Philip F Halloran
Contact
Professor, Faculty of Medicine & Dentistry - Medicine Dept
- phallora@ualberta.ca
- Phone
- (780) 492-6160
- Address
-
3-036 Li Ka Shing Centre For Research
8602 112 St NWEdmonton ABT6G 2E1
Overview
Area of Study / Keywords
organ transplantation
About
Halloran is a nephrologist – researcher with a focus on organ transplantation and organ diseases, at both the clinical and basic levels. He received his MD and nephrology training from the University of Toronto and his PhD from the University of London. He served on the faculty of the University of Toronto before joining the University of Alberta. His research interests include the mechanisms of organ transplant rejection and injury, and the development of treatments to improve outcomes in transplantation and primary organ diseases. He has studied T cell-mediated rejection and described antibody-mediated kidney rejection, now as the leading cause of late kidney transplant loss (1;2). Halloran is an author of over 300 reviewed publications.Halloran developed the Alberta Transplant Applied Genomics Centre (ATAGC), the world’s leading for molecular studies of organ transplants and organ diseases (http://atagc.med.ualberta.ca/). He has recently developed the Molecular Microscope® Diagnostic System (), a system for reading organ transplant biopsies using microarrays that now being licensed commercially (6).
He was the founding Editor-in-Chief of the world’s leading transplantation journal, the American Journal of Transplantation from 2000 to 2010. He is also the Chairman of the Board of Trustees of the Roche Organ Transplant Research Foundation, a Swiss-based charity. He is an Officer of the Order of Canada, a Fellow of the Royal Society of Canada, and an elected member of the American Society of Clinical Investigation. He is the first recipient of the Paul Terasaki Award from the American Society for Histocompatibility and Immunogenetics. In 2016 he was awarded the medical research Prix Galien for Canada and was named honorary professor at the University of Paris.
Featured Publications
Ulcerative Colitis Disease Activity is Dominated by Features of Innate Immunity
Am J Gastroenterol. 2021;116(Supplement):S394.. 2022 October;
Disease Activity in Ulcerative Colitis is Strongly Associated with the Injury-Repair Response
Am J Gastroenterol. 2021;116(Supplement):S394.. 2022 October;
Madill-Thomsen KS, Reeve J, Aliabadi AZ, Cadeiras M, Crespo-Leiro M, Depasquale EC, Deng M, Goekler J, Kim DH, Kobashigawa J, MacDonald P, Potena L, Shah K, Stehlik J, Zuckermann A, Halloran PF.
Transplantation. 2022 August; 2022 Aug 15. doi: 10.1097/TP.0000000000004231. Online ahead of print. 10.1097/TP.0000000000004231
Halloran P.F., Madill-Thomsen K.S., Pon S., Sikosana M.L.N., Böhmig G.A., Bromberg J., Einecke G., Eskandary F., Gupta G., Hidalgo L.G., Myslak M., Viklicky O., Perkowska-Ptasinska A.
American Journal of Transplantation. 2022 August; 22 (8):1976-1991 10.1111/ajt.17092
Schachtner, T., von Moos, S., Kokkonen, S.M., Helmchen, B., Gaspert, A., Mackova, M., Halloran, P.F., Mueller, T.F.
Transplantation. 2022 August; In press. 10.1097/TP.00000000000042xx
Borski, A., Eskandary, F., Haindl, S., Doberer, K., Muhlbacher, J., Mayer, K. A., Budde, K., Halloran, P. F., Chong, E., Jilma, B., Bohmig, G. A., Wahrmann, M.
