Daniel Moreno De Luca, MD, MSc

CASA Research Chair, Faculty of Medicine & Dentistry - Psychiatry Dept

Personal Website: https://www.precisionmedicineinautism.org

Curriculum Vitæ

Contact Publications

Contact

CASA Research Chair, Faculty of Medicine & Dentistry - Psychiatry Dept

Email: daniel.morenodeluca@ualberta.ca
Address: 5020-K Katz Group Centre For Research
11315 - 87 Ave NW

Edmonton AB

T6G 2H5

Featured Publications

17q12 Recurrent Deletion Syndrome

Mitchel MW, Moreno-De-Luca D, Myers SM, Levy RV, Turner S, Ledbetter DH, Martin CL

2025 February;

Leveraging neuroscience education to address stigma related to opioid use disorder in the community: a pilot study.

Kyzar EJ, Arbuckle MR, Abba-Aji A, Balachandra K, Cooper J, Dela Cruz A, Edens E, Heward B, Jibson M, Jordan A, Moreno-De-Luca D, Pazderka H, Ross DA

Frontiers in psychiatry. 2024 March; 10.3389/fpsyt.2024.1360356

Genetics for mental health clinicians: a call for a globally accessible and equitable psychiatric genetics education.

Education Committee, International Society of Psychiatric Genetics (ISPG)

World psychiatry : official journal of the World Psychiatric Association (WPA). 2024 February; 10.1002/wps.21173

Development and Implementation of an Autism Spectrum and Intellectual Developmental Disorders Specialty Track Within Child and Adolescent Psychiatry Fellowship

Julia Katz, Jeffrey Hunt, Karen Cammuso, Daniel Moreno-De-Luca

Academic Psychiatry. 2023 May; 10.1007/s40596-023-01797-3

Actionable Genomics in Clinical Practice: Paradigmatic Case Reports of Clinical and Therapeutic Strategies Based upon Genetic Testing

Merlin G. Butler, Daniel Moreno-De-Luca, Antonio M. Persico

Genes. 2022 February; 10.3390/genes13020323

All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders.

Moreno-De-Luca D, Martin CL

Current opinion in genetics & development. 2021 March; 10.1016/j.gde.2021.02.015

Trains and Outer Space-The Unique Worlds Within Autism.

Moreno-De-Luca D

JAMA. 2020 October; 10.1001/jama.2020.19051

Clinical Genetic Testing in Autism Spectrum Disorder in a Large Community-Based Population Sample.

Moreno-De-Luca D, Kavanaugh BC, Best CR, Sheinkopf SJ, Phornphutkul C, Morrow EM

JAMA psychiatry. 2020 September; 10.1001/jamapsychiatry.2020.0950

Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study.

McCormick CEB, Kavanaugh BC, Sipsock D, Righi G, Oberman LM, Moreno De Luca D, Gamsiz Uzun ED, Best CR, Jerskey BA, Quinn JG, Jewel SB, Wu PC, Morrow EM

Autism research : official journal of the International Society for Autism Research. 2020 January; 10.1002/aur.2261

Mosaic trisomy 20 and mitigation in capital crimes sentencing: A review and case report.

Montplaisir R, Lee E, Moreno-De-Luca D, Myers WC

Behavioral sciences & the law. 2019 August; 10.1002/bsl.2422

Found in Translation: Autism Genetics and the Quest for Its Rosetta Stone

Jonathan Goldstein, David A. Ross, Daniel Moreno De Luca

Biological Psychiatry. 2019 April; 10.1016/j.biopsych.2019.02.001

21st-Century Genetics in Psychiatric Residency Training: How Do We Get There?

Besterman AD, Moreno-De-Luca D, Nurnberger JI

JAMA psychiatry. 2019 March; 10.1001/jamapsychiatry.2018.3872

What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.

Nurnberger JI, Austin J, Berrettini WH, Besterman AD, DeLisi LE, Grice DE, Kennedy JL, Moreno-De-Luca D, Potash JB, Ross DA, Schulze TG, Zai G

The Journal of clinical psychiatry. 2018 November; 10.4088/jcp.17nr12046

Leveraging the Power of Genetics to Bring Precision Medicine to Psychiatry: Too Little of a Good Thing?

Moreno-De-Luca D, Ross ME, Ross DA

Biological psychiatry. 2018 April; 10.1016/j.biopsych.2018.02.013

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium

Molecular autism. 2017 May; 10.1186/s13229-017-0137-9

Autism genetics: opportunities and challenges for clinical translation.

Vorstman JAS, Parr JR, Moreno-De-Luca D, Anney RJL, Nurnberger JI, Hallmayer JF

Nature reviews. Genetics. 2017 March; 10.1038/nrg.2017.4

Behavioral and neuroanatomical analyses in a genetic mouse model of 2q13 duplication.

