Gavin Oudit

Area of Study / Keywords

hypertension pediatric heart failure apoptosis heart failure atherosclerosis diabetes echocardiography blood pressure cardiac function pharmacology cardiovascular medicine cardiology

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About

Personal Statement:

Heart failure occurs when the heart has been damaged by heart attack or stroke. Approximately 600,000 Canadians live with heart failure and those numbers are increasing. Heart failure costs our health system about $2.4 billion annually. My goal is to use the knowledge and collaborative strengths we have to translate basic discoveries in the lab into therapies to reduce the burden of heart disease on individuals, their families and the health system.  

Clinician scientist Dr. Oudit’s medical degree, internal medicine and adult cardiology specialty training and PhD were all completed at the University of Toronto. He is a translational researcher whose work with patients at the Mazankowski Alberta Heart Institute informs his research endeavours to discover new therapies for heart failure. 

Leadership and Collaborations:

Dr. Oudit established the Human Explanted Heart Program and is director of the Heart Function Clinic at the Mazankowski Alberta Heart Institute.

Clinical Interests

Dr. Oudit is a clinician-scientist with the Mazankowski Alberta Heart Institute.

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Research

Dr. Oudit holds the Canada Research Chair in Heart Failure. He spends 65 per cent of his time investigating the molecular and cellular aspects of heart failure and arrythmias with the goal of  identifying new drug and therapy targets. His research spans many aspects of heart failure, including the role of gender in iron-overload cardiomyopathy, investigating cardiotoxicity from breast cancer chemotherapy, identifying diagnoses and treatment of Fabry disease, discovering biomarkers for heart failure, as well as research into kidney and vascular diseases. A discovery by Dr. Oudit of a molecule called ACE2 that protects against heart failure, coupled with his use of a new genetic mapping technology to more clearly observe sub-cellular processes involved in heart failure, led to the development of a biologic to treat the disease. The new heart failure drug has been successfully tested in clinical trials and is expected to be available within five years. Dr. Oudit’s work with ACE2 shows that it also plays major roles in diabetes and lung diseases and he is developing potential therapies. 

Dr. Oudit’s research is funded by the Women and Children's Health Research Institute, University Hospital Foundation, Heart & Stroke Foundation of Canada, Canadian Institutes of Health Research. He completed research grants with the Canadian Diabetes Association and Alberta Innovates. He has partnerships with GlaxoSmith Kline and Apeiron Biologics.

Dr. Oudit is an active review committee for the Heart and Stroke Foundation of Canada and has more than 300 scientific papers and abstracts in publication. 

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Teaching

Dr. Oudit teaches graduate students, post-doctoral fellows and cardiology and nephrology residents. 

Mahmud Z, Tikunova S, Belevych N, Wagg CS, Zhabyeyev P, Liu PB, Rasicci DV, Yengo CM, Oudit GY, Lopaschuk GD, Reiser PJ, Davis JP, Hwang PM

Frontiers in Physiology. 2022 June; 13 10.3389/fphys.2022.892979

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Zhang H, Jamieson K, Grenier J, Nikhanj A, Tang Z, Wang F, Wang SH, Seidman J, Seidman C, Thompson R, Seubert J, Oudit GY

Journal of the American Heart Association. 2022 June; 11 (11):e022853 10.1161/JAHA.121.022853

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 May; 10.1096/fasebj.2022.36.S1.0R588

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Kumaran M, Pham TM, Wang K, Usman H, Oudit GY, Norris CM, Macdonald J, Saini V, Sikdar KC

Frontiers in Public Health. 2022 May; 10 10.3389/fpubh.2022.838514

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 May; 10.1096/fasebj.2022.36.S1.0R342

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Sosnowski DK, Jamieson KL, Darwesh AM, Valencia R, Zhang H, Viveiros A, Edin ML, Zeldin, D, Oudit GY, Seubert JM

Frontiers in Cardiovascular Medicine. 2022 May; 9 10.3389/fcvm.2022.879209

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Gheblawi M., de Oliveira A.A., Williams V.R., John R., Grant M.B., Scholey J.W., Oudit G.Y.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2022 April; 169 10.1016/j.yjmcc.2022.04.015

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Parikh M., Seidman M., Oudit G.Y.

