Peter Senior

Professor, Faculty of Medicine & Dentistry - Medicine Dept
Director, Faculty of Medicine & Dentistry - Alberta Diabetes Research Institute

Contact

Professor, Faculty of Medicine & Dentistry - Medicine Dept
Email
psenior@ualberta.ca

Director, Faculty of Medicine & Dentistry - Alberta Diabetes Research Institute
Email
psenior@ualberta.ca
Address
1.005 Li Ka Shing Centre For Research
8602 112 St NW
Edmonton AB
T6G 2E1

Overview

Area of Study / Keywords

Coronary artery disease PET-CT Diabetes Insulin analog CSII cardiovascular disease primary prevention anti-platelet islet transplant incretin nephropathy proteinuria PDE-5 inhibitor diabetes gastroparesis motilin agonist type 1 diabetes immunotherapy clinical trial intervention


About

Charles A Allard Chair in Diabetes Research

Director, Alberta Diabetes Institute

Professor, Division of Endocrinology & Metabolism

Degrees

  • BMedSci (Hons) University of Newcastle Upon Tyne 1992
  • MBBS (Hons) University of Newcastle Upon Tyne 1993
  • PhD University of Newcastle Upon Tyne 2002

Clinical Expertise

  • Type 1 Diabetes
  • Complex Diabetes
  • Clinical Islet Transplantation
  • Insulin Pump Therapy
  • General Endocrinology
  • Diabetic Nephropathy



Clinical Interests

  • Type 1 diabetes
  • Hypoglycemia
  • Insulin Pump Therapy
  • Automated insulin delivery
  • Diabetic Nephropathy
  • Atypical types of diabetes
    • Monogenic
    • Pancreatogenic

Research

Research

Clinical Islet Transplantation

  • refining and enhancing the edmonton Protocol
  • describing clinical and metabolic outcomes after islet transplant
  • developing clinical tools to track islet function over time
  • testing new sites for islet transplantation
  • phase 1/2 trials of stem cell derived beta cells

Diabetic Nephropathy 

  • health services research examining the effectiveness of community diabetic nephropathy prevention clinics
  • Preventing Early Renal Loss in Diabetes (www.perl-study.org)

Clinical Trials

  • interventions for new onset type 1 diabetes
  • phase 2 and 3 clinical trials of new agents to treat diabetes or its complications

Autoimmune Complications of Lymphodepleting Therapies in MS


Teaching

Teaching

Clinical Teaching

much of my teaching is done in clinics and the hospital

Classroom Teaching

DMED 513, PMCOL 402/502, MED 608

Continuing Medical Education

regularly deliver CME locally, nationally, and internationally 

Featured Publications

Taylor PN, Collins KS, Lam A, Karpen SR, Greeno B, Walker F, Lozano A, Atabakhsh E, Ahmed ST, Marinac M, Latres E, Senior PA, Rigby M, Gottlieb PA, Trial Outcome Markers Initiative collaboration

The lancet. Diabetes & endocrinology. 2023 November; 10.1016/s2213-8587(23)00267-x


Liyanage V, Barrett O, Ngwezi D, Savu A, Senior P, Yeung RO, Butalia S, Kaul P

Diabetic medicine : a journal of the British Diabetic Association. 2023 October; 10.1111/dme.15247


Diabetes Canada Clinical Practice Guidelines Expert Working Group:, Lega IC, Yale JF, Chadha A, Paty B, Roscoe R, Snider M, Steier J, Sherifali D

Canadian journal of diabetes. 2023 October; 10.1016/j.jcjd.2023.08.003


Galderisi A, Carr ALJ, Martino M, Taylor P, Senior P, Dayan C

Diabetologia. 2023 September; 10.1007/s00125-023-06011-5


Ilana J. Halperin, Alanna Chambers, Lynda Covello, Kate Farnsworth, Amy E. Morrison, Udo Schuklenk, Holly O. Witteman, Peter Senior, Harpreet S. Bajaj, Tracy Barnes, Jeremy Gilbert, Kristin Honshorst, James Kim, Joanne Lewis, Barbara MacDonald, Dylan Mackay, Kerry Mansell, Doreen Rabi, Peter Senior, Diana Sherifali