Transplantation. 2022 August; 2022 Aug 15. doi: 10.1097/TP.0000000000004285. Online ahead of print. 10.1097/TP.0000000000004285
Top Molecules Associated with CLAD in Lung Transplants Are Shared Between Mucosal Biopsies, Transbronchial Biopsies, and Kidney Transplant Biopsies at Risk of Progression
Am J Transplant. 2022; 22 (suppl 3):480.. 2022 June;
Three-Way Comparison of Central DSA, %dd-cf DNA, and Molecular Biopsy Findings in the Trifecta Study
Am J Transplant. 2022; 22 (suppl 3):386.. 2022 June;
The relative association of clinical variables and histologic lesions with molecular rejection in kidney transplant biopsies
Am J Transplant. 2022;22(S3):428.. 2022 June;
TCMR in Late Kidney Transplant Biopsies Shows Less Molecular TCMR Activity and More Fibrosis Despite Persistence of Tubulitis and Interstitial Infiltrate
Am J Transplant. 2022; 22 (suppl 3):427.. 2022 June;
Molecular associations in kidney transplant biopsies in the Trifecta study indicate that at least three distinct processes release dd-cfDNA: ABMR, TCMR, and injury
Am J Transplant. 2022; 22 (suppl 3):427. . 2022 June;
Defining new arterial and arteriolar lesions accompanying transplant glomerulopathy: Potential additions to the histologic assessment of ABMR
Am J Transplant. 2022;22(S3):960.. 2022 June;
Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of T-cell Mediated Rejection in Kidney Transplant Biopsies
Am J Transplant. 2022;22(S3):1079.. 2022 June;
Halloran PF, Reeve J, Madill-Thomsen KS, Kaur N, Ahmed E, Cantos C, Al Haj Baddar N, Demko Z, Liang N, Swenerton RK, Zimmermann BG, Van Hummelen P, Prewett A, Rabinowitz M, Tabriziani H, Gauthier P, Billings P, Trifecta Investigators
Transplantation. 2022 June; 2022 Jun 29. doi: 10.1097/TP.0000000000004212. Online ahead of print. 10.1097/TP.0000000000004212
A New Algorithm Combining Donor Derived Cell-Free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses
Am J Transplant. 2022;22(S3):802.. 2022 June;
Histologic Borderline reflects molecular injury not rejection: results from the Trifecta study
Am J Transplant. 2022; 22 (suppl 3):1078.. 2022 June;
Gupta G., Moinuddin I., Kamal L., King A.L., Winstead R., Demehin M., Kang L., Kimball P., Levy M., Bhati C., Massey H.D., Kumar D., Halloran P.F.
Transplantation. 2022 May; 106 (5):1061-1070 10.1097/TP.0000000000003838
Halloran P.F., Madill-Thomsen K.S.
Journal of Heart and Lung Transplantation. 2022 May; 41 (5):668-669 10.1016/j.healun.2022.02.006
Parkes M.D., Halloran K., Hirji A., Pon S., Weinkauf J., Timofte I.L., Snell G.I., Westall G.P., Havlin J., Lischke R., Zajacová A., Hachem R., Kreisel D., Levine D., Kubisa B., Piotrowska M., Juvet S., Keshavjee S., Jaksch P., Klepetko W., Halloran P.F.
American Journal of Transplantation. 2022 April; 22 (4):1054-1072 10.1111/ajt.16895
Mayer K.A., Budde K., Halloran P.F., Doberer K., Rostaing L., Eskandary F., Christamentl A., Wahrmann M., Regele H., Schranz S., Ely S., Firbas C., Schörgenhofer C., Kainz A., Loupy A., Härtle S., Boxhammer R., Jilma B., Böhmig G.A.
Trials. 2022 April; 23 (1) 10.1186/s13063-022-06198-9
Halloran P.F., Böhmig G.A., Bromberg J., Einecke G., Eskandary F.A., Gupta G., Myslak M., Viklicky O., Perkowska-Ptasinska A., Madill-Thomsen K.S.
Frontiers in Medicine. 2022 April; 9 (2022 Apr 7;9:817324. doi: 10.3389/fmed.2022.817324. eCollection 2022.) 10.3389/fmed.2022.817324
Deletion of the Natural Killer Cell Receptor NKG2C Encoding KLR2C Gene and Kidney Transplant Outcome
Vietzen H., Döhler B., Tran T.H., Süsal C., Halloran P.F., Eskandary F., Herz C.T., Mayer K.A., Kozakowski N., Wahrmann M., Ely S., Haindl S., Puchhammer-Stöckl E., Böhmig G.A.
Frontiers Immunology. 2022 March; 13 (2022 Mar 24;13:829228. doi: 10.3389/fimmu.2022.829228. eCollection 2022.) 10.3389/fimmu.2022.829228
Halloran P.F., Madill-Thomsen K., Aliabadi-Zuckermann A.Z., Cadeiras M., Crespo-Leiro M.G., Depasquale E.C., Deng M., Gökler J., Kim D.H., Kobashigawa J., Macdonald P., Potena L., Shah K., Stehlik J., Zuckermann A.
Journal of Heart and Lung Transplantation. 2022 March; 41 (3):334-344 10.1016/j.healun.2021.08.004
Madill-Thomsen K.S., Abouljoud M., Bhati C., Ciszek M., Durlik M., Feng S., Foroncewicz B., Francis I., Grat M., Jurczyk K., Klintmalm G., Krasnodebski M., McCaughan G., Miquel R., Montano-Loza A., Moonka D., Mucha K., Myslak M., Paczek L., Perkowska-Ptasinska A., Piecha G., Reichman T., Sanchez-Fueyo A., Tronina O., Wawrzynowicz-Syczewska M., Wiecek A., Zieniewicz K., Halloran P.F.