CANADIAN JOURNAL OF CARDIOLOGY. 2022 March; 38 (3):309-310 10.1016/j.cjca.2022.01.012

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Viveiros A., Gheblawi M., Aujla P.K., Sosnowski D.K., Seubert J.M., Kassiri Z., Oudit G.Y.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2022 March; 164 10.1016/j.yjmcc.2021.11.003

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Parikh M., Shah S., Basu R., Famulski K.S., Kim D., Mullen J.C., Halloran P.F., Oudit G.Y.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022 February; 23 (4):2050 10.3390/ijms23042050

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Wang K., Gheblawi M., Nikhanj A., Munan M., MacIntyre E., O’Neil C., Poglitsch M., Colombo D., Del Nonno F., Kassiri Z., Sligl W., Oudit G.Y.

HYPERTENSION. 2022 February; 79 (2):365-378 10.1161/HYPERTENSIONAHA.121.18295

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Yogasundaram H., Nikhanj A., Chatur S., Qi A., Hagen L., Bailey L., Khan A., Hopkin R.J., Fine N.M., Jefferies J.L., Oudit G.Y.

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY. 2022 February; 35 (2):236-238 10.1016/j.echo.2021.09.013

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Chute M., Aujla P.K., Li Y., Jana S., Zhabyeyev P., Rasmuson J., Owen C.A., Abraham T., Oudit G.Y., Kassiri Z.

MATRIX BIOLOGY. 2022 January; 105 10.1016/j.matbio.2021.12.002

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de Oliveira A.A., Vergara A., Wang X., Vederas J.C., Oudit G.Y.

PEPTIDES. 2022 January; 147 10.1016/j.peptides.2021.170697

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Jordà P., Oudit G.Y., Tadros R.

CANADIAN JOURNAL OF CARDIOLOGY. 2022 January; 38 (1):3-5 10.1016/j.cjca.2021.11.013

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Xu L., Pagano J., Chow K., Oudit G.Y., Haykowsky M.J., Mikami Y., Howarth A.G., White J.A., Howlett J.G., Dyck J.R.B., Anderson T.J., Ezekowitz J.A., Thompson R.B., Paterson D.I.

ESC Heart Failure. 2021 December; 8 (6):5352-5362 10.1002/ehf2.13626

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Gagnon L.R., Sadasivan C., Perera K., Oudit G.Y.

CANADIAN JOURNAL OF CARDIOLOGY. 2021 November; S0828-282X (21):00809-6 10.1016/j.cjca.2021.10.008

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Nikhanj A., Yogasundaram H., Kimber S., Siddiqi Z.A., Oudit G.Y.

ANNALS OF NONINVASIVE ELECTROCARDIOLOGY. 2021 November; 26 (6) 10.1111/anec.12876

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Lim K.R.Q., Sadasivan C., Oudit G.Y.

CANADIAN JOURNAL OF CARDIOLOGY. 2021 November; 37 (11):1699-1701 10.1016/j.cjca.2021.06.019

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Lim K.R.Q., Shah M.N.A., Woo S., Wilton-Clark H., Zhabyeyev P., Wang F., Maruyama R., Oudit G.Y., Yokota T.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021 November; 22 (23):12617 10.3390/ijms222312617

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Jana S., Aujla P., Hu M., Kilic T., Zhabyeyev P., McCulloch C.A., Oudit G.Y., Kassiri Z.

FASEB JOURNAL. 2021 October; 35 (10) 10.1096/fj.202100038RR

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Chen X., Zhabyeyev P., Azad A.K., Vanhaesebroeck B., Grueter C.E., Murray A.G., Kassiri Z., Oudit G.Y.

Journal of Molecular and Cellular Cardiology. 2021 August; 157 10.1016/j.yjmcc.2021.04.004

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Fernandez K.X., Fischer C., Vu J., Gheblawi M., Wang W., Gottschalk S., Iturrioz X., Llorens-Cortés C., Oudit G.Y., Vederas J.C.