Canadian Journal of Diabetes. 2023 July; 10.1016/j.jcjd.2023.05.006


Diabetes Canada Clinical Practice Guidelines Expert Working Group:, Robinson DJ, Hanson K, Jain AB, Kichler JC, Mehta G, Melamed OC, Vallis M, Senior P

Canadian journal of diabetes. 2023 June; 10.1016/j.jcjd.2023.04.009


Racey M, Whitmore C, Alliston P, Cafazzo JA, Crawford A, Castle D, Dragonetti R, Fitzpatrick-Lewis D, Jovkovic M, Melamed OC, Naeem F, Senior P, Sherifali D

JMIR diabetes. 2023 May; 10.2196/44652


Verhoeff K, Marfil-Garza BA, Czarnecka Z, Cuesta-Gomez N, Tewari Jasra I, Dadheech N, Senior PA, Shapiro AMJ

The Journal of clinical endocrinology and metabolism. 2023 May; 10.1210/clinem/dgad257


Chetboun M, Drumez E, Ballou C, Maanaoui M, Payne E, Barton F, Kerr-Conte J, Vantyghem MC, Piemonti L, Rickels MR, Labreuche J, Pattou F, Collaborative Islet Transplant Registry (CITR) Investigators study group

The lancet. Diabetes & endocrinology. 2023 April; 10.1016/s2213-8587(23)00082-7


Diabetes Canada Clinical Practice Guidelines Expert Working Group:, Gilbert J, McFarlane P, Kim J, Jin S, Senior P, Diabetes Canada Clinical Practice Guidelines Dissemination & Implementation Committee and the Clinical Practice Guidelines Steering Committee, Dissemination & Implementation Committee:, Gilbert J, Bajaj HS, Jin S, Kim J, Steering Committee:, Bajaj HS, Gilbert J, Houlden R, Kim J, MacDonald B, MacKay D, Mansell K, Rabi D, Sherifali D, Senior P

Canadian journal of diabetes. 2023 January; 10.1016/j.jcjd.2023.01.006


Senior, Peter A

Canadian Diabetes & Endocrinology Today. 2023 January; 10.58931/cdet.2023.1211


Multiple Sclerosis Journal - Experimental, Translational and Clinical. 2023 January; 10.1177/20552173221142741


Anna Lam, Richard Oram, Shareen Forbes, Tolu Olateju, Sharleen Imes, Andrew J Malcolm, AM James Shapiro, Peter A Senior

TRANSPLANT INTERNATIONAL. 2022 July; 35 10.3389/ti.2022.10335


Amy E.Morrison, Peter A.Senior, TaniaBubela, KateFarnsworth, HollyWitteman, AnnaLam

Canadian Journal of Diabetes. 2022 June; https://doi.org/10.1016/j.jcjd.2022.06.003


Kevin Verhoeff, Braulio A Marfil-Garza, Gurpal Sandha, David Cooper, Khaled Dajani, David L Bigam, Blaire Anderson, Tatsuya Kin, Anna Lam, Doug O’Gorman, Peter A Senior, Camillo Ricordi, AM James Shapiro

TRANSPLANTATION. 2022 June; DOI: 10.1097/TP.0000000000004180


KellyPicard, Peter A.Senior, AshleyWilmott, KailashJindal, CarolineRichard, Diana R.Mager

CANADIAN JOURNAL OF DIETETIC PRACTICE AND RESEARCH. 2022 May; https://doi.org/10.3148/cjdpr-2022-009


Marfil-Garza B.A., Imes S., Verhoeff K., Hefler J., Lam A., Dajani K., Anderson B., O'Gorman D., Kin T., Bigam D., Senior P.A., Shapiro A.M.J.

Lancet Diabetes & Endocrinology. 2022 May; 10 (7):519-532 10.1016/S2213-8587(22)00114-0


Lane W., Favaro E., Jódar E., Kelkar P., Oviedo A., Sivarathinasami R., Senior P.A., Sesti G., Franek E.

Diabetes Therapy. 2022 April; 13 (4):761-774 10.1007/s13300-022-01213-3


IMPROVED GLYCEMIA AND QUALITY OF LIFE AMONG LOOP USERS-A RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA FROM A SINGLE CENTRE.