American Journal of Transplantation. 2022 March; 22 (3):909-926 10.1111/ajt.16890
Halloran P.F., Reeve J., Madill-Thomsen K.S., Demko Z., Prewett A., Billings P.
Journal of the American Society of Nephrology. 2022 February; 33 (2):387-400 10.1681/ASN.2021091191
Parikh M., Shah S., Basu R., Famulski K.S., Kim D., Mullen J.C., Halloran P.F., Oudit G.Y.
International Journal of Molecular Sciences. 2022 February; 23 (4):2050 10.3390/ijms23042050
Halloran P.F., Einecke G., Sikosana M.L.N., Madill-Thomsen K.
Handbook of Experimental Pharmacology. 2022 January; 272 10.1007/164_2021_557
Hruba P., Madill-Thomsen K., Mackova M., Klema J., Maluskova J., Voska L., Parikova A., Slatinska J., Halloran P.F., Viklicky O.
Scientific Reports. 2021 December; 11 (1) 10.1038/s41598-021-88190-y
Agbor-Enoh S., Oellerich M., Wu A., Halloran P.F., De Vlaminck I., Keller M.
Clinical Chemistry. 2021 November; 67 (11):1443-1449 10.1093/clinchem/hvab183
Halloran P.F., Madill-Thomsen K.S., Böhmig G.A., Myslak M., Gupta G., Kumar D., Viklicky O., Perkowska-Ptasinska A., Famulski K.S.
Transplantation. 2021 November; 105 (11):2374-2384 10.1097/TP.0000000000003884
Madill-Thomsen K.S., Böhmig G.A., Bromberg J., Einecke G., Eskandary F., Gupta G., Hidalgo L.G., Myslak M., Viklicky O., Perkowska-Ptasinska A., Halloran P.F., Mannon R., Serón D., Sellarés J., Akalin E., de Freitas D., Picton M., Weir M., Budde K., Heinbokel T., Yang H., Narins S., Samaniego-Picota M., Lefaucheur C., Loupy A., Bingaman A., Brennan D., Malone A., Kasiske B., Matas A., Djamali A.
Journal of the American Society of Nephrology. 2021 November; 32 (11):2743-2758 10.1681/ASN.2021040433
DSA-negative HLA antibody-negative molecular ABMR releases donor-derived cell-free DNA in the Trifecta study
Human Immunology. 2021;82(ASHI Supplement):96.. 2021 September;
Mühlbacher J., Schörgenhofer C., Doberer K., Dürr M., Budde K., Eskandary F., Mayer K.A., Schranz S., Ely S., Reiter B., Chong E., Adler S.H., Jilma B., Böhmig G.A.
TRANSPLANT INTERNATIONAL. 2021 June; doi: 10.1111/tri.13954. Online ahead of print. 10.1111/tri.13954
Gaurav Gupta, Irfan Moinuddin, Layla Kamal, Anne L King, Ryan Winstead, Moses Demehin, Le Kang, Pamela Kimball, Marlon Levy, Chandra Bhati, H Davis Massey, Dhiren Kumar, Philip F Halloran
TRANSPLANTATION. 2021 May; online ahead of print 10.1097/TP.0000000000003838
Discovering novel injury features in kidney transplant biopsies associated with TCMR and donor aging
Halloran P.F., Böhmig G.A., Bromberg J.S., Budde K., Gupta G., Einecke G., Eskandary F., Madill-Thomsen K., Reeve J., Picton M., Heinbokel T., Yang H., Narins S., Lefaucheur C., Loupy A., Myslak M., Kasiske B., Matas A., Djamali A.
American Journal of Transplantation. 2021 May; 21 (5):1725-1739 10.1111/ajt.16374
Hruba P., Madill-Thomsen K., Mackova M., Maluskova J., Voska L., Slatinska J., Halloran P.F., Viklicky O.
Transplant International. 2021 May; 34 (5):974-985 10.1111/tri.13856
Molecular definition of Chronic Lung Allograft Dysfunction: Results from a Multicenter International Cohort
Journal of Heart and Lung Transplantation. 2021 April;
VP2 MRNA Distinguishes the Direct Injury and Inflammation Effects of Polyoma Virus (BK) Infection from the Cognate TCMR Response That Follows Immunosuppressive Minimization
American Journal of Transplantation. 2021 April;
The Trifecta Study: Calibrating Circulating Donor-Derived Cell-Free DNA at the Time of Indication Biopsies Against the Molecular Phenotype of the Biopsy Reveals a Prominent Association With NK Cell Genes
American Journal of Transplantation. 2021 April;
Relationship Between %dd-cfDNA, MMDx Molecular Diagnoses, and Donor-specific Antibody in the Trifecta Study
American Journal of Transplantation. 2021 April;
Reassessing TCMR in Kidney Transplant Indication Biopsies: Emerging Evidence for Partial Exhaustion in Late TCMR
American Journal of Transplantation. 2021 April;
New molecular classification of rejection in heart transplant biopsies reveals relatively little three year graft loss in antibody-mediated rejection
Journal of Heart and Lung Transplantation. 2021 April;
Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss
American Journal of Transplantation. 2021 April;
Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding
American Journal of Transplantation. 2021 April;
Halloran P.F.
