Journal. 2021 September; 374 10.1136/bmj.n2209

Sex, Race, and Age Differences in Cardiovascular Outcomes in Implantable Cardioverter-Defibrillator Randomized Controlled Trials: A Systematic Review and Meta-analysis

Syed M.K., Sheikh H.I., McKay B., Tseng N., Pakosh M., Caterini J.E., Sharma A., Colella T.J.F., Konieczny K.M., Connelly K.A., Graham M.M., McDonald M., Banks L., Randhawa V.K.

CJC Open. 2021 September; 3 (12):S209-S217 10.1016/j.cjco.2021.09.015

Sex, Race, and Age Differences of Cardiovascular Outcomes in Cardiac Resynchronization Therapy RCTs: A Systematic Review and Meta-analysis

McKay B., Tseng N.W.H., Sheikh H.I., Syed M.K., Pakosh M., Caterini J.E., Sharma A., Colella T.J.F., Konieczny K.M., Connelly K.A., Graham M.M., McDonald M., Banks L., Randhawa V.K.

CJC Open. 2021 September; 3 (12):S192-S201 10.1016/j.cjco.2021.09.005

Effect of patient-centered transitional care services on patient-reported outcomes in heart failure: sex-specific analysis of the PACT-HF randomized controlled trial

Blumer V., Gayowsky A., Xie F., Greene S.J., Graham M.M., Ezekowitz J.A., Perez R., Ko D.T., Thabane L., Zannad F., Van Spall H.G.C.

EUROPEAN JOURNAL OF HEART FAILURE. 2021 September; 23 (9):1488-1498 10.1002/ejhf.2312

Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study

Kontopantelis E., Mamas M.A., Webb R.T., Castro A., Rutter M.K., Gale C.P., Ashcroft D.M., Pierce M., Abel K.M., Price G., Faivre-Finn C., Van Spall H.G.C., Graham M.M., Morciano M., Martin G.P., Doran T.

Lancet Regional Health Europe. 2021 August; 7 10.1016/j.lanepe.2021.100144

Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team

Paterson I., Ramanathan K., Aurora R., Bewick D., Chow C.M., Clarke B., Cowan S., Ducharme A., Gin K., Graham M., Gupta A., Jassal D.S., Kazmi M., Krahn A., Lamarche Y., Marelli A., Roifman I., Ruel M., Singh G., Sterns L., Turgeon R., Virani S., Wong K.K., Zieroth S.

CANADIAN JOURNAL OF CARDIOLOGY. 2021 August; 37 10.1016/j.cjca.2021.05.011

Risk of Pneumonia with Ticagrelor Versus Clopidogrel: a Population-Based Cohort Study

Turgeon R.D., Youngson E., Graham M.M.

JOURNAL OF GENERAL INTERNAL MEDICINE. 2021 July; 36 (7):2158-2160 10.1007/s11606-020-06131-3

The Perioperative Surgical Home, Enhanced Recovery after Surgery and how integration of these models may improve care for medically complex patients

Harrison T.G., Ronksley P.E., James M.T., Brindle M.E., Ruzycki S.M., Graham M.M., McRae A.D., Zarnke K.B., McCaughey D., Ball C.G., Dixon E., Hemmelgarn B.R.

CANADIAN JOURNAL OF SURGERY. 2021 July; 64 (4):E381-E390 10.1503/CJS.002020

Effectiveness and Utilization of Cardiac Rehabilitation Among People With CKD

Thompson S., Wiebe N., Arena R., Rouleau C., Aggarwal S., Wilton S.B., Graham M.M., Hemmelgarn B., James M.T.

Kidney International Reports. 2021 June; 6 (6):1537-1547 10.1016/j.ekir.2021.03.889

Cardiovascular Care Delivery During the Second Wave of COVID-19 in Canada

Roifman I., Arora R.C., Bewick D., Chow C.M., Clarke B., Cowan S., Ducharme A., Gin K., Graham M., Gupta A., Hardiman S., Hartleib M., Jackson S., Jassal D., Kazmi M., Lamarche Y., Légaré J.F., Leong-Poi H., Mansour S., Marelli A., Ruel M., Small G., Sterns L., Turgeon R., Virani S., Wijeysundera H.C., Wong K., Wood D.A., Zieroth S., Singh G., Krahn A.D.

CANADIAN JOURNAL OF CARDIOLOGY. 2021 May; 37 (5):790-793 10.1016/j.cjca.2020.11.016

Cardiovascular Physicians, Scientists, and Trainees Balancing Work and Caregiving Responsibilities in the COVID-19 Era: Sex and Race-Based Inequities

Banks L., Randhawa V.K., Colella T.J.F., Dhanvantari S., Connelly K.A., Robinson L., Mak S., Ouzounian M., Mulvagh S.L., Straus S., Allan K., Yin Yip C.Y., Graham M.M.

CJC Open. 2021 May; 3 (5):627-630 10.1016/j.cjco.2020.12.027

Patient Experience After Risk Stratification and Follow-up for Acute Kidney Injury After Cardiac Catheterization: Patient Survey

Natha J., Javaheri P.A., Kruger D., Benterud E., Pearson W., Tan Z., Ma B., Tyrrell B.D., Har B.J., Graham M.M., James M.T.

CJC Open. 2021 March; 3 (3):337-344 10.1016/j.cjco.2020.10.019

Development of Acute Myocardial Infarction Mortality and Readmission Models for Public Reporting on Hospital Performance in Canada

Ko D.T., Ahmed T., Austin P.C., Cantor W.J., Dorian P., Goldfarb M., Gong Y., Graham M.M., Gu J., Hawkins N.M., Huynh T., Humphries K.H., Koh M., Lamarche Y., Lambert L.J., Lawler P.R., Légaré J.F., Ly H.Q., Qiu F., Quraishi A.u.R., So D.Y., Welsh R.C., Wijeysundera H.C., Wong G., Yan A.T., Gurevich Y.

CJC Open. 2021 January; 10.1016/j.cjco.2021.04.012

Despite Having Worse Risk Profiles, Northern Albertans Wait Longer for Specialist Follow-up After Emergency Department Visits for Atrial Fibrillation

Rowe B.H., McAlister F.A., Graham M.M., Holroyd B.R., Rosychuk R.J.

CJC Open. 2020 November; 2 (6):610-618 10.1016/j.cjco.2020.07.018

Sex, Gender, and Equity in Cardiovascular Medicine, Surgery, and Science in Canada: Challenges, Successes, and Opportunities for Change

Banks L., Randhawa V.K., Caterini J., Colella T.J.F., Dhanvantari S., McMurtry S., Connelly K.A., Robinson L., Anand S.S., Ouzounian M., Zieroth S., Mak S., Straus S., Graham M.M.

CJC Open. 2020 November; 2 (6):522-529 10.1016/j.cjco.2020.06.016