DIABETES TECHNOLOGY & THERAPEUTICS. 2022 April;


Bonhoure A., Potter K.J., Reynaud Q., Boudreau V., Senior P.A., Tremblay F., Lavoie A., Durieu I., Rabasa-Lhoret R.

Canadian Journal of Diabetes. 2022 April; 46 (3):294-301.e2 10.1016/j.jcjd.2021.11.004


Severity of proteinuria is associated with incident fragility fractures in patients with chronic kidney disease independent of estimated glomerular filtration rate.

JOURNAL OF BONE AND MINERAL RESEARCH. 2022 April;


WHO IS USING DO-IT-YOURSELF ARTIFICIAL PANCREAS SYSTEMS AND WHY

DIABETES TECHNOLOGY & THERAPEUTICS. 2022 April;


Peter Senior, Martin Drage, Anneliese Flatt, Chris Callaghan

Oxford Textbook of Endocrinology and Diabetes. 2022 March; (3rd edition) 10.1093/med/9780198870197.003.0258


Yewande Kofoworola Ogundejia, Amity Quinn, Meaghan Lunney, Christy Chong, Derek Chew, Shelley Duggan, Alun Edwards, Peter Senior, Glen Sumner, Jennifer Williams, Kelly Zarnke, Braden Manns

The American Journal of Accountable Care. 2022 March; 10 (1):8-18 https://doi.org/10.37765/ajac.2022.88847


Mathe N., Ryan A., Cook A., Sargious P., Senior P., Johnson J.A., Yeung R.O.

Canadian Journal of Diabetes. 2022 January; 10.1016/j.jcjd.2021.12.001


Marasinghe D.H., Butalia S., Garies S., Drummond N., Kim J.W., Senior P.A.

Canadian Journal of Diabetes. 2022 January; 10.1016/j.jcjd.2022.02.002


A Hemoglobin A1c Greater Than 6.0% is Associated With Lower Lung Function in Adults at Risk for Cystic Fibrosis-Related Diabetes

Canadian Journal of Diabetes. 2021 December;


Transplantation. 2021 December; 10.1097/01.tp.0000804384.59881.c9


Syron L., Cheng A.Y.Y., Senior P.

Canadian Journal of Diabetes. 2021 December; 45 (8):695-696 10.1016/j.jcjd.2021.10.009


Characterization of Intermittently Scanned Glucose Monitoring Profiles in Patients at Risk for Cystic Fibrosis-Related Diabetes

Canadian Journal of Diabetes. 2021 December;


Connect1d Canada Validation Study in Patient-Driven Design to Accelerate Research in Type 1 Diabetes

Canadian Journal of Diabetes. 2021 December;


Effect of a Resistance Exercise Intervention on Frailty Outcomes in Adults With Diabetes Mellitus

Canadian Journal of Diabetes. 2021 December;


Insulinogenic Index and Early Phase Insulin Secretion Predict Increased Risk of Worsening Glucose Tolerance and of Cystic Fibrosis-Related Diabetes

Canadian Journal of Diabetes. 2021 December;


Marginal Association of Fasting Blood Glucose With the Risk of Cystic Fibrosis Related Diabetes

Canadian Journal of Diabetes. 2021 December;


Mind the Gap: Low Use of Guideline Recommended Cardiorenal Protective Antihyperglycemics in Primary Care

Canadian Journal of Diabetes. 2021 December;


Transplantation. 2021 December; 10.1097/01.tp.0000804504.96321.95


Prevalence of Post-Glucose Challenge Hypoglycemia in Adult Patients with Cystic Fibrosis and Relevance to the Risk of Cystic Fibrosis-Related Diabetes

Canadian Journal of Diabetes. 2021 December;


Starting the Process of Quality Improvement in Edmonton’s Tertiary Diabetes Clinics: Getting Our Data Ducks in a Row

Canadian Journal of Diabetes. 2021 December;


Senior P.A.

ATHEROSCLEROSIS. 2021 October; 335 10.1016/j.atherosclerosis.2021.09.001


Cheng A.Y.Y., Feig D.S., Ho J., Siemens R., Bajaj H., Gilbert J., Houlden R., Kim J., Mackay D., Rabi D.M., Sherifali D. Senior P.