Clinical Transplantation. 2021 April; 35 (4) 10.1111/ctr.14244
Einecke G., Reeve J., Gupta G., Böhmig G.A., Eskandary F., Bromberg J.S., Budde K., Halloran P.F., Picton M., Heinbokel T., Yang H., Narins S., Lefaucheur C., Loupy A., Myslak M., Kasiske B., Matas A., Djamali A.
American Journal of Transplantation. 2021 April; 21 (4):1391-1401 10.1111/ajt.16161
DSA is Associated With Molecular Changes in Many Hearts With Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection
American Journal of Transplantation. 2021 April;
DSA Causes Mild Molecular ABMR-like Changes in Many Biopsies Not Diagnosed as Rejection
American Journal of Transplantation. 2021 April;
A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies
American Journal of Transplantation. 2021 April;
Molecular Assessment of Fibrosis and Steatohepatitis in the INTERLIVER Study
American Journal of Transplantation. 2021 April;
Doberer K., Duerr M., Halloran P.F., Eskandary F., Budde K., Regele H., Reeve J., Borski A., Kozakowski N., Reindl-Schwaighofer R., Waiser J., Lachmann N., Schranz S., Firbas C., Mühlbacher J., Gelbenegger G., Perkmann T., Wahrmann M., Kainz A., Ristl R., Halleck F., Bond G., Chong E., Jilma B., Böhmig G.A.
Journal of the American Society of Nephrology. 2021 March; 32 (3):708-722 10.1681/ASN.2020071106
Mayer K.A., Doberer K., Eskandary F., Halloran P.F., Bohmig G.A.
Current Opinion in Organ Transplantation. 2021 February; 26 (1):97-105 10.1097/MOT.0000000000000832
Alam A., Halloran P.F., Mathew C., Fathima S., Ghazi A., Kale P., Hall S.A.
Methodist Debakey Cardiovasc J. 2021 January; 17 (2):e14-e17 10.14797/PREM9909
Doberer K., Kläger J., Gualdoni G.A., Mayer K.A., Eskandary F., Farkash E.A., Agis H., Reiter T., Reindl-Schwaighofer R., Wahrmann M., Cohen G., Haslacher H., Bond G., Simonitsch-Klupp I., Halloran P.F., Böhmig G.A.
Transplantation. 2021 January; 10.1097/TP.0000000000003247
Riddell P., Moshkelgosha S., Levy L., Chang N., Pal P., Halloran K., Halloran P., Parkes M., Singer L.G., Keshavjee S., Martinu T., Juvet S.C.
Clinical & Translational Immunology. 2021 January; 10 (2) 10.1002/cti2.1243
Riddell P., Moshkelgosha S., Levy L., Chang N., Pal P., Halloran K., Halloran P., Parkes M., Singer L.G., Keshavjee S., Martinu T., Juvet S.C.
Clinical and Translational Immunology. 2021 January; 10 (2) 10.1002/cti2.1243
Kumar D., Raynaud M., Chang J., Reeve J., Yakubu I., Kamal L., Levy M., Bhati C., Kimball P., King A., Massey D., Halloran P., Gupta G.
Transplantation. 2021 January; 10.1097/TP.0000000000003278
Hruba P., Madill-Thomsen K., Mackova M., Klema J., Maluskova J., Voska L., Parikova A., Slatinska J., Halloran P.F., Viklicky O.
Scientific Reports. 2020 December; 10 (1) 10.1038/s41598-020-79332-9
Discovering novel injury features in kidney transplant biopsies associated with TCMR and donor aging
Halloran P.F., Böhmig G.A., Bromberg J.S., Budde K., Gupta G., Einecke G., Eskandary F., Madill-Thomsen K., Reeve J., Picton M., Heinbokel T., Yang H., Narins S., Lefaucheur C., Loupy A., Myslak M., Kasiske B., Matas A., Djamali A.
AMERICAN JOURNAL OF TRANSPLANTATION. 2020 November; 21 (5):1725-1739 10.1111/ajt.16374
The Trifecta study: Calibrating circulating donor-derived cell-free DNA at the time of indication biopsies against the molecular phenotype of the biopsy
Human Immunology. 2020 October;