Kishimoto K, Nomura J, Ellegood J, Fukumoto K, Lerch JP, Moreno-De-Luca D, Bourgeron T, Tamada K, Takumi T

Genes to cells : devoted to molecular & cellular mechanisms. 2017 March; 10.1111/gtc.12487

Beyond the Diagnosis: A Path Toward Understanding Behavior Through the Lens of Rare Genetics.

Moreno-De-Luca D

Biological psychiatry. 2016 July; 10.1016/j.biopsych.2016.05.020

Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.

Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF, Klei L, State MW

Neuron. 2015 September; 10.1016/j.neuron.2015.09.016

Loss of δ-catenin function in severe autism.

Turner TN, Sharma K, Oh EC, Liu YP, Collins RL, Sosa MX, Auer DR, Brand H, Sanders SJ, Moreno-De-Luca D, Pihur V, Plona T, Pike K, Soppet DR, Chakravarti A

Nature. 2015 March; 10.1038/nature14186

The role of parental cognitive, behavioral, and motor profiles in clinical variability in individuals with chromosome 16p11.2 deletions.

Moreno-De-Luca A, Evans DW, Boomer KB, Hanson E, Bernier R, Goin-Kochel RP, Myers SM, Challman TD, Moreno-De-Luca D, Slane MM, Hare AE, Chung WK, Ledbetter DH

JAMA psychiatry. 2015 February; 10.1001/jamapsychiatry.2014.2147

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.

Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium

Nature neuroscience. 2015 January; 10.1038/nn.3922

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.

Maier R, Moser G, Chen GB, Ripke S, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell W, Potash JB, Scheftner WA, Shi J, Lee SH

American journal of human genetics. 2015 January; 10.1016/j.ajhg.2014.12.006

A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?

Chaste P, Klei L, Sanders SJ, Hus V, Murtha MT, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Devlin B

Biological psychiatry. 2014 September; 10.1016/j.biopsych.2014.09.017

Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2.

Chaste P, Sanders SJ, Mohan KN, Klei L, Song Y, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Kim SJ

Autism research : official journal of the International Society for Autism Research. 2014 May; 10.1002/aur.1378

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)

Nature genetics. 2013 August; 10.1038/ng.2711

Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait.

Chaste P, Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Kim SJ

Biological psychiatry. 2013 June; 10.1016/j.biopsych.2013.04.018

Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence.

Moreno-De-Luca A, Myers SM, Challman TD, Moreno-De-Luca D, Evans DW, Ledbetter DH

The Lancet. Neurology. 2013 March; 10.1016/s1474-4422(13)70011-5

Common genetic variants, acting additively, are a major source of risk for autism.

Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Devlin B

Molecular autism. 2012 October; 10.1186/2040-2392-3-9

Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts.

Moreno-De-Luca D, Sanders SJ, Willsey AJ, Mulle JG, Lowe JK, Geschwind DH, State MW, Martin CL, Ledbetter DH

Molecular psychiatry. 2012 October; 10.1038/mp.2012.138

An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities.

Kaminsky EB, Kaul V, Paschall J, Church DM, Bunke B, Kunig D, Moreno-De-Luca D, Moreno-De-Luca A, Mulle JG, Warren ST, Richard G, Compton JG, Martin CL

Genetics in medicine : official journal of the American College of Medical Genetics. 2011 September; 10.1097/gim.0b013e31822c79f9

Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.

Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, State MW

Neuron. 2011 June; 10.1016/j.neuron.2011.05.002

Copy number variants: a new molecular frontier in clinical psychiatry.

Moreno-De-Luca D, Cubells JF

Current psychiatry reports. 2011 April; 10.1007/s11920-011-0183-5

Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia.

Moreno-De-Luca D, SGENE Consortium, Mulle JG, Simons Simplex Collection Genetics Consortium, Kaminsky EB, Sanders SJ, GeneSTAR, Myers SM, Adam MP, Ledbetter DH

American journal of human genetics. 2010 November; 10.1016/j.ajhg.2010.10.004

Paracentric inversion of chromosome 2 associated with cryptic duplication of 2q14 and deletion of 2q37 in a patient with autism.

Devillard F, Guinchat V, Moreno-De-Luca D, Tabet AC, Gruchy N, Guillem P, Nguyen Morel MA, Leporrier N, Leboyer M, Jouk PS, Lespinasse J, Betancur C

American journal of medical genetics. Part A. 2010 September; 10.1002/ajmg.a.33601

Chiari I malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiency.

Carr CW, Moreno-De-Luca D, Parker C, Zimmerman HH, Ledbetter N, Martin CL, Dobyns WB, Abdul-Rahman OA

European journal of human genetics : EJHG. 2010 June; 10.1038/ejhg.2010.96

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