RSC Medicinal Chemistry. 2021 July; 12 (8):1402-1413 10.1039/d1md00120e

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Hu M., Jana S., Kilic T., Wang F., Shen M., Winkelaar G., Oudit G.Y., Rayner K., Zhang D.W., Kassiri Z.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021 June; 41 (6):1874-1889 10.1161/ATVBAHA.120.315522

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Bozso S.J., Kang J.J.H., Basu R., Adam B., Dyck J.R.B., Oudit G.Y., Moon M.C., Freed D.H., Nagendran J., Nagendran J.

J Cardiovasc Transl Res. 2021 June; 14 (3):503-512 10.1007/s12265-020-10080-x

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Wang K., Youngson E., Bakal J.A., Thomas J., McAlister F.A., Oudit G.Y.

ESC Heart Failure. 2021 May; 8 (4):3106-3118 10.1002/ehf2.13417

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Labib D., Satriano A., Dykstra S., Hansen R., Mikami Y., Guzzardi D.G., Slavikova Z., Feuchter P., Flewitt J., Rivest S., Sandonato R., Lydell C.P., Howarth A.G., Kolman L., Clarke B., Paterson D.I., Oudit G.Y., Pituskin E., Cheung W.Y., Lee J., White J.A.

Journal of the American Heart Association. 2021 May; 10 (9) 10.1161/JAHA.120.019811

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Greenwell A.A., Gopal K., Altamimi T.R., Saed C.T., Wang F., Tabatabaei Dakhili S.A., Ho K.L., Zhang L., Eaton F., Kruger J., Batran R.A., Lopaschuk G.D., Oudit G.Y., Ussher J.R.

Am J Physiol Heart Circ Physiol. 2021 April; 320 (6):H2255-H2269 10.1152/AJPHEART.00873.2020

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Yogasundaram H., Alhumaid W., Dzwiniel T., Christian S., Oudit G.Y.

Canadian Journal of Cardiology. 2021 April; 37 (4):547-559 10.1016/j.cjca.2021.01.016

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Zhabyeyev P., Oudit G.Y.

Blood. 2021 March; 137 (9):1138-1139 10.1182/blood.2020009690

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Muus C., Luecken M.D., Eraslan G., Sikkema L., Waghray A., Heimberg G., Kobayashi Y., Vaishnav E.D., Subramanian A., Smillie C., Jagadeesh K.A., Duong E.T., Fiskin E., Triglia E.T., Ansari M., Cai P., Lin B., Buchanan J., Chen S., Shu J., Haber A.L., Chung H., Montoro D.T., Adams T., Aliee H., Allon S.J., Andrusivova Z., Angelidis I., Ashenberg O., Bassler K., Bécavin C., Benhar I., Bergenstråhle J., Bergenstråhle L., Bolt L., Braun E., Bui L.T., Callori S., Chaffin M., Chichelnitskiy E., Chiou J., Conlon T.M., Cuoco M.S., Cuomo A.S.E., Deprez M., Duclos G., Fine D., Fischer D.S., Ghazanfar S., Gillich A., Giotti B., Gould J., Guo M., Gutierrez A.J., Habermann A.C., Harvey T., He P., Hou X., Hu L., Hu Y., Jaiswal A., Ji L., Jiang P., Kapellos T.S., Kuo C.S., Larsson L., Leney-Greene M.A., Lim K., Litvinuková M., Ludwig L.S., Lukassen S., Luo W., Maatz H., Madissoon E., Mamanova L., Manakongtreecheep K., Leroy S., Mayr C.H., Mbano I.M., McAdams A.M., Nabhan A.N., Nyquist S.K., Penland L., Poirion O.B., Poli S., Qi C.C., Queen R., Reichart D., Rosas I., Schupp J.C., Shea C.V., Shi X., Sinha R., Sit R.V., Slowikowski K., Slyper M., Smith N.P., Sountoulidis A., Strunz M., Sullivan T.B., Sun D., Talavera-López C., Tan P., Tantivit J., Travaglini K.J., Tucker N.R., Vernon K.A., Wadsworth M.H., Waldman J., Wang X., Xu K., Yan W., Zhao W., Ziegler C.G.K.

