Stephanie Keeling

Professor, Faculty of Medicine & Dentistry - Medicine Dept

Contact

Professor, Faculty of Medicine & Dentistry - Medicine Dept
Email
myckatyn@ualberta.ca
Phone
(780) 492-7500

Overview

Area of Study / Keywords

systemic lupus erythematosus rheumatoid arthritis psoriatic arthritis dermatomyositis pregnancy co-morbidities guidelines


About

Rheumatological diseases span many disorders and are among the most prevalent in society, affecting people of all ages. While my practice includes all types of rheumatic disease, one area that I am particularly interested in is lupus, because it affects the whole person—physical, cognitive, emotional and social—and is so variable in how it affects people. My research aims to discover ways to diagnose lupus early in its development and to ensure all lupus patients receive consistent high-quality care so that the disease is optimally managed. In parallel, I continue to evaluate patients with inflammatory arthritis (including rheumatoid arthritis, psoriatic arthritis and spondyloarthritis), both for optimizing the best treatments and managing associated co-morbidities including cardiovascular disease and osteoporosis. The ONTRAAC program is a state-of-the-art clinical research program which aims to provide the best care of these patients while studying factors which impact how they do. My past close collaborations with dermatology have led to the ongoing treatment of patients with dermatomyositis, which has led to new collaborations with rheumatologists and neurologists across the country to study how to best personalize treatment for these complex patients with varying disease presentations. I have recently collaborated with VIGOUR (Drs. Padma Kaul and Anamaria Savu) to study the impact of rheumatic diseases on the pregnancy outcomes of women in Alberta. 

Dr. Stephanie Keeling completed her master’s degree in experimental medicine studying inflammatory back pain in spondyloarthritis. 

Leadership and Collaborations:

Dr. Keeling established the Lupus Clinical of Northern Alberta (LUNA) with conjoint clinics in Dermatology. She has also collaborated with Cardiology at the Mazankowski Heart Institute and conducted a Cardiovascular Risk Reduction Clinic for Inflammatory Rheumatic Diseases which has now evolved into the new ON-Traac (On Treating Rheumatoid Arthritis, Access to Care) program with co-director Steven Katz. This treat-to-target clinic for inflammatory arthritis includes co-morbidity management for osteoporosis and cardiovascular risk utilizing a shared care model with allied health professionals.  

Dr. Keeling is a member of the Canadian Network of Improved Outcomes in SLE (CaNIOS), a Canada-wide group of rheumatologists collaborating to study Canadian SLE patients and the Lupus Clinical Investigation Network (LUCIN), a North American network of rheumatologists who are working to improve the lives of patients with lupus.

She is the principal investigator of GRADE-based recommendations for the diagnosis and management of lupus in Canada. She is a board member of the Canadian Rheumatology Association and the Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus, and is a medical advisory and board member of the Alberta Arthritis Society.



Clinical Interests

Dr. Keeling cares for patients as part of the Alberta Rheumatology unit at the Kaye Edmonton Clinic. In addition to the LUNA and ONTRAAC clinics, her rheumatology practice includes a large population of patients with dermatomyositis and spondyloarthritis and newer medications for these complex diseases.


Research

Dr. Keeling is a clinical researcher who is the local principal investigator for several clinical trials for lupus. The Arthritis Society of Canada named the evidence-based, clinical practice guidelines for lupus care across Canada, developed by Canadian SLE (Systemic Lupus Erythematosus) working group led by Dr. Keeling, as one of the top ten research advances in 2018. She has published her research findings in such journals as The Journal of Rheumatology. She has also written articles about lupus for the public in on-line publications such as Personal Health News.


Teaching

Dr. Keeling teaches and supervises medical students, residents and fellows. She is part of a team that is developing a mobile app called the Dermatology Rheumatology Educational Tool for Autoimmune Manifestations (DREAM) Tool, which was a finalist in the Excellence in Education category at the 2018 SKINPACT awards. 