Canadian Journal of Diabetes. 2021 October; 45 (7):580-587 10.1016/j.jcjd.2021.07.003


Potter K.J., Reynaud Q., Boudreau V., Racine F., Tremblay F., Lavoie A., Carricart M., Mailhot G., Durieu I., Senior P.A., Rabasa-Lhoret R.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021 October; 106 (10):E3901-E3910 10.1210/clinem/dgab384


Potter K.J., Boudreau V., Shohoudi A., Mailhot M., Tremblay F., Lavoie A., Carricart M., Senior P.A., Rabasa-Lhoret R.

Journal of Cystic Fibrosis. 2021 September; 20 (5):803-809 10.1016/j.jcf.2020.11.022


Ogundeji Y.K., Quinn A., Lunney M., Chong C., Chew D., Hopkin G., Senior P., Sumner G., Williams J., Manns B.

Healthcare Policy. 2021 August; 17 (1):58-72 10.12927/HCPOL.2021.26577


Diabetes. 2021 June; 10.2337/db21-731-P


Picard K., Senior P.A., Adame Perez S., Jindal K., Richard C., Mager D.R.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 2021 May; 31 (5):1445-1453 10.1016/j.numecd.2021.02.002


Outcomes in Alemtuzumab-Treated Patients With Thyroid Adverse Events: 6-Year Pooled CARE-MS Data

Neurology Apr 2021, 96 (15 Supplement) 1509. 2021 April;


von Herrath M., Bain S.C., Bode B., Clausen J.O., Coppieters K., Gaysina L., Gumprecht J., Hansen T.K., Mathieu C., Morales C., Mosenzon O., Segel S., Tsoukas G., Pieber T.R., Ludvik B., Prager R., Paulweber B., Ebenbichler C.F., Keymeulen B., De Block C., Grossman L., Houlden R., Perron P., Ransom T., Senior P., Weisnagel S.J., Woo V., Dumas R., Thompson D., Vilsbøll T., Gram J., Juhl C.B., Hukkanen J., Lahtela J., Niskanen L., O'Shea D., O'Brien T., Sreenan S., Wainstein J., Phillip M., Knobler H., Dotta F., Piatti P.M., Roberto T., Gnasso A., Gulseth H., Cooper J., Pankowska E., Lukaszewicz M., Wolnik B., Manita I., Marques O., Roque C., Príncipe R.M., Neves C., Heitor S., Ruyatkina L., Dvoryashina I., Vagapova G., Belousova L., Sergeeva-Kondrachenko M., Peskov A., Frolova E., Golovach A., Kunitsyna M., Krasnopeeva (Kabachkova) N., Ipatko I., De la Cuesta C., Tinahones F.J., Rigla M., Merino J.F., Gómez L.A., Fernández M., Simó R., Rydén M., Jendle J., Filipsson K., Eliasson B., Mankovsky B., Lymar I., Sokolova L., Myshanych G., Zlova T., Vlasenko M., Kuskalo P., Courtney H., Dayan C., English P., Heller S., Johnson A.B., Nair S., Leslie R.D., Narendran P., Oliver N., Ramtoola S., Shaw J., Viljoen A., Al-Karadsheh A., Dostou J.M., Gangi S., Gottlieb P., Jerkins T., Magnotti M., Marks J., Nakhle S., Bonabi G., Myers L., Pratley R., Hagopian W., Pettus J., von Scholten B.J., Wesley J.D., Kreiner F.F.

Lancet Diabetes & Endocrinology. 2021 April; 9 (4):212-224 10.1016/S2213-8587(21)00019-X


CONNECT1D-A NATIONAL, DIGITAL-FIRST, T1D REGISTRY TO ACCELERATE PATIENT-ORIENTED RESEARCH, POLICY, AND CLINICAL CARE.

DIABETES TECHNOLOGY & THERAPEUTICS. 2021 April;


Ogundeji Y.K., Quinn A., Lunney M., Chong C., Chew D., Danso G., Duggan S., Edwards A., Hopkin G., Senior P., Sumner G., Williams J., Manns B.