Nature medicine. 2021 March; 27 (3):546-559 10.1038/s41591-020-01227-z

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Kirkham AA, Pituskin E, Thompson RB, Mackey JR, Koshman SL, Jassal D, Pitz M, Haykowsky MJ, Pagano JJ, Chow K, Tsui AK, Ezekowitz JA, Oudit GY, Paterson DI

Eur Heart J Cardiovasc Pharmacother. 2021 February; 10.1093/ehjcvp/pvab016

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Jamieson K.L., Darwesh A.M., Sosnowski D.K., Zhang H., Shah S., Zhabyeyev P., Yang J., Hammock B.D., Edin M.L., Zeldin D.C., Oudit G.Y., Kassiri Z., Seubert J.M.

International Journal of Molecular Sciences. 2021 February; 22 (4):1-22 10.3390/ijms22041691

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Putko B.N., Savu A., Kaul P., Ezekowitz J., Dyck J.R., Anderson T.J., White J.A., Paterson D.I., Thompson R.B., Oudit G.Y.

European Heart Journal Cardiovascular Imaging. 2021 February; 22 (2):220-228 10.1093/ehjci/jeaa041

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Hu M., Jana S., Kilic T., Wang F., Shen M., Winkelaar G., Oudit G.Y., Rayner K., Zhang D.W., Kassiri Z.

Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 January; 10.1161/ATVBAHA.120.315522

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Viveiros A., Rasmuson J., Vu J., Mulvagh S.L., Yip C.Y.Y., Norris C.M., Oudit G.Y.

American Journal of Physiology - Heart and Circulatory Physiology. 2021 January; 320 (1):H296-H304 10.1152/AJPHEART.00755.2020

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Zhang H., Viveiros A., Nikhanj A., Nguyen Q., Wang K., Wang W., Freed D.H., Mullen J.C., MacArthur R., Kim D.H., Tymchak W., Sergi C.M., Kassiri Z., Wang S., Oudit G.Y.

Biochimica et Biophysica Acta - Molecular Basis of Disease. 2021 January; 1867 (1) 10.1016/j.bbadis.2020.165995

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Jantuan E., Chiu B., Chiu B., Shen F., Oudit G.Y., Sergi C.

Transl Oncol. 2021 January; 14 (1) 10.1016/j.tranon.2020.100911

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Lee S.H., Hadipour-Lakmehsari S., Kim D.H., Di Paola M., Kuzmanov U., Shah S., Lee J.J.H., Kislinger T., Sharma P., Oudit G.Y., Gramolini A.O.

Sci Data. 2020 December; 7 (1) 10.1038/s41597-020-00762-1

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Litvinuková M., Talavera-López C., Maatz H., Reichart D., Worth C.L., Lindberg E.L., Kanda M., Polanski K., Heinig M., Lee M., Nadelmann E.R., Roberts K., Tuck L., Fasouli E.S., DeLaughter D.M., McDonough B., Wakimoto H., Gorham J.M., Samari S., Mahbubani K.T., Saeb-Parsy K., Patone G., Boyle J.J., Zhang H., Zhang H., Viveiros A., Oudit G.Y., Bayraktar O.A., Seidman J.G., Seidman C.E., Noseda M., Hubner N., Teichmann S.A.

Nature. 2020 December; 588 (7838):466-472 10.1038/s41586-020-2797-4

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Xu L., Pagano J.J., Haykowksy M.J., Ezekowitz J.A., Oudit G.Y., Mikami Y., Howarth A., White J.A., Dyck J.R.B., Anderson T., Paterson D.I., Thompson R.B., Narine K., Beck J., Tanguay L., Armstrong B., Irwin M.

J Cardiovasc Magn Reson. 2020 December; 22 (1) 10.1186/s12968-020-00680-6