Featured Publications

Characteristics of Emergency Department and Urgent Care Center Use by Patients With Inflammatory Arthritis Conditions

Journal of Rheumatology Canadian Rheumatology Association Annual Scientific Meeting 2022. 2022 July;


Discontinuation/Switching After Etanercept Biosimilar (ETA-B) and Originator (ETA-O) Initiation in Rheumatoid Arthritis

Journal of Rheumatology Canadian Rheumatology Association Annual Scientific Meeting 2022. 2022 July;


Early Switching and Smoking Associated With BDMARD Refractory Disease: A 15-year Follow-up of the Alberta Biologics Pharmacovigilance Cohort

Journal of Rheumatology Canadian Rheumatology Association Annual Scientific Meeting 2022. 2022 July;


Impact of Inflammatory Arthritis on COVID-19 Outcomes: The Impact Study

Journal of Rheumatology Canadian Rheumatology Association Annual Scientific Meeting 2022. 2022 July;


Work Disability and Function in Systematic Lupus Erythematosus (SLE): Early Results of an Exploratory National Study

Journal of Rheumatology Canadian Rheumatology Association Annual Scientific 2022 Meeeting. 2022 July;


Fortin P.R., Da Costa D., Neville C., Julien A.S., Rahme E., Haroun V., Singer W., Nimigon-Young J., Morrison A.L., Eng D., Peschken C.A., Vinet E., Hudson M., Smith D., Matsos M., Pope J.E., Clarke A.E., Keeling S., Avina-Zubieta J.A., Rochon M.

Arthritis Care and Research. 2022 July; 74 (7):1113-1121 10.1002/acr.24542


Does Imaging of the Sacroiliac Joint and Spine Differ in Patients Presenting with Undiagnosed Back Pain and Psoriasis, Acute Anterior Uveitis, and Colitis: An Inception Cohort Study

American College fo Rheumatology Convergence Conference 2021. 2021 November;


Switching Biologics and Failure to Attain Remission in the First Year Predicts bDMARD Refractory Disease in Rheumatoid Arthritis: A 15-year Follow up of the Alberta Biologics Pharmacovigilance Cohort

American College of Rheumatology Convergence 2021 Online Meeting. 2021 November;


Johnson D., van Eeden C., Moazab N., Redmond D., Phan C., Keeling S., Gniadecki R., Cohen Tervaert J.W., Osman M.

Frontiers in Medicine. 2021 August; 8 10.3389/fmed.2021.708432


Keeling S., Maksymowych W.P.

Expert Review of Clinical Immunology. 2021 May; 17 (7):701-715 10.1080/1744666X.2021.1925541


Al Hamarneh Y.N., Marra C., Gniadecki R., Keeling S., Morgan A., Tsuyuki R.

BMJ Open. 2021 March; 11 (3) 10.1136/bmjopen-2020-043612


Biologic Refractory Rheumatoid Arthritis: A Report From the Rheumatoid Arthritis Pharmacovigilance Program and Outcomes Research in Therapeutics (RAPPORT)

Canadian Rheumatology Association Annual Scientific Meeting - Virtual. 2021 February;


Evaluation of Comorbidities and Damage in Canadian Patients with Systemic Lupus Erythematosus

Canadian Rheumatology Association Annual Scientific Meeting - Virtual conference. 2021 February;


Paul R Fortin 1, Deborah Da Costa 2, Carolyn Neville 2, Anne-Sophie Julien 3, Elham Rahme 2, Vinita Haroun 4, Wendy Singer 4, Jodie Nimigon-Young 4, Anna-Lisa Morrison 4, Davy Eng 1, Christine A Peschken 5, Evelyne Vinet 2, Marie Hudson 6, Doug Smith 7, Mark Matsos 8, Janet E Pope 9, Ann E Clarke 10, Stephanie Keeling 11, J Antonio Avina-Zubieta 12, Murray Rochon 13

Arthritis Care Res (Hoboken). 2020 December; 10.1002/acr.24542


Dissanayake T.D., Maksymowych W.P., Keeling S.O.

Scientific Reports. 2020 December; 10 (1) 10.1038/s41598-020-60451-2


Performance of Three Referral Algorithms for Diagnosing Axial Spondyloarthritis: Results from the Screening in Axial Spondyloarthritis for Psoriasis, Iritis, and Colitis Cohort

Arthritis & Rheumatology. 2020 October;


The Relative Diagnostic Utility of Inflammatory Back Pain Criteria in an Inception Cohort of Patients with Psoriasis, Iritis, and Colitis Presenting with Undiagnosed Back Pain

Arthritis & Rheumatology. 2020 October;