HEALTH POLICY. 2021 April; 125 (4):442-449 10.1016/j.healthpol.2020.12.014


Outcomes in Alemtuzumab-Treated Patients With Thyroid Adverse Events: 6-Year Pooled CARE-MS Data

Neurology. 2021 April;


Markmann J.F., Rickels M.R., Eggerman T.L., Bridges N.D., Lafontant D.E., Qidwai J., Foster E., Clarke W.R., Kamoun M., Alejandro R., Bellin M.D., Chaloner K., Czarniecki C.W., Goldstein J.S., Hering B.J., Hunsicker L.G., Kaufman D.B., Korsgren O., Larsen C.P., Luo X., Naji A., Oberholzer J., Posselt A.M., Ricordi C., Senior P.A., Shapiro A.M.J., Stock P.G., Turgeon N.A.

AMERICAN JOURNAL OF TRANSPLANTATION. 2021 April; 21 (4):1477-1492 10.1111/ajt.16174


Haddadi D., Rosolowsky E., Pacaud D., McKeen J., Young K., Madrick B., Domaschuk L., Sargious P., Conroy S., Senior P.A.

Canadian Journal of Diabetes. 2021 April; 45 (3):228-235.e4 10.1016/j.jcjd.2020.08.097


Outcomes in alemtuzumab-treated patients with thyroid adverse events: 6-year pooled care-ms data

MULTIPLE SCLEROSIS JOURNAL 26 (3_ SUPPL), 179-180. 2021 February;


Bajaj H.S., Bergenstal R.M., Christoffersen A., Davies M.J., Gowda A., Isendahl J., Lingvay I., Senior P.A., Silver R.J., Trevisan R., Rosenstock J.

DIABETES CARE. 2021 January; 44 (7):1586-1594 10.2337/dc20-2877


Open Forum Infect Dis. 2020 Oct; 7(Suppl 1): S576.. 2020 December; 10.1093/ofid/ofaa439.1279


Rosenstock J., Bajaj H.S., Jane� A., Silver R., Begtrup K., Hansen M.V., Jia T., Goldenberg R.

NEW ENGLAND JOURNAL OF MEDICINE. 2020 November; 383 (22):2107-2116 10.1056/NEJMoa2022474


Canadian Journal of Diabetes VOLUME 44, ISSUE 7, SUPPLEMENT , S22-S23, . 2020 October; https://doi.org/10.1016/j.jcjd.2020.08.058


Residents’ Perspectives on Management of Diabetic Ketoacidosis in a Large Teaching Hospital

Can J Diabetes. 2020 October;


Senior P.A., Houlden R.L., Kim J., Mackay D., Nagpal S., Rabi D., Sherifali D., Bajaj H.S.

Canadian Journal of Diabetes. 2020 October; 44 (7):592-596 10.1016/j.jcjd.2020.08.002


Lipscombe L., Butalia S., Dasgupta K., Eurich D.T., MacCallum L., Shah B.R., Simpson S., Senior P.A.

Canadian Journal of Diabetes. 2020 October; 44 (7):575-591 10.1016/j.jcjd.2020.08.001


Infectious Complications after Pancreatic Islet Transplantation

Open Forum Infectious Diseases. 2020 October;


Senior P., Lam A., Farnsworth K., Perkins B., Rabasa-Lhoret R.

Current Diabetes Reports. 2020 October; 20 (10):52 10.1007/s11892-020-01339-3


Efficacy and safety of fast-acting insulin aspart in adults with type 2 diabetes with different insulin requirements

DIABETOLOGIA 63 (SUPPL 1), S330-S330. 2020 September;


Efficacy and safety of fast-acting insulin aspart in adults with type 2 diabetes with different insulin requirements

Diabetologia. 2020 September;


Colomba J., Rabasa-Lhoret R., Bonhoure A., Bergeron C., Boudreau V., Tremblay F., Senior P., Potter K.

Journal of Cystic Fibrosis. 2020 September; 19 (5):704-711 10.1016/j.jcf.2020.04.004


Building a clinical trial simulation tool for disease modifying therapies in type 1 diabetes (TOMI-T1D)

DIABETOLOGIA 63 (SUPPL 1), S160-S161. 2020 September;


Building a clinical trial simulation tool for disease modifying therapies in type 1 diabetes (TOMI-T1D)

Diabetologia. 2020 September;


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