Nikolai Malykhin, MD, PhD

Area of Study / Keywords

neuromaging memory emotions hippocampus cognitive aging stress depression

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About

Dr. Nikolai Malykhin is currently appointed as Professor in the Department of Psychiatry in the Faculty of Medicine & Dentistry.

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Research

1. Computational neuroanatomy

   We have developed ultrahigh resolution volumetric and functional Magnetic Resonance Imaging (MRI) methods to analyze in vivo different brain structures such as hippocampal subfields and amygdala sub-nuclei. Application of these unique techniques allows us for the first time to study hippocampal and amygdala function in-vivo that has been impossible to date.  

   Aging brain

   Our second research area is normal and pathological aging. Our group demonstrated a specific anterior-posterior gradient of hippocampal volume loss and relative amygdala preservation associated with normal aging that contrasts with the preferential reduction of anterior hippocampal volumes in Alzheimer’s and Parkinson’s diseases. We also combine neuroanatomical and cognitive measures to reveal if and how structural brain changes correspond to age-related decline in cognitive functions. 

   Major depression

   Our third research focus is on brain changes in major depressive disorder (MDD). Our group demonstrated for the first time that hippocampal volume changes in depression are mainly localized to specific hippocampal subfields and subregions and that these volume reductions are also associated with past childhood abuse. These results provided the first  in vivo evidence that hippocampal subfields are differentially affected in MDD and by antidepressants.

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Teaching

Neuro 525 (Neuroimaging in Neuroscience)

Arash Aghamohammadi-Sereshki, Wojciech Pietrasik, Nikolai V. Malykhin

Brain Structure and Function. 2024 February; 10.1007/s00429-023-02753-5

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Kim Ngan Hoang, Yushan Huang, Esther Fujiwara, Nikolai Malykhin

Hippocampus. 2024 February; 10.1002/hipo.23592

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Nikolai Malykhin, Wojciech Pietrasik, Kim Ngan Hoang, Yushan Huang

Neurobiology of Aging. 2024 January; 10.1016/j.neurobiolaging.2023.10.006

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Nikolai Malykhin, Wojciech Pietrasik, Arash Aghamohammadi‐Sereshki, Kim Ngan Hoang, Esther Fujiwara, Fraser Olsen

Journal of Neuroscience Research. 2023 March; 10.1002/jnr.25152

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Aghamohammadi-Sereshki A., Olsen F., Seres P., Malykhin N.V.

Brain Connectivity. 2022 March; 12 (2):146-163 10.1089/brain.2020.0919

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Arash Aghamohammadi-Sereshki, Fraser Olsen, Peter Seres, Nikolai V. Malykhin

Brain Connectivity. 2021 June; 10.1089/brain.2020.0919

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Hrybouski S., Cribben I., McGonigle J., Olsen F., Carter R., Seres P., Madan C.R., Malykhin N.V.

Brain Structure & Function. 2021 May; 226 (4):1067-1098 10.1007/s00429-021-02226-7

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Aghamohammadi-Sereshki A., Coupland N.J., Silverstone P.H., Huang Y., Hegadoren K.M., Carter R., Seres P., Malykhin N.V.

Journal of Psychiatry and Neuroscience . 2021 January; 46 (1):E186-E195 10.1503/jpn.200034

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Nikolai V. Malykhin, Scott Travis, Esther Fujiwara, Yushan Huang, Richard Camicioli, Fraser Olsen

Hippocampus. 2020 October; 10.1002/hipo.23217

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Arash Aghamohammadi‐Sereshki, Stanislau Hrybouski, Scott Travis, Yushan Huang, Fraser Olsen, Rawle Carter, Richard Camicioli, Nikolai V. Malykhin

Human Brain Mapping. 2019 January; 10.1002/hbm.24353

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Nikolai V. Malykhin, Yushan Huang, Stanislau Hrybouski, Fraser Olsen

Neurobiology of Aging. 2017 November; 10.1016/j.neurobiolaging.2017.08.001

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