Ryan Noyce, PhD, BSc

Area of Study / Keywords

poxvirus-host interactions oncolytic viruses synthetic virology emerging pathogens vaccines

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About

Dr. Noyce is an early career researcher in Medical Microbiology and Immunology at the University of Alberta. He received his PhD in Biochemistry and Biomedical Sciences from McMaster University where he studied how viruses trigger innate antiviral signaling pathways in host cells (mentor Dr. Karen Mossman). He completed postdoctoral studies at Dalhousie University, where he identified a novel cellular receptor used by morbilliviruses (mentor Dr. Christopher Richardson). He continued his training in molecular virology as a research associate at the University of Alberta where he applied synthetic virology approaches to rapidly assemble poxvirus vectors (mentor Dr. David Evans). Versions of these modified poxvirus vectors have been successfully used as oncolytic virus therapies in preclinical tumor studies as well as vaccine vectors against emerging viral pathogens, such as monkeypox virus, SARS-CoV-2, and Chikungunya virus. He joined the University of Alberta Department of Medical Microbiology and Immunology in June 2023 as an Assistant Professor to apply novel synthetic virology approaches to study virus-host interactions and develop novel therapeutics and virus-based vaccines.

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Research

The Noyce laboratory are interested in developing novel synthetic virology approaches to rapidly build poxvirus vectors to study host-pathogen interactions and develop therapeutics to emerging viruses like SARS-CoV-2, Monkeypox Virus, and Chikungunya virus. We are also studying how these viral vectors can be modulated to induce anti-tumour immune responses during oncolytic virotherapy in a variety of tumour models, including brain, breast, skin, and bladder cancer.

YC Lin, DH Evans, RS Noyce

Methods in Molecular Biology: Vaccinia, Mpox, and other Poxviruses. 2025 January; 2860 10.1007/978-1-0716-4160-6_7

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Brittany A. Umer, Ryan S. Noyce, Quinten Kieser, Nicole A. Favis, Mira M. Shenouda, Kim J. Rans, Jackie Middleton, Mary M. Hitt, David H. Evans

PLOS ONE. 2024 March; 10.1371/journal.pone.0298437

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Hajar Miranzadeh Mahabadi, Y. C. James Lin, Natacha S. Ogando, Eman W. Moussa, Nazanin Mohammadzadeh, Olivier Julien, Neal M. Alto, Ryan S. Noyce, David H. Evans, Christopher Power

Proceedings of the National Academy of Sciences. 2024 February; 10.1073/pnas.2315653121

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Mayanka Awasthi, Anthony Macaluso, Dawn Myscofski, Jon Prigge, Fusataka Koide, Ryan S. Noyce, Siobhan Fogarty, Helen Stillwell, Scott J. Goebel, Bruce Daugherty, Farooq Nasar, Sina Bavari, Seth Lederman

Vaccines. 2023 November; 10.3390/vaccines11111682

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Storozynsky QT, Agopsowicz KC, Noyce RS, Bukhari AB, Han X, Snyder N, Umer BA, Gamper AM, Godbout R, Evans DH, Hitt MM

Cancer letters. 2023 April; 10.1016/j.canlet.2023.216169

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Noyce RS, Westfall LW, Fogarty S, Gilbert K, Mpanju O, Stillwell H, Esparza J, Daugherty B, Koide F, Evans DH, Lederman S

Viruses. 2023 January; 15 (2):356 10.3390/v15020356

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Viveiros A, Noyce RS, Gheblawi M, DANIELE COLOMBO, Bilawchuk LM, Clemente-Casares X, David J. Marchant, zamaneh kassiri, franca del nonno, Evans DH, Gavin Oudit

American journal of physiology. Heart and circulatory physiology. 2022 November; 10.1152/ajpheart.00578.2022

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Shenouda MM, Noyce RS, Lee SZ, Wang JL, Yi-Chan James Lin, Favis NA, Desaulniers MA

PLoS pathogens. 2022 March; 10.1371/journal.ppat.1010392

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Greg Vallée, Peter Norris, Patrick Paszkowski, Ryan S. Noyce, David H. Evans

Journal of Virology. 2021 June; 10.1128/JVI.00